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1. 发明授权

US07803149B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US07803149B2
公开(公告)日：2010-09-28
申请号：US10618977
申请日：2003-07-14
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

2. 发明授权

US07731685B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US07731685B2
公开(公告)日：2010-06-08
申请号：US11234702
申请日：2005-09-23
申请人： Anthony O. Ragheb , Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon
发明人： Anthony O. Ragheb , Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device adapted for introduction into a passage or vessel of a patient is provided. The medical device is preferably an implantable balloon with a bioactive deposited or within the balloon. The balloon can further include a hydrophilic material positioned between the balloon and a bioactive material posited on the balloon.
摘要翻译：提供适于引入患者的通道或容器中的涂覆医疗装置。医疗装置优选地是具有生物活性沉积的或在球囊内的可植入气球。球囊可以进一步包括位于球囊和放置在球囊上的生物活性物质之间的亲水材料。

3. 发明授权

US10532190B2 Coated medical device 有权
公开(公告)号：US10532190B2
公开(公告)日：2020-01-14
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61M31/00 , A61M25/10 , A61F2/82 , A61L27/54 , A61L31/16 , A61L29/16 , A61F2/844 , A61F2/958 , A61L29/08 , A61L29/18 , A61L31/14 , A61F2/86
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

4. 发明申请

US20110015725A1 COATED MEDICAL DEVICE 审中-公开
标题翻译：涂层医疗器械
公开(公告)号：US20110015725A1
公开(公告)日：2011-01-20
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61F2/82
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

5. 发明申请

US20080183268A1 COATED IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US20080183268A1
公开(公告)日：2008-07-31
申请号：US11965385
申请日：2007-12-27
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma , David D. Grewe , Darin G. Schaeffer , JiChao Sun
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma , David D. Grewe , Darin G. Schaeffer , JiChao Sun
IPC分类号： A61F2/82
CPC分类号： A61F2/885 , A61F2/0077 , A61F2250/0068
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 以及至少一层生物活性材料层18，其被定位在涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物，并且通过其提供生物活性材料的受控释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

6. 发明授权

US06447540B1 Stent deployment device including splittable sleeve containing the stent 失效
标题翻译：支架展开装置，包括含支架的可拆卸套筒
公开(公告)号：US06447540B1
公开(公告)日：2002-09-10
申请号：US08971113
申请日：1997-11-14
申请人： Arthur B. Fontaine , Susan DosPassos , Brian L. Bates , Scott E. Boatman , Michael C. Hoffa , Thomas A. Osborne
发明人： Arthur B. Fontaine , Susan DosPassos , Brian L. Bates , Scott E. Boatman , Michael C. Hoffa , Thomas A. Osborne
IPC分类号： A61F206
CPC分类号： A61F2/97 , A61F2/95 , A61F2/958 , A61F2002/9511 , A61F2002/9583 , A61M25/0668 , A61M25/10
摘要： A stent deployment device (10) includes a catheter (12), a stent (14) positioned on the catheter (12), and a sleeve (16) carried on the catheter (12). The sleeve (16) has a portion (18) extending fully over and containing the stent (14). The stent deployment device (10) also includes a mechanism (20) for splitting at least the portion (18) of the sleeve (16) extending over the stent (14) and, preferably, for splitting the entire sleeve (16). Splitting of the sleeve portion (18) permits expansion of the stent (14). The mechanism (20) can include an inflatable, nondistending balloon (22) carried on the catheter (12), the stent (14) and the sleeve portion (18) being positioned over the balloon (22). The stent (14) can be self-expanding or can be expanded by the balloon (22) itself. Alternatively, the mechanism (20) can include a bulbous end (24) on the catheter (12). Longitudinal movement of the bulbous catheter end (24) with respect to the sleeve (16) splits at least the sleeve portion (18), permitting expansion of the stent (14). As further alternatives, the mechanism (20) can include a garrote (66) connected to the sleeve or a partial segment (62) of the sleeve (16) folded back alongside the stent (14). The sleeve (16) can be the same length as the catheter (12) or can be shorter than the catheter (12). In the former case, the mechanism (20) can include a pair of graspable wings (56) for splitting the full length of the sleeve (16). It is preferred that at least the portion (18) of the sleeve (16) extending over the stent (14) includes a longitudinally extending structure 46 for ensuring that the sleeve portion (18) will in fact split upon operation of the mechanism (20).
摘要翻译：支架展开装置（10）包括导管（12），定位在导管（12）上的支架（14）和承载在导管（12）上的套筒（16）。套筒（16）具有完全延伸并且容纳支架（14）的部分（18）。支架展开装置（10）还包括一个机构（20），用于至少分开延伸在支架（14）上的套筒（16）的部分（18），并且优选地用于分割整个套筒（16）。套筒部分（18）的分裂允许支架（14）膨胀。机构（20）可以包括承载在导管（12）上的可膨胀的非重排球囊（22），支架（14）和套筒部分（18）定位在球囊（22）上方。支架（14）可以是自膨胀的，或者可以由气囊（22）自身扩张。或者，机构（20）可以包括在导管（12）上的球根端（24）。球根导管端部（24）相对于套筒（16）的纵向移动至少分开套筒部分（18），从而允许支架（14）的膨胀。作为另外的替代方案，机构（20）可以包括连接到套筒的衣壳（66）或套管（16）的沿着支架（14）折回的部分段（62）。套筒（16）可以与导管（12）的长度相同，或者可以比导管（12）短。在前一种情况下，机构（20）可以包括用于分离套筒（16）的全长的一对可抓握翼（56）。优选地，延伸在支架（14）上的套筒（16）的至少部分（18）包括纵向延伸的结构46，用于确保套筒部分（18）实际上将在

7. 发明授权

US06231598B1 Radially expandable stent 有权
标题翻译：径向扩张支架
公开(公告)号：US06231598B1
公开(公告)日：2001-05-15
申请号：US09160122
申请日：1998-09-24
申请人： Dale T. Berry , Coy M. Herald , Brian L. Bates , Scott E. Boatman , Michael C. Hoffa , Neal E. Fearnot , William D. Voorhees, III
发明人： Dale T. Berry , Coy M. Herald , Brian L. Bates , Scott E. Boatman , Michael C. Hoffa , Neal E. Fearnot , William D. Voorhees, III
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/88 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583 , A61F2230/0054 , A61F2250/0036 , A61F2250/0098 , A61L31/022 , A61L31/18
摘要： A radially expandable stent (10) made from a cannula or sheet of biocompatible material that includes at least one longitudinal segment (14) comprised of a series of laterally interconnected closed cells (13). Each closed cell of a longitudinal segment is defined laterally by a pair of longitudinal struts (15, 16) that are interconnected at each end by a circumferentially adjustable member (19, 20). When the stent is expanded using a balloon (47), the opposing circumferentially adjustable members deform to allow circumferential expansion of the longitudinal segment, while the length of the segment, as defined by the longitudinal struts, is maintained. Self-expanding versions of the stent utilize a nickel-titanium alloy. Adjacent longitudinal segments are joined by flexible interconnection segments (21) that permit the stent to bend laterally. The flexible interconnection segment is comprised of curvilinear struts (22, 23) that form a series of serpentine bends (81) that distribute lateral bending forces. In a preferred embodiment, a short strut interconnects longitudinal segments and an adjacent interconnection segment. Each interconnection strut attaches to the longitudinal segment within a region (27) at the end (17) of a longitudinal strut (15) dividing two adjacent closed cells.
摘要翻译：一种由包括生物相容性材料的套管或片材制成的径向可扩张的支架（10），其包括由一系列横向互连的闭孔（13）构成的至少一个纵向段（14）。纵向段的每个闭合单元由一对纵向支柱（15,16）侧向地限定，所述纵向支柱在每个端部由周向可调节构件（19,20）互连。当使用球囊（47）扩张支架时，相对的周向可调部件变形以允许纵向段的周向膨胀，而由纵向支柱限定的段的长度保持。自扩张型支架采用镍钛合金。相邻的纵向段通过柔性互连段（21）连接，允许支架横向弯曲。柔性互连部分由曲线支柱（22,23）组成，其形成分布横向弯曲力的一系列蛇形弯曲部（81）。在优选实施例中，短支柱将纵向段和相邻互连段互连。每个互连支柱在分开两个相邻闭孔的纵向支柱（15）的端部（17）处的区域（27）内附接到纵向段。

8. 发明授权

US08673387B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US08673387B2
公开(公告)日：2014-03-18
申请号：US12359884
申请日：2009-01-26
申请人： Brian L. Bates , Anthony O. Ragheb , William J. Bourdeau , Neal E. Fearnot
发明人： Brian L. Bates , Anthony O. Ragheb , William J. Bourdeau , Neal E. Fearnot
IPC分类号： A61M25/10 , A61M31/00 , A61L33/00
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

9. 发明授权

US08172793B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US08172793B2
公开(公告)日：2012-05-08
申请号：US11141574
申请日：2005-05-31
申请人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
发明人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
IPC分类号： A61M37/00 , A61M29/00 , A61F2/06
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

10. 发明申请

US20110264197A1 COATED MEDICAL DEVICE 有权
公开(公告)号：US20110264197A1
公开(公告)日：2011-10-27
申请号：US13072332
申请日：2011-03-25
申请人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
发明人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
IPC分类号： A61F2/82
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

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