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1. 发明申请

US20080183268A1 COATED IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US20080183268A1
公开(公告)日：2008-07-31
申请号：US11965385
申请日：2007-12-27
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma , David D. Grewe , Darin G. Schaeffer , JiChao Sun
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma , David D. Grewe , Darin G. Schaeffer , JiChao Sun
IPC分类号： A61F2/82
CPC分类号： A61F2/885 , A61F2/0077 , A61F2250/0068
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 以及至少一层生物活性材料层18，其被定位在涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物，并且通过其提供生物活性材料的受控释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

2. 发明授权

US07731685B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US07731685B2
公开(公告)日：2010-06-08
申请号：US11234702
申请日：2005-09-23
申请人： Anthony O. Ragheb , Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon
发明人： Anthony O. Ragheb , Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device adapted for introduction into a passage or vessel of a patient is provided. The medical device is preferably an implantable balloon with a bioactive deposited or within the balloon. The balloon can further include a hydrophilic material positioned between the balloon and a bioactive material posited on the balloon.
摘要翻译：提供适于引入患者的通道或容器中的涂覆医疗装置。医疗装置优选地是具有生物活性沉积的或在球囊内的可植入气球。球囊可以进一步包括位于球囊和放置在球囊上的生物活性物质之间的亲水材料。

3. 发明授权

US10532190B2 Coated medical device 有权
公开(公告)号：US10532190B2
公开(公告)日：2020-01-14
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61M31/00 , A61M25/10 , A61F2/82 , A61L27/54 , A61L31/16 , A61L29/16 , A61F2/844 , A61F2/958 , A61L29/08 , A61L29/18 , A61L31/14 , A61F2/86
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

4. 发明申请

US20110015725A1 COATED MEDICAL DEVICE 审中-公开
标题翻译：涂层医疗器械
公开(公告)号：US20110015725A1
公开(公告)日：2011-01-20
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61F2/82
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

5. 发明授权

US07803149B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US07803149B2
公开(公告)日：2010-09-28
申请号：US10618977
申请日：2003-07-14
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

6. 发明授权

US09155641B2 Expandable stent grafts 有权
标题翻译：可扩展支架移植物
公开(公告)号：US09155641B2
公开(公告)日：2015-10-13
申请号：US11714058
申请日：2007-03-05
申请人： Darin G. Schaeffer , David D. Grewe
发明人： Darin G. Schaeffer , David D. Grewe
IPC分类号： A61F2/07 , A61F2/88 , A61F2/30 , A61F2/915
CPC分类号： A61F2/885 , A61F2/07 , A61F2/88 , A61F2/915 , A61F2002/075 , A61F2002/30459 , A61F2002/30461 , A61F2002/3052 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075
摘要： This invention relates to a medical device and, in particular, to a prosthesis or stent graft assembly for use within the human or animal body and, more particularly, to the fastening of a stent to the graft material of the stent graft assembly or prosthesis.
摘要翻译：本发明涉及一种医疗装置，特别涉及一种在人体或动物体内使用的假体或支架移植物组件，更具体地说，涉及将支架固定在支架移植物组件或假体的移植材料上。

7. 发明授权

US09974674B2 Branch vessel prothesis with positional indicator system and method 有权
公开(公告)号：US09974674B2
公开(公告)日：2018-05-22
申请号：US10984416
申请日：2004-11-08
申请人： Darin G. Schaeffer
发明人： Darin G. Schaeffer
IPC分类号： A61F2/954 , A61F2/07 , A61F2/856 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2/958 , A61B17/11 , A61F2/06 , A61F2/82 , A61F2/848 , A61F2/95 , A61F2/89
CPC分类号： A61F2/954 , A61B2017/1107 , A61B2017/1139 , A61F2/064 , A61F2/07 , A61F2/856 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/075 , A61F2002/821 , A61F2002/8483 , A61F2002/8486 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/9511 , A61F2210/0076 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2250/0018 , A61F2250/0039 , A61F2250/0097 , A61F2250/0098
摘要： A stent graft system for intraluminal deployment in an aorta and a branch vessel includes an aorta stent graft with a fenestration aligned with a branch vessel and a branch vessel prosthesis with a flaring portion at a proximal end and a tubular portion. When deployed, the flaring portion of the branch vessel prosthesis is retained within the aorta stent graft, and the tubular portion extends through the fenestration and into the branch vessel. The system includes at least one positional indicator, including a positional indicator associated with the branch vessel prosthesis for indicating the position of a point along the branch vessel prosthesis predetermined for optimal alignment with the fenestration during deployment.

8. 发明授权

US09358141B2 Stent deployment device 有权
标题翻译：支架部署装置
公开(公告)号：US09358141B2
公开(公告)日：2016-06-07
申请号：US11547020
申请日：2005-03-22
申请人： Scott E. Boatman , Michael C. Hoffa , Kimberly D. Roberts , Darin G. Schaeffer
发明人： Scott E. Boatman , Michael C. Hoffa , Kimberly D. Roberts , Darin G. Schaeffer
IPC分类号： A61F2/958 , A61F2/82
CPC分类号： A61F2/958 , A61F2002/821
摘要： A stent deployment device (110) is provided for deploying a stent in a lumen of a patient. The device can include a catheter (112), a first balloon (122) positioned near a distal end of the catheter and a second balloon (123) adjacent to the first balloon. Alternatively, the second balloon can be positioned over the first balloon. The device also includes an expandable stent (210) positioned over the first balloon and the second balloon. The first balloon comprises a semi-compliant material, a noncompliant material or a compliant material. Similarly, the second balloon comprises a semi-compliant material, a noncompliant material or a compliant material. The first balloon is expandable to a first diameter, while the second balloon can be expandable to a second diameter.
摘要翻译：提供支架展开装置（110）用于将支架展开在患者的内腔中。该装置可以包括导管（112），定位在导管的远端附近的第一球囊（122）和邻近第一球囊的第二球囊（123）。或者，第二气球可以位于第一气球上方。该装置还包括位于第一球囊和第二球囊之上的可扩张支架（210）。第一气囊包括半柔顺材料，不符合材料或柔顺材料。类似地，第二气囊包括半柔顺材料，不合格材料或顺应性材料。第一气囊可扩张至第一直径，而第二球囊可扩张至第二直径。

9. 发明授权

US09132260B2 Therapeutic agent delivery device with a dual balloon having distal taper apertures 有权
标题翻译：具有双气囊的治疗剂递送装置具有远端锥形孔
公开(公告)号：US09132260B2
公开(公告)日：2015-09-15
申请号：US12825965
申请日：2010-06-29
申请人： Darin G. Schaeffer , William F. Moore
发明人： Darin G. Schaeffer , William F. Moore
IPC分类号： A61M25/10
CPC分类号： A61M25/1011 , A61M25/104 , A61M2025/1013 , A61M2025/105 , A61M2025/1052
摘要： The present disclosure generally provides a multiple balloon assembly used as part of the distal region of a medical device that is capable of delivering a therapeutic agent into a body vessel having bodily fluid. The multiple balloon assembly comprises an inner balloon and an outer balloon. The outer balloon further comprises a proximal taper region, a middle region, and a distal taper region. The inflation of the inner balloon causes the middle region of the outer balloon to contact the inner wall of the body vessel, thereby, occluding the flow of fluid through the body vessel. The proximal taper region and the distal taper region are configured such that they do not touch the inner wall of the body vessel. One of the distal taper and proximal taper regions has a plurality of apertures configured to allow for the therapeutic agent to be delivered into the body vessel at a predetermined rate. A medical device that incorporates the multiple balloon assembly of the present disclosure, as well as a method for using the medical device and multiple balloon assembly are further disclosed.
摘要翻译：本公开通常提供多个气囊组件，其被用作医疗装置的远侧区域的一部分，其能够将治疗剂递送到具有体液的身体容器中。多球囊组件包括内球囊和外球囊。外球囊还包括近端锥形区域，中间区域和远端锥形区域。内球囊的膨胀导致外球囊的中间区域接触身体血管的内壁，从而阻塞通过体血管的流体流动。近端锥形区域和远端锥形区域构造成使得它们不接触身体血管的内壁。远端锥形和近端锥形区域中的一个具有多个孔，其构造成允许治疗剂以预定速率输送到体内容器。还公开了一种结合本公开的多球囊组件的医疗装置，以及用于使用医疗装置和多气囊组件的方法。

10. 发明申请

US20130018453A1 ARTIFICIAL VALVE PROSTHESIS WITH IMPROVED FLOW DYNAMICS 审中-公开
标题翻译：人工阀具有改进的流动动力学
公开(公告)号：US20130018453A1
公开(公告)日：2013-01-17
申请号：US13550229
申请日：2012-07-16
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that is configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，所述支撑结构被构造成扩大与所述瓣膜结构相邻的区域，使得逆行流的流动模式以便于在所述瓣膜区域的底部冲洗所述凹穴以防止停滞的方式被修改的体液，其在静脉系统中可导致血栓形成。可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成扩大的口袋区域，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。

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