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1. 发明申请

US20080199507A1 Therapeutic Polymeric Pouch 审中-公开
标题翻译：治疗性聚合物袋
公开(公告)号：US20080199507A1
公开(公告)日：2008-08-21
申请号：US11917828
申请日：2006-06-19
申请人： Gary A. Skarja , Rebecca K. Ho , Michael H. May
发明人： Gary A. Skarja , Rebecca K. Ho , Michael H. May
IPC分类号： A61L27/54 , A61L27/56
CPC分类号： A61L27/54 , A61K9/0024 , A61K9/009 , A61L27/16 , A61L27/56 , A61L2300/00 , C08L33/12
摘要： An implantable or surface-applied device comprising a porous polymeric pouch containing a therapeutic polymer sealed in the pouch, to provide a localized therapeutic effect at the site of the application. The pores in the polymeric pouch being smaller than the therapeutic polymer, allowing body fluid to enter and exit the pouch and interact with the therapeutic polymer in the pouch in use, but not permitting the therapeutic polymer to leave the pouch.
摘要翻译：一种可植入或表面施用的装置，其包含密封在袋中的治疗性聚合物的多孔聚合物袋，以在应用部位提供局部治疗效果。聚合物小袋中的孔小于治疗性聚合物，允许体液进入和离开小袋并在使用中与袋中的治疗性聚合物相互作用，但不允许治疗性聚合物离开小袋。

2. 发明授权

US06261585B1 Generating blood vessels with angiogenic material containing a biocompatible polymer and polymerizable compound 失效
标题翻译：用包含生物相容性聚合物和可聚合化合物的血管生成材料产生血管
公开(公告)号：US06261585B1
公开(公告)日：2001-07-17
申请号：US09069544
申请日：1998-04-30
申请人： Michael Vivian Sefton , Julia E. Babensee , Michael H. May
发明人： Michael Vivian Sefton , Julia E. Babensee , Michael H. May
IPC分类号： A61F200
CPC分类号： A61K9/5089
摘要： An angiogenic material is provided which promotes extensive vascularization when implanted in animal tissue. The angiogenic material contains a biocompatible polymer and a vascularizing polymerizable compound capable of forming anions. The polymer may be a polyacrylate, and the polymerizable compound includes compounds having ionizable groups selected from sulfates, sulfonic acid groups and carboxyl groups. These compounds include acrylic acid, methacrylic acid, crotonic acid, itaconic acid, vinylsulfonic acid and vinylacetic acid. The angiogenic material is preferably used in microcapsule coatings and microspheres for implantation in animals. In microcapsules, the angiogenic material promotes better exchange of nutrients, waste products and cellular products between encapsulated cells and the circulatory system of the host animal. Microspheres containing the angiogenic material may be used to assist in recovery of ischemic heart muscle by injection of the microspheres into the heart muscle or blood vessels serving the ischemic area. Also provided is a method of forming small microcapsules and microspheres by passing cell aggregates or air bubbles through layers of a density gradient to obtain microcapsules or microspheres having a diameter no greater than 500 &mgr;m that contain cells or do not contain cells. When cells are present, a semi-permeable coating of the angiogenic material surrounds the cells.
摘要翻译：提供血管生成材料，其在植入动物组织时促进广泛的血管形成。血管生成材料含有能够形成阴离子的生物相容性聚合物和血管化聚合性化合物。聚合物可以是聚丙烯酸酯，可聚合化合物包括具有选自硫酸盐，磺酸基和羧基的离子化基团的化合物。这些化合物包括丙烯酸，甲基丙烯酸，巴豆酸，衣康酸，乙烯基磺酸和乙烯基乙酸。血管生成材料优选用于微胶囊包衣和用于植入动物的微球体中。在微胶囊中，血管生成物质促进包封的细胞与宿主动物的循环系统之间的营养物，废物和细胞产物的更好的交换。含有血管生成物质的微球可以用于通过将微球注入心肌或用于缺血区域的血管来帮助恢复缺血性心脏肌肉。还提供了通过使细胞聚集体或气泡通过密度梯度层形成小微胶囊和微球的方法，以获得包含细胞或不含细胞的直径不大于500μm的微胶囊或微球。当存在细胞时，血管生成材料的半透膜包围细胞。

3. 发明授权

US07160931B2 Thermally reversible implant and filler 失效
标题翻译：热可逆植入物和填充物
公开(公告)号：US07160931B2
公开(公告)日：2007-01-09
申请号：US10428520
申请日：2003-05-02
申请人： Yu-Ling Cheng , Michael H. May , John L. Semple , Hai-Hui Lin
发明人： Yu-Ling Cheng , Michael H. May , John L. Semple , Hai-Hui Lin
IPC分类号： A61F2/00 , C08L51/00 , C08L53/00
CPC分类号： C08F283/06 , A61L24/06 , A61L27/16 , A61L27/50 , A61L27/52 , C08F293/00 , C08F297/00 , C08L51/003 , C08L51/08 , C08L53/00 , C08L53/005 , C08L33/26 , C08L2666/24 , C08L2666/02
摘要： The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.
摘要翻译：本发明涉及热可逆凝胶如共聚物组合物作为生物填料或植入物的用途。凝胶在体温下具有半固体形式，但是当冷却到低于阈值水平时，凝胶被液化，并且可以重新成形，重新调整尺寸，操作或从身体去除。凝胶可以用作皮肤植入物，生物填充剂，关节或组织间隔物，用于皱纹填充或其它化妆品植入物，作为用于重建手术的软组织替代物，或作为生物结构内腔内的屏障，例如作为血管。植入物可用于通过提供例如子宫颈的可逆屏障或输精管腔的可逆阻塞来提供可逆的节育。

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