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1. 发明授权

US08715738B2 Fullerene-silica nanoparticles with improved fluorescence, preparation method thereof and use thereof 有权
标题翻译：具有改进荧光的富勒烯二氧化硅纳米颗粒，其制备方法和用途
公开(公告)号：US08715738B2
公开(公告)日：2014-05-06
申请号：US12993908
申请日：2009-01-06
申请人： Bong Hyun Chung , Jinyoung Jeong , Nam Woong Song
发明人： Bong Hyun Chung , Jinyoung Jeong , Nam Woong Song
IPC分类号： A61K9/14
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/152 , C09K11/02 , C09K11/65
摘要： The present invention relates to fullerene-silica nanoparticles with improved fluorescence, a preparation method of the fullerene-silica nanoparticles, and use thereof. More specifically, the present invention relates to fullerene-silica nanoparticles with improved fluorescence in which fullerene and silica are covalently linked, a preparation method of the fullerene-silica nanoparticles, and use thereof. The preparation method of the fullerene-silica nanoparticles comprises the steps of: adding a surfactant to a non-polar organic solvent and a polar solvent and stirring them to form reverse micelles (step 1); adding fullerene to the reverse micelles formed in the step 1 and stirring them (step 2); and adding a silica precursor and a catalyst to a reaction solution containing the fullerene prepared in the step 2 and stirring them to prepare fullerene-silica nanoparticles (step 3). According to the present invention, fullerene-silica nanoparticles in the form of a uniform spherical shape of tens of nanometers can be prepared. As such prepared fullerene-silica nanoparticles have a large surface area due to a nanometer-sized structure, they have good reactivity. Compared with heavy metals or metal nanoparticles, the fullerene-silica nanoparticles, because of using silica, are harmless to a living body. Further, as the fullerene-silica nanoparticles exhibit strong fluorescence, they can be used as a contrast agent for in-vivo imaging or as a drug delivery carrier.
摘要翻译：本发明涉及具有改进荧光的富勒烯二氧化硅纳米粒子，富勒烯 - 二氧化硅纳米粒子的制备方法及其应用。更具体地，本发明涉及富勒烯和二氧化硅共价连接的具有改进荧光的富勒烯二氧化硅纳米粒子，富勒烯二氧化硅纳米粒子的制备方法及其用途。富勒烯二氧化硅纳米粒子的制备方法包括以下步骤：向非极性有机溶剂和极性溶剂中加入表面活性剂并搅拌形成反胶束（步骤1）。向步骤1中形成的反胶束中加入富勒烯并搅拌（步骤2）; 并将二氧化硅前体和催化剂加入到包含步骤2中制备的富勒烯的反应溶液中并搅拌以制备富勒烯二氧化硅纳米颗粒（步骤3）。根据本发明，可以制备数十纳米的均匀球形形式的富勒烯二氧化硅纳米颗粒。由于这种制备的富勒烯二氧化硅纳米颗粒由于纳米尺寸的结构而具有大的表面积，所以它们具有良好的反应性。与重金属或金属纳米粒子相比，由于使用二氧化硅，富勒烯二氧化硅纳米粒子对生物体无害。此外，由于富勒烯二氧化硅纳米粒子表现出强烈的荧光，因此它们可以用作体内成像的造影剂或药物递送载体。

2. 发明申请

US20110171097A1 FULLERENE-SILICA NANOPARTICLES WITH IMPROVED FLUORESCENCE, PREPARATION METHOD THEREOF AND USE THEREOF 有权
标题翻译：具有改进荧光的富勒烯二氧化硅纳米颗粒，其制备方法及其用途
公开(公告)号：US20110171097A1
公开(公告)日：2011-07-14
申请号：US12993908
申请日：2009-01-06
申请人： Bong Hyun Chung , Jinyoung Jeong , Nam Woong Song
发明人： Bong Hyun Chung , Jinyoung Jeong , Nam Woong Song
IPC分类号： C01B33/00 , B82Y30/00 , B82Y40/00
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/152 , C09K11/02 , C09K11/65
摘要： The present invention relates to fullerene-silica nanoparticles with improved fluorescence, a preparation method of the fullerene-silica nanoparticles, and use thereof. More specifically, the present invention relates to fullerene-silica nanoparticles with improved fluorescence in which fullerene and silica are covalently linked, a preparation method of the fullerene-silica nanoparticles, and use thereof. The preparation method of the fullerene-silica nanoparticles comprises the steps of: adding a surfactant to a non-polar organic solvent and a polar solvent and stirring them to form reverse micelles (step 1); adding fullerene to the reverse micelles formed in the step 1 and stirring them (step 2); and adding a silica precursor and a catalyst to a reaction solution containing the fullerene prepared in the step 2 and stirring them to prepare fullerene-silica nanoparticles (step 3). According to the present invention, fullerene-silica nanoparticles in the form of a uniform spherical shape of tens of nanometers can be prepared. As such prepared fullerene-silica nanoparticles have a large surface area due to a nanometer-sized structure, they have good reactivity. Compared with heavy metals or metal nanoparticles, the fullerene-silica nanoparticles, because of using silica, are harmless to a living body. Further, as the fullerene-silica nanoparticles exhibit strong fluorescence, they can be used as a contrast agent for in-vivo imaging or as a drug delivery carrier.
摘要翻译：本发明涉及具有改进荧光的富勒烯二氧化硅纳米粒子，富勒烯 - 二氧化硅纳米粒子的制备方法及其应用。更具体地，本发明涉及富勒烯和二氧化硅共价连接的具有改进荧光的富勒烯二氧化硅纳米粒子，富勒烯二氧化硅纳米粒子的制备方法及其用途。富勒烯二氧化硅纳米粒子的制备方法包括以下步骤：向非极性有机溶剂和极性溶剂中加入表面活性剂并搅拌形成反胶束（步骤1）。向步骤1中形成的反胶束中加入富勒烯并搅拌（步骤2）; 并将二氧化硅前体和催化剂加入到包含步骤2中制备的富勒烯的反应溶液中并搅拌以制备富勒烯二氧化硅纳米颗粒（步骤3）。根据本发明，可以制备数十纳米的均匀球形形式的富勒烯二氧化硅纳米颗粒。由于这种制备的富勒烯二氧化硅纳米颗粒由于纳米尺寸的结构而具有大的表面积，所以它们具有良好的反应性。与重金属或金属纳米粒子相比，由于使用二氧化硅，富勒烯二氧化硅纳米粒子对生物体无害。此外，由于富勒烯二氧化硅纳米粒子表现出强烈的荧光，因此它们可以用作体内成像的造影剂或药物递送载体。

3. 发明授权

US08734762B2 Perfluorocarbon nano-emulsion containing quantum dot nanoparticles and method for preparing the same 有权
标题翻译：含有量子点纳米粒子的全氟化碳纳米乳液及其制备方法
公开(公告)号：US08734762B2
公开(公告)日：2014-05-27
申请号：US12738394
申请日：2008-08-20
申请人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
IPC分类号： A61B5/00 , A61B8/00 , A61K9/66
CPC分类号： C09K11/565 , C09K11/02 , C09K11/883
摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.
摘要翻译：本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地涉及制备多功能全氟碳纳米乳液的方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。

4. 发明授权

US08541005B2 Cysteine-tagged streptococcal protein G variant 有权
标题翻译：半胱氨酸标记的链球菌蛋白G变体
公开(公告)号：US08541005B2
公开(公告)日：2013-09-24
申请号：US12306903
申请日：2007-06-20
申请人： Bong Hyun Chung , Jeong Min Lee , Sun-Ok Jung , Yongwon Jung
发明人： Bong Hyun Chung , Jeong Min Lee , Sun-Ok Jung , Yongwon Jung
IPC分类号： A61K39/09 , A61K39/085 , C12Q1/00
CPC分类号： C07K14/31 , C07K17/00 , C07K2319/00 , C07K2319/20 , G01N33/54366 , G01N33/54393 , G01N33/56938 , G01N33/6854 , G01N2333/31 , G01N2333/315
摘要： The present invention relates to an N-terminal cysteine-tagged Streptococcal protein G variant. Since the variant binds in a directional manner to a surface of a biochip or a biosensor, the variant provides a biochip and a biosensor having an improved antibody-immobilizing capability, compared with an untagged protein G variant.
摘要翻译：本发明涉及N-末端半胱氨酸标记的链球菌蛋白G变体。由于变体以定向方式结合生物芯片或生物传感器的表面，与未标记的蛋白G变体相比，该变体提供具有改进的抗体固定能力的生物芯片和生物传感器。

5. 发明申请

US20130149374A1 Asymmetric Liposomes for the Highly Efficient Encapsulation of Nucleic Acids and Hydrophilic Anionic Compounds, and Method for Preparing Same 有权
标题翻译：用于高效包封核酸和亲水阴离子化合物的不对称脂质体及其制备方法
公开(公告)号：US20130149374A1
公开(公告)日：2013-06-13
申请号：US13697705
申请日：2010-11-12
申请人： Myung Kyu Lee , Abbas Mokhtarieh Amir , Bong Hyun Chung , Jong Min Choi
发明人： Myung Kyu Lee , Abbas Mokhtarieh Amir , Bong Hyun Chung , Jong Min Choi
IPC分类号： A61K9/127 , A61K31/713
CPC分类号： A61K9/1272 , A61K9/1271 , A61K9/1277 , A61K31/122 , A61K31/70 , A61K31/713
摘要： The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.
摘要翻译：本发明涉及用于核酸和亲水性阴离子化合物的高包封效率的不对称脂质体及其制备方法，具体涉及由具有小头基团作为内部脂质和中性的阳离子脂质组成的不对称脂质体或具有大头基的聚乙二醇化脂质作为外部脂质，其中核酸和/或阴离子化合物包封在内部脂质中。根据本发明，可以制备其中核酸和亲水性阴离子化合物以高效率包封的不对称脂质体，因此可以用于各种目的，例如基因治疗和递送亲水性阴离子药物其难以作为前药制备，并且药物递送，成像等可以通过将荧光对比剂包封在脂质体中来进行。

6. 发明申请

US20120220734A1 Reversible Fluorescence Photoswitch based on Dye-Crosslinked Dendritic Nanoclusters for High-Contrast Imaging of Living Biological Systems 有权
标题翻译：基于染料交联树枝状纳米团簇的可逆荧光光电开关，用于生物生物系统的高对比度成像
公开(公告)号：US20120220734A1
公开(公告)日：2012-08-30
申请号：US13218608
申请日：2011-08-26
申请人： Yoonkyung Kim , Hye-Youn Jung , Bong Hyun Chung
发明人： Yoonkyung Kim , Hye-Youn Jung , Bong Hyun Chung
IPC分类号： C09B69/10 , B82Y5/00 , B82Y15/00
CPC分类号： B82Y15/00 , C09B69/00
摘要： The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.
摘要翻译：本发明涉及一种基于染料交联树枝状纳米团簇的可逆荧光光电开关，用于生物体系的高对比度成像。根据本发明的树枝状纳米团簇由两个或更多个交联的树枝状聚合物组成，从而整体上具有球状，从而提高荧光强度并提高单体树枝状大分子的检测灵敏度。此外，发现根据本发明的树突状纳米簇独立地通过皮肤渗透和显微注射而内在化为活的斑马鱼。此外，根据本发明的树突状纳米簇显示低毒性，因此其可用于体内和体外成像以及离体细胞追踪应用。

7. 发明申请

US20110212032A1 POLYMER PARTICLES FOR NIR/MR BIMODAL MOLECULAR IMAGING AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用于NIR / MR双模分子成像的聚合物颗粒及其制备方法
公开(公告)号：US20110212032A1
公开(公告)日：2011-09-01
申请号：US12672185
申请日：2008-08-20
申请人： Bong Hyun Chung , Yong Taik LIm , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik LIm , Jung Hyun Han
IPC分类号： A61K49/12 , C12Q1/02
CPC分类号： C08J5/005 , A61K49/0002 , A61K49/0034 , A61K49/0067 , A61K49/0093 , A61K49/1824 , B82Y30/00 , C08J3/12 , C08J3/2053 , C08J3/215 , C08J2367/02 , G01R33/0213 , G01R33/1269 , G01R33/281 , G01R33/4808 , G01R33/5601
摘要： The present invention relates to polymer particles showing magnetic properties and fluorescent properties simultaneously and a preparation method thereof More specifically, relates to polymer particles for near infrared (NIR)/magnetic resonance (MR) bimodal molecular imaging, contain a magnetic nanomaterial and an NIR fluorescent material, and a preparation method thereof The disclosed polymer particles show magnetic properties and fluorescent properties simultaneously, and thus are useful as contrast agents for NIR/MR bimodal molecular imaging.
摘要翻译：本发明涉及同时显示磁特性和荧光特性的聚合物颗粒及其制备方法更具体地，涉及用于近红外（NIR）/磁共振（MR）双峰分子成像的聚合物颗粒，其含有磁性纳米材料和NIR荧光材料及其制备方法所公开的聚合物颗粒同时显示磁性和荧光特性，因此可用作NIR / MR双峰分子成像的造影剂。

8. 发明申请

US20100233094A1 PERFLUOROCARBON NANO-EMULSION CONTAINING QUANTUM DOT NANOPARTICLES AND METHOD FOR PREPARING THE SAME 有权
标题翻译：含有量子纳米粒子的全氟烷纳米乳液及其制备方法
公开(公告)号：US20100233094A1
公开(公告)日：2010-09-16
申请号：US12738394
申请日：2008-08-20
申请人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
IPC分类号： A61B5/055
CPC分类号： C09K11/565 , C09K11/02 , C09K11/883
摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.
摘要翻译：本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地涉及制备多功能全氟碳纳米乳液的方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。

9. 发明申请

US20100040693A1 SILICA CAPSULES HAVING NANO-HOLES OR NANO-PORES ON THEIR SURFACES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：在其表面上具有纳米孔或纳米孔的二氧化硅颗粒及其制备方法
公开(公告)号：US20100040693A1
公开(公告)日：2010-02-18
申请号：US12376798
申请日：2007-08-01
申请人： Bong Hyun Chung , Yong Taik Lim , Jin Kyeong Kim
发明人： Bong Hyun Chung , Yong Taik Lim , Jin Kyeong Kim
IPC分类号： A61K9/14 , B32B5/16 , H01F1/00 , G02F1/361 , A61K38/43 , A61K38/02 , C09K11/06
CPC分类号： B01J13/02 , A61K9/5115 , A61K9/5192 , Y10T428/2982
摘要： The present invention relates to silica capsules having nano-holes or nano-pores on the surface thereof, and preparation methods thereof. More specifically, relates to silica capsules having holes with a size ranging from a few nanometers (nm) to a few hundreds of nanometers (nm), on the surface thereof, multifunctional silica capsules containing magnetic nanoparticles and optical nanoparticles, and preparation methods thereof. According to the present invention, the silica capsules having holes on the surface thereof can be prepared by making an emulsion system using two fluids having different surface tensions, and selectively evaporating only one fluid of the two fluids during a process of forming a silica layer. In addition, the multifunctional silica capsules containing magnetic nanoparticles and optical nanoparticles can be prepared by loading various multifunctional nanoparticles into the two fluids.
摘要翻译：本发明涉及在其表面具有纳米孔或纳米孔的二氧化硅胶囊及其制备方法。更具体地，涉及具有尺寸范围从几纳米（nm）到几百纳米（nm）的孔的二氧化硅胶囊，其表面上含有磁性纳米颗粒和光学纳米颗粒的多功能硅胶胶囊及其制备方法。根据本发明，其表面上具有孔的二氧化硅胶囊可以通过制备使用具有不同表面张力的两种流体的乳液体系，并且在形成二氧化硅层的过程中仅选择性地蒸发两种流体的一种流体来制备。另外，含有磁性纳米粒子和光学纳米粒子的多功能二氧化硅胶囊可以通过将各种多功能纳米粒子加载到两种流体中来制备。

10. 发明申请

US20090318376A1 High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby 审中-公开
标题翻译：通过筛选caspase3和XIAP结合抑制剂之间的结合抑制剂的高通量筛选方法
公开(公告)号：US20090318376A1
公开(公告)日：2009-12-24
申请号：US12304766
申请日：2006-06-12
申请人： Bong Hyun Chung , Kwang-Hee Son , Moonil Kim , Kyoungsook Park , Byoung-Mog Kwon , Hyun Jung Junn , Dong Cho Han , Sun-Hee Jeon
发明人： Bong Hyun Chung , Kwang-Hee Son , Moonil Kim , Kyoungsook Park , Byoung-Mog Kwon , Hyun Jung Junn , Dong Cho Han , Sun-Hee Jeon
IPC分类号： A61K31/702 , G01N33/573 , C07H15/24
CPC分类号： A61K31/702 , G01N33/574 , G01N2333/96469 , G01N2500/02
摘要： The present invention relates to a high throughput screening method of a binding inhibitor between caspase3 and xIAP and chromomycin screened using the same, and more specifically, the present invention provides a method for screening anticancer substance, the method comprising the steps of reacting caspase3 or xIAP and candidate inhibitors of the binding between caspase3 and xIAP on a biochip for detecting caspase3:xIAP interaction, and selecting a candidate substance inhibiting the binding of caspase3 to xIAP as an anticancer substance, and an anticancer agent inhibiting caspase3:xIAP binding, which is screened by the above method. According to present invention, it is possible to develop a target-oriented anticancer agent focused on xIAP and caspase3, apoptosis-related proteins and thus it can be applied to tailored medication and combination therapy. Moreover, glycoside antibiotic chromomycin, screened by the present invention has inhibitory activity of the binding between xIAP and caspase3 involved in apoptosis, so that it can be used as a therapeutic agent for myelogenous leukemia and solid tumors.
摘要翻译：本发明涉及使用其筛选的胱天蛋白酶3和xIAP之间的结合抑制剂的高通量筛选方法，更具体地说，本发明提供了筛选抗癌物质的方法，所述方法包括以下步骤：使半胱天冬酶3或xIAP 以及用于检测胱天蛋白酶3：xIAP相互作用的生物芯片上的半胱天冬酶3和xIAP之间的结合的候选抑制剂，并且选择抑制半胱天冬酶3与作为抗癌物质的xIAP的结合的候选物质，以及抑制胱天蛋白酶3的抗癌剂：xIAP结合通过上述方法。根据本发明，可以开发聚焦于xIAP和caspase3的靶向抗癌剂，凋亡相关蛋白，因此可以应用于定制药物和联合治疗。此外，通过本发明筛选的糖苷抗生素chromomycin具有抑制参与凋亡的xIAP和半胱天冬酶3之间的结合的活性，因此可以用作骨髓性白血病和实体瘤的治疗剂。

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