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1. 发明申请

US20100216740A1 Cereal-based Infant Nutrition with Fibre 审中-公开
标题翻译：基于谷物的婴幼儿营养与纤维
公开(公告)号：US20100216740A1
公开(公告)日：2010-08-26
申请号：US12532583
申请日：2008-03-21
申请人： Bernd Stahl , Martine Sandra Alles , Brigitte Antonia Maria Borgmann
发明人： Bernd Stahl , Martine Sandra Alles , Brigitte Antonia Maria Borgmann
IPC分类号： A61K31/715 , A23L1/00 , A61P1/12 , A61P25/20
CPC分类号： A23L33/21 , A23L7/198 , A23L33/40 , A23V2002/00 , A23V2250/5116 , A23V2200/328 , A23V2250/061 , A23V2250/606 , A23V2250/612 , A23V2250/5118 , A23V2250/5072 , A23V2250/5062 , A23V2200/32 , A23V2250/5114
摘要： Cereal-based semi-liquid and/or semi-solid compositions suitable for supporting the transition period wherein the infant changes from a diet consisting of breast milk or liquid infant formula to solid adult foods, comprising uronic acid carbohydrates with a degree of polymerisation (DP) between 10 and 300 and also uses thereof are disclosed.
摘要翻译：适用于支持过渡期的谷物型半液体和/或半固体组合物，其中婴儿由母乳或液体婴儿配方食物组成的饮食改变成固体成年食品，包括具有聚合度的糖醛酸碳水化合物（DP ）在10和300之间，并且还公开了其用途。

2. 发明申请

US20090305996A1 USE OF NON-DIGESTABLE SACHARIDES FOR GIVING AN INFANT THE BEST START AFTER BIRTH 审中-公开
标题翻译：使用不可食用的沙发提供婴儿是出生后最好的开始
公开(公告)号：US20090305996A1
公开(公告)日：2009-12-10
申请号：US12282302
申请日：2007-03-09
申请人： Christopher Beermann , Jan Knol , Martine Sandra Alles , Bernd Stahl , Günther Boehm
发明人： Christopher Beermann , Jan Knol , Martine Sandra Alles , Bernd Stahl , Günther Boehm
IPC分类号： A61K31/70 , A61K31/702 , A61P37/00
CPC分类号： A61K31/702 , A23L33/115 , A23L33/21 , A23L33/30 , A23V2002/00 , A23V2200/324 , A23V2250/28 , A23V2250/1882 , A61K2300/00
摘要： A food or supplement for pregnant women comprising water soluble, non-digestible saccharides is described. The composition is used to improve the flora and/or immune system of the pregnant women, to improve the immune system of the infant and to improve the intestinal flora of the infant after birth.
摘要翻译：描述了包含水溶性，不可消化的糖的孕妇的食物或补充剂。该组合物用于改善孕妇的植物和/或免疫系统，改善婴儿的免疫系统并改善出生后的婴儿肠道菌群。

3. 发明授权

US08715769B2 Preventing diseases in infants delivered via caesarean section 有权
标题翻译：预防通过剖宫产分娩的婴儿的疾病
公开(公告)号：US08715769B2
公开(公告)日：2014-05-06
申请号：US12091011
申请日：2006-10-06
申请人： Joachim Schmitt , Bernd Stahl , Jan Knol
发明人： Joachim Schmitt , Bernd Stahl , Jan Knol
IPC分类号： A23L1/29
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section.
摘要翻译：本发明提供包含不消化的寡糖的组合物在通过剖宫产递送的婴儿制造用于肠内给药的组合物中的用途。

4. 发明申请

US20120195975A1 IMMUNE STIMULATORY INFANT NUTRITION 有权
标题翻译：免疫刺激性哺乳动物营养
公开(公告)号：US20120195975A1
公开(公告)日：2012-08-02
申请号：US13360508
申请日：2012-01-27
申请人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'Rabet , Johan Garssen
发明人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'Rabet , Johan Garssen
IPC分类号： A61K38/16 , A61K33/30 , A61P17/00 , A61P37/08 , A61P29/00 , A61P1/12
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition comprising fat, protein, carbohydrate, whey and casein is provided. The composition has a weight ratio of casein to whey between 1:1 to 1:2.4 and comprises: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids selected from docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. Methods of treatment by administering the composition are also provided.
摘要翻译：提供了包含脂肪，蛋白质，碳水化合物，乳清和酪蛋白的营养或药物组合物。该组合物的酪蛋白与乳清的重量比在1:1至1:2.4之间，包括：a）每100克蛋白质至少3克精氨酸; b）至少10wt。％亚油酸基于总脂肪酸; c）至少1wt。基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。基于选自二十二碳六烯酸，花生四烯酸和二十碳五烯酸的总脂肪酸的％; e）5至25wt。至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和f）2至12克不可消化的低聚糖，其聚合度为每100克组合物干重2至100。还提供了施用该组合物的治疗方法。

5. 发明申请

US20120178674A1 MIXTURE OF NON-DIGESTIBLE OLIGOSACCHARIDES FOR STIMULATING THE IMMUNE SYSTEM 审中-公开
标题翻译：用于刺激免疫系统的非可溶性寡糖混合物的混合物
公开(公告)号：US20120178674A1
公开(公告)日：2012-07-12
申请号：US13383823
申请日：2010-07-12
申请人： Bernd Stahl , Alma Jildou Nauta , Johan Garssen , Eric Samain , Sophie Drouillard
发明人： Bernd Stahl , Alma Jildou Nauta , Johan Garssen , Eric Samain , Sophie Drouillard
IPC分类号： A61K31/715 , A61P37/06 , A61P37/04 , A61P31/00 , A61K38/02 , A61P3/02
摘要： Nutritional compositions with fucosyllactose and betagalactooligosaccharides for use in stimulation of the immune system. The composition is suitable for infants.
摘要翻译：具有岩藻糖基乳糖和低聚半乳糖的营养组合物用于刺激免疫系统。该组合物适用于婴儿。

6. 发明申请

US20110150851A1 NUTRITIONAL COMPOSITION FOR INFANTS DELIVERED VIA CAESAREAN SECTION 审中-公开
标题翻译：通过CAESAREAN部分提供的婴儿的营养成分
公开(公告)号：US20110150851A1
公开(公告)日：2011-06-23
申请号：US13001991
申请日：2009-06-19
申请人： Joachim Schmitt , Francis Lecroix , Pierre Jesenne , Bernd Stahl , Günther Boehm , Emmanuel Perrin
发明人： Joachim Schmitt , Francis Lecroix , Pierre Jesenne , Bernd Stahl , Günther Boehm , Emmanuel Perrin
IPC分类号： A61K35/74 , A61P31/04
CPC分类号： A23C9/1234 , A23C9/1236 , A23C21/026 , A23L29/30 , A23L33/135 , A23L33/21 , A23L33/40 , A23V2002/00 , A61K35/744 , A61K35/745 , A61K35/747 , A23V2200/3204 , A23V2200/3202 , A23V2250/28 , A23V2200/32
摘要： The present invention relates to compositions to be administered to infants delivered via caesarean section and in particular to a product comprising inactivated cells and/or bacterial cell fragments of Gram-negative bacteria and of optionally inactivated Gram-positive bacteria. Thereby it is possible to stimulate a fast colonisation of the intestinal microbiota of said infants.
摘要翻译：本发明涉及给予通过剖宫产递送的婴儿的组合物，特别涉及包含革兰氏阴性细菌的灭活细胞和/或细菌细胞片段以及任选灭活的革兰氏阳性细菌的产品。因此，可以刺激所述婴儿的肠道微生物群的快速定植。

7. 发明申请

US20110086814A1 INHIBITING E.SAKAZAKII GROWTH 审中-公开
标题翻译：抑制EASAZZAKII增长
公开(公告)号：US20110086814A1
公开(公告)日：2011-04-14
申请号：US12995994
申请日：2009-06-05
申请人： Bernd Stahl , Matthias Fischer
发明人： Bernd Stahl , Matthias Fischer
IPC分类号： A61K31/732 , A61P31/04
CPC分类号： A23L3/3562 , A23L3/3463 , A23L29/03
摘要： The present invention concerns the use of uronic acid saccharide for preventing growth of Enterobacter sakazakii.
摘要翻译：本发明涉及糖醛糖用于预防阪崎肠杆菌生长的用途。

8. 发明授权

US07655784B2 Trans-sialidases obtained from Trypanosoma congolense 失效
标题翻译：来自锥虫的转唾液酸酶
公开(公告)号：US07655784B2
公开(公告)日：2010-02-02
申请号：US10538840
申请日：2003-12-11
申请人： Joachim Schmitt , Gunter Boehm , Bernd Stahl , Roland Schauer , Evelin Tiralongo , Silke Schrader
发明人： Joachim Schmitt , Gunter Boehm , Bernd Stahl , Roland Schauer , Evelin Tiralongo , Silke Schrader
IPC分类号： C07H21/02 , C07H21/04 , A61K39/00
CPC分类号： C12N9/1081
摘要： The invention relates to novel enzymes, which transfer sialic acid from a donor molecule onto an acceptor molecule (trans-sialidases). The enzymes are isolated from the protozoan Trypanosoma congolense. The invention also relates to functional equivalents of said enzymes, to the nucleic acid sequences and amino acid sequences that code for the enzymes and their functional equivalents, to expression constructs and vectors that contain said sequences, to recombinant microorganisms that carry the inventive coding nucleic-acid sequences, to a method for the recombinant production of the inventive enzymes, to a method for isolating said enzyme from Trypanosoma congolense, to a method for the enzymatic sialization of acceptor molecules using the inventive enzymes, to effectors of the inventive trans-sialidases, to the use of the nucleic acid sequences, amino acid sequences, enzymes, effectors or sialization products for producing vaccines, medicaments, foodstuffs or food additives, in addition to the latter products obtained by the inventive method.
摘要翻译：本发明涉及将唾液酸从供体分子转移到受体分子（反唾液酸酶）上的新型酶。这些酶是从原生动物锥虫中分离的。本发明还涉及所述酶的功能等同物，编码酶及其功能等同物的核酸序列和氨基酸序列，含有所述序列的表达构建体和载体，携带本发明编码核酸的重组微生物，酸序列，重组生产本发明酶的方法，用于将所述酶与锥虫属分离的方法，使用本发明酶将受体分子酶促唾液酸化的方法用于本发明的反唾液酸酶的实施者，使用除了通过本发明方法获得的后一种产品之外的核酸序列，氨基酸序列，酶，效应物或用于生产疫苗，药物，食品或食品添加剂的唾液化产品。

9. 发明申请

US20100016214A1 CARBOHYDRATES MIXTURE 有权
标题翻译：碳酸氢钾混合物
公开(公告)号：US20100016214A1
公开(公告)日：2010-01-21
申请号：US12565512
申请日：2009-09-23
申请人： Gunther SAWATZKI , Bernd Stahl
发明人： Gunther SAWATZKI , Bernd Stahl
IPC分类号： A61K38/28 , A61K31/715 , A61K31/702 , A23L1/00 , A23J1/00
CPC分类号： A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/21 , A23L33/40 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/733 , A61K31/7004 , A61K2300/00
摘要： A carbohydrate mixture for dietetic foods and pharmaceuticals containing several carbohydrates is provided according to the present invention. Said carbohydrate mixture is characterized in that they contain or consist of two different, substantially soluble carbohydrate components A and B, which remain undigested in the gastrointestinal tract and enter the large intestine without being resorbed, that said carbohydrate component A is composed of at least one monosaccharide or of at least one oligosaccharide (disaccharide to hexasaccharide) or of a mixture of two or more of these saccharides, that the carbohydrate component B is composed of a polysaccharide (from heptasaccharide onwards) or of a mixture of two or more polysaccharides, that the carbohydrate component A=5 to 95 wt-% and the carbohydrate component B=5 to 95 wt-% of the sum of the carbohydrate components A+B (=100 wt-%), and that at least 80 wt-% of the carbohydrates/saccharides of the carbohydrate components A and B have a prebiotic effect. The inventive carbohydrate mixture have not only a nutritive effect but they also stimulate health-promoting microorganisms present in the natural flora of the large intestine.
摘要翻译：根据本发明提供了含有几种碳水化合物的饮食食品和药物的碳水化合物混合物。所述碳水化合物混合物的特征在于它们含有两种不同的，基本上可溶的碳水化合物组分A和B，其中所述碳水化合物组分A和B在胃肠道中未消化并进入大肠而不被再吸收，所述碳水化合物组分A由至少一种单糖或至少一种寡糖（二糖与六糖）或两种或多种这些糖的混合物，碳水化合物组分B由多糖（来自七糖以上）或两种或多种多糖的混合物组成，该碳水化合物组分A = 5至95重量％，碳水化合物组分B = 5至95重量％的碳水化合物组分A + B（= 100重量％）和至少80重量％的碳水化合物组分碳水化合物组分A和B的碳水化合物/糖具有益生元效应。本发明的碳水化合物混合物不仅具有营养效果，而且还刺激存在于大肠的天然菌群中的健康促进微生物。

10. 发明申请

US20070054877A1 Antiadhesive carbohydrates 有权
标题翻译：防粘碳水化合物
公开(公告)号：US20070054877A1
公开(公告)日：2007-03-08
申请号：US11511500
申请日：2006-08-29
申请人： Bernd Stahl , Gunther Boehm
发明人： Bernd Stahl , Gunther Boehm
IPC分类号： A61K31/715
CPC分类号： A61K31/7012 , A23L5/00 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/00 , A23L33/10 , A23L33/125 , A61K31/702 , A61K31/715
摘要： Provided is a pharmaceutical or dietetic product, which serves for reducing and/or blocking the adhesion of pathogenic substances and organisms to eucaryontic cells, in particular mammal cells. Said preparation contains at least one carbohydrate having an uronic acid unit on one of the ends thereof. 10 to 100% of the present, terminal uronic acid units pertaining to the carbohydrates are provided with a double bond that is especially situated between the C4 and C5 atom.
摘要翻译：提供了一种药物或饮食产品，其用于减少和/或阻断致病物质和生物体对真核细胞特别是哺乳动物细胞的粘附。所述制剂包含至少一种在其一个端部具有糖醛酸单元的碳水化合物。本发明的碳原子数为10〜100％的末端糖醛酸单元具有特别位于C 4〜C 5原子之间的双键。

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