会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • DNA encoding and 18 KD CDK6 inhibiting protein
    • DNA编码和18KD CDK6抑制蛋白
    • US5631156A
    • 1997-05-20
    • US263935
    • 1994-06-21
    • Yue XiongKunliang Guan
    • Yue XiongKunliang Guan
    • A61K38/00C07K14/47C12N9/12C12N15/12C12N1/21C12N5/10C12N15/63
    • C12N9/12C07K14/4738A61K38/00
    • A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are refered to as p18.sup.INK6 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.
    • 编码CDK抑制蛋白质,特别是CDK6抑制蛋白质的核酸选自:(a)具有本文给出的核苷酸序列的SEQ ID NO:1的DNA(其编码具有给定氨基酸序列的蛋白质) 本文作为SEQ ID NO:2),并且其被称为p18INK6; (b)与上述(a)的DNA杂交并编码CDK抑制蛋白质的核酸; 和(c)由于遗传密码的简并性而编码由上述(a)或(b)的DNA编码的CDK抑制蛋白的上述(a)或(b)的DNA不同的核酸。 还公开了含有此类DNA的构建体,含有此类构建体的细胞,由此DNA编码的蛋白质,与其结合的抗体,对应于该DNA的反义寡核苷酸及其使用方法。
    • 4. 发明授权
    • Isolated DNA encoding cullin regulators ROC1 and ROC2, isolated proteins encoded by the same, and methods utilizing the same
    • 编码cullin调节剂ROC1和ROC2的分离的DNA,由其编码的分离的蛋白质,以及利用其的方法
    • US07625732B2
    • 2009-12-01
    • US11483907
    • 2006-07-10
    • Yue XiongTomohiko Ohta
    • Yue XiongTomohiko Ohta
    • C12N9/00C07K14/00C07H21/00C12P21/00C12N15/00C12N5/10C12N1/21
    • C07K14/4702
    • The present invention provides isolated polynucleotide sequences encoding the proteins ROC1 and ROC2, the isolated proteins themselves, expression vectors containing at least a fragment of the ROC1 and ROC2 polynucleotide sequences, and host cells comprising the same. Methods of producing the ROC1 and ROC2 proteins are also disclosed, and methods of detecting the polynucleotides in samples are included in this invention, as are antibodies to the ROC1 and ROC2 proteins and antisense molecules complementary to polynucleotides encoding the same. The present invention further includes methods for screening bioactive agents that are capable of binding to a ROC protein, methods of screening bioactive agents capable of interfering with the binding of ROC proteins, and methods of screening bioactive agents capable of modulating the activity of a ROC protein. Such screening methods are capable of identifying compounds that have pharmacological. Pharmaceutical formulations comprising such pharmacologically active compounds and methods of administering the same are an additional aspect of this invention.
    • 本发明提供编码蛋白质ROC1和ROC2的分离的多核苷酸序列,分离的蛋白质本身,含有至少一个ROC1和ROC2多核苷酸序列片段的表达载体,以及含有该多核苷酸序列的宿主细胞。 还公开了生产ROC1和ROC2蛋白的方法,并且检测样品中多核苷酸的方法包括在本发明中,ROC1和ROC2蛋白的抗体以及与编码它们的多核苷酸互补的反义分子也是如此。 本发明还包括用于筛选能够结合ROC蛋白的生物活性剂的方法,筛选能够干扰ROC蛋白结合的生物活性剂的方法以及筛选能够调节ROC蛋白活性的生物活性剂的方法 。 这种筛选方法能够鉴定具有药理学的化合物。 包含这种药理活性化合物的药物制剂及其施用方法是本发明的另外的方面。
    • 5. 发明授权
    • DNA encoding an 18 KD CDK6 inhibiting protein and antibodies thereto
    • 编码18KD CDK6抑制蛋白质的DNA及其抗体
    • US5629407A
    • 1997-05-13
    • US486410
    • 1995-06-07
    • Yue XiongKunliang Guan
    • Yue XiongKunliang Guan
    • A61K38/00C07K14/47C12N9/12C12N15/12C07K16/00
    • C12N9/12C07K14/4738A61K38/00
    • A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are refered to as p18.sup.INK6 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.
    • 编码CDK抑制蛋白质,特别是CDK6抑制蛋白质的核酸选自:(a)具有本文给出的核苷酸序列的SEQ ID NO:1的DNA(其编码具有给出的氨基酸序列的蛋白质) 本文作为SEQ ID NO:2),并且其被称为p18INK6; (b)与上述(a)的DNA杂交并编码CDK抑制蛋白质的核酸; 和(c)由于遗传密码的简并性而编码由上述(a)或(b)的DNA编码的CDK抑制蛋白的上述(a)或(b)的DNA不同的核酸。 还公开了含有此类DNA的构建体,含有此类构建体的细胞,由此DNA编码的蛋白质,与其结合的抗体,对应于该DNA的反义寡核苷酸及其使用方法。
    • 7. 发明授权
    • DNA encoding an 18 Kd CDK6 inhibiting protein
    • 编码18Kd CDK6抑制蛋白的DNA
    • US5621082A
    • 1997-04-15
    • US482069
    • 1995-06-07
    • Yue XiongKunliang Guan
    • Yue XiongKunliang Guan
    • A61K38/00C07K14/47C12N9/12C12N15/12C07H21/04
    • C12N9/12C07K14/4738A61K38/00
    • A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are refered to as p18.sup.INK6 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.
    • 编码CDK抑制蛋白质,特别是CDK6抑制蛋白质的核酸选自:(a)具有本文给出的核苷酸序列的SEQ ID NO:1的DNA(其编码具有给定氨基酸序列的蛋白质) 本文作为SEQ ID NO:2),并且其被称为p18INK6; (b)与上述(a)的DNA杂交并编码CDK抑制蛋白质的核酸; 和(c)由于遗传密码的简并性而编码由上述(a)或(b)的DNA编码的CDK抑制蛋白的上述(a)或(b)的DNA不同的核酸。 还公开了含有此类DNA的构建体,含有此类构建体的细胞,由此DNA编码的蛋白质,与其结合的抗体,对应于该DNA的反义寡核苷酸及其使用方法。