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1. 发明申请

US20090163405A1 Angiogenic peptides and uses thereof 审中-公开
标题翻译：血管生成肽及其用途
公开(公告)号：US20090163405A1
公开(公告)日：2009-06-25
申请号：US12292876
申请日：2008-11-28
申请人： Britta Hardy , Alexander Battler , Annat Raiter , Ran Kornowski , Chana Weiss
发明人： Britta Hardy , Alexander Battler , Annat Raiter , Ran Kornowski , Chana Weiss
IPC分类号： A61K38/12 , A61K38/10 , C07H21/00 , C12Q1/02 , C07K7/50 , C07K7/06
CPC分类号： G01N33/5064 , A61K38/08 , A61K38/10 , A61K47/64 , C07K14/52 , G01N33/6896 , G01N2333/4709
摘要： A peptide comprising an amino acid sequence as set forth in SEQ ID NO: 2, 4, 6, 8, 10 or 12 is provided. The peptide being at least 6 and no more than 50 amino acid residues in length. Also provided are therapeutic applications using such peptides.
摘要翻译：提供包含SEQ ID NO：2,4,6,8,10或12所示氨基酸序列的肽。该肽长度为至少6个且不超过50个氨基酸残基。还提供了使用这种肽的治疗应用。

2. 发明申请

US20070082849A1 Angiogenic peptides and uses thereof 失效
标题翻译：血管生成肽及其用途
公开(公告)号：US20070082849A1
公开(公告)日：2007-04-12
申请号：US10577679
申请日：2004-10-28
申请人： Britta Hardy , Alexander Battler , Annat Raiter , Ran Kornowski , Chana Weiss
发明人： Britta Hardy , Alexander Battler , Annat Raiter , Ran Kornowski , Chana Weiss
IPC分类号： A61K38/12 , A61K38/10 , C07K7/08 , C07K7/64
CPC分类号： G01N33/5064 , A61K38/08 , A61K38/10 , A61K47/64 , C07K14/52 , G01N33/6896 , G01N2333/4709
摘要： A peptide comprising an amino acid sequence as set forth in SEQ ID NO: 2, 4, 6, 8, 10 or 12 is provided. The peptide being at least 6 and no more than 50 amino acid residues in length. Also provided are therapeutic applications using such peptides.
摘要翻译：提供包含SEQ ID NO：2,4,6,8,10或12所示氨基酸序列的肽。该肽长度为至少6个且不超过50个氨基酸残基。还提供了使用这种肽的治疗应用。

3. 发明授权

US07473682B2 Angiogenic peptides and uses thereof 失效
公开(公告)号：US07473682B2
公开(公告)日：2009-01-06
申请号：US10577679
申请日：2004-10-28
申请人： Britta Hardy , Alexander Battler , Annat Raiter , Ran Kornowski , Chana Weiss
发明人： Britta Hardy , Alexander Battler , Annat Raiter , Ran Kornowski , Chana Weiss
IPC分类号： A61K38/10 , A61K38/16
CPC分类号： G01N33/5064 , A61K38/08 , A61K38/10 , A61K47/64 , C07K14/52 , G01N33/6896 , G01N2333/4709
摘要： A peptide comprising an amino acid sequence as set forth in SEQ ID NO: 2, 4, 6, 8, 10 or 12 is provided. The peptide being at least 6 and no more than 50 amino acid residues in length. Also provided are therapeutic applications using such peptides.

4. 发明授权

US06595979B1 Methods for sterile aspiration/reinjection of bodily fluid 有权
标题翻译：无菌吸入/注射体液的方法
公开(公告)号：US06595979B1
公开(公告)日：2003-07-22
申请号：US09999765
申请日：2001-10-23
申请人： Stephen Epstein , Shmuel Fuchs , Ran Kornowski
发明人： Stephen Epstein , Shmuel Fuchs , Ran Kornowski
IPC分类号： A61M3100
CPC分类号： A61M5/1456 , A61B2090/062 , A61M1/0005 , A61M5/14566 , A61M25/0084 , A61M2025/0089 , A61M2202/0413 , A61M2205/75 , Y10S977/906 , A61M2202/0021
摘要： Methods for aspiration and filtering of a bodily fluid containing undesired components are provided and for treatment of the bodily fluids in a sterile environment in preparation for reinjection of treated aspirate into a donor subject. The invention methods are particularly designed to facilitate transfection of aspirated cells with angiogenesis promoting molecules without danger to the technician or the donor prior to reinjection of the treated cells, either percutaneously or via a surgical opening via a catheter or injection needle. A pressure actuator attached to the sterile container is used to express treated fluids in precisely controlled volumes. The invention methods include delivery of treated fluids using a hand-held device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.
摘要翻译：提供了含有不需要的组分的体液的抽吸和过滤的方法，并用于在无菌环境中处理体液以准备将经处理的抽吸物再注射到供体受试者中。本发明的方法特别设计用于促进血管生成促进分子的吸出细胞的转染，而不经由经皮经皮或通过经由导管或注射针的外科手术开口重新注入处理的细胞而对技术人员或供体造成危险。附接到无菌容器的压力致动器用于以精确控制的体积表示经处理的流体。本发明的方法包括使用具有对应于操作员选择的注射体积的听觉提示的手持装置递送处理的流体和/或对应于由操作者选择的穿针深度的可听见的线索。

5. 发明申请

US20100081933A1 TREATING WEAKENED VESSEL WALL SUCH AS VULNERABLE PLAQUE OR ANEURYSMS 审中-公开
标题翻译：处理弱化的船只等作为易受伤害的人群或风险
公开(公告)号：US20100081933A1
公开(公告)日：2010-04-01
申请号：US12449725
申请日：2008-02-21
申请人： Ariel Sverdlik , Shmuel Einav , Zeev Aronis , Ran Kornowski , Ifat Lavi
发明人： Ariel Sverdlik , Shmuel Einav , Zeev Aronis , Ran Kornowski , Ifat Lavi
IPC分类号： A61N7/02 , A61B8/00
CPC分类号： A61N7/00 , A61B5/0048 , A61B8/485 , A61B2017/00106 , A61B2017/22001 , A61B2017/22081 , A61N2007/0078
摘要： Described is a method of stabilizing blood vessel wall abnormality. The method includes ultrasonically heating at least a portion of the blood vessel wall having the abnormality; monitoring a parameter related to a property of at least a portion of the heated portion of the blood vessel wall; and stopping the heating when the monitored parameter changes by a predetermined factor or after the monitored parameter changes in a slow enough rate. The slow enough rate may be, for instance, a predetermined fraction of a maximal rate change observed during heating.
摘要翻译：描述了一种稳定血管壁异常的方法。该方法包括对具有异常的血管壁的至少一部分进行超声波加热; 监测与血管壁的加热部分的至少一部分的性质相关的参数; 并且当所监视的参数改变预定因子时或在所监视的参数以足够慢的速率改变之后停止加热。足够慢的速率可以是例如在加热期间观察到的最大速率变化的预定分数。

6. 发明授权

US10463886B2 Treating weakened vessel wall such as vulnerable plaque or aneurysms 有权
公开(公告)号：US10463886B2
公开(公告)日：2019-11-05
申请号：US12449725
申请日：2008-02-21
申请人： Ariel Sverdlik , Shmuel Einav , Zeev Aronis , Ran Kornowski , Ifat Lavi
发明人： Ariel Sverdlik , Shmuel Einav , Zeev Aronis , Ran Kornowski , Ifat Lavi
IPC分类号： A61N7/00 , A61B5/00 , A61B8/08 , A61B17/00 , A61B17/22
摘要： Described is a method of stabilizing blood vessel wall abnormality. The method includes ultrasonically heating at least a portion of the blood vessel wall having the abnormality; monitoring a parameter related to a property of at least a portion of the heated portion of the blood vessel wall; and stopping the heating when the monitored parameter changes by a predetermined factor or after the monitored parameter changes in a slow enough rate. The slow enough rate may be, for instance, a predetermined fraction of a maximal rate change observed during heating.

7. 发明授权

US10039896B2 Deployment mechanism for body vessel insertion devices 有权
公开(公告)号：US10039896B2
公开(公告)日：2018-08-07
申请号：US14119873
申请日：2012-05-23
申请人： Ran Kornowski , Dvir Keren
发明人： Ran Kornowski , Dvir Keren
IPC分类号： A61M25/00 , A61M25/04 , A61B18/14 , A61B17/22 , A61B18/00 , A61B90/00
摘要： An aspect of some embodiments of the invention relates to a microcatheter comprising a deployment element disposed about around at least a portion of an exterior of a distal end of the microcatheter, the deployment element configured for repeatedly expanding and collapsing, the distal end arranged to allow forward or reverse axial displacement while the deployment element maintains a position, the deployment element arranged for positioning the microcatheter distal end approximately in the middle of a vessel. A method of traversing tortuous vessels using the microcatheter, in accordance with an exemplary embodiment of the invention, is also described.

8. 发明申请

US20060094657A1 Inhibiting development of microvessels within coronary or peripheral vessel walls for restenosis/atherosclerosis prevention or therapy 审中-公开
标题翻译：抑制冠状动脉或外周血管壁内微血管的发展，用于再狭窄/动脉粥样硬化的预防或治疗
公开(公告)号：US20060094657A1
公开(公告)日：2006-05-04
申请号：US11295095
申请日：2005-12-06
申请人： Stephen Epstein , Ran Kornowski , Shmuel Fuchs , Martin Leon
发明人： Stephen Epstein , Ran Kornowski , Shmuel Fuchs , Martin Leon
IPC分类号： A61K38/17 , A61K48/00
CPC分类号： A61K45/06 , A61K38/179 , A61K38/1891
摘要： Disclosed and claimed are compositions and methods for therapy and/or prevention of restenosis and/or atherosclerosis. The compositions can include an agent for inhibiting VEGF and an agent for including vessel maturation; for instance, the soluble VEGF receptor and ang-1. Embodiments can include kits.
摘要翻译：公开并要求保护的是用于治疗和/或预防再狭窄和/或动脉粥样硬化的组合物和方法。组合物可以包括用于抑制VEGF的试剂和用于包括血管成熟的试剂; 例如，可溶性VEGF受体和ang-1。实施例可以包括套件。

9. 发明申请

US20080064917A1 Amplification-Based Cardiac Assist Device 审中-公开
标题翻译：基于放大的心脏辅助装置
公开(公告)号：US20080064917A1
公开(公告)日：2008-03-13
申请号：US10575312
申请日：2004-10-15
申请人： Eli Bar , Benny Rousso , Ran Kornowski
发明人： Eli Bar , Benny Rousso , Ran Kornowski
IPC分类号： A61M1/12
CPC分类号： A61M1/1058 , A61M1/1008 , A61M1/1055 , A61M1/1056 , A61M1/106 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61M2205/8243
摘要： Apparatus (20) is provided for compressing at least one ventricle of a heart (40). The apparatus includes a plurality of inflatable elements (64) and a pump (24) in fluid communication with the inflatable elements. At least one band (68) is in mechanical communication with the inflatable elements. A portion of the band is adapted to be placed around at least a portion of the heart in mechanical communication with the portion of the heart. The inflatable elements are arranged such that when the inflatable elements are inflated by the pump, the inflatable elements apply more force to the heart via shortening of the portion of the band than via expansion of the inflatable elements against the heart.
摘要翻译：设置有用于压缩心脏（40）的至少一个心室的装置（20）。该装置包括多个可膨胀元件（64）和与可膨胀元件流体连通的泵（24）。至少一个带（68）与可膨胀元件机械连通。带的一部分适于放置在与心脏部分机械连通的心脏的至少一部分周围。可膨胀元件被布置成使得当可膨胀元件被泵充气时，可充气元件通过缩短带的部分而不是通过膨胀可膨胀元件抵靠心脏而对心脏施加更多的力。

10. 发明授权

US07097832B1 Intramyocardial injection of autologous bone marrow 有权
标题翻译：心肌内注射自体骨髓
公开(公告)号：US07097832B1
公开(公告)日：2006-08-29
申请号：US09868411
申请日：2000-03-30
申请人： Ran Kornowski , Shmuel Fuchs , Stephen E. Epstein , Martin B. Leon
发明人： Ran Kornowski , Shmuel Fuchs , Stephen E. Epstein , Martin B. Leon
IPC分类号： A01N63/00 , C12N5/00 , C12N5/06
CPC分类号： A61K38/193 , A61K35/28 , A61K38/1709 , A61K2300/00
摘要： A method of treating cardiac or myocardial conditions comprises the administration of an effective amount of autologous bone marrow. The bone marrow may optionally be stimulated and/or administered in combination with a pharmaceutical drug, protein, gene or other factor or therapy that may enhance bone marrow production of angiogenic growth factors and/or promote endothelial cell proliferation or migration or blood vessel formation.
摘要翻译：治疗心脏或心肌病症的方法包括施用有效量的自体骨髓。骨髓可以任选地与可以增强血管生成生长因子的骨髓产生和/或促进内皮细胞增殖或迁移或血管形成的药物，蛋白质，基因或其他因子或治疗组合而被刺激和/或施用。

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