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1. 发明授权

US5626877A Polymer-based drug delivery system 失效
标题翻译：基于聚合物的药物输送系统
公开(公告)号：US5626877A
公开(公告)日：1997-05-06
申请号：US193997
申请日：1994-02-09
申请人： Brian G. Amsden , Yu-Ling Cheng
发明人： Brian G. Amsden , Yu-Ling Cheng
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/26 , A61K38/18 , A61K38/47 , A61K9/14
CPC分类号： A61K38/47 , A61K38/1808 , A61K9/0004 , A61K9/2009 , A61K9/2027
摘要： Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmotically active excipient and not more than about 10% by weight of drug. The system is particularly well suited for delivery of therapeutic macromolecules such as protein drugs. Delivery of epidermal growth factor is exemplified.
摘要翻译：本文描述了一种药物递送系统，其用于以持续的方式和以受控的速率向患者递送低剂量水平的药物。该系统包括可湿性聚合物基质，其中分散有多个颗粒，其含有基本均匀的渗透活性赋形剂混合物和不超过约10重量％的药物。该系统特别适用于递送治疗性大分子如蛋白质药物。例举表皮生长因子的递送。

2. 发明授权

US5302397A Polymer-based drug delivery system 失效
标题翻译：基于聚合物的药物输送系统
公开(公告)号：US5302397A
公开(公告)日：1994-04-12
申请号：US793836
申请日：1991-11-19
申请人： Brian G. Amsden , Yu-Ling Cheng
发明人： Brian G. Amsden , Yu-Ling Cheng
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/26 , A61K38/18 , A61K38/47
CPC分类号： A61K38/47 , A61K38/1808 , A61K9/0004 , A61K9/2009 , A61K9/2027
摘要： Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmotically active excipient and not more than about 10% by weight of drug. The system is particularly well suited for delivery of therapeutic macromolecules such as protein drugs. Delivery of epidermal growth factor is exemplified.
摘要翻译：本文描述了一种药物递送系统，其用于以持续的方式和以受控的速率向患者递送低剂量水平的药物。该系统包括可湿性聚合物基质，其中分散有多个颗粒，其含有基本均匀的渗透活性赋形剂混合物和不超过约10重量％的药物。该系统特别适用于递送治疗性大分子如蛋白质药物。例举表皮生长因子的递送。

3. 发明授权

US4788062A Transdermal administration of progesterone, estradiol esters, and mixtures thereof 失效
标题翻译：透皮给药孕酮，雌二醇酯及其混合物
公开(公告)号：US4788062A
公开(公告)日：1988-11-29
申请号：US19162
申请日：1987-02-26
申请人： Robert M. Gale , David J. Enscore , Diane E. Nedberge , Melinda Nelson , Yu-Ling Cheng , Shari B. Libicki
发明人： Robert M. Gale , David J. Enscore , Diane E. Nedberge , Melinda Nelson , Yu-Ling Cheng , Shari B. Libicki
IPC分类号： A61K9/00 , A61K9/70 , A61K31/565 , A61K31/57 , A61K47/14 , A61K47/26 , A61F13/00
CPC分类号： A61K9/7053 , A61K31/565 , A61K31/57 , A61K47/14 , A61K47/26 , A61K9/0014 , A61K9/7076 , A61K9/7084
摘要： A transdermal delivery system for the administering of progesterone and an estradiol ester alone or in combination utilizing a polymer matrix having the drug(s) along with a permeation enhancer dispersed throughout.

4. 发明授权

US07160931B2 Thermally reversible implant and filler 失效
标题翻译：热可逆植入物和填充物
公开(公告)号：US07160931B2
公开(公告)日：2007-01-09
申请号：US10428520
申请日：2003-05-02
申请人： Yu-Ling Cheng , Michael H. May , John L. Semple , Hai-Hui Lin
发明人： Yu-Ling Cheng , Michael H. May , John L. Semple , Hai-Hui Lin
IPC分类号： A61F2/00 , C08L51/00 , C08L53/00
CPC分类号： C08F283/06 , A61L24/06 , A61L27/16 , A61L27/50 , A61L27/52 , C08F293/00 , C08F297/00 , C08L51/003 , C08L51/08 , C08L53/00 , C08L53/005 , C08L33/26 , C08L2666/24 , C08L2666/02
摘要： The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.
摘要翻译：本发明涉及热可逆凝胶如共聚物组合物作为生物填料或植入物的用途。凝胶在体温下具有半固体形式，但是当冷却到低于阈值水平时，凝胶被液化，并且可以重新成形，重新调整尺寸，操作或从身体去除。凝胶可以用作皮肤植入物，生物填充剂，关节或组织间隔物，用于皱纹填充或其它化妆品植入物，作为用于重建手术的软组织替代物，或作为生物结构内腔内的屏障，例如作为血管。植入物可用于通过提供例如子宫颈的可逆屏障或输精管腔的可逆阻塞来提供可逆的节育。

5. 发明授权

US4746515A Skin permeation enhancer compositions using glycerol monolaurate 失效
标题翻译：使用甘油单月桂酸酯的皮肤渗透促进剂组合物
公开(公告)号：US4746515A
公开(公告)日：1988-05-24
申请号：US19470
申请日：1987-02-26
申请人： Yu-Ling Cheng , Diane E. Nedberge , Edna Sugihara
发明人： Yu-Ling Cheng , Diane E. Nedberge , Edna Sugihara
IPC分类号： A61K9/00 , A61K9/70 , A61K47/00 , A61K47/14 , A61F13/00
CPC分类号： A61K9/7084 , A61K47/14 , A61K9/0014 , Y10S514/946
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with glycerol monolaurate. Preferred embodiments of therapeutic systems for delivering drug and glycerol monolaurate employ matrix containing drug at a concentration above saturation.

6. 发明申请

US20070110784A1 Thermally reversible implant 审中-公开
标题翻译：热可逆植入
公开(公告)号：US20070110784A1
公开(公告)日：2007-05-17
申请号：US10555455
申请日：2004-05-03
申请人： Yu-Ling Cheng , Michael May , John Semple , Hai-Hui Lin
发明人： Yu-Ling Cheng , Michael May , John Semple , Hai-Hui Lin
IPC分类号： A61F2/02 , A61K8/73 , A61K8/81
CPC分类号： A61F2/0059
摘要： The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.
摘要翻译：本发明涉及热可逆凝胶如共聚物组合物作为生物填料或植入物的用途。凝胶在体温下具有半固体形式，但是当冷却到低于阈值水平时，凝胶被液化，并且可以重新成形，重新调整尺寸，操作或从身体去除。凝胶可以用作皮肤植入物，生物填充剂，关节或组织间隔物，用于皱纹填充或其它化妆品植入物，作为用于重建手术的软组织替代物，或作为生物结构内腔内的屏障，例如作为血管。植入物可用于通过提供例如子宫颈的可逆屏障或输精管腔的可逆阻塞来提供可逆的节育。

7. 发明授权

US4940586A Skin permeation enhancer compositions using sucrose esters 失效
标题翻译：使用蔗糖酯的皮肤渗透促进剂组合物
公开(公告)号：US4940586A
公开(公告)日：1990-07-10
申请号：US257487
申请日：1988-10-13
申请人： Yu-Ling Cheng , Robert M. Gale , Edna Sugihara , Harold F. Sanders
发明人： Yu-Ling Cheng , Robert M. Gale , Edna Sugihara , Harold F. Sanders
IPC分类号： A61K9/70 , A61K47/26
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7069 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
摘要翻译：描述了通过完整皮肤增强透皮递送药物的透皮通量的方法，其中药物与蔗糖单月桂酸酯或主要是蔗糖单月桂酸酯的椰子脂肪酸的蔗糖酯的混合物同时递送。用于递送药物和蔗糖酯的治疗系统的优选实施方案使用含有高于饱和浓度的药物的基质。

8. 发明授权

US4900555A Skin permeation enhancer compositions using sucrose esters 失效
标题翻译：使用蔗糖酯的皮肤渗透促进剂组合物
公开(公告)号：US4900555A
公开(公告)日：1990-02-13
申请号：US257481
申请日：1988-10-13
申请人： Yu-Ling Cheng , Robert M. Gale , Edna Sugihara , Harold F. Sanders
发明人： Yu-Ling Cheng , Robert M. Gale , Edna Sugihara , Harold F. Sanders
IPC分类号： A61K9/70 , A61K47/26
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7069 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominatly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
摘要翻译：描述了通过完整皮肤增强透皮递送药物的经皮通量的方法，其中药物与蔗糖单月桂酸酯或主要是蔗糖单月桂酸酯的椰子脂肪酸的蔗糖酯的混合物同时递送。用于递送药物和蔗糖酯的治疗系统的优选实施方案使用含有高于饱和浓度的药物的基质。

9. 发明申请

US20180092371A1 PASTEURIZATION FOR SMALL CONTAINERS USING A PHASE CHANGE MATERIAL 审中-公开
公开(公告)号：US20180092371A1
公开(公告)日：2018-04-05
申请号：US15723992
申请日：2017-10-03
申请人： Micaela Langille Collins , Scott Nicholas Genin , Jayesh Kumar Srivastava , Yu-Ling Cheng
发明人： Micaela Langille Collins , Scott Nicholas Genin , Jayesh Kumar Srivastava , Yu-Ling Cheng
IPC分类号： A23C3/02 , A23C9/20 , A23L3/10
CPC分类号： A23C3/02 , A23C3/023 , A23C9/206 , A23L3/10 , A23V2300/24 , Y02P60/85
摘要： A pasteurization device comprising an insulated heating tub, a metal grid heat sink, 69° C. melt-point paraffin wax, wherein the metal grid heat sink and the paraffin wax are combined inside the insulated heating tub; a temperature sensor connected to a microprocessor controlled device, suitable to measure temperature and to generate an alarm, a top plate, and a material suitable to cover the wax; wherein the top plate comprises a plurality of openings corresponding to an opening in the metal grid heat sink of suitable size to accept a baby bottle; wherein the insulated heating tub can be heated to at least 73° C. and wherein the microprocessor controlled device provides an audible tone upon the temperature sensor reading 73° C. for at least 30 seconds.

10. 发明授权

US06331578B1 Process for preparing interpenetrating polymer networks of controlled morphology 失效
标题翻译：制备控制形态的互穿聚合物网络的方法
公开(公告)号：US06331578B1
公开(公告)日：2001-12-18
申请号：US09442830
申请日：1999-11-17
申请人： Josephine Turner , Yu-Ling Cheng
发明人： Josephine Turner , Yu-Ling Cheng
IPC分类号： C08J716
CPC分类号： C08J3/246 , C08F283/12 , C08G77/442 , Y10S525/903 , C08F220/06
摘要： The invention relates to a method of making an interpenetrating polymer network (IPN) of at least a first polymer and a second polymer from a first and second component wherein the first component is the first polymer, or a polymerizable reactant selected from monomers or pre-polymers polymerizable to the first polymer and mixtures thereof, and the second component is a polymerizable reactant selected from monomers or pre-polymers polymerizable to the second polymer and mixtures thereof, the method comprising the steps of forming a reaction mixture of at least the first component, the second component, an initiator or catalyst and a crosslinker, effecting polymerization and crosslinking of polymerizable reactant, and recovering the IPN so obtained, wherein during the polymerization and crosslinking, a surface of the reaction mixture is maintained in contact with a third component comprising each said polymerizable reactant at a chemical potential similar to the chemical potential of the same reactant in the reaction mixture.
摘要翻译：本发明涉及一种从第一和第二组分制备至少第一聚合物和第二聚合物的互穿聚合物网络（IPN）的方法，其中第一组分是第一聚合物，或可选择的单体或预聚物的可聚合反应物，可聚合到第一聚合物的聚合物及其混合物，第二组分是选自可聚合到第二聚合物的单体或预聚物及其混合物的可聚合反应物，该方法包括以下步骤：形成至少第一组分，第二组分，引发剂或催化剂和交联剂，进行可聚合反应物的聚合和交联，并回收如此获得的IPN，其中在聚合和交联期间，反应混合物的表面保持与包含每个所述可聚合反应物具有类似于s的化学势的化学势在反应混合物中的反应物。

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