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1. 发明授权

US5876984A Sequiterpene derivatives having antiviral activity 失效
标题翻译：具有抗病毒活性的顺反萜衍生物
公开(公告)号：US5876984A
公开(公告)日：1999-03-02
申请号：US43449
申请日：1998-03-20
申请人： Toshiyuki Kamigauchi , Tamio Fujiwara , Hiroyoshi Tani , Yoshimi Kawamura , Isao Horibe
发明人： Toshiyuki Kamigauchi , Tamio Fujiwara , Hiroyoshi Tani , Yoshimi Kawamura , Isao Horibe
IPC分类号： C07D491/052 , C12P17/18 , A61K00/00 , C07D209/56 , C12P1/02 , C07D311/79
CPC分类号： C12P17/18 , C12P17/181
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt, or a hydrate thereof, a process for preparing said compound, and a pharmaceutical composition having antiviral activity which comprise said compound.
摘要翻译： PCT No.PCT / JP96 / 02749第 371日期：1998年3月20日 102（e）1998年3月20日PCT PCT 1996年9月25日PCT公布。第WO97 / 11947号公报日期：1997年4月3日制备所述化合物的方法和含有所述化合物的抗病毒活性的药物组合物，式（I）化合物：其中R 1，R 2，

2. 发明授权

US3998697A Process for preparing 2-keto-L-gulonic acid 失效
标题翻译：制备2-酮-L-古洛糖酸的方法
公开(公告)号：US3998697A
公开(公告)日：1976-12-21
申请号：US569852
申请日：1975-04-21
申请人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
发明人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
IPC分类号： C07H7/027 , C12P7/42 , C12P7/58 , C12P7/60 , C12D1/06
CPC分类号： C07H7/027 , C12P7/58 , C12P7/60 , Y10S435/823 , Y10S435/84 , Y10S435/843
摘要： 2-Keto-L-gulonic acid is prepared directly from D-glucose by microbial conversion utilizing mixed culturing on or mixed contacting with a medium containing D-glucose, employing at least two kind of microorganisms; 2,5-diketo-D-gluconic acid producing strains which belong to the genera of Acetobacter, Acetomonas and Gluconobacter and strains capable of converting the 2,5-diketo-D-gluconic acid into 2-keto-L-gulonic acid which belong to the general of Brevibacterium and Corynebacterium. Both the incubation of the microorganisms in a medium containing D-glucose and the direct contact of any products obtained from the cells of the microorganisms with the substrate may be used in the disclosed process. By-production of the undesired optical isomer, 2-keto-D-gluconic acid, of the intended product is effectively prevented by employing the mixed culturing or contacting because of the presence of the 2,5-diketo-D-gluconic acid producing strain or any products thereof in the medium during at least part of the entire process.
摘要翻译：通过使用至少两种微生物的混合培养或与含有D-葡萄糖的培养基混合接触，通过微生物转化直接由D-葡萄糖制备2-酮-L-古洛糖酸; 属于醋杆菌属，醋酸杆菌属和葡萄糖酸杆菌属的2,5-二酮-D-葡萄糖酸生产菌株和能够将2,5-二酮-D-葡萄糖酸转化成2-酮-L-古洛糖酸的菌株，其属于到短杆菌属和棒杆菌属的一般。在所公开的方法中可以使用在含有D-葡萄糖的培养基中培养微生物和从微生物细胞获得的任何产物与底物的直接接触。由于存在2,5-二酮-D-葡糖酸生产菌株，通过使用混合培养或接触有效地防止了所需产物的不需要的光学异构体2-酮-D-葡萄糖酸的副产物或其整个过程的至少部分期间在介质中的任何产物。

3. 发明授权

US3963574A Process for producing 2-keto-L-gulonic acid 失效
标题翻译： 2-酮-L-古洛糖酸的制备方法
公开(公告)号：US3963574A
公开(公告)日：1976-06-15
申请号：US560886
申请日：1975-03-21
申请人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
发明人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
IPC分类号： C12P7/60 , C12D1/02
CPC分类号： C12P7/60 , Y10S435/84
摘要： 2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism available for this microbial conversion includes strains which belong to the species of the Brevibacterium nov. sp. ASM-856-4, ATCC 31083. The incubation of the microorganism in a medium containing 2,5-diketo-D-gluconic acid as well as the direct contact of any products obtained from the microbial cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.
摘要翻译： 2-酮-L-古洛糖酸通过微生物转化由2,5-二酮-D-葡萄糖酸制备。可用于该微生物转化的2-酮-L-古洛糖酸生物微生物包括属于Brevibacterium nov的物种的菌株。 sp。 ASM-856-4，ATCC 31083.微生物在含有2,5-二酮-D-葡萄糖酸的培养基中的温育以及从微生物细胞获得的任何产物与含有所述2,5 - 二酮-D-葡萄糖酸可用于所公开的方法。

4. 发明授权

US3959076A Process for producing 2-keto-L-gulonic acid 失效
标题翻译： 2-酮-L-古洛糖酸的制备方法
公开(公告)号：US3959076A
公开(公告)日：1976-05-25
申请号：US560885
申请日：1975-03-21
申请人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
发明人： Takayasu Sonoyama , Hiroyoshi Tani , Bunji Kageyama , Kobee Kobayashi , Tahiko Honjo , Shigeo Yagi
IPC分类号： C12P7/60 , C12D1/02
CPC分类号： C12P7/60 , Y10S435/843
摘要： 2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism available for this microbial conversion includes strains which belong to the genus Corynebacterium. The incubation of the microorganism in a medium containing 2,5-diketo-D-gliconic acid as well as the direct contact of any products obtained from the microbial cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.
摘要翻译： 2-酮-L-古洛糖酸通过微生物转化由2,5-二酮-D-葡萄糖酸制备。可用于该微生物转化的2-酮-L-古洛糖酸生产微生物包括属于棒杆菌属的菌株。微生物在含有2,5-二酮-D-葡萄糖酸的培养基中的培养以及从微生物细胞获得的任何产物与含有2,5-二酮-D-葡萄糖酸的底物的直接接触可以是用于所公开的过程。

5. 发明授权

US4287137A Vane-type fluid impeller and method of aerating a liquid 失效
标题翻译：叶片型流体叶轮及液体充气方法
公开(公告)号：US4287137A
公开(公告)日：1981-09-01
申请号：US110444
申请日：1980-01-08
申请人： Takayasu Sonoyama , Hiroyoshi Tani , Kobee Kobayashi
发明人： Takayasu Sonoyama , Hiroyoshi Tani , Kobee Kobayashi
IPC分类号： B01F7/00 , B01F3/04 , B01J10/00 , B01J19/00 , C02F3/20 , C12M1/06
CPC分类号： B01J19/0066 , B01F3/04539 , B01F3/04602 , B01J19/006 , C02F3/205 , C02F3/207 , C12M27/02 , B01F2003/04546 , B01F2003/04687 , B01F7/00291 , B01F7/00341 , B01F7/00425 , B01J2219/00772 , B01J2219/00779 , Y02W10/15
摘要： A provision of the disclosed grating composed of closed loops of plurality of parallelly-arranged straps with clearances between adjacent straps is made to encompass a space of a body of a revolution defined by a vane-type impeller. It proves to be effective for improving gas-absorption by a better gas-liquid contact in a chemical process or fermentation process.
摘要翻译：设置由多个平行布置的带状的带有相邻带之间的间隙的闭合环构成的光栅，以包围由叶片式叶轮限定的旋转体的空间。证明在化学过程或发酵过程中通过更好的气 - 液接触来改善气体吸收是有效的。

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