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1. 发明授权

US06783767B2 Low temperature disinfectant/sterilant for medical devices and topical applications 失效
标题翻译：用于医疗器械和局部应用的低温消毒剂/灭菌剂
公开(公告)号：US06783767B2
公开(公告)日：2004-08-31
申请号：US10071051
申请日：2002-02-08
申请人： Braham Shroot , Lawton A. Seal , James R. Hunt , Jonathan Sterling , Kathy Bolsen , Penny L. Sitka
发明人： Braham Shroot , Lawton A. Seal , James R. Hunt , Jonathan Sterling , Kathy Bolsen , Penny L. Sitka
IPC分类号： A01N2512
CPC分类号： A61Q17/005 , A01N37/16 , A01N59/14 , A61K8/22 , A61K8/24 , A61K8/37 , A61K8/466 , A61K2800/52 , A61L2/16 , A61L2/186 , A61L2/23 , A61L2202/24 , C11D3/391 , C11D3/3942 , A01N2300/00
摘要： A powder composition which reacts in water to form in situ peroxycarboxylic acids at an anti-microbially effective concentration. Importantly, its utility is both for topical anti-microbial application and for effective low temperature disinfection/sterilization of instruments. It comprises the combination of a perborate, one or more novel acyl and/or aroyl donors, a buffering system which allows the pH to arise to about 9 for rapid formation of the peroxycarboxylic acids and then drop to about 7.5 for sustained stability and microbial kill. It preferably includes a surfactant facilitating antimicrobial efficacy, as well as other minors.
摘要翻译：在水中反应形成原生过氧羧酸的抗微生物有效浓度的粉末组合物。重要的是，其实用性用于局部抗微生物应用和有效的低温消毒/灭菌仪器。它包括过硼酸盐，一种或多种新型酰基和/或芳酰基供体的组合，一种缓冲体系，其允许pH高达约9以快速形成过氧羧酸，然后降至约7.5以持续稳定和微生物杀灭。其优选包括促进抗微生物功效的表面活性剂以及其它未成熟剂。

2. 发明授权

US06248791B1 Stimulating the differentiation of preadipocytic cells and therapies based thereon 有权
标题翻译：基于此，刺激前脂肪细胞的分化和疗法
公开(公告)号：US06248791B1
公开(公告)日：2001-06-19
申请号：US09127734
申请日：1998-08-03
申请人： Gérard Ailhaud , Paul Grimaldi , Irina Safonova , Braham Shroot , Uwe Reichert
发明人： Gérard Ailhaud , Paul Grimaldi , Irina Safonova , Braham Shroot , Uwe Reichert
IPC分类号： A61K3107
CPC分类号： A61K31/195 , A61K31/20 , A61K31/19 , A61K2300/00
摘要： The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-&agr; receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
摘要翻译：前脂肪细胞分化为脂肪细胞，特别是用于校正哺乳动物生物体，特别是人类中的胰岛素抗性疾病状态，例如II型糖尿病和心血管疾病如高血压和动脉粥样硬化，通过治疗这种前脂肪细胞被刺激，或需要这种治疗的患者，有效量的（a）至少一种对视黄酸和/或其异构体的核受体显示亲和力的配体，优选至少一种对RAR受体显示特异性亲和力的配体，甚至更多优选RAR-α受体和（b）至少一种脂肪酸，例如多不饱和脂肪酸。

3. 发明授权

US5667961A Skin substitute 失效
标题翻译：皮肤替代品
公开(公告)号：US5667961A
公开(公告)日：1997-09-16
申请号：US471359
申请日：1995-06-06
申请人： Bruno Bernard , Marie-Cecile Lenoir , Braham Shroot , Yves-Michel Darmon , Daniel Asselineau
发明人： Bruno Bernard , Marie-Cecile Lenoir , Braham Shroot , Yves-Michel Darmon , Daniel Asselineau
IPC分类号： A61F2/00 , A61F2/10 , A61K35/12 , A61L27/00 , A61L27/24 , A61L27/60 , C12N5/02 , C12N5/071 , A01N1/02 , C12N5/06
CPC分类号： C12N5/0698 , A61F2/105 , A61L27/24 , A61L27/60 , A61F2310/00365 , A61K35/12 , C12N2500/25 , C12N2500/40 , C12N2501/11 , C12N2501/39 , C12N2501/395 , C12N2501/81 , C12N2502/092 , C12N2502/094 , C12N2502/1323
摘要： The invention concerns a skin substitute composed of a dermis equivalent covered with an epidermis equivalent. The dermis equivalent is a film formed from a type I collagen gel containing fibroblasts. The epidermis equivalent incorporates a basal membrane equivalent, basal layer cells, in a palisade arrangement attached to the membrane equivalent by hemidesmosomes, cells of the suprabasal layers, granular cells, and flat, keratinized cells arranged near the free surface.
摘要翻译：本发明涉及由表皮等效物覆盖的真皮等效物组成的皮肤替代物。真皮等效物是由含有成纤维细胞的I型胶原凝胶形成的膜。表皮等价物包含基底膜等效物，基底层细胞，连接到膜上相当于膜片的栅栏布置，上基层的细胞，颗粒细胞和平坦的角质化细胞排列在自由表面附近。

4. 发明授权

US5602104A Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same 失效
标题翻译：多环芳族衍生物，其制备方法和含有该多环芳族衍生物的药物和化妆品组合物
公开(公告)号：US5602104A
公开(公告)日：1997-02-11
申请号：US421235
申请日：1995-04-13
申请人： Braham Shroot , Jacques Eustache , Oliver Watts , Jean-Michel Bernardon , Philippe Nedoncelle
发明人： Braham Shroot , Jacques Eustache , Oliver Watts , Jean-Michel Bernardon , Philippe Nedoncelle
IPC分类号： C07C43/23 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/49 , A61K31/045 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61P17/00 , A61P27/02 , A61P43/00 , A61Q5/02 , C07C27/00 , C07C29/147 , C07C33/18 , C07C33/34 , C07C41/30 , C07C43/303 , C07C45/00 , C07C47/52 , C07C51/00 , C07C63/331 , C07C63/49 , C07C65/24 , C07C65/26 , C07C67/00 , C07C69/76 , C07C69/94 , C07C233/65 , C07C233/68 , C07C235/42 , C07D307/42 , C07D307/68 , C07D311/92 , C07D319/06 , C07D333/38 , C07H13/08 , C07H13/10 , A01N43/08 , C07D307/02 , C07D333/16
CPC分类号： C07C65/24 , C07C63/331 , C07C63/49 , C07D307/68 , C07D311/92 , C07D333/38 , Y10S514/844 , Y10S514/859 , Y10S514/863 , Y10S514/864 , Y10S514/886
摘要： A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula,X represents --CH.dbd.CH--, O or S,R.sub.1 represents hydrogen, branched alkyl having 3-15 carbon atoms, alkoxy having 1-6 carbon atoms or 1-adamantyl, R.sub.2 represents hydroxy, hydrogen, linear or branched alkyl having 1-15 carbon atoms Or alkoxy having 1-6 carbon atoms, with the proviso that R.sub.1 and R.sub.2 are not simultaneously hydrogen, or R.sub.1 and R.sub.2 together with the adjacent carbon atoms of the naphthalene ring form a 5 or 6 chain ring optionally substituted by at least one lower alkyl radical, or interrupted by an oxygen atom,R.sub.3 represents --CH.sub.2 OH or --COR.sub.4, or --CH.sub.3 when R.sub.1 and R.sub.2 taken together form a 5 or 6 chain ring,R.sub.4 represents --OR.sub.5 or ##STR2## R.sub.5 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl optionally substituted, or the residue of a sugar or the radical ##STR3## p is 1, 2 or 3, r' and r" represent hydrogen, lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl optionally substituted or the residue of an amino acid or the residue of an amino sugar, or taken together form a heterocycle.
摘要翻译：具有式（I）的多环芳族化合物及其盐具有有用的治疗和美容作用，特别是在牛皮癣中。在该式中，X表示-CH = CH-，O或S，R 1表示氢，具有3-15个碳原子的支链烷基，具有1-6个碳原子的烷氧基或1-金刚烷基，R2表示羟基，氢，直链或支链具有1-15个碳原子的烷基或具有1-6个碳原子的烷氧基，条件是R1和R2不同时为氢，或者R1和R2与萘环的相邻碳原子一起形成5或6个链环，被至少一个低级烷基取代或被氧原子中断时，R 3表示-CH 2 OH或-COR 4，或者当R 1和R 2一起形成5或6个环时为-CH 3，R 4表示-OR 5或R 5 表示氢，具有1-20个碳原子的烷基，单羟基烷基，多羟基烷基，任选取代的芳基或芳烷基，或糖或基团的残基p是1,2或3，r'和r“表示氢，低级烷基，单羟基烷基，多羟基烷基，任选取代的芳基或氨基酸的残基o r氨基糖的残基，或一起形成杂环。

5. 发明授权

US5468897A Bi-aromatic esters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compositions 失效
标题翻译：双芳族酯，其制备方法及其在人或兽医学和化妆品组合物中的应用
公开(公告)号：US5468897A
公开(公告)日：1995-11-21
申请号：US237991
申请日：1994-05-04
申请人： Braham Shroot , Jean-Michel Bernardon , William R. Pilgrim
发明人： Braham Shroot , Jean-Michel Bernardon , William R. Pilgrim
IPC分类号： A61K31/235 , A61K8/00 , A61K8/30 , A61K8/33 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61P11/00 , A61P17/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61Q5/00 , A61Q19/00 , C07C67/14 , C07C69/00 , C07C69/76 , C07C69/773 , C07C69/78 , C07C69/88 , C07C69/94 , C07C309/42 , C07C309/58 , C07C311/29 , C07C317/22 , C07C317/44 , C07C323/62 , C07C321/00
CPC分类号： C07C323/62 , C07C69/94 , C07C2103/74
摘要： Bi-aromatic esters have the formula ##STR1## wherein R.sub.1 represents H, OH, --CH.sub.3, --CH.sub.2 OH, --CH(OH)CH.sub.3, --COOR.sub.9, ##STR2## or SO.sub.2 R.sub.10 ; R.sub.9 represents H, C.sub.1 -C.sub.6 alkyl or mono or polyhydroxyalkyl; R.sub.10 represents OH, C.sub.1 -C.sub.6 alkyl or ##STR3## r' and r" represent H, C.sub.1 -C.sub.6 alkyl, aryl, aralkyl, mono or polyhydroxyalkyl, or r' and r" taken together form a heterocycle; R.sub.2 represents H, C.sub.1 -C.sub.6 alkyl, OR.sub.9, F or --CF.sub.3 ; R.sub.3, R.sub.4 and R.sub.5 represent H, F, OH, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --COOH or --CH.sub.2 OH; R.sub.6 and R.sub.8 represent H, .alpha.-substituted C.sub.3 -C.sub.15 alkyl, .alpha., .alpha.'-disubstituted C.sub.4 -C.sub.12 alkyl, C.sub.3 -C.sub.12 cycloalkyl, C.sub.5 -C.sub.12 mono or polycyclic cycloalkyl whose linking carbon is trisubstituted, --SR.sub.11, --SO.sub.2 R.sub.11 or --SOR.sub.11 ; R.sub.11 represents C.sub.1 -C.sub.6 alkyl or cycloalkyl; R.sub.6 and R.sub.8 cannot simultaneously represent H; R.sub.7 represents H, C.sub.1 -C.sub.6 alkyl, alkenyl, alkenyloxy, OR.sub.12 or SR.sub.13 ; R.sub.12 represents H, C.sub.1 -C.sub.6 alkyl or alkenyl; R.sub.3 represents H, C1-C.sub.6 alkyl or aralkyl; with the proviso that when R.sub.1 represents ##STR4## and R.sub.2 represents H then: (i) either R.sub.3 and R.sub.4 are other than H or --CH.sub.3, (ii) or R.sub.7 is other than OR.sub.12 and R.sub.6 or R.sub.8 is cycloalkyl having more than 7 carbon atoms, (iii) or R.sub.7 is OR.sub.12 but R.sub.6 and R.sub.8 are other than H, (iv) or R.sub.7 is OR.sub.12 but R.sub.5 is other than H.The bi-aromatic esters are employed in human and veterinary medicine and in cosmetic compositions.
摘要翻译：双芳族酯具有式（I）其中R 1表示H，OH，-CH 3，-CH 2 OH，-CH（OH）CH 3，-COOR 9，或SO 2 R 10; R9表示H，C1-C6烷基或单或多羟基烷基; R 10表示OH，C 1 -C 6烷基或R 3'，R“表示H，C 1 -C 6烷基，芳基，芳烷基，单或多羟基烷基，或r'和r”一起形成杂环; R 2表示H，C 1 -C 6烷基，OR 9，F或-CF 3; R3，R4和R5表示H，F，OH，-CH3，-OCH3，-CF3，-COOH或-CH2OH; R 6和R 8表示H，α-取代的C 3 -C 15烷基，α，α'-二取代的C 4 -C 12烷基，C 3 -C 12环烷基，连接碳是三取代的C 5 -C 12单环或多环环烷基，-SR 11，-SO 2 R 11或 - SOR11; R11表示C1-C6烷基或环烷基; R6和R8不能同时代表H; R7表示H，C1-C6烷基，烯基，烯氧基，OR12或SR13; R12表示H，C1-C6烷基或烯基; R3表示H，C1-C6烷基或芳烷基; 条件是当R1表示且R2表示H时：（i）R3和R4不是H或-CH3，（ii）或R7不是OR12，R6或R8是大于7的环烷基碳原子，（iii）或R7是OR12，但R6和R8不是H，（iv）或R7是OR12，但R5不是H.双芳族酯用于人类和兽医学和化妆品组合物中。

6. 发明授权

US5268494A Sulphur-containing eicosanoides and their application in pharmacy and in cosmetics 失效
标题翻译：含硫二氰菊酯及其在药房和化妆品中的应用
公开(公告)号：US5268494A
公开(公告)日：1993-12-07
申请号：US893820
申请日：1992-06-04
申请人： Braham Shroot , Christopher Hensby , Jean Maignan , Gerard Lang , Michel Colin
发明人： Braham Shroot , Christopher Hensby , Jean Maignan , Gerard Lang , Michel Colin
IPC分类号： A61K8/14 , A61K8/46 , A61Q19/00 , C07C317/44 , C07C323/52 , C07C323/60 , C07C233/00
CPC分类号： C07C323/52 , A61K8/14 , A61K8/46 , A61Q19/00 , C07C317/44 , C07C323/60
摘要： Compounds corresponding to the formula: ##STR1## wherein A represents --CH.sub.2).sub.2 or --C.tbd.C--;n is equal to 0, 1 or 2;R represents hydroxyl, alkoxy having the formula --OR.sub.1, or amino having the formula ##STR2## R.sub.1 represents alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl;R.sub.2 and R.sub.3 represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl;R.sub.2 and R.sub.3 form, with the nitrogen atom, a heterocyclic ring.Application of these compounds in pharmacy and cosmetics.
摘要翻译：对应于下式的化合物：其中A代表-CH2）2或-C3ONDC-; n等于0,1或2; R表示羟基，具有式-OR 1的烷氧基或具有下式的氨基R1表示烷基，单羟基烷基，多羟基烷基，芳基或芳烷基; R2和R3表示氢，烷基，单羟基烷基，多羟基烷基，芳基或苄基; R2和R3与氮原子形成杂环。这些化合物在药房和化妆品中的应用。

7. 发明授权

US5093516A Aromatic compounds, a process for their preparation and their use in human and veterinary medicine and for cosmetic compositions 失效
标题翻译：芳香化合物，其制备方法及其在人和兽医学和化妆品组合物中的应用
公开(公告)号：US5093516A
公开(公告)日：1992-03-03
申请号：US33690
申请日：1987-04-03
申请人： Jean Maignan , Gerard Lang , Gerard Malle , Serge Restle , Braham Shroot
发明人： Jean Maignan , Gerard Lang , Gerard Malle , Serge Restle , Braham Shroot
IPC分类号： C07C41/00 , A61K8/00 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/46 , A61K31/045 , A61K31/075 , A61K31/11 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/395 , A61Q5/00 , A61Q19/10 , C07C33/18 , C07C33/24 , C07C33/26 , C07C33/28 , C07C33/34 , C07C33/36 , C07C33/38 , C07C39/15 , C07C39/17 , C07C39/205 , C07C43/14 , C07C43/178 , C07C43/20 , C07C43/23 , C07C43/257 , C07C43/295 , C07C43/30 , C07C43/315 , C07C45/30 , C07C47/542 , C07C49/76 , C07C49/86 , C07C51/00 , C07C59/48 , C07C59/64 , C07C59/84 , C07C63/36 , C07C65/01 , C07C65/105 , C07C65/11 , C07C65/17 , C07C65/26 , C07C65/32 , C07C65/34 , C07C65/36 , C07C65/40 , C07C67/00 , C07C69/738 , C07C69/76 , C07C69/773 , C07C229/06 , C07C231/00 , C07C231/02 , C07C235/84 , C07C239/00 , C07C317/22 , C07C317/44 , C07C323/19 , C07D295/18
CPC分类号： C07C65/40 , C07C33/26 , C07C45/305 , C07C49/86 , C07C59/84 , C07C65/105 , C07C65/11 , C07C65/17 , C07C65/34 , C07C65/36
摘要： An aromatic compound of the formula ##STR1## wherein n is 0 or 1,(1) when n is 1,R' represents hydrogen or C.sub.1 -C.sub.4 alkoxy,R" represents hydrogen, OH, C.sub.1 -C.sub.4 acyloxy, C.sub.1 -C.sub.4 alkoxy or amino,or R' and R" taken together form an oxo, methano or hydroxy-imino radical,R.sub.1 represents--CH.sub.2 OH or --COR.sub.10,R.sub.10 represents hydrogen, OR.sub.11 or ##STR2## R.sub.11 represents hydrogen, C.sub.1 -C.sub.20 alkyl, monohydroxyalkyl, polyhydroxy alkyl, aryl, aralkyl, the residue of a sugar or ##STR3## p is 1,2 or 3, r' and r" represent hydrogen, lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of an amino acid or the residue of an aminated sugar, of r' and r" taken together form a heterocycle,R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 represent hydrogen, OH, C.sub.1 -C.sub.12 alkyl, cycloalkyl, cycloalkenyl, phenyl or a radical of the formulas (i)--X--C.sub.6 H.sub.5, (ii)--X--R.sub.12 or (iii)--NHCOR.sub.13,X is --0--,--S--,--SO--,--SO.sub.2 -- or--OCO,R.sub.12 is alkyl or fluoroalkyl,R.sub.13 is alkyl or phenyl,with at least one or R.sub.2 to R.sub.6 being other than hydrogen,R.sub.7, R.sub.8 and R.sub.9 represent hydrogen or methyl, R.sub.7 and R.sub.9, taken together, being able to form, with the benzene ring, a naphthalene ring, with the exclusion of compounds of formula (I) wherein R.sub.7 is hydrogen or methyl when R.sub.4 represents methyl or OH when R.sub.2, R.sub.3, R.sub.5 and R.sub.6 represent hydrogen or when R.sub.6 represents hydroxyl,(2) when n is 0,R' represents hydrogen,R" represents OH,or R' and R" taken together form an oxo radical,R.sub.1 represents --CH.sub.2 OH, --CH.dbd.0 or --COOR.sub.11,R.sub.11 represents hydrogen or alkyl,R.sub.2 and R.sub.3 represents hydrogen or C.sub.3 -C.sub.6 alkyl,R.sub.5 represents(i) C.sub.3 -C.sub.6 cycloalkyl or alkyl in which case, R.sub.4 represents alkyl, hydroxy or alkoxy, or(ii) hydrogen, in which case R.sub.4 represents alkyl,R.sub.6 represents hydrogen, andR.sub.7 represents hydrogen or methyl, and the salts of said aromatic compound as well as its optical and geometric isomers.These compounds are useful in human and veterinary medicines and in cosmetic compositions.

8. 发明授权

US4961922A Complexes based on anthralin and a sterol, a process for obtaining them and their use in therapeutics and cosmetics 失效
标题翻译：基于蒽醌和固醇的复合物，获得它们的方法及其在治疗和化妆品中的应用
公开(公告)号：US4961922A
公开(公告)日：1990-10-09
申请号：US337800
申请日：1989-04-13
申请人： Braham Shroot , Daniele Caron , Jean-Claude Caron , Alain Brzokewicz
发明人： Braham Shroot , Daniele Caron , Jean-Claude Caron , Alain Brzokewicz
IPC分类号： A61K31/05 , A61K8/00 , A61K8/25 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/63 , A61K8/89 , A61K8/891 , A61K31/575 , A61K47/28 , A61P17/00 , A61P29/00 , A61Q3/00 , A61Q5/00 , A61Q17/00 , A61Q19/00 , C07C37/86 , C07C39/12 , C07J9/00 , C07J75/00 , C08L83/07
CPC分类号： C07J9/00 , A61K31/575 , A61K8/347 , A61K8/63 , A61Q19/00 , A61Q3/00 , A61Q5/00 , A61K2800/28 , Y10S514/861 , Y10S514/863 , Y10S514/88
摘要： A complex based on anthralin and a sterol, characterized in that its melting point is 10 to 25 degrees Celsius lower than that of the constituent of the complex melting at the lowest temperature and that the proportion of anthralin varies between 10 and 90 mol %.
摘要翻译：基于蒽醌和固醇的复合物，其特征在于，其熔点比在最低温度下熔化的络合物的成分低10至25摄氏度，并且所述蒽醌的比例在10至90摩尔％之间变化。

9. 发明授权

US4940696A Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions 失效
标题翻译：苯并萘衍生物及其在治疗和美容组合物中的用途
公开(公告)号：US4940696A
公开(公告)日：1990-07-10
申请号：US120958
申请日：1987-11-16
申请人： Braham Shroot , Jacques Eustache , Jean-Michel Bernardon
发明人： Braham Shroot , Jacques Eustache , Jean-Michel Bernardon
IPC分类号： C07C43/20 , A61K8/00 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/42 , A61K8/49 , A61K8/58 , A61K31/045 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/445 , A61K31/535 , A61K31/70 , A61K31/7024 , A61P11/00 , A61P17/00 , A61P27/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/08 , A61Q5/00 , A61Q19/00 , C07C27/00 , C07C33/18 , C07C33/34 , C07C39/14 , C07C39/17 , C07C41/00 , C07C43/23 , C07C51/00 , C07C63/34 , C07C63/36 , C07C65/11 , C07C65/17 , C07C65/24 , C07C65/26 , C07C67/00 , C07C69/00 , C07C69/035 , C07C69/76 , C07C69/94 , C07C233/12 , C07C233/65 , C07C235/66 , C07C313/00 , C07C323/62 , C07D295/18 , C07D295/185 , C07D295/192 , C07F7/18 , C07H13/08 , C07H15/203
CPC分类号： C07D295/185 , A61K8/368 , A61Q19/00 , A61Q19/008 , A61Q5/00 , A61Q7/00 , C07C235/66 , C07C323/62 , C07C63/36 , C07C65/11 , C07C65/17 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/94 , C07D295/192 , C07F7/1856 , A61K2800/92 , C07C2103/74 , Y10S514/844 , Y10S514/845 , Y10S514/859 , Y10S514/863 , Y10S514/88 , Y10S514/885 , Y10S514/886 , Y10S514/887 , Y10S514/912 , Y10S514/913 , Y10S514/914
摘要： A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radical; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues. The compound also possesses anti-tumor acitivity.

10. 发明授权

US4892864A Pharmaceutical and cosmetic compositions containing as an active component 10-acetyl-1,8,9-triacetoxy anthracene 失效
标题翻译：含有作为活性成分的10-乙酰基-1,8,9-三乙酰氧基蒽的药物和化妆品组合物
公开(公告)号：US4892864A
公开(公告)日：1990-01-09
申请号：US153600
申请日：1988-02-08
申请人： Braham Shroot , Gerard Lang , Jean Maignan
发明人： Braham Shroot , Gerard Lang , Jean Maignan
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/31 , A61K8/65 , A61K31/22 , A61K31/225 , A61P17/00 , A61P29/00 , A61P43/00 , A61Q5/02 , A61Q17/00 , C07C69/18
CPC分类号： A61K31/225 , Y10S514/861 , Y10S514/864
摘要： Pharmaceutical and cosmetic compositions contain as the active component 10-acetyl-1,8,9-triacetoxy anthracene.
摘要翻译：药物和化妆品组合物含有作为活性成分的10-乙酰基-1,8,9-三乙酰氧基蒽。

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