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1. 发明申请

US20060259128A1 Method for implanting prosthetic valves 审中-公开
标题翻译：植入人工瓣膜的方法
公开(公告)号：US20060259128A1
公开(公告)日：2006-11-16
申请号：US11404439
申请日：2006-04-14
申请人： Dusan Pavcnik , Brian Case , Ram Paul , Jacob Flagle
发明人： Dusan Pavcnik , Brian Case , Ram Paul , Jacob Flagle
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2427 , A61F2/2475 , A61F2250/0002 , A61F2250/0096
摘要： Methods for implanting a prosthetic valve in a body vessel having a fluid flow therethrough are provided. One method includes identifying a position of an existing valve and determining a factor affecting fluid flow in at least one of a first direction and a second direction at the existing valve. The method includes selecting the implantation position for a prosthetic valve at a distance away from the existing valve position in consideration of the factor. The method further includes providing the prosthetic valve for delivery to the implantation position, delivering and implanting the prosthetic valve at the position. The prosthetic valve includes at least one flexible member movable between a first position that permits fluid flow in the first direction and the second position that substantially prevents fluid flow in a second direction.
摘要翻译：提供了将人造瓣植入具有流体流体的体内容器中的方法。一种方法包括识别现有阀的位置并且确定影响现有阀处的第一方向和第二方向中的至少一个中的流体流动的因素。该方法包括考虑到该因素，在离开现有阀位置的距离处选择假体瓣膜的植入位置。该方法还包括提供用于输送到植入位置的人造瓣膜，将该假体瓣膜输送和植入该位置。假体瓣膜包括至少一个柔性构件，其可在第一位置和第二位置之间移动，所述第一位置允许流体在第一方向上流动，而第二位置基本上防止流体沿第二方向流动。

2. 发明申请

US20060149309A1 Inverting occlusion devices, methods, and systems 有权
标题翻译：反相闭塞装置，方法和系统
公开(公告)号：US20060149309A1
公开(公告)日：2006-07-06
申请号：US11322145
申请日：2005-12-29
申请人： Ram Paul , Brian Case , Jacob Flagle
发明人： Ram Paul , Brian Case , Jacob Flagle
IPC分类号： A61M29/02
CPC分类号： A61B17/00008 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12181 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括在插管内反转的闭塞装置的经皮递送，其展开和填充，以封闭或消除血管容器的一部分。

3. 发明申请

US20080051879A1 METHODS OF TREATING VENOUS VALVE RELATED CONDITIONS WITH A FLOW-MODIFYING IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用流动修改植入式医疗装置处理通气阀相关条件的方法
公开(公告)号：US20080051879A1
公开(公告)日：2008-02-28
申请号：US11844003
申请日：2007-08-23
申请人： Brian Case , Gary Shirley , Ram Paul , Jacob Flagle
发明人： Brian Case , Gary Shirley , Ram Paul , Jacob Flagle
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/07 , A61F2002/068
摘要： Implantable medical devices adapted to modify fluid flow within a body vessel are provided herein. The medical devices may include a fluid flow restricting channel configured to reduce longitudinal fluid flow in a retrograde direction or in an antegrade direction. Preferably, the medical devices are flow-modifying devices that reduce fluid flow through the medical device to a greater extent in a retrograde direction than in an antegrade direction. Methods of treatment comprising the step of implanting a flow-modifying medical device within a body vessel are also provided. Flow-modifying devices are useful, for example, in treating venous valve related conditions.
摘要翻译：本文提供了适于改变体内容器内的流体流动的植入式医疗装置。医疗装置可以包括流体流动限制通道，该流体流动限制通道构造成减小沿逆行方向或顺行方向的纵向流体流动。优选地，医疗装置是流动改变装置，其减少流体通过医疗装置的流体在逆行方向上比在顺行方向上更大程度地流动。还提供了包括在身体容器内植入流动改变医疗装置的步骤的治疗方法。流动改变装置例如在治疗静脉瓣相关病症中是有用的。

4. 发明申请

US20060161197A1 Inflatable occlusion devices, methods, and systems 有权
标题翻译：充气闭塞装置，方法和系统
公开(公告)号：US20060161197A1
公开(公告)日：2006-07-20
申请号：US11294998
申请日：2005-12-06
申请人： Ram Paul , Jacob Flagle , Brian Case
发明人： Ram Paul , Jacob Flagle , Brian Case
IPC分类号： A61M29/02
CPC分类号： A61L29/005 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment and filling of an inflatable occlusion device via a percutaneous procedure, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括经由经皮程序展开和填充可充气闭塞装置，从而封闭或消除血管容器的一部分。

5. 发明申请

US20060136044A1 Medical device with bioactive agent 有权
公开(公告)号：US20060136044A1
公开(公告)日：2006-06-22
申请号：US11244991
申请日：2005-10-06
申请人： Thomas Osborne , Jacob Flagle , Brian Case , Joseph Obermiller , Ram Paul
发明人： Thomas Osborne , Jacob Flagle , Brian Case , Joseph Obermiller , Ram Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.

6. 发明申请

US20050192606A1 Valvulotome with a cutting edge 有权
标题翻译：瓣切开术带有切削刃
公开(公告)号：US20050192606A1
公开(公告)日：2005-09-01
申请号：US11070130
申请日：2005-02-28
申请人： Ram Paul , Brian Case , Jacob Flagle
发明人： Ram Paul , Brian Case , Jacob Flagle
IPC分类号： A61B17/22 , A61B17/32
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices comprising a cutting edge are provided. Some valvulotome devices incisably engage a venous valve leaflet within a body vessel while at least a portion of the cutting edge is oriented substantially parallel to the longitudinal axis of the valvulotome device. Valvulotome devices are preferably configured to slidably engage a venous valve leaflet upon translation of the valvulotome device along the longitudinal axis of a body vessel. A valvulotome device can further comprise one or more valvulotome arms of variable lengths and dimensions. In some embodiments, the valvulotome device can be self expanding. Embodiments of the invention also provide delivery systems comprising a valvulotome device. The present invention also provides for methods of using a valvulotome device. Kits comprising a valvulotome device are also provided.
摘要翻译：提供包括切削刃的瓣膜切开装置。一些瓣膜切开装置可切割地与身体血管内的静脉瓣膜接合，同时切割边缘的至少一部分基本上平行于瓣膜切开装置的纵向轴线定向。瓣膜切开装置优选地构造成在沿着身体血管的纵向轴线平移瓣膜切开装置时可滑动地接合静脉瓣膜瓣。瓣膜切开装置还可以包括一个或多个可变长度和尺寸的瓣膜切开臂。在一些实施例中，瓣膜切开装置可以是自膨胀的。本发明的实施例还提供包括瓣膜切开装置的输送系统。本发明还提供了使用瓣膜切开装置的方法。还提供了包括瓣膜切开装置的套件。

7. 发明申请

US20060276882A1 Medical device including remodelable material attached to frame 审中-公开
标题翻译：医疗设备包括连接到框架上的可重塑材料
公开(公告)号：US20060276882A1
公开(公告)日：2006-12-07
申请号：US11435508
申请日：2006-05-17
申请人： Brian Case , Jacob Flagle , Ram Paul , Sean Chambers
发明人： Brian Case , Jacob Flagle , Ram Paul , Sean Chambers
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. Medical devices preferably comprise a remodelable material attached to a frame with a tension that can change upon implantation of the medical device within the lumen of a body vessel. Controlled fracture or bioabsorption of frame material can, in some embodiments, decrease the tension on the remodelable material after implantation. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置优选地包括附着到框架上的可重塑材料，其具有张力，所述张力可以在将医疗装置植入身体容器的内腔中时改变。在一些实施方案中，框架材料的受控断裂或生物吸收可以在植入后降低可重塑材料上的张力。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

8. 发明申请

US20070292472A1 METHODS, SYSTEMS AND DEVICES FOR THE DELIVERY OF ENDOLUMINAL PROSTHESES 有权
标题翻译：用于输送内镜前列腺的方法，系统和装置
公开(公告)号：US20070292472A1
公开(公告)日：2007-12-20
申请号：US11763773
申请日：2007-06-15
申请人： Ram Paul , Brian Case , Jacob Flagle
发明人： Ram Paul , Brian Case , Jacob Flagle
IPC分类号： A61F2/00
CPC分类号： A61B17/12031 , A61B17/12022 , A61B17/12109 , A61B17/12181 , A61B17/1219 , A61B2017/00778 , A61B2017/00867 , A61B2017/00898 , A61B2017/1205 , A61B2017/22038
摘要： Described are devices, methods, and systems for achieving occlusion of vascular vessels. Further described are certain reduced or low profile procedures and devices for the percutaneous occlusion of the saphenous vein, such as in the treatment of a varicose vein condition caused by venous reflux.
摘要翻译：描述了用于实现血管血管闭塞的装置，方法和系统。进一步描述了用于经皮闭塞隐静脉的某些缩减或低调程序和装置，例如用于治疗由静脉回流引起的静脉曲张病症。

9. 发明申请

US20070106372A1 IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
标题翻译：具有约束扩张的可植入医疗装置
公开(公告)号：US20070106372A1
公开(公告)日：2007-05-10
申请号：US11539925
申请日：2006-10-10
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的医疗装置。根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

10. 发明申请

US20060136045A1 Methods and systems for modifying vascular valves 有权
标题翻译：改变血管瓣膜的方法和系统
公开(公告)号：US20060136045A1
公开(公告)日：2006-06-22
申请号：US11260360
申请日：2005-10-27
申请人： Jacob Flagle , Brian Case
发明人： Jacob Flagle , Brian Case
IPC分类号： A61F2/06
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶通过患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

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