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1. 发明授权

US07045299B2 Physiologically active peptide and use thereof 失效
标题翻译：生理活性肽及其用途
公开(公告)号：US07045299B2
公开(公告)日：2006-05-16
申请号：US10333192
申请日：2001-07-17
申请人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani
发明人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani
IPC分类号： G01N33/53 , C12P2/06 , C07K14/00 , C07K2/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/566 , G01N33/74 , G01N2500/02
摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc.The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.
摘要翻译：本发明意图提供一种新的肽及其用途。更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

2. 发明授权

US6040156A DNA encoding glucuronyltransferase 失效
标题翻译：编码葡糖醛酸转移酶的DNA
公开(公告)号：US6040156A
公开(公告)日：2000-03-21
申请号：US59369
申请日：1998-04-14
申请人： Toshisuke Kawasaki , Shogo Oka
发明人： Toshisuke Kawasaki , Shogo Oka
IPC分类号： C12N15/09 , C07H21/04 , C12N9/10 , C12P21/02 , C12R1/91 , C12P2/06 , C07H17/00
CPC分类号： C12N9/1051
摘要： A DNA having a base sequence encoding a polypeptide of a glucuronyltransferase characterized in that:A) action:said glucuronyltransferase transfers glucuronic acid from a glucuronic acid donor to a glucuronic acid acceptor;B) substrate specificity:said glucuronyltransferase selectively transfers glucuronic acid to N-acetyllactosamine residue of asialoorosomucoid and neural cell adhesion molecule;C) optimum reaction pH:said glucuronyltransferase has an optimum pH of about 6.0 to 6.5 (in 100 mM, MES buffer at 37.degree. C.);D) inhibition and activation:said glucuronyltransferase is activated by Mn.sup.2+ and the activity is maintained in the presence of 5 mM of neolactotetraose-phenyl-C.sub.14 H.sub.29 ; andE) molecular weight:said glucuronyltransferase has a molecular weight of about 45,000 dalton measured by reductive SDS-polyacrylamide gel electrophoresis and a molecular weight of about 90,000 dalton measured by gel filtration.
摘要翻译：具有编码葡萄糖醛酸转移酶多肽的碱基序列的DNA，其特征在于：A）作用：所述葡糖醛酸转移酶将葡糖醛酸从葡萄糖醛酸供体转移到葡萄糖醛酸受体; B）底物特异性：所述葡糖醛酸转移酶选择性地将葡萄糖醛酸转移至非血浆类粘蛋白和神经细胞粘附分子的N-乙酰乳糖胺残基; C）最佳反应pH：所述葡糖醛酸转移酶具有约6.0至6.5的最适pH（在100mM，37℃的MES缓冲液中）; D）抑制和活化：所述葡糖醛酸转移酶由Mn2 +活化，活性保持在5mM的新乳糖四糖 - 苯基-C14H29的存在下; 和E）分子量：所述葡糖醛酸基转移酶通过还原性SDS-聚丙烯酰胺凝胶电泳测量的分子量为约45,000道尔顿，通过凝胶过滤测量分子量为约90,000道尔顿。

3. 发明授权

US08263376B2 Lipoxygenase 失效
标题翻译：脂氧合酶
公开(公告)号：US08263376B2
公开(公告)日：2012-09-11
申请号：US13076803
申请日：2011-03-31
申请人： Akiko Sugio , Shinobu Takagi
发明人： Akiko Sugio , Shinobu Takagi
IPC分类号： C12N9/02 , C12P2/06 , C11D3/386
CPC分类号： C12P7/6427 , A21D8/042 , A23L33/195 , C11D3/386 , C12N9/0069 , C12Y113/11012
摘要： The present disclosure relates to an isolated lipoxygenase. The lipoxygenase of the present disclosure includes polypeptide with at least 80% sequence homology to the mature peptide shown in SEQ ID NO: 2. Lipoxygenase of the present disclosure is suitable for use in, among other things, baking and in detergent compositions.
摘要翻译：本公开涉及分离的脂氧合酶。本公开的脂氧合酶包括与SEQ ID NO：2所示的成熟肽具有至少80％的序列同源性的多肽。本公开的脂氧合酶适合用于烘烤和洗涤剂组合物中。

4. 发明授权

US07078203B1 Isolated DNA encoding cullin regulators ROC1 and ROC2, isolated proteins encoded by the same, and methods utilizing the same 失效
公开(公告)号：US07078203B1
公开(公告)日：2006-07-18
申请号：US09541462
申请日：2000-03-31
申请人： Yue Xiong , Tomohiko Ohta
发明人： Yue Xiong , Tomohiko Ohta
IPC分类号： C12N15/00 , C12N5/00 , C12N1/20 , C12P2/06 , C07H21/02 , C07H21/04 , C12N9/00 , C12N9/10 , C12Q1/00 , C12Q1/48
CPC分类号： C07K14/4702
摘要： The present invention provides isolated polynucleotide sequences encoding the proteins ROC1 and ROC2, the isolated proteins themselves, expression vectors containing at least a fragment of the ROC1 and ROC2 polynucleotide sequences, and host cells comprising the same. Methods of producing the ROC1 and ROC2 proteins are also disclosed, and methods of detecting the polynucleotides in samples are included in this invention, as are antibodies to the ROC1 and ROC2 proteins and antisense molecules complementary to polynucleotides encoding the same. The present invention further includes methods for screening bioactive agents that are capable of binding to a ROC protein, methods of screening bioactive agents capable of interfering with the binding of ROC proteins, and methods of screening bioactive agents capable of modulating the activity of a ROC protein. Such screening methods are capable of identifying compounds that have pharmacological. Pharmaceutical formulations comprising such pharmacologically active compounds and methods of administering the same are an additional aspect of this invention.

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