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1. 发明申请

US20120035691A1 SYSTEM AND METHOD FOR SECURING A LEAD IN A VESSEL 审中-公开
标题翻译：用于保护船只中的引导件的系统和方法
公开(公告)号：US20120035691A1
公开(公告)日：2012-02-09
申请号：US13198505
申请日：2011-08-04
申请人： Bruce A. Tockman , Juan Gabriel Hincapie Ordonez , Shantha Arcot-Krishnamurthy , Lili Liu
发明人： Bruce A. Tockman , Juan Gabriel Hincapie Ordonez , Shantha Arcot-Krishnamurthy , Lili Liu
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61N1/36114
摘要： A two-part system for securing and stabilizing a lead at a location within a patient's internal jugular vein adjacent a region of the vagus nerve to be stimulated is described. The two-part system includes a lead and a stent-like fixation member that is provided separate from the lead. The stent-like fixation member is used to secure an electrode region of the lead at a location within the internal jugular vein adjacent the vagus nerve. The stent-like fixation member urges the electrode region of the lead against the vessel walls of the internal jugular vein such that at least one electrode is oriented in a direction towards the vagus nerve. In one example, the stent-like fixation member includes a channel sized to receive and retain a portion of the lead therein.
摘要翻译：描述了一种两部分系统，用于在邻近待刺激的迷走神经的区域的患者的颈内静脉内的位置处固定和稳定铅。两部分系统包括与引线分离设置的引线和支架状固定构件。支架状固定构件用于将铅的电极区域固定在与迷走神经相邻的颈内静脉内的位置处。支架状固定构件将引线的电极区域推压到颈内静脉的血管壁，使得至少一个电极朝向迷走神经的方向。在一个示例中，支架状固定构件包括通道，其尺寸设置成在其中接收和保持引线的一部分。

2. 发明申请

US20120022617A1 MINIMALLY INVASIVE LEAD SYSTEM FOR VAGUS NERVE STIMLATION 有权
标题翻译：用于VAGUS神经刺激的最小入侵引导系统
公开(公告)号：US20120022617A1
公开(公告)日：2012-01-26
申请号：US13186203
申请日：2011-07-19
申请人： Bruce A. Tockman , Juan Gabriel Hincapie Ordonez , Lili Liu
发明人： Bruce A. Tockman , Juan Gabriel Hincapie Ordonez , Lili Liu
IPC分类号： A61N1/372
CPC分类号： A61N1/36114 , A61N1/0556 , A61N1/0558 , A61N1/36185
摘要： A system including two neurostimulation leads can be used for stimulating a select region of a nerve within a nerve bundle. For example, two leads can be used to stimulate a select region of the vagus nerve located within a patient's carotid sheath. The first neurostimulation is positioned within the carotid sheath and the second neurostimulation lead is positioned external to the carotid sheath. Each of the first and second neurostimulation leads includes at least one electrode defining an electrode array about the select region of the nerve. The electrode array, and more particularly, the different possible electrode vector combinations provided by the first and second neurostimulation leads facilitate steering of stimulation current density fields as needed or desired between the electrodes to effectively and efficiently treat a particular medical, psychiatric, or neurological disorder.
摘要翻译：包括两个神经刺激引线的系统可用于刺激神经束内的神经的选择区域。例如，可以使用两个引线来刺激位于患者颈动脉鞘内的迷走神经的选择区域。第一神经刺激位于颈动脉鞘内，第二神经刺激引线位于颈动脉鞘外。第一和第二神经刺激引线中的每一个包括限定围绕神经的选择区域的电极阵列的至少一个电极。电极阵列，更具体地，由第一和第二神经刺激引线提供的不同的可能的电极向量组合有助于在电极之间根据需要或期望的刺激电流密度场的转向，以有效和有效地治疗特定的医学，精神病学或神经障碍。

3. 发明授权

US08620450B2 Minimally invasive lead system for vagus nerve stimulation 有权
标题翻译：迷走神经刺激微创引导系统
公开(公告)号：US08620450B2
公开(公告)日：2013-12-31
申请号：US13186203
申请日：2011-07-19
申请人： Bruce A. Tockman , Juan Gabriel Hincapie Ordonez , Lili Liu
发明人： Bruce A. Tockman , Juan Gabriel Hincapie Ordonez , Lili Liu
IPC分类号： A61N1/372
CPC分类号： A61N1/36114 , A61N1/0556 , A61N1/0558 , A61N1/36185
摘要： A system including two neurostimulation leads can be used for stimulating a select region of a nerve within a nerve bundle. For example, two leads can be used to stimulate a select region of the vagus nerve located within a patient's carotid sheath. The first neurostimulation is positioned within the carotid sheath and the second neurostimulation lead is positioned external to the carotid sheath. Each of the first and second neurostimulation leads includes at least one electrode defining an electrode array about the select region of the nerve. The electrode array, and more particularly, the different possible electrode vector combinations provided by the first and second neurostimulation leads facilitate steering of stimulation current density fields as needed or desired between the electrodes to effectively and efficiently treat a particular medical, psychiatric, or neurological disorder.
摘要翻译：包括两个神经刺激引线的系统可用于刺激神经束内的神经的选择区域。例如，可以使用两个引线来刺激位于患者颈动脉鞘内的迷走神经的选择区域。第一神经刺激位于颈动脉鞘内，第二神经刺激引线位于颈动脉鞘外。第一和第二神经刺激引线中的每一个包括限定围绕神经的选择区域的电极阵列的至少一个电极。电极阵列，更具体地，由第一和第二神经刺激引线提供的不同的可能的电极向量组合有助于在电极之间根据需要或期望的刺激电流密度场的转向，以有效和有效地治疗特定的医学，精神病学或神经障碍。

4. 发明申请

US20100063569A1 CONFORMAL ELECTRODES FOR SHAPED MEDICAL DEVICE LEAD BODY SEGMENTS 有权
标题翻译：用于形状医疗器械引导身体部位的一致电极
公开(公告)号：US20100063569A1
公开(公告)日：2010-03-11
申请号：US12541461
申请日：2009-08-14
申请人： Bruce A. Tockman , Timothy R. Jackson , Brendan E. Koop , Lili Liu , Kimberly A. Morris , David J. Parins
发明人： Bruce A. Tockman , Timothy R. Jackson , Brendan E. Koop , Lili Liu , Kimberly A. Morris , David J. Parins
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A medical lead includes a lead body having at least one conductor extending from a proximal end of the lead body to a distal end of the lead body. The proximal end is adapted to be connected to a pulse generator, and the distal end includes a curved portion. One or more electrodes are operatively connected to the at least one conductor and coupled to the curved portion of the lead body. At least a portion of each of the one or more electrodes includes an arrangement of interconnected, spaced-apart elements that are selectively configured to allow the one or more electrodes to conform to contours of the curved portion during and after implantation of the medical lead.
摘要翻译：医疗用引线包括具有至少一个导体的引线体，导体从引线主体的近端延伸到引线主体的远端。近端适于连接到脉冲发生器，并且远端包括弯曲部分。一个或多个电极可操作地连接到至少一个导体并且耦合到引线主体的弯曲部分。一个或多个电极中的每一个的至少一部分包括互连的间隔开的元件的布置，其被选择性地配置成允许一个或多个电极在植入医疗引线期间和之后使其符合弯曲部分的轮廓。

5. 发明授权

US06178356B1 Coronary venous lead having fixation mechanism 有权
标题翻译：冠状静脉导管具有固定机制
公开(公告)号：US06178356B1
公开(公告)日：2001-01-23
申请号：US09280128
申请日：1999-03-26
申请人： Stuart A. Chastain , Bruce A. Tockman , Randy W. Westlund , Lili Liu
发明人： Stuart A. Chastain , Bruce A. Tockman , Randy W. Westlund , Lili Liu
IPC分类号： A61N105
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A body implantable lead for placement in a selected coronary vein includes a resilient retention structure for inhibiting displacement of the lead because of heart beat action, breathing or other body movement. The retention structure includes a plurality of resilient projections that are attached to the lead body and which are adapted to project at a predetermined acute angle to the axis of the lead body when unconstrained. Prior to being routed through the vascular system, the projections can be bonded to the lead body to provide a low profile with a biodegradable adhesive. Following exposure to body fluids, the adhesive dissolves, releasing the projections so that they can engage the walls of the vein in which the lead is disposed.
摘要翻译：用于放置在所选择的冠状静脉中的身体可植入引线包括弹性保持结构，用于抑制由于心跳动作，呼吸或其他身体运动引起的位移。保持结构包括多个弹性突起，其附接到引线主体并且适于在不受约束时以与引线主体的轴线成预定的锐角突出。在被引导通过血管系统之前，突起可以结合到引线主体以通过可生物降解的粘合剂提供低轮廓。在暴露于体液后，粘合剂溶解，释放突起使得它们可以与引导物置于其中的静脉的壁接合。

6. 发明授权

US5931864A Coronary venous lead having fixation mechanism 失效
标题翻译：冠状静脉导管具有固定机制
公开(公告)号：US5931864A
公开(公告)日：1999-08-03
申请号：US27288
申请日：1998-02-20
申请人： Stuart R. Chastain , Bruce A. Tockman , Randy W. Westlund , Lili Liu
发明人： Stuart R. Chastain , Bruce A. Tockman , Randy W. Westlund , Lili Liu
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A body implantable lead for placement in a selected coronary vein includes a resilient retention structure for inhibiting displacement of the lead because of heart beat action, breathing or other body movement. The retention structure includes a plurality of resilient projections that are attached to the lead body and which are adapted to project at a predetermined acute angle to the axis of the lead body when unconstrained. Prior to being routed through the vascular system, the projections can be bonded to the lead body to provide a low profile with a biodegradable adhesive. Following exposure to body fluids, the adhesive dissolves, releasing the projections so that they can engage the walls of the vein in which the lead is disposed.
摘要翻译：用于放置在所选择的冠状静脉中的身体可植入引线包括弹性保持结构，用于抑制由于心跳动作，呼吸或其他身体运动引起的位移。保持结构包括多个弹性突起，其附接到引线主体并且适于在不受约束时以与引线主体的轴线成预定的锐角突出。在被引导通过血管系统之前，突起可以结合到引线主体以通过可生物降解的粘合剂提供低轮廓。在暴露于体液后，粘合剂溶解，释放突起使得它们可以与引导物置于其中的静脉的壁接合。

7. 发明授权

US08340767B2 Implantable lead and coronary venous pressure sensor apparatus and method 有权
标题翻译：植入式铅和冠状静脉压力传感器的设备及方法
公开(公告)号：US08340767B2
公开(公告)日：2012-12-25
申请号：US12539832
申请日：2009-08-12
申请人： Lili Liu , Mohan Krishnan , Bruce A. Tockman , David R. Wulfman
发明人： Lili Liu , Mohan Krishnan , Bruce A. Tockman , David R. Wulfman
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61M25/0041 , A61M2025/0002 , A61M2205/3344 , A61N1/056 , A61N1/3627 , A61N1/36585 , A61N2001/0585
摘要： A cardiac rhythm management system comprises a medical electrical lead, a pressure sensing element, and an implantable pulse generator. The lead is sized to be advanced through the right atrium and coronary sinus into a coronary vein adjacent to the left ventricle. The lead includes an opening intermediate its proximal and distal ends, and a lumen extending longitudinally within the body in communication with the opening. The pressure sensing element is movably disposed in lead lumen and is dimensioned to extend through the opening in the lead, and includes a flexible, elongated conductive member having a distal end, and a pressure transducer coupled to the distal end of the conductive member. The pulse generator is configured to receive cardiac rhythm signals from the electrode and fluid pressure signals from the pressure transducer.
摘要翻译：心律管理系统包括医疗电引线，压力感测元件和可植入脉冲发生器。铅的大小可以通过右心房和冠状窦进入与左心室相邻的冠状静脉。引线包括在其近端和远端之间的开口，以及在主体内与开口连通的纵向延伸的内腔。压力感测元件可移动地设置在引导腔中，并且其尺寸设计成延伸穿过引线中的开口，并且包括具有远端的柔性细长导电构件和耦合到导电构件的远端的压力传感器。脉冲发生器被配置为从电极接收心律信号和来自压力传感器的流体压力信号。

8. 发明申请

US20130090701A1 IMPLANTABLE LEAD AND CORONARY VENOUS PRESSURE SENSOR APPARATUS AND METHOD 有权
标题翻译：可伸缩铅和冠状压力传感器装置及方法
公开(公告)号：US20130090701A1
公开(公告)日：2013-04-11
申请号：US13690068
申请日：2012-11-30
申请人： Lili Liu , Mohan Krishnan , Bruce A. Tockman , David R. Wulfman
发明人： Lili Liu , Mohan Krishnan , Bruce A. Tockman , David R. Wulfman
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61M25/0041 , A61M2025/0002 , A61M2205/3344 , A61N1/056 , A61N1/3627 , A61N1/36585 , A61N2001/0585
摘要： A cardiac rhythm management system comprises a medical electrical lead, a pressure sensing element, and an implantable pulse generator. The lead is sized to be advanced through the right atrium and coronary sinus into a coronary vein adjacent to the left ventricle. The lead includes an opening intermediate its proximal and distal ends, and a lumen extending longitudinally within the body in communication with the opening. The pressure sensing element is movably disposed in lead lumen and is dimensioned to extend through the opening in the lead, and includes a flexible, elongated conductive member having a distal end, and a pressure transducer coupled to the distal end of the conductive member. The pulse generator is configured to receive cardiac rhythm signals from the electrode and fluid pressure signals from the pressure transducer.
摘要翻译：心律管理系统包括医疗电引线，压力感测元件和可植入脉冲发生器。铅的大小可以通过右心房和冠状窦进入与左心室相邻的冠状静脉。引线包括在其近端和远端之间的开口，以及在主体内与开口连通的纵向延伸的内腔。压力感测元件可移动地设置在引导腔中，并且其尺寸设计成延伸穿过引线中的开口，并且包括具有远端的柔性细长导电构件和耦合到导电构件的远端的压力传感器。脉冲发生器被配置为从电极接收心律信号和来自压力传感器的流体压力信号。

9. 发明申请

US20100042175A1 IMPLANTABLE LEAD AND CORONARY VENOUS PRESSURE SENSOR APPARATUS AND METHOD 有权
标题翻译：可伸缩铅和冠状压力传感器装置及方法
公开(公告)号：US20100042175A1
公开(公告)日：2010-02-18
申请号：US12539832
申请日：2009-08-12
申请人： Lili Liu , Mohan Krishnan , Bruce A. Tockman , David R. Wulfman
发明人： Lili Liu , Mohan Krishnan , Bruce A. Tockman , David R. Wulfman
IPC分类号： A61N1/368 , A61N1/365
CPC分类号： A61N1/36564 , A61M25/0041 , A61M2025/0002 , A61M2205/3344 , A61N1/056 , A61N1/3627 , A61N1/36585 , A61N2001/0585
摘要： A cardiac rhythm management system comprises a medical electrical lead, a pressure sensing element, and an implantable pulse generator. The lead is sized to be advanced through the right atrium and coronary sinus into a coronary vein adjacent to the left ventricle. The lead includes an opening intermediate its proximal and distal ends, and a lumen extending longitudinally within the body in communication with the opening. The pressure sensing element is movably disposed in lead lumen and is dimensioned to extend through the opening in the lead, and includes a flexible, elongated conductive member having a distal end, and a pressure transducer coupled to the distal end of the conductive member. The pulse generator is configured to receive cardiac rhythm signals from the electrode and fluid pressure signals from the pressure transducer.
摘要翻译：心律管理系统包括医疗电引线，压力感测元件和可植入脉冲发生器。铅的大小可以通过右心房和冠状窦进入与左心室相邻的冠状静脉。引线包括在其近端和远端之间的开口，以及在主体内与开口连通的纵向延伸的内腔。压力感测元件可移动地设置在引导腔中，并且其尺寸设计成延伸穿过引线中的开口，并且包括具有远端的柔性细长导电构件和耦合到导电构件的远端的压力传感器。脉冲发生器被配置为从电极接收心律信号和来自压力传感器的流体压力信号。

10. 发明授权

US08655458B2 Conformal electrodes for shaped medical device lead body segments 有权
标题翻译：用于成形医疗器械引线体段的保形电极
公开(公告)号：US08655458B2
公开(公告)日：2014-02-18
申请号：US12541461
申请日：2009-08-14
申请人： Bruce A. Tockman , Timothy R. Jackson , Brendan E. Koop , Lili Liu , Kimberly A. Morris , David J. Parins
发明人： Bruce A. Tockman , Timothy R. Jackson , Brendan E. Koop , Lili Liu , Kimberly A. Morris , David J. Parins
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A medical lead includes a lead body having at least one conductor extending from a proximal end of the lead body to a distal end of the lead body. The proximal end is adapted to be connected to a pulse generator, and the distal end includes a curved portion. One or more electrodes are operatively connected to the at least one conductor and coupled to the curved portion of the lead body. At least a portion of each of the one or more electrodes includes an arrangement of interconnected, spaced-apart elements that are selectively configured to allow the one or more electrodes to conform to contours of the curved portion during and after implantation of the medical lead.
摘要翻译：医疗用引线包括具有至少一个导体的引线体，导体从引线主体的近端延伸到引线主体的远端。近端适于连接到脉冲发生器，并且远端包括弯曲部分。一个或多个电极可操作地连接到至少一个导体并且耦合到引线主体的弯曲部分。一个或多个电极中的每一个的至少一部分包括互连的间隔开的元件的布置，其被选择性地配置成允许一个或多个电极在植入医疗引线期间和之后使其符合弯曲部分的轮廓。

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