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1. 发明公开

EP3591053A1 RESPIRATORY DISEASE-RELATED GENE SPECIFIC SIRNA, DOUBLE-HELICAL OLIGO RNA STRUCTURE CONTAINING SIRNA, COMPOSITON CONTAINING SAME FOR PREVENTING OR TREATING RESPIRATORY DISEASE 审中-公开
公开(公告)号：EP3591053A1
公开(公告)日：2020-01-08
申请号：EP19180054.9
申请日：2014-07-04
申请人： Bioneer Corporation , Yuhan Corporation
发明人： CHAE, Jeiwook , PARK, Han Oh , YOON, Pyoung Oh , HAN, Boram , KIM, Mi Na
IPC分类号： C12N15/113 , C07H21/02 , A61K48/00 , A61P11/00
摘要： The present invention relates to respiratory diseases, especially to gene specific siRNA related to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD), and a highly efficient double-helical oligo RNA structure containing the same, wherein the double-helical oligo RNA structure has a structure in which hydrophilic and hydrophobic materials are bonded at the both ends of the double-helical RNA (siRNA) using a simple covalent bond or a linker-mediated covalent bond to be effectively transferred into a cell, and is converted into nanoparticles by the hydrophobic interaction of the double-helical oligo RNA structure in a solution. It is desirable that the siRNA contained in the double-helical oligo RNA structure is a siRNA specific to a CTGF, Cyr61, or Plekhol, which are genes related to respiratory diseases, particularly idiopathic pulmonary fibrosis and COPD. In addition, the present invention relates to a method for producing the double-helical oligo RNA structure and a pharmaceutical composition containing the double-helical oligo RNA structure for preventing or treating respiratory diseases, particularly idiopathic pulmonary fibrosis and COPD.

3. 发明公开

EP3018209A2 RESPIRATORY DISEASE-RELATED GENE SPECIFIC SIRNA, DOUBLE-HELICAL OLIGO RNA STRUCTURE CONTAINING SIRNA, COMPOSITON CONTAINING SAME FOR PREVENTING OR TREATING RESPIRATORY DISEASE 有权转让
标题翻译：呼吸系统疾病相关的基因特异性的siRNA，用siRNA双螺旋寡RNA结构及组成以防止或呼吸系统疾病的治疗
公开(公告)号：EP3018209A2
公开(公告)日：2016-05-11
申请号：EP14820458.9
申请日：2014-07-04
申请人： Bioneer Corporation , Yuhan Corporation
发明人： CHAE, Jeiwook , PARK, Han Oh , YOON, Pyoung Oh , HAN, Boram , KIM, Mi Na
IPC分类号： C12N15/113 , C07H21/02 , A61K48/00 , A61P11/00
摘要： The present invention relates to respiratory diseases, especially to gene specific siRNA related to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD), and a highly efficient double-helical oligo RNA structure containing the same, wherein the double-helical oligo RNA structure has a structure in which hydrophilic and hydrophobic materials are bonded at the both ends of the double-helical RNA (siRNA) using a simple covalent bond or a linker-mediated covalent bond to be effectively transferred into a cell, and is converted into nanoparticles by the hydrophobic interaction of the double-helical oligo RNA structure in a solution. It is desirable that the siRNA contained in the double-helical oligo RNA structure is a siRNA specific to a CTGF, Cyr61, or Plekho1, which are genes related to respiratory diseases, particularly idiopathic pulmonary fibrosis and COPD. In addition, the present invention relates to a method for producing the double-helical oligo RNA structure and a pharmaceutical composition containing the double-helical oligo RNA structure for preventing or treating respiratory diseases, particularly idiopathic pulmonary fibrosis and COPD.
摘要翻译：本发明涉及一种呼吸性疾病，爱尤其是基因相关的特发性肺纤维化和慢性阻塞性肺病（COPD）特异siRNA，和高效率的双螺旋寡RNA结构含有相同，worin双螺旋寡RNA结构具有在其中亲水性和疏水性材料在使用简单的共价键或接头 - 介导的共价键的双螺旋RNA（siRNA）的两端键合的结构，以有效地传递到细胞中，并通过转化成纳米颗粒在溶液中的双螺旋寡RNA结构的疏水性相互作用。期望做包含在双螺旋结构的低聚RNA所述siRNA是特定于CTGF，Cyr61的，或Plekho1，这是相关的呼吸系统疾病，特别是特发性肺纤维化和慢性阻塞性肺病的基因的siRNA一个。此外，本发明涉及一种用于制造双螺旋寡RNA结构且含有用于预防或治疗呼吸系统疾病，特别是特发性肺纤维化和慢性阻塞性肺病的双螺旋寡RNA结构的药物组合物的方法。

4. 发明申请

WO2012023722A2 LOW HEAT CAPACITY COMPOSITE FOR THERMAL CYCLER 审中-公开
标题翻译：用于热循环的低热容复合材料
公开(公告)号：WO2012023722A2
公开(公告)日：2012-02-23
申请号：PCT/KR2011/005756
申请日：2011-08-08
申请人： BIONEER CORPORATION. , PARK, Han Oh , KIM, Jae Ha
发明人： PARK, Han Oh , KIM, Jae Ha
IPC分类号： C09K5/14 , C22C26/00 , B01L7/00
CPC分类号： B01L7/52 , B22F2998/10 , B22F2999/00 , C09K5/14 , C22C1/0416 , C22C1/0425 , C22C1/0466 , C22C1/0483 , C22C13/00 , C22C13/02 , C22C26/00 , C22C1/1084 , B22F3/14 , B22F3/18 , C22C1/02
摘要： Provided is a low heat capacity composite for a thermal cycler. The low heat capacity composite of the present invention is a low heat capacity composite for a thermal cycler capable of overcoming difficulty in manufacture and reproducibility due to uniqueness of the existing PCR thermal cycler only. The low heat capacity composite of the present invention can reduce the cost of raw material and retain excellent heat property due to the improvement in low heat capacity and physical and mechanical properties, thereby remarkably shortening PCR reaction time and saving energy when used as a thermal block for a thermal cycler.
摘要翻译：提供用于热循环仪的低热容量复合材料。本发明的低热容复合材料是用于热循环仪的低热容复合材料，由于现有PCR热循环仪的独特性，所述复合材料能够克服制造和再现性的困难。本发明的低热容量复合材料由于改善了低热容量和物理机械性能，因此可以降低原料成本并保持优异的热性能，因此当用作热块时显着缩短PCR反应时间并节省能量用于热循环仪。

5. 发明申请

WO2011049312A9 HIGH THROUGHPUT OLIGONUCLEOTIDE SYNTHESIZER 审中-公开
公开(公告)号：WO2011049312A9
公开(公告)日：2011-04-28
申请号：PCT/KR2010/006933
申请日：2010-10-11
申请人： BIONEER CORPORATION , PARK, Han Oh , PARK, Han Ee , SONG, Gu Young , LEE, Yang Won , JANG, Dae Jin
发明人： PARK, Han Oh , PARK, Han Ee , SONG, Gu Young , LEE, Yang Won , JANG, Dae Jin
IPC分类号： C12M1/36 , G01N35/00 , C12Q1/68
摘要： There is provided a high throughput oligonucleotide synthesizer used for the chemical synthesis of oligo DNA/RNA or protein in which a high throughput oligonucleotide synthesizer in which one or more synthetic reactor modules (plate) with hundreds or thousands of individual synthetic reactors are installed, a reagent valve for inputting a reagent required to synthesis into each of the individual synthetic reactors is mounted, the synthetic reactor modules are moved and arranged to match valve nozzles (inlets), and the reagents are divisionally provided to the individual synthetic reactors in sequence in accordance with sequence information (arrangement) which is inputted by a user to chemically synthesize oligo DNA/RNA or protein with a reactive microparticle media in the synthetic reactor module, in an automation synthesizer used for the chemical synthesis of oligo DNA/RNA or protein.

6. 发明申请

WO2007094581A1 DRIED OLIGONUCLEOTIDE COMPOSITION AND METHOD OF PRODUCING THE SAME 审中-公开
标题翻译：干燥寡核苷酸组合物及其制备方法
公开(公告)号：WO2007094581A1
公开(公告)日：2007-08-23
申请号：PCT/KR2007/000662
申请日：2007-02-07
申请人： BIONEER CORPORATION , PARK, Han Oh , KIM, Jae Ha
发明人： PARK, Han Oh , KIM, Jae Ha
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The present invention relates to a dried oligonucleotide composition and a method for producing the same. More specifically, it relates to a dried oligonucleotide composition produced by the steps comprising adding a substance for preventing the oligonucleotide from being separated and lost, which is adhesive to a storage container containing the oligonucleotide composition, in order to prevent the oligonucleotide from being separated and lost during manufacturing and distributing the dried oligonucleotide composition, optionally adding a non-reactive dye substance, and drying the resulting solution. The dried oligonucleotide composition of the present invention can be prevented from being separated and lost during manufacturing step, or transporting step after packaging, and the presence or absence of the oligonucleotide in the storage container can be easily confirmed with naked eyes. Accordingly, unnecessary labor waste and time waste caused by the separation of the oligonucleotide upon experiment can be overcome.
摘要翻译：本发明涉及干燥的寡核苷酸组合物及其制备方法。更具体地说，涉及通过以下步骤制备的干燥的寡核苷酸组合物：为了防止寡核苷酸分离，添加防止寡核苷酸分离和丢失的物质，其与含有寡核苷酸组合物的储存容器粘合，在制备和分配干燥的寡核苷酸组合物期间损失，任选地加入非活性染料物质，并干燥所得溶液。可以防止本发明的干燥的寡核苷酸组合物在制造步骤或包装后的运输步骤中分离和丢失，并且可以用肉眼容易地确认存储容器中存在或不存在寡核苷酸。因此，可以克服由实验中的寡核苷酸分离引起的不必要的劳动力浪费和时间浪费。

7. 发明申请

WO2015005669A1 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性siRNA，包含siRNA的双链寡聚RNA分子，以及用于预防或治疗包含其的癌症的组合物
公开(公告)号：WO2015005669A1
公开(公告)日：2015-01-15
申请号：PCT/KR2014/006145
申请日：2014-07-09
申请人： BIONEER CORPORATION , SANOFI-AVENTIS KOREA CO., LTD.
发明人： CHAE, Jeiwook , PARK, Han Oh , YOON, Pyoung Oh , HAN, Boram , KIM, Han-Na , YUN, Sung-Il , PARK, Jun Hong , KO, Youngho , CHOI, Gi-Eun , JUNG, Junsoo , KIM, Jae Eun
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , A61P35/00
CPC分类号： C12N15/1135 , A61K9/0019 , A61K9/51 , A61K31/713 , A61K47/60 , C12N2310/14
摘要： There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly Gankyrin or BMI-1 specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
摘要翻译：提供了与相关肝癌相关的特异性siRNA和高效双链寡聚RNA分子。双链寡RNA分子具有通过简单的共价键或连接体介导的共价键将亲水和疏水化合物与双链寡RNA分子的两端缀合以便有效地递送到细胞中的结构，可以通过双链寡聚RNA分子的疏水相互作用在水溶液中转化成纳米颗粒。双链寡核苷酸分子中含有的siRNA可能是肝癌相关基因，特别是Gankyrin或BMI-1特异性siRNA。此外，本发明涉及制备双链寡聚RNA分子的方法和用于预防或治疗包含双链寡RNA分子的癌症，特别是肝癌的药物组合物。

8. 发明申请

WO2012157955A2 OIL PURIFICATION METHOD AND APPARATUS WITH POROUS MEMBRANE 审中-公开
标题翻译：油多孔方法和装置
公开(公告)号：WO2012157955A2
公开(公告)日：2012-11-22
申请号：PCT/KR2012/003836
申请日：2012-05-16
申请人： BIONEER CORPORATION , PARK, Han Oh , KIM, Jae Ha , KIM, Jun Pyo
发明人： PARK, Han Oh , KIM, Jae Ha , KIM, Jun Pyo
CPC分类号： B01D69/12 , B01D71/021 , B01D71/022 , B01D71/024 , B01D2311/04 , C10M175/0091 , B01D2311/103
摘要： Provided is a method of purifying oil by which nano particles are effectively removed from the oil. According to the oil purifying method, oil is effectively purified at a high temperature using a carbon nanostructure-metal or -metal oxide composite nano porous membrane composed of a carbon nanostructure-metal composite.
摘要翻译：提供了一种净化油的方法，通过该方法可以有效地从油中除去纳米颗粒。根据油净化方法，使用由碳纳米结构金属复合材料构成的碳纳米结构金属或金属氧化物复合纳米多孔膜，在高温下有效地纯化油。

9. 发明申请

WO2009045067A2 PRIMERS FOR PCR AMPLIFICATION COMPRISING ABASIC PARTS WITHIN THE PRIMER SEQUENCES 审中-公开
标题翻译：用于在放大器序列中包含ABASIC部分的PCR扩增的引物
公开(公告)号：WO2009045067A2
公开(公告)日：2009-04-09
申请号：PCT/KR2008/005821
申请日：2008-10-02
申请人： BIONEER CORPORATION , KIM, Hyun Bae , KIM, Seong Youl , GIL, Jun Mo , PARK, Hae Joon , PARK, Han Oh
发明人： KIM, Hyun Bae , KIM, Seong Youl , GIL, Jun Mo , PARK, Hae Joon , PARK, Han Oh
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2525/119
摘要： The present invention relates to primers for PCR amplification comprising abasic parts within the primer sequences and a method for PCR amplification using the same. More precisely, the present invention relates to primers capable of amplifying different templates and having abasic parts complementary to mutated site or polymorphic site of template DNA and a method for PCR amplification comprising the steps of mixing the composition for PCR amplification comprising the primers with nucleic acid template; and performing PCR with the mixture. The primers for PCR amplification of the present invention contain abasic parts not having specific coding information in their nucleotide sequences, so that they can amplify different templates having mutated sites at the same time.
摘要翻译：本发明涉及用于PCR扩增的引物，其包括引物序列内的无碱部分和使用其的PCR扩增方法。更确切地说，本发明涉及能够扩增不同模板并具有与模板DNA的突变位点或多态位点互补的脱碱基的引物，以及用于PCR扩增的方法，其包括将包含引物的PCR扩增组合物与核酸模板; 并用混合物进行PCR。用于本发明的PCR扩增的引物含有在其核苷酸序列中不具有特定编码信息的脱碱基，从而可以同时扩增具有突变位点的不同模板。

10. 发明申请

WO2009002034A3 REAL-TIME PCR MONITORING APPARATUS 审中-公开
标题翻译：实时PCR监测装置
公开(公告)号：WO2009002034A3
公开(公告)日：2008-12-31
申请号：PCT/KR2008/003408
申请日：2008-06-17
申请人： BIONEER CORPORATION , PARK, Hanee , CHOI, il kyu , PARK, Han Oh
发明人： PARK, Hanee , CHOI, il kyu , PARK, Han Oh
IPC分类号： C12Q1/68
摘要： The present invention relates to a real-time PCR monitoring apparatus for real-time monitoring production of reaction product produced during the reaction while performing nucleic acid amplification such as PCR for various kinds of trace samples. Specifically, the present invention relates to an apparatus for real-time monitoring biochemical reaction for efficiently dividing interference between an excitation light and a fluorescence, which includes a polarizer, a polarizing beam splitter, a polarization converter and so on.
摘要翻译：本发明涉及一种实时PCR监测装置，用于实时监测反应过程中产生的反应产物的生产，同时对各种痕量样品进行核酸扩增如PCR。具体而言，本发明涉及一种用于实时监测生物化学反应的装置，用于有效地分隔激发光和荧光之间的干涉，其包括偏振器，偏振分束器，偏振转换器等。

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