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1. 发明授权

US06963767B2 Pulse oximeter 有权
标题翻译：脉搏血氧仪
公开(公告)号：US06963767B2
公开(公告)日：2005-11-08
申请号：US10136956
申请日：2002-05-02
申请人： Borje Rantala , Erno Muuranta , Markku Spoof , Matti Huiku
发明人： Borje Rantala , Erno Muuranta , Markku Spoof , Matti Huiku
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/14532 , A61B5/7221
摘要： The invention relates to pulse oximeters used to measure blood oxygenation. The current trend towards lower power consumption has brought a problem of erroneous readings caused by intrachannel crosstalk, i.e. errors due to the coupling of undesired capacitive, inductive, or conductive (resistive) pulse power from the emitting side of the pulse oximeter directly to the detecting side of the oximeter. The pulse oximeter of the invention is therefore provided with means for detecting whether intrachannel crosstalk is present and whether it will cause erroneous results in the oxygenation measurements. The pulse oximeter is preferably further provided with means for eliminating intrachannel crosstalk which are adapted to control the measurement so that measurement signals can be obtained which are substantially void of crosstalk components.
摘要翻译：本发明涉及用于测量血氧的脉搏血氧仪。目前降低功耗的趋势带来了由通道内串扰引起的错误读数的问题，即由脉冲血氧计的发射侧直接与检测的不需要的电容，电感或导电（电阻）脉冲功率的耦合引起的误差血液计的一侧。因此，本发明的脉搏血氧计提供了用于检测是否存在通道内串扰以及是否会在氧合测量中导致错误结果的装置。脉搏血氧计优选还具有用于消除通道内串扰的装置，其适于控制测量，从而可以获得基本上无串扰分量的测量信号。

2. 发明申请

US20080242955A1 RELIABILITY IN DETERMINATION OF CLINICAL STATE OF A SUBJECT 审中-公开
标题翻译：确定受试者临床状态的可靠性
公开(公告)号：US20080242955A1
公开(公告)日：2008-10-02
申请号：US11693895
申请日：2007-03-30
申请人： Kimmo Uutela , Borje Rantala , Minna Kymalainen , Matti Huiku , Petri Karkas
发明人： Kimmo Uutela , Borje Rantala , Minna Kymalainen , Matti Huiku , Petri Karkas
IPC分类号： A61B5/00
CPC分类号： A61B5/0402 , A61B5/021 , A61B5/4821 , A61B5/4824 , G16H50/20
摘要： The invention relates to the determination of a diagnostic index indicative of the clinical state, especially nociceptive state, of a subject. In order to improve the quality of the determination process, desired input signals derived from the subject are monitored and the quality of the process is improved based on the monitoring. This is implemented by increasing user awareness of the reliability of the index or by controlling the measurement set-up. Quality information indicative of the reliability of the current index values may be produced based on the input signals. The quality information may then be employed to give an indication of the current reliability of the index and a warning if the reliability of the diagnostic index becomes compromised.
摘要翻译：本发明涉及确定指示受试者的临床状态，特别是伤害感受状态的诊断指标。为了提高确定处理的质量，监视从对象导出的期望的输入信号，并且基于监视提高处理的质量。这是通过提高用户对指标可靠性的认识或通过控制测量设置来实现的。可以基于输入信号来产生指示当前索引值的可靠性的质量信息。然后可以采用质量信息来给出索引的当前可靠性的指示和如果诊断索引的可靠性变得损害的警告。

3. 发明申请

US20120253147A1 CALIBRATION METHOD AND ARRANGEMENT AND SENSOR FOR NON-INVASIVELY MEASURING BLOOD CHARACTERISTICS OF A SUBJECT 审中-公开
标题翻译：校准方法和安排和传感器对非主动测量血液学特性的影响
公开(公告)号：US20120253147A1
公开(公告)日：2012-10-04
申请号：US13076622
申请日：2011-03-31
申请人： Matti Huiku , Antti Tolonen , Victor Petrovich Ostroverkhov , Katja Urpalainen
发明人： Matti Huiku , Antti Tolonen , Victor Petrovich Ostroverkhov , Katja Urpalainen
IPC分类号： A61B5/1455
CPC分类号： A61B5/1495 , A61B5/14546 , A61B5/14551
摘要： A calibration method for an apparatus for non-invasively monitoring blood characteristics of a subject is disclosed. The apparatus is provided with a computational model representing a relationship between in-vivo measurement signals obtained from the subject and the blood characteristics. The providing includes employing at least one tissue property variable in the computational model, in which the at least one tissue property variable is indicative of absorption and scattering characteristics of the subject's tissue. An arrangement for determining blood characteristics of a subject and a sensor for the arrangement are also disclosed.
摘要翻译：公开了一种用于非侵入性地监测对象的血液特性的装置的校准方法。该装置设置有表示从受试者获得的体内测量信号与血液特性之间的关系的计算模型。提供包括在计算模型中采用至少一个组织属性变量，其中至少一个组织属性变量指示受试者组织的吸收和散射特征。还公开了一种用于确定对象的血液特性和用于该装置的传感器的装置。

4. 发明授权

US07925338B2 Determination of the anesthetic state of a patient 有权
标题翻译：确定患者的麻醉状态
公开(公告)号：US07925338B2
公开(公告)日：2011-04-12
申请号：US11089529
申请日：2005-03-24
申请人： Matti Huiku
发明人： Matti Huiku
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/02 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/0402 , A61B5/0476 , A61B5/4064 , A61B5/4076 , A61B5/4824 , A61B5/4839
摘要： The invention relates to the determination of the anesthetic state of a patient. In order to achieve a mechanism that enables establishment and maintenance of balanced anesthesia, values are established for a set of diagnostic indices. The set includes at least two diagnostic indices of which a first diagnostic index is indicative of the level of hypnosis and a second diagnostic index of the level of nociception in the patient. The combination of the at least two index values obtained is employed for indicating the anesthetic state of the patient. The combination of the at least two index values may further be employed to control the administration of drugs to the patient.
摘要翻译：本发明涉及确定患者的麻醉状态。为了实现能够建立和维持平衡麻醉的机制，建立了一组诊断指标的值。该组包括至少两个诊断指标，其中第一诊断指标指示催眠水平，以及患者中伤害水平水平的第二诊断指标。获得的至少两个指标值的组合用于指示患者的麻醉状态。还可以使用至少两个指标值的组合来控制向患者施用药物。

5. 发明申请

US20110077474A1 METHOD, ARRANGEMENT AND APPARATUS FOR ASSESSING FLUID BALANCE STATUS OF A SUBJECT 审中-公开
标题翻译：用于评估主体流体平衡状态的方法，装置和装置
公开(公告)号：US20110077474A1
公开(公告)日：2011-03-31
申请号：US12569118
申请日：2009-09-29
申请人： Matti Huiku
发明人： Matti Huiku
IPC分类号： A61B5/0205
CPC分类号： A61B5/4875 , A61B5/021 , A61B5/02416 , A61B5/14551 , A61B5/412 , A61M16/024
摘要： A method, arrangement and apparatus for assessing fluid balance status of a subject are disclosed. At least one physiological parameter responsive to blood volume changes in the subject is determined and a predetermined change in the ventilation of the subject is produced. The response that the predetermined change of ventilation causes in at least one of the at least one physiological parameter is then determined, thereby to obtain at least one measure of change. The fluid balance status of the subject may be assessed based on the at least one measure of change. The subject is typically connected to a ventilator and the predetermined change is produced by controlling the ventilator.
摘要翻译：公开了一种用于评估受试者的液体平衡状态的方法，装置和装置。确定响应受试者的血容量变化的至少一个生理参数，并且产生对象的通气的预定变化。然后确定在至少一个生理参数中的至少一个生理参数中引起通气的预定变化的响应，从而获得至少一个变化量度。可以基于至少一种变化量来评估受试者的液体平衡状态。受试者通常连接到呼吸机，并且通过控制呼吸机产生预定的变化。

6. 发明申请

US20090076354A1 COMPENSATION OF HUMAN VARIABILITY IN PULSE OXIMETRY 有权
标题翻译：脉冲OXIMETRY中人类可变性的补偿
公开(公告)号：US20090076354A1
公开(公告)日：2009-03-19
申请号：US12233251
申请日：2008-09-18
申请人： Matti Huiku
发明人： Matti Huiku
IPC分类号： A61B5/145
CPC分类号： A61B5/14551 , A61B5/1495
摘要： The invention relates to a method of calibrating a pulse oximeter, in which the effects caused by tissue of a subject can be taken into account. A detector output signal is measured when living tissue of the subject is present between emitters and the detector in a sensor. Nominal calibration and nominal calibration characteristics are read from a memory, whereupon values for the same nominal characteristics for the sensor on living tissue of the subject are established using the detector output signal. Then, changes in the nominal calibration characteristics induced by the living tissue are calculated and a subject-specific calibration is formed by correcting the nominal calibration with the changes. Finally, the hemoglobin fractions are solved using the corrected nominal calibration. The invention also relates to a pulse oximeter having pre-stored data in a memory comprising data of initial characterization measurements, data of nominal characteristics describing calibration conditions under which a predetermined calibration of the apparatus has been applied, and data of nominal calibration and nominal calibration characteristics. An extinction coefficient compensation block is operatively connected to the first signal processing means and to the memory for reading data, said block comprising first calculation means adapted to correct the nominal characteristics of the sensor on living tissue of the subject. A transformation compensation block is operatively connected to the first signal processing means for receiving the DC signals and to the memory for reading data, said block comprising second calculation means adapted to correct the transformation values based on the changes in the DC signals induced by tissue of the subject. Alternatively, said data may be stored in the sensor part of the pulse oximeter.
摘要翻译：本发明涉及校准脉搏血氧计的方法，其中可以考虑由受试者的组织引起的影响。当传感器中的发射器和检测器之间存在主体的生物体组织时，测量检测器输出信号。从存储器读取标称校准和标称校准特性，由此使用检测器输出信号建立对象的活体组织上的传感器的相同标称特性的值。然后，计算由活体组织引起的标称校准特性的变化，并通过用变化校正标称校准来形成对象特异性校准。最后，使用校正的标称校准来解决血红蛋白级分。本发明还涉及在存储器中具有预存数据的脉冲血氧计，其包括初始表征测量的数据，描述已经应用了装置的预定校准的校准条件的标称特性的数据，以及额定校准和标称校准的数据特点消光系数补偿块可操作地连接到第一信号处理装置和用于读取数据的存储器，所述块包括适于校正被摄体的活体组织上的传感器的标称特性的第一计算装置。变换补偿块可操作地连接到用于接收DC信号的第一信号处理装置和用于读取数据的存储器，所述块包括第二计算装置，其适于基于由组织引起的DC信号的变化来校正变换值主题。或者，所述数据可以存储在脉搏血氧计的传感器部分中。

7. 发明授权

US07407485B2 Monitoring pain-related responses of a patient 有权
标题翻译：监测患者的疼痛相关反应
公开(公告)号：US07407485B2
公开(公告)日：2008-08-05
申请号：US10863719
申请日：2004-06-08
申请人： Matti Huiku
发明人： Matti Huiku
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/4035 , A61B5/0059 , A61B5/0456 , A61B5/0488 , A61B5/0816 , A61B5/4824
摘要： The invention relates to monitoring of pain-related responses in a patient in order to detect the level of pain experienced by the patient. At least one first measurement signal is acquired from the patient and at least one of the signals is transformed into a normalized signal having a predetermined value range. Based on the at least one normalized signal obtained in this way, a threshold condition is set and a rate at which at least one second measurement signal fulfills the threshold condition is monitored, wherein each of the at least one second measurement signal is derivable from a corresponding normalized signal and indicative of pain-related activity in the patient. The level of pain experienced by the patient depends on the rate monitored.
摘要翻译：本发明涉及对患者疼痛相关反应的监测，以便检测患者经历的疼痛水平。从患者获取至少一个第一测量信号，并且至少一个信号被变换成具有预定值范围的归一化信号。基于以这种方式获得的至少一个归一化信号，设置阈值条件，并且监视至少一个第二测量信号满足阈值条件的速率，其中至少一个第二测量信号中的每一个可从相应的归一化信号并指示患者疼痛相关活动。患者经历的疼痛程度取决于监测的速度。

8. 发明授权

US08715193B2 Determination of the clinical state of a subject 有权
标题翻译：确定受试者的临床状态
公开(公告)号：US08715193B2
公开(公告)日：2014-05-06
申请号：US11089528
申请日：2005-03-24
申请人： Panu Takala , Matti Huiku
发明人： Panu Takala , Matti Huiku
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/4821 , A61B5/02 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/0402 , A61B5/0816 , A61B5/4824
摘要： The invention relates to the determination of the clinical state of a subject. In order to bring about an uncomplicated method for monitoring the clinical state of a subject and for accomplishing a diagnostic scale, such as a nociception scale, on which a certain reading corresponds to the same level for all patients, a normalization transform is applied to a measurement signal containing physiological data obtained from a patient, whereby a normalized measurement signal having a predetermined value range is obtained. The normalization transform is dependent on predetermined history data, such as previous signal data of said measurement signal. A diagnostic index dependent on the normalized measurement signal is then formed, the diagnostic index serving as a measure of the clinical state of the patient. The diagnostic index may be formed based on one or more normalized measurement signals.
摘要翻译：本发明涉及确定受试者的临床状态。为了实现用于监测受试者的临床状态和完成诊断量表（例如伤害感受量表）的简单方法，其中某个读数对应于所有患者的相同水平，归一化变换被应用于测量信号，其包含从患者获得的生理数据，由此获得具有预定值范围的归一化测量信号。归一化变换取决于预定历史数据，例如所述测量信号的先前信号数据。然后形成依赖于归一化测量信号的诊断指标，诊断指标用作患者临床状态的量度。诊断指标可以基于一个或多个归一化的测量信号形成。

9. 发明授权

US08574156B2 Determination of the clinical state of a subject 有权
标题翻译：确定受试者的临床状态
公开(公告)号：US08574156B2
公开(公告)日：2013-11-05
申请号：US11174763
申请日：2005-07-05
申请人： Kimmo Uutela , Matti Huiku , Juha Virtanen
发明人： Kimmo Uutela , Matti Huiku , Juha Virtanen
IPC分类号： A61B5/00 , A61B5/0476 , A61B5/04 , G06F19/00
CPC分类号： G06F19/3431 , A61B5/0006 , A61B5/0205 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/04001 , A61B5/04004 , A61B5/0402 , A61B5/0452 , A61B5/0476 , A61B5/4035 , A61B5/4821 , A61B5/4824 , A61B5/4839 , A61B5/7275 , A61B5/7282 , G06F19/00 , G06F19/34 , G06K9/00523 , G16H50/20 , G16H50/30 , Y10S128/92
摘要： The invention relates to the determination of the clinical state of a subject. A respective adaptive transform is applied to at least one measurement signal acquired from the subject, each adaptive transform being dependent on previously acquired history data, and a diagnostic index is formed, which is dependent on the transformed measurement signal(s) and serves as a measure of the clinical state of the subject. In order to reliably evaluate the clinical state of a subject on a fixed diagnostic scale during changes in the state of the subject, some or all of the previously acquired history data on which an adaptive transform is currently dependent is replaced with other previously acquired history data when a predetermined event is detected. The predetermined event is indicative of a change in the respective measurement signal, and the introduction of the said other previously acquired history data sets the transform ready for the change.
摘要翻译：本发明涉及确定受试者的临床状态。相应的自适应变换被应用于从对象获取的至少一个测量信号，每个自适应变换依赖于先前获取的历史数据，并且形成诊断索引，其依赖于变换的测量信号并且用作测量受试者的临床状态。为了在受试者的状态改变期间可靠地评估受试者在固定诊断量表上的临床状态，其中自适应变换当前依赖的先前获取的历史数据中的一些或全部被替换为其他先前获得的历史数据当检测到预定事件时。预定事件表示各测量信号的变化，并且所述其它先前获取的历史数据的引入将变换准备就绪。

10. 发明申请

US20120209095A1 SENSOR, APPARATUS AND METHOD FOR NON-INVASIVELY MONITORING BLOOD CHARACTERISTICS OF A SUBJECT 有权
标题翻译：传感器，装置和方法，用于非主动监测主体的血液特性
公开(公告)号：US20120209095A1
公开(公告)日：2012-08-16
申请号：US13027544
申请日：2011-02-15
申请人： Matti Huiku
发明人： Matti Huiku
IPC分类号： A61B5/1468
CPC分类号： A61B5/14551
摘要： A sensor, apparatus and method for non-invasively monitoring blood characteristics of a subject are disclosed. The sensor comprises an emitter unit configured to emit radiation through the tissue of the subject at a plurality of measurement wavelengths and a detector unit that comprises photo detectors. To achieve a simple sensor assembly, the photo detectors are together adapted to receive the radiation at the plurality of wavelengths and to produce in-vivo measurement signals corresponding to the plurality of measurement wavelengths, the in-vivo measurement signals being indicative of absorption caused by blood of the subject. Furthermore, the photo detectors are mounted so that optical paths from the emitter unit to the photo detectors are different, and the plurality of wavelengths are divided between the photo detectors so that two spectrally adjacent photo detectors have at least one common wavelength. The apparatus comprises a path normalization unit configured to normalize the in-vivo measurement signals to an optical path specific to one of the photo detectors.
摘要翻译：公开了一种用于非侵入性地监测受试者的血液特性的传感器，装置和方法。传感器包括被配置为以多个测量波长发射穿过被检体的组织的辐射器单元和包括光电检测器的检测器单元。为了实现简单的传感器组件，光检测器一起适于接收多个波长的辐射并产生对应于多个测量波长的体内测量信号，体内测量信号表示由受试者的血液。此外，光检测器被安装成使得从发射器单元到光电检测器的光路不同，并且多个波长在光电检测器之间被分开，使得两个光谱相邻的光电检测器具有至少一个共同的波长。该装置包括路径归一化单元，其被配置为将体内测量信号归一化为特定于一个光检测器的光路。

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