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1. 发明专利

JP2006016301A Platelet aggregation suppressant of anhydro fuluctose and its derivative 审中-公开
标题翻译：非离子型氟利昂及其衍生物的PLATELET聚合抑制剂
公开(公告)号：JP2006016301A
公开(公告)日：2006-01-19
申请号：JP2002333502
申请日：2002-11-18
申请人： Biomedical Technology Hybrid Ltd , Susumu Hisaku , Yukiro Maruyama , Nihon Starch Co Ltd , 征郎丸山 , 日本澱粉工業株式会社 , 株式会社ビーエムティーハイブリッド , 進檜作
发明人： MARUYAMA YUKIRO , HISAKU SUSUMU , YAMAJI KATSUYO
IPC分类号： A61K31/715 , A23L1/30 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61P7/02
CPC分类号： A61K31/702 , A61K31/7004 , A61K31/7016 , A61K31/715
摘要： PROBLEM TO BE SOLVED: To provide a new type platelet aggregation suppressant. SOLUTION: This platelet aggregation suppressant contains 1,5-anhydro-D-fluctose or its certain derivative as an effective component. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供新型血小板聚集抑制剂。
解决方案：该血小板聚集抑制剂含有1,5-脱水-D-波动或其某些衍生物作为有效成分。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2005154425A Antitumoral agent 有权
标题翻译：抗菌剂
公开(公告)号：JP2005154425A
公开(公告)日：2005-06-16
申请号：JP2004313560
申请日：2004-10-28
申请人： Yukiro Maruyama , Nihon Starch Co Ltd , 征郎丸山 , 日本澱粉工業株式会社
发明人： MARUYAMA YUKIRO , ABEYAMA KAZUHIRO , YOSHIMOTO YASUSHI
IPC分类号： A61K31/351 , A61K31/7004 , A61P35/00 , A61P35/04
摘要： PROBLEM TO BE SOLVED: To obtain an antitumoral agent expected to prevent propagation, metastasis, and inflammation of a tumor, while scarcely causing a side effect, and capable of giving excellent prognosis. SOLUTION: This antitumoral agent for the tumor contains 1,5-D-anhydrofructose and/or ascopyrone as antitumoral ingredients. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：为了获得预期能够防止肿瘤的扩散，转移和炎症的抗肿瘤剂，同时几乎不引起副作用，并且能够给出良好的预后。解决方案：该肿瘤用抗肿瘤药物含有作为抗肿瘤成分的1,5-D-脱水果糖和/或番茄红素。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2006306814A Anti-inflammatory agent 审中-公开
标题翻译：抗炎剂
公开(公告)号：JP2006306814A
公开(公告)日：2006-11-09
申请号：JP2005133307
申请日：2005-04-28
申请人： Yukiro Maruyama , Nihon Starch Co Ltd , 征郎丸山 , 日本澱粉工業株式会社
发明人： ABEYAMA KAZUHIRO , MARUYAMA YUKIRO , YOSHIMOTO YASUSHI , YOSHINAGA KAZUHIRO
IPC分类号： A61K31/7016 , A61K31/7004 , A61K31/702 , A61K31/715 , A61P9/10 , A61P19/00 , A61P19/02 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To provide an anti-inflammatory agent whose side effects are reduced and which is safe and exhibits an excellent effect.
SOLUTION: This anti-inflammatory agent is characterized by containing 1,5-D-anhydrofrcutose and/or a compound of formula (1): G-(G)
n -AF (1), wherein AF is 1,5-D-anhydrofructose residue; G is glucose residue; (n) is an integer of 0 to 20.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供其副作用降低并且安全并具有优异效果的抗炎剂。解决方案：该抗炎剂的特征在于含有1,5-脱水糠醛和/或式（1）的化合物：G-（G） -AF（1）其中AF为1,5-脱水果糖残基; G是葡萄糖残基; （n）为0〜20的整数。（C）2007，JPO＆INPIT

4. 发明专利

JP2007029716A Porous substrate 有权
标题翻译：多孔基片
公开(公告)号：JP2007029716A
公开(公告)日：2007-02-08
申请号：JP2006169538
申请日：2006-06-20
申请人： Mitsuru Akashi , Biomedical Technology Hybrid Ltd , Yukiro Maruyama , Toray Ind Inc , 征郎丸山 , 満明石 , 東レ株式会社 , 株式会社ビーエムティーハイブリッド
发明人： UENO YOSHIYUKI , SUGAYA HIROYUKI , FUNAKI TAKAFUMI , KATO MASAYA , AKASHI MITSURU , MARUYAMA YUKIRO
IPC分类号： A61L33/00 , A61M1/16 , B01D69/02 , D01F1/08
摘要： PROBLEM TO BE SOLVED: To provide an antithrombogenic porous substrate having high protein C activation potential.
SOLUTION: The porous substrate is used as a carrier, 1 g dry weight of the carrier has 1 μg or more of a physiologically active substance which activates protein C, and the physiologically active substance which activates protein C is introduced into an internal porous section of the carrier as well as on a surface where the carrier and blood are brought into direct contact with each other. Consequently, the antithrombogenic porous substrate having high protein C activation potential is obtained.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有高蛋白C活化电位的抗血栓形成多孔底物。解决方案：多孔底物用作载体，1g干重载体具有1μg或更多的活化蛋白C的生理活性物质，将活化蛋白C的生理活性物质引入内部载体的多孔部分以及载体和血液彼此直接接触的表面上。因此，获得具有高蛋白C活化电位的抗血栓形成多孔质底物。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006271839A Auxiliary appliance for medical column for extracorporeal circulation 有权
标题翻译：医用柱辅助器械用于超声波循环
公开(公告)号：JP2006271839A
公开(公告)日：2006-10-12
申请号：JP2005098639
申请日：2005-03-30
申请人： Mitsuru Akashi , Biomedical Technology Hybrid Ltd , Yukiro Maruyama , Toray Ind Inc , 征郎丸山 , 満明石 , 東レ株式会社 , 株式会社ビーエムティーハイブリッド
发明人： UENO YOSHIYUKI , SUGAYA HIROYUKI , FUNAKI TAKAFUMI , KATO MASAYA , AKASHI MITSURU , MARUYAMA YUKIRO
IPC分类号： A61M1/36 , A61M1/02 , A61M1/14
摘要： PROBLEM TO BE SOLVED: To improve a therapeutic effect of a medical column for extracorporeal circulation by providing an auxiliary appliance for the medical column for the extracorporeal circulation which plays an auxiliary role for the medical column for the extracorporeal circulation used for an original purpose and to reduce an anxiety of side-effects of medial agent by non-use or reduction of anticoagulant.
SOLUTION: This auxiliary appliance for the medical column for the extracorporeal circulation is an auxiliary appliance for use in a pretreatment and/or posttreatment of the medical column for the extracorporeal circulation and is characterized in that a physiologically active substance is immobilized to the auxiliary appliance for the medical column for the extracorporeal circulation.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过提供用于体外循环的医用柱的辅助器具来提高医用柱体外循环的治疗效果，其对于用于原始体外的体外循环的医用柱起辅助作用目的，并通过不使用或减少抗凝血剂减少内侧药物副作用的焦虑。解决方案：用于体外循环的用于医疗柱的辅助装置是用于体外循环的医用柱的预处理和/或后处理的辅助装置，其特征在于将生理活性物质固定在用于体外循环医用柱的辅助器具。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2006271809A Irradiated modified base material 有权
标题翻译： IRRADIATED改性基材
公开(公告)号：JP2006271809A
公开(公告)日：2006-10-12
申请号：JP2005098154
申请日：2005-03-30
申请人： Mitsuru Akashi , Biomedical Technology Hybrid Ltd , Yukiro Maruyama , Toray Ind Inc , 征郎丸山 , 満明石 , 東レ株式会社 , 株式会社ビーエムティーハイブリッド
发明人： UENO YOSHIYUKI , SUGAYA HIROYUKI , FUNAKI TAKAFUMI , KATO MASAYA , AKASHI MITSURU , MARUYAMA YUKIRO
IPC分类号： A61L33/00 , A61F2/06 , A61M1/16
摘要： PROBLEM TO BE SOLVED: To provide an antithrombogenic modified base material which is sterilized by irradiation and is capable of activating protein C. SOLUTION: The modified base material is irradiated with radiation in the presence of a physiologically active substance to activate protein C therein and capable of activating protein C. The modified base material is sterilized by irradiation excellent in activating protein C and antithrombogenicity. The irradiation minimizes amount of physiologically active substance elution in spite of any induction method of the base material with the physiologically active substance is employed. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供通过照射灭菌并能够活化蛋白质C的抗血栓形成改性基础材料。解决方案：将改性的基材在生理活性物质的存在下用辐射照射至在其中活化蛋白质C并能够激活蛋白质C.经修饰的基材通过激活蛋白C和抗血栓形成性优异的照射而灭菌。尽管使用了具有生理活性物质的基材的任何诱导方法，照射使生理活性物质洗脱的量最小化。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2007091644A Immunosuppressant and antiallergic agent 审中-公开
标题翻译：免疫抑制剂和抗微生物剂
公开(公告)号：JP2007091644A
公开(公告)日：2007-04-12
申请号：JP2005283867
申请日：2005-09-29
申请人： Nihon Starch Co Ltd , 日本澱粉工業株式会社
发明人： ABEYAMA KAZUHIRO , MARUYAMA YUKIRO , YOSHIMOTO YASUSHI , YOSHINAGA KAZUHIRO
IPC分类号： A61K31/7004 , A23L1/30 , A61K31/7024 , A61P13/06 , A61P19/02 , A61P19/06 , A61P27/14 , A61P29/00 , A61P37/06 , A61P37/08 , C07H3/10 , C08B37/00
摘要： PROBLEM TO BE SOLVED: To provide an immunosuppressant and an antiallergic agent safe and/or having excellent effects with diminished side effects. SOLUTION: The immunosuppressant or antiallergic agent comprises 1,5-D-anhydrofructose and/or a compound of the formula(1):G-(G) n -AF( wherein, AF is a 1,5-D-anhydrofructose residue; G is a glucose residue; and n is an integer of 0-20; wherein other glucose unit(s) may be bound in a glycoside linkage manner as side chain(s) to the glucose residue ). COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供免疫抑制剂和抗过敏剂安全和/或具有优异的效果，副作用减少。解决方案：免疫抑制剂或抗过敏剂包含1,5-脱水果糖和/或式（1）的化合物：G-（G） -AF（其中AF为 1,5-脱水果糖残基; G是葡萄糖残基; n是0-20的整数;其中其它葡萄糖单元可以以糖苷键连接的方式作为侧链与葡萄糖结合残留物）。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2006273751A Antitumor agent 有权
标题翻译：抗菌剂
公开(公告)号：JP2006273751A
公开(公告)日：2006-10-12
申请号：JP2005095146
申请日：2005-03-29
申请人： Kagoshima Univ , Nihon Starch Co Ltd , 国立大学法人鹿児島大学 , 日本澱粉工業株式会社
发明人： ABEYAMA KAZUHIRO , MARUYAMA YUKIRO , YOSHIMOTO YASUSHI , YOSHINAGA KAZUHIRO
IPC分类号： A61K31/351 , A61K31/203 , A61K31/7004 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a safe and excellent antitumor agent having reduced side effects with the use of 1,5-D-anhydrofructose or ascopyrone. SOLUTION: The antitumor agent or a kit contains (1) 1,5-D-anydrofructose and/or ascopyrone and (2) at least one selected from the group consisting of vitamin A and vitamin A derivatives as active ingredients. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供使用1,5-脱水果糖或异黄酮具有降低的副作用的安全和优异的抗肿瘤剂。解决方案：抗肿瘤剂或试剂盒含有（1）1,5-脱氧果糖和/或正康复酮，（2）选自维生素A和维生素A衍生物中的至少一种作为活性成分。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2006306810A Anti-inflammatory agent 有权
标题翻译：抗炎剂
公开(公告)号：JP2006306810A
公开(公告)日：2006-11-09
申请号：JP2005133080
申请日：2005-04-28
申请人： Nihon Starch Co Ltd , 日本澱粉工業株式会社
发明人： ABEYAMA KAZUHIRO , MARUYAMA YUKIRO , YOSHIMOTO YASUSHI
IPC分类号： A61K31/351 , A61P9/10 , A61P19/02 , A61P19/06 , A61P29/00 , C07D309/32
摘要： PROBLEM TO BE SOLVED: To provide an anti-inflammatory agent whose side effects are reduced and which is safe and exhibits an excellent effect.
SOLUTION: This anti-inflammatory agent is characterized by containing ascopyrone. The anti-inflammatory agent, wherein the ascopyrone is ascopyrone P.
COPYRIGHT: (C)2007,JPO&INPIT

10. 发明专利

JP2007298486A Method and apparatus for observing blood clot using vascular endothelial cell 有权
标题翻译：使用血管内皮细胞观察血液衣服的方法和装置
公开(公告)号：JP2007298486A
公开(公告)日：2007-11-15
申请号：JP2006129077
申请日：2006-05-08
申请人： Fujimori Kogyo Co Ltd , Yukiro Maruyama , 征郎丸山 , 藤森工業株式会社
发明人： MARUYAMA YUKIRO , HOSOKAWA KAZUYA
IPC分类号： G01N33/86 , C12M1/34 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide an apparatus and a method for comprehensively evaluating blood coagulation and the formation of blood clots in an environment equivalent to a blood stream. SOLUTION: Anticoagulated blood is made to flow through a cell culture chamber of which at least inside part is stained with vascular endothelial cells while relieving it of anticoagulation to observe the formation of blood clots in the cell culture chamber in the blood clot formation observing method. Anticoagulated blood is made to flow through a channel simulating a blood vessel while relieving it of anticoagulation to observe the formation of blood clots in the blood clot observing apparatus. The blood clot observing apparatus comprises the cell culture chamber of which at least inside part is stained with vascular endothelial cells; an inflow tube connected to the cell culture chamber to make blood flow in the cell culture chamber; and a chemical tube connected to the inflow tube to inject a chemical, which relieves anticoagulation, to the inflow tube. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种在与血流相当的环境中综合评价血液凝固和血块形成的装置和方法。解决方案：使抗凝血液流过其中至少内部部分被血管内皮细胞染色的细胞培养室，同时缓解其抗凝，以观察血液凝块形成细胞培养室中血凝块的形成观察方法。使抗凝血液流过模拟血管的通道，同时缓解其抗凝，观察血块观察装置中的血块形成。血液凝块观察装置包括细胞培养室，其至少内部部分被血管内皮细胞染色; 连接到细胞培养室的流入管，使细胞培养室内的血液流动; 以及连接到流入管的化学管，以将抵抗抗凝的化学品注入到流入管中。版权所有（C）2008，JPO＆INPIT

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