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1. 发明申请

WO2015005669A1 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性siRNA，包含siRNA的双链寡聚RNA分子，以及用于预防或治疗包含其的癌症的组合物
公开(公告)号：WO2015005669A1
公开(公告)日：2015-01-15
申请号：PCT/KR2014/006145
申请日：2014-07-09
申请人： BIONEER CORPORATION , SANOFI-AVENTIS KOREA CO., LTD.
发明人： CHAE, Jeiwook , PARK, Han Oh , YOON, Pyoung Oh , HAN, Boram , KIM, Han-Na , YUN, Sung-Il , PARK, Jun Hong , KO, Youngho , CHOI, Gi-Eun , JUNG, Junsoo , KIM, Jae Eun
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , A61P35/00
CPC分类号： C12N15/1135 , A61K9/0019 , A61K9/51 , A61K31/713 , A61K47/60 , C12N2310/14
摘要： There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly Gankyrin or BMI-1 specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
摘要翻译：提供了与相关肝癌相关的特异性siRNA和高效双链寡聚RNA分子。双链寡RNA分子具有通过简单的共价键或连接体介导的共价键将亲水和疏水化合物与双链寡RNA分子的两端缀合以便有效地递送到细胞中的结构，可以通过双链寡聚RNA分子的疏水相互作用在水溶液中转化成纳米颗粒。双链寡核苷酸分子中含有的siRNA可能是肝癌相关基因，特别是Gankyrin或BMI-1特异性siRNA。此外，本发明涉及制备双链寡聚RNA分子的方法和用于预防或治疗包含双链寡RNA分子的癌症，特别是肝癌的药物组合物。

2. 发明申请

WO2015005670A1 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性siRNA，包含siRNA的双链寡聚RNA分子，以及用于预防或治疗包含其的癌症的组合物
公开(公告)号：WO2015005670A1
公开(公告)日：2015-01-15
申请号：PCT/KR2014/006146
申请日：2014-07-09
申请人： BIONEER CORPORATION , SANOFI-AVENTIS KOREA CO., LTD.
发明人： CHAE, Jeiwook , YOON, Pyoung Oh , KIM, Han-Na , PARK, Han Oh , HAN, Boram , KO, Youngho , CHOI, Gi-Eun , KIM, Jae Eun
IPC分类号： C12N15/113 , A61K48/00 , A61K31/7088 , A61P35/00
CPC分类号： C12N15/1137 , A61K9/1075 , A61K31/713 , A61K47/6907 , C12N15/113 , C12N15/1135 , C12N2310/14 , C12N2310/31 , C12N2310/351 , C12N2320/30
摘要： There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly ZBTB7A, YAP1 or CHD1L specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
摘要翻译：提供了与相关肝癌相关的特异性siRNA和高效双链寡聚RNA分子。双链寡RNA分子具有通过简单的共价键或连接体介导的共价键将亲水和疏水化合物与双链寡RNA分子的两端缀合以便有效地递送到细胞中的结构，可以通过双链寡聚RNA分子的疏水相互作用在水溶液中转化成纳米颗粒。双链寡核苷酸分子中包含的siRNA可能是肝癌相关基因，特别是ZBTB7A，YAP1或CHD1L特异性siRNA。此外，本发明涉及制备双链寡聚RNA分子的方法和用于预防或治疗包含双链寡RNA分子的癌症，特别是肝癌的药物组合物。

3. 发明公开

EP3019612A1 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性的siRNA，双OLIGO RNA分子的siRNA及组成预防和治疗癌症的任何保证，
公开(公告)号：EP3019612A1
公开(公告)日：2016-05-18
申请号：EP14823194.7
申请日：2014-07-09
申请人： Bioneer Corporation , Sanofi-Aventis Korea Co. Ltd.
发明人： CHAE, Jeiwook , YOON, Pyoung Oh , KIM, Han-Na , PARK, Han Oh , HAN, Boram , KO, Youngho , CHOI, Gi-Eun , KIM, Jae Eun
IPC分类号： C12N15/113 , A61K48/00 , A61K31/7088 , A61P35/00
CPC分类号： C12N15/1137 , A61K9/1075 , A61K31/713 , A61K47/6907 , C12N15/113 , C12N15/1135 , C12N2310/14 , C12N2310/31 , C12N2310/351 , C12N2320/30
摘要： There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly ZBTB7A, YAP1 or CHD1L specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
摘要翻译：提供了相关的特异性siRNA和高效率双链寡RNA分子含有其的肝癌。该双链寡RNA分子具有其中亲水性和疏水性化合物通过简单的共价键或在顺序的接头 - 介导的共价键结合到双链寡RNA分子的两端的结构被有效地递送到细胞和可以在由双链寡RNA分子的疏水性相互作用wässrige溶液被转化成纳米颗粒英寸中含有的双链寡RNA分子的siRNA可以是肝癌相关基因，尤其是ZBTB7A，YAP1或CHD1L特异siRNA。此外，本发明涉及制备该双链寡RNA分子的方法，以及用于预防或治疗癌症，特别是肝癌，通过含有双链寡RNA分子的药物组合物。

4. 发明公开

EP3019611A1 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性siRNA，包含该siRNA的双链寡核苷酸分子，以及用于预防或治疗包含该癌症的癌症的组合物
公开(公告)号：EP3019611A1
公开(公告)日：2016-05-18
申请号：EP14822311.8
申请日：2014-07-09
申请人： Bioneer Corporation , Sanofi-Aventis Korea Co. Ltd.
发明人： CHAE, Jeiwook , PARK, Han Oh , YOON, Pyoung Oh , HAN, Boram , KIM, Han-Na , YUN, Sung-Il , PARK, Jun Hong , KO, Youngho , CHOI, Gi-Eun , JUNG, Junsoo , KIM, Jae Eun
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , A61P35/00
CPC分类号： C12N15/1135 , A61K9/0019 , A61K9/51 , A61K31/713 , A61K47/60 , C12N2310/14
摘要： There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly Gankyrin or BMI-1 specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
摘要翻译：提供了肝癌相关特异性siRNA和包含其的高效双链寡RNA分子。双链寡RNA分子具有这样的结构，其中亲水性和疏水性化合物通过简单的共价键或接头介导的共价键与双链寡RNA分子的两个末端缀合，以便有效递送到细胞中，并且可以通过双链寡RNA分子的疏水相互作用转化成水溶液中的纳米颗粒。包含在双链寡RNA分子中的siRNA可以是肝癌相关基因，特别是Gankyrin或BMI-1特异性siRNA。此外，本发明涉及制备双链寡RNA分子的方法，以及用于预防或治疗癌症，特别是包含双链寡RNA分子的肝癌的药物组合物。

5. 发明授权

EP3018208B1 IMPROVED NANOPARTICLE TYPE OLIGONUCLEOTIDE STRUCTURE HAVING HIGH EFFICIENCY AND METHOD FOR PREPARING SAME 有权
公开(公告)号：EP3018208B1
公开(公告)日：2020-05-27
申请号：EP14819529.0
申请日：2014-07-04
申请人： Bioneer Corporation
发明人： PARK, Han Oh , CHAE, Jeiwook , YOON, Pyoung Oh , HAN, Boram , CHOI, Gi-Eun , KO, Youngho , KWON, Taewoo , LEE, Jae Don , KIM, Sun Gi
IPC分类号： C12N15/113 , A61K9/127 , A61K47/54 , A61K47/69

6. 发明公开

EP3018208A1 IMPROVED NANOPARTICLE TYPE OLIGONUCLEOTIDE STRUCTURE HAVING HIGH EFFICIENCY AND METHOD FOR PREPARING SAME 有权
标题翻译： WITH其制造效率高，方法，通过改进寡核苷酸纳米微粒结构
公开(公告)号：EP3018208A1
公开(公告)日：2016-05-11
申请号：EP14819529.0
申请日：2014-07-04
申请人： Bioneer Corporation
发明人： PARK, Han Oh , CHAE, Jeiwook , YOON, Pyoung Oh , HAN, Boram , CHOI, Gi-Eun , KO, Youngho , KWON, Taewoo , LEE, Jae Don , KIM, Sun Gi
IPC分类号： C12N15/113 , C07H21/00 , A61K48/00
摘要： The present invention relates to an oligonucleotide structure and a method for preparing the same and, more particularly, to an oligonucleotide structure in which a polymer compound is linked to an oligonucleotide via a covalent bond to improve in vivo stability of the oligonucleotide and cellular delivery efficiency of the oligonucleotide; and to a method for preparing the same. The oligonucleotide structure is improved into a homogenous material, thereby solving the problem in material verification due to polydispersion characteristics occurring when a hydrophilic material linked to the oligonucleotide is a synthetic polymer; the nucleotide structure is easy to synthesize compared with the existing process; and the size of a double helix oilgo-RNA structure can be accurately adjusted through the control of the number of repetitions of a hydrophilic material block, and thus, the gene expression regulation function of the oligonucleotide does not deteriorate through the synthesis of the optimized oligonucleotide structure, and the oligonucleotide can be delivered into cells at even a relatively low-concentration dosage. Therefore, the oligonucleotide structure of the present invention can be useful as a novel type oligonucleotide delivery system as well as a tool for treating cancers, infectious diseases, and the like.
摘要翻译：本发明涉及到在寡核苷酸结构内，并用于制备方法中的相同，并且，更具体地，涉及在寡核苷酸结构，其中的聚合物化合物通过共价键连接到在寡核苷酸在所述寡核苷酸的体内稳定性和细胞递送效率，以改善寡核苷酸; 以及用于制备其的方法。所述寡核苷酸结构进行了改进成均匀的材料，从而解决该问题，在材料验证由于多分散性的特征时发生连接到寡核苷酸的亲水性材料是合成聚合物; 对核苷酸结构是易于合成与现有的工艺相比; 和双螺旋oilgo RNA结构的尺寸可以精确地设置为通过亲水性材料块的重复数的控制来调整，因此，寡核苷酸的基因表达调控功能不通过优化寡核苷酸的合成恶化结构，并且所述寡核苷酸可以在即使是相对低浓度的剂量被递送到细胞中。因此，本发明的寡核苷酸结构可以是作为一种新的类型的寡核苷酸递送系统以及用于治疗癌症，感染性疾病的工具，等是有用的。

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