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1. 发明申请

WO2013056379A1 SYSTEM FOR NONINVASIVE OPTICAL MEASUREMENTS OF PHYSIOLOGICAL PROPERTIES IN TISSUE 审中-公开
标题翻译：非组织光学测量系统在组织中的生理特性
公开(公告)号：WO2013056379A1
公开(公告)日：2013-04-25
申请号：PCT/CH2011/000247
申请日：2011-10-19
申请人： BIOVOTION AG , ZAKHAROV, Pavel , TALARY, Mark , CADUFF, Andreas
发明人： ZAKHAROV, Pavel , TALARY, Mark , CADUFF, Andreas
IPC分类号： A61B5/1455
CPC分类号： A61B5/0295 , A61B5/02416 , A61B5/1107 , A61B5/14551 , A61B5/721 , G06F19/00
摘要： Embodiments of the present invention comprise systems and methods for noninvasive measurements of physiological properties of tissue. The system comprises a light emitter, an optical detector, a mechanical sensor and a processor. The light emitter is capable of emitting light of at least two different wavelengths and comprises at least one light source. The processor is capable of evaluating physiological properties of the tissues from measurements of the optical and the mechanical sensor. More precisely, the processor is capable of evaluating physiological properties of venous blood by using data measured by the mechanical sensor and the optical detector. For example, the oxygenation of venous blood can be measured. Furthermore, the systems can optionally comprise a light emitter which emits three wavelengths and/or the light emitter and the optical detector are arranged in reflection geometry and are located at a distance of at most 10 mm from each other.
摘要翻译：本发明的实施例包括用于非侵入性测量组织生理特性的系统和方法。该系统包括光发射器，光学检测器，机械传感器和处理器。光发射器能够发射至少两个不同波长的光，并且包括至少一个光源。处理器能够通过光学和机械传感器的测量来评估组织的生理特性。更准确地说，处理器能够通过使用由机械传感器和光学检测器测量的数据来评估静脉血的生理特性。例如，可以测量静脉血的氧合。此外，系统可以可选地包括发射三个波长的光发射器和/或光发射器，并且光学检测器以反射几何形状布置并且位于彼此至多10mm的距离处。

2. 发明公开

EP2429380A1 WIDE BAND FIELD RESPONSE MEASUREMENT FOR GLUCOSE DETERMINATION 审中-公开
标题翻译：宽带光谱应对措施葡萄糖测定
公开(公告)号：EP2429380A1
公开(公告)日：2012-03-21
申请号：EP09775717.3
申请日：2009-04-17
申请人： Biovotion AG
发明人： CADUFF, Andreas , TALARY, Mark, Stuart , MÜLLER, Martin , DE FEO, Oscar
IPC分类号： A61B5/00 , A61B5/053
CPC分类号： A61B5/4869 , A61B5/01 , A61B5/0507 , A61B5/0531 , A61B5/0537 , A61B5/14532 , A61B5/1455 , A61B2560/0252 , A61B2562/0209 , A61B2562/043 , A61B2562/046
摘要： A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.

3. 发明授权

EP2555676B1 WEARABLE SENSOR DEVICE 有权转让
标题翻译：便携式传感器设备
公开(公告)号：EP2555676B1
公开(公告)日：2015-10-14
申请号：EP10708087.1
申请日：2010-02-05
申请人： Biovotion AG
发明人： CADUFF, Andreas , KREBS, Hans-Joachim , STALDER, Gianlucca , TALARY, Mark, Stuart
IPC分类号： A61B5/053 , A44C5/00 , G04G17/00 , A41D20/00 , G04B37/00
CPC分类号： A61B5/6831 , A44C5/00 , A45F3/14 , A45F5/00 , A61B5/0059 , A61B5/01 , A61B5/02055 , A61B5/02438 , A61B5/0261 , A61B5/0265 , A61B5/053 , A61B5/14532 , A61B5/1455 , A61B5/6824 , A61B5/6843 , A61B5/7207 , A61B8/06

4. 发明授权

EP1954175B1 DEVICE FOR DETERMINING THE GLUCOSE LEVEL IN BODY TISSUE 有权转让
标题翻译：一种用于确定血糖镜身体组织
公开(公告)号：EP1954175B1
公开(公告)日：2016-07-13
申请号：EP05798813.1
申请日：2005-11-10
申请人： Biovotion AG
发明人： CADUFF, Andreas , TALARY, Mark, Stuart , DEWARRAT, François , HUBER, Daniel , STALDER, Gianluca
IPC分类号： A61B5/00
CPC分类号： A61B5/6843 , A61B5/0261 , A61B5/0531 , A61B5/11 , A61B5/14532 , A61B5/721 , A61B2560/0242 , A61B2562/0219 , A61B2562/0247
摘要： The apparatus for the non-invasive glucose detection comprises an electrical detection device (2) for measuring the response of the tissue or blood to an electric field at low frequencies below 1 MHz and at high frequencies above 10 MHz. The former is primarily dominated by skin hydration and sweat, while the latter contains contributions from the current glucose level. Combining the two signals allows an increased degree of accuracy. The apparatus further comprises a force or acceleration sensor (4, 5), which allows to detect the pressure of the apparatus against the skin and/or quick movements. Further sensor modules, such as a temperature sensor (6) or alternative perfusion sensor (7), improve the accuracy of the measured result.

5. 发明公开

EP2563207A1 OPTICAL DETERMINATION OF BLOOD PERFUSION AND SIMILAR PARAMETERS 有权转让
标题翻译：光学测定血液灌注和类似的参数
公开(公告)号：EP2563207A1
公开(公告)日：2013-03-06
申请号：EP10707430.4
申请日：2010-02-26
申请人： Biovotion AG
发明人： CADUFF, Andreas , KREBS, Hans-Joachim , TALARY, Mark Stuart , ZAKHAROV, Pavel
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14552 , A61B5/1491 , A61B5/441
摘要： A parameter affecting the absorptivity or the concentration of blood in tissue is measured using a semiconductor light source (7) and a light detector (8). The semiconductor light source (7) is operated at several operating conditions, at which it has different temperatures and therefore different emission spectra. In particular, the operating conditions correspond to different time intervals after switching the light source (7) on, while the light source (7) has not yet reached thermal equilibrium. This allows to perform a spectroscopic measurement using one light source only, which increases accuracy and reduces device cost.

6. 发明公开

EP2768391A1 SYSTEM FOR NONINVASIVE OPTICAL MEASUREMENTS OF PHYSIOLOGICAL PROPERTIES IN TISSUE 有权转让
标题翻译： SYSTEM FOR组织的非侵入光学测量生理学特性
公开(公告)号：EP2768391A1
公开(公告)日：2014-08-27
申请号：EP11773662.9
申请日：2011-10-19
申请人： Biovotion AG
发明人： ZAKHAROV, Pavel , TALARY, Mark , CADUFF, Andreas
IPC分类号： A61B5/1455
CPC分类号： A61B5/0295 , A61B5/02416 , A61B5/1107 , A61B5/14551 , A61B5/721 , G06F19/00
摘要： Embodiments of the present invention comprise systems and methods for noninvasion measurements of physiological properties of tissues. The system comprises a light emitter, an optical detector, a mechanical sensor and a processor. The light emitter is capable of emitting light of at least two different wavelengths and comprises at least one light source. The processor is capable of evaluating physiological properties of the tissues from measurements of the optical and the mechanical sensor. More precisely, the processor is capable of evaluating physiological properties of venous blood by using data measured by the mechanical sensor and the optical detector. For example, the oxygenation of venous blood can be measured. Furthermore, the systems can optionally comprise a light emitter which emits three wavelengths and/or the light emitter and the optical detector are arranged in reflection geometry and are located at a distance of at most 10 mm from each other.

7. 发明公开

EP2555676A1 WEARABLE SENSOR DEVICE 有权转让
标题翻译：便携式传感器设备
公开(公告)号：EP2555676A1
公开(公告)日：2013-02-13
申请号：EP10708087.1
申请日：2010-02-05
申请人： Biovotion AG
发明人： CADUFF, Andreas , KREBS, Hans-Joachim , STALDER, Gianlucca , TALARY, Mark, Stuart
IPC分类号： A61B5/053 , A44C5/00 , G04G17/00 , A41D20/00 , G04B37/00
CPC分类号： A61B5/6831 , A44C5/00 , A45F3/14 , A45F5/00 , A61B5/0059 , A61B5/01 , A61B5/02055 , A61B5/02438 , A61B5/0261 , A61B5/0265 , A61B5/053 , A61B5/14532 , A61B5/1455 , A61B5/6824 , A61B5/6843 , A61B5/7207 , A61B8/06
摘要： A sensor device comprises a sensor (1) to be held against the wearer's skin. The sensor (1) is arranged on one side of a housing (2), and the housing is connected to a band (5) for mounting it to a body part, such as an arm or leg. Various stopper devices (10, 14, 20) are arranged on the side of the housing (2) and the band (5) that face the skin. The stopper devices improve static friction, thereby holding the housing (2) in place.

8. 发明公开

EP2419012A1 SENSING DEVICE FOR BODY TISSUE PROPERTIES 有权转让
标题翻译：用于测量身体组织的性质
公开(公告)号：EP2419012A1
公开(公告)日：2012-02-22
申请号：EP09775716.5
申请日：2009-04-17
申请人： Biovotion AG
发明人： CADUFF, Andreas , TALARY, Mark, Stuart , KREBS, Hans-Joachim , MEGEJ, Alexander , DEWARRAT, François
IPC分类号： A61B5/053 , A61B5/00 , A61B5/026
CPC分类号： A61B5/0531 , A61B5/0261 , A61B5/14532 , A61B5/6824 , A61B5/6828
摘要： A device is described for measuring a parameter of living tissue, in particular a glucose level, which parameter affects a response of said tissue to an electric field. The device comprises a substrate (2), which carries a ground electrode (10) as well as a plurality of signal electrodes (12a, 12b, 13a-13c, 14). The gaps (15) between the ground electrode and the signal electrodes are filled with a solid filler material (16) in order to provide an even surface. Optical reflection detectors (23a, 23b, 23c) can also be located in these gaps in order to avoid field distortions and obtain a compact design. The backside of substrate (2) carries electronic high-frequency components for improving signal quality.

9. 发明授权

EP2563207B1 OPTICAL DETERMINATION OF BLOOD PERFUSION AND SIMILAR PARAMETERS 有权转让
公开(公告)号：EP2563207B1
公开(公告)日：2019-11-13
申请号：EP10707430.4
申请日：2010-02-26
申请人： Biovotion AG
发明人： CADUFF, Andreas , KREBS, Hans-Joachim , TALARY, Mark Stuart , ZAKHAROV, Pavel
IPC分类号： A61B5/00

10. 发明授权

EP2321613B1 METHOD FOR CHARACTERIZING THE EFFECT OF A SKIN TREATMENT AGENT ON SKIN 有权转让
公开(公告)号：EP2321613B1
公开(公告)日：2019-09-04
申请号：EP08757269.9
申请日：2008-06-18
申请人： Biovotion AG
发明人： MEGEJ, Alexander , CADUFF, Andreas , TALARY, Mark
IPC分类号： G01B7/26 , A61B5/103 , G01N27/00 , H01P3/00 , A61B18/18 , G01R27/26 , A61B5/00 , A61B5/053 , A61K49/00

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