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1. 发明申请

US20080049232A1 APPARATUS AND METHODS FOR ENHANCING OPTICAL COHERENCE TOMOGRAPHY IMAGING USING VOLUMETRIC FILTERING TECHNIQUES 有权
标题翻译：使用体积滤波技术增强光学相干成像的装置和方法
公开(公告)号：US20080049232A1
公开(公告)日：2008-02-28
申请号：US11844454
申请日：2007-08-24
申请人： Benjamin J. Vakoc , Adrien Desjardins , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Benjamin J. Vakoc , Adrien Desjardins , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： A61B3/1225 , A61B5/0066 , A61B5/0073 , A61B5/6852
摘要： Apparatus and method can be provided, whereas a particular radiation which includes at least one first electro-magnetic radiation can be directed to at least one sample and at least one second electro-magnetic radiation can be directed to a reference. The first electro-magnetic radiation having a particular cross-sectional width may be applied to at least one portion of the sample to generate at least one third electro-magnetic radiation. The first electro-magnetic radiation can be provided in the portion along a particular axis for a distance between a multiplier of 0.5 and 100 of the particular cross-sectional width. An interference can be detected between the third electro-magnetic radiation associated with the first electro-magnetic radiation and at least one fourth electro-magnetic radiation associated with the second electro-magnetic radiation. Further, an asymmetrical cross-sectional area of the first electro-magnetic radiation can be provided.
摘要翻译：可以提供装置和方法，而包括至少一个第一电磁辐射的特定辐射可以被引导到至少一个样品，并且至少一个第二电磁辐射可以被引导到参考。具有特定横截面宽度的第一电磁辐射可以被施加到样品的至少一部分以产生至少一个第三电磁辐射。第一电磁辐射可以沿着特定轴线的部分设置在特定横截面宽度的0.5和100之间的距离上。可以在与第一电磁辐射相关联的第三电磁辐射与与第二电磁辐射相关联的至少一个第四电磁辐射之间检测到干扰。此外，可以提供第一电磁辐射的不对称横截面面积。

2. 再颁专利

USRE46412E1 Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography 有权
公开(公告)号：USRE46412E1
公开(公告)日：2017-05-23
申请号：US14184537
申请日：2014-02-19
申请人： Adrien Desjardins , Benjamin J. Vakoc , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Adrien Desjardins , Benjamin J. Vakoc , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02 , G01N21/47 , A61B5/00
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0073 , G01B9/02043 , G01B9/02087 , G01B9/02091 , G01B2290/70 , G01N2021/4714
摘要： Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro-magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third electro-magnetic radiations can be simultaneously detected, with the signals being associated with information for the sample at a plurality of depths thereof. The depths can be determined using at least one of the third electro-magnetic radiations without a need to utilize another one of the third electro-magnetic radiations.

3. 发明授权

US07920271B2 Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques 有权
标题翻译：使用体积滤波技术增强光学相干断层成像的装置和方法
公开(公告)号：US07920271B2
公开(公告)日：2011-04-05
申请号：US11844454
申请日：2007-08-24
申请人： Benjamin J. Vakoc , Adrien Desjardins , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Benjamin J. Vakoc , Adrien Desjardins , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： A61B3/1225 , A61B5/0066 , A61B5/0073 , A61B5/6852
摘要： Apparatus and method can be provided, whereas a particular radiation which includes at least one first electro-magnetic radiation can be directed to at least one sample and at least one second electro-magnetic radiation can be directed to a reference. The first electro-magnetic radiation having a particular cross-sectional width may be applied to at least one portion of the sample to generate at least one third electro-magnetic radiation. The first electro-magnetic radiation can be provided in the portion along a particular axis for a distance between a multiplier of 0.5 and 100 of the particular cross-sectional width. An interference can be detected between the third electro-magnetic radiation associated with the first electro-magnetic radiation and at least one fourth electro-magnetic radiation associated with the second electro-magnetic radiation. Further, an asymmetrical cross-sectional area of the first electro-magnetic radiation can be provided.
摘要翻译：可以提供装置和方法，而包括至少一个第一电磁辐射的特定辐射可以被引导到至少一个样品，并且至少一个第二电磁辐射可以被引导到参考。具有特定横截面宽度的第一电磁辐射可以被施加到样品的至少一部分以产生至少一个第三电磁辐射。第一电磁辐射可以沿着特定轴线的部分设置在特定横截面宽度的0.5和100之间的距离上。可以在与第一电磁辐射相关联的第三电磁辐射与与第二电磁辐射相关联的至少一个第四电磁辐射之间检测到干扰。此外，可以提供第一电磁辐射的不对称横截面面积。

4. 发明授权

US07982879B2 Methods and systems for performing angle-resolved fourier-domain optical coherence tomography 有权
标题翻译：用于进行角度分辨的傅里叶变换光学相干断层扫描的方法和系统
公开(公告)号：US07982879B2
公开(公告)日：2011-07-19
申请号：US11677278
申请日：2007-02-21
申请人： Adrien E. Desjardins , Benjamin J. Vakoc , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Adrien E. Desjardins , Benjamin J. Vakoc , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0073 , G01B9/02043 , G01B9/02087 , G01B9/02091 , G01B2290/70 , G01N2021/4714
摘要： Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro-magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third electro-magnetic radiations can be simultaneously detected, with the signals being associated with information for the sample at a plurality of depths thereof. The depths can be determined using at least one of the third electro-magnetic radiations without a need to utilize another one of the third electro-magnetic radiations.
摘要翻译：根据本发明的示例性实施例提供了安排，装置和方法。特别地，可以接收至少一个第一电磁辐射，并且将立体角内的至少一个第二电磁辐射转发到样品。第二电磁辐射可以与第一电磁辐射相关联。可以从与第二电磁辐射相关联的样品接收多个第三电磁辐射，并且第三电磁辐射的至少一部分设置在立体角的外围。可以同时检测与每个第三电磁辐射相关联的信号，其中信号与样品在其多个深度处的信息相关联。可以使用第三电磁辐射中的至少一个来确定深度，而不需要利用第三电磁辐射中的另一个。

5. 发明授权

US09060689B2 Apparatus, method and system for performing phase-resolved optical frequency domain imaging 有权
标题翻译：用于执行相位分辨光学频域成像的装置，方法和系统
公开(公告)号：US09060689B2
公开(公告)日：2015-06-23
申请号：US11445990
申请日：2006-06-01
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Johannes F. De Boer , Benjamin J. Vakoc , Seok-Hyun Yun
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Johannes F. De Boer , Benjamin J. Vakoc , Seok-Hyun Yun
IPC分类号： G01N21/55 , A61B5/00 , G01N21/45 , G01N21/47 , G01N21/49 , G01B9/02
CPC分类号： A61B5/0073 , A61B5/0066 , A61B2560/0223 , G01B9/02091 , G01N21/45 , G01N21/4795 , G01N21/49
摘要： Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electro-magnetic radiation directed to the sample and at least one second electro-magnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component of the interference, and compare the particular signal to at least one particular information. Further, it is possible to receive at least one portion of the radiation and provide a further radiation, such that the particular signal can be calibrated based on the further signal.
摘要翻译：提供了使用从参考和样本接收的信号的装置，系统和方法。特别地，提供了一种辐射，其包括指向样品的至少一个第一电磁辐射和指向该参考的至少一个第二电磁辐射。辐射的频率随时间而变化。可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。可以获得与干扰的至少一个频率分量的至少一个相位相关联的特定信号，并将特定信号与至少一个特定信息进行比较。此外，可以接收辐射的至少一部分并提供另外的辐射，使得可以基于另外的信号来校准特定信号。

6. 发明授权

US07538859B2 Methods and systems for monitoring and obtaining information of at least one portion of a sample using conformal laser therapy procedures, and providing electromagnetic radiation thereto 有权
标题翻译：用于使用保形激光治疗程序监测和获得样品的至少一部分的信息并向其提供电磁辐射的方法和系统
公开(公告)号：US07538859B2
公开(公告)日：2009-05-26
申请号：US11670058
申请日：2007-02-01
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
IPC分类号： G01L1/24
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/6852 , A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/207 , A61B2090/306 , A61B2090/3614
摘要： In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro-magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.
摘要翻译：在本发明的一个示例性实施例中，可以提供方法和系统来获得与样本的至少一部分相关联的信息。例如，可以在样品的部分中引起温度变化。至少一个第一电磁辐射可以转发到样品附近或部分的部分。可以在多个深度处识别该部分的变形作为（i）从该部分提供的至少一个第二电磁辐射的相位和/或（ii）相的变化率和 /或第二电磁辐射的振幅。在本发明的另一示例性实施例中，可以提供方法和系统来控制样品中的温度分布。例如，可以以特定波长向样品中的部分提供电磁辐射。当电磁辐射提供给该部分时，可以通过修改电磁辐射的特定波长来控制温度分布。

7. 发明授权

US09646377B2 Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof 有权
公开(公告)号：US09646377B2
公开(公告)日：2017-05-09
申请号：US14243508
申请日：2014-04-02
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： A61B5/00 , G06T7/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

8. 发明授权

US07872759B2 Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures 有权
标题翻译：用于提供一个或多个生物结构的多模态显微镜成像的布置和方法
公开(公告)号：US07872759B2
公开(公告)日：2011-01-18
申请号：US11537343
申请日：2006-09-29
申请人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.
摘要翻译：可以提供根据本发明的示例性实施例的方法和装置。例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于第二种模式与第一种模式不同。可以接收与参考相关联的第三数据。可以基于第一，第二和第三数据生成进一步的数据。此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

9. 发明授权

US09441948B2 Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography 有权
标题翻译：用于在光学相干断层摄影中执行基于偏振的正交解调的装置，方法和存储介质
公开(公告)号：US09441948B2
公开(公告)日：2016-09-13
申请号：US11502330
申请日：2006-08-09
申请人： Benjamin J. Vakoc , Seok-Hyun Yun , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Benjamin J. Vakoc , Seok-Hyun Yun , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02 , G01N21/21 , G01N21/47 , A61B5/00 , G01J3/45 , G01J9/02 , G01N21/27
CPC分类号： G01B9/02044 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02072 , G01B9/02081 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/45 , G01J2009/0265 , G01N21/21 , G01N21/274 , G01N21/4795
摘要： Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample and at least one second electromagnetic radiation to a reference, such that the first and/or second electromagnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation associated with the first radiation can be combined with a second polarization component of at least one fourth radiation associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another.
摘要翻译：可以向样品提供至少一个第一电磁辐射和至少一个第二电磁辐射至参考物的装置，方法和存储介质，使得第一和/或第二电磁辐射具有随时间变化的光谱。此外，与第一辐射相关联的至少一个第三辐射的第一偏振分量可以与与第二辐射相关联的至少一个第四辐射的第二偏振分量彼此组合。可以将第一和第二偏振特别地控制为至少大致彼此正交。

10. 发明授权

US09186066B2 Apparatus for applying a plurality of electro-magnetic radiations to a sample 有权
标题翻译：用于将多个电磁辐射施加到样品的装置
公开(公告)号：US09186066B2
公开(公告)日：2015-11-17
申请号：US11670027
申请日：2007-02-01
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
IPC分类号： A61B18/18 , A61B5/00 , A61B18/24 , A61B17/00 , A61B17/22 , A61B18/20 , A61B19/00
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/6852 , A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/207 , A61B2090/306 , A61B2090/3614
摘要： An apparatus for applying a plurality of electro-magnetic radiations to a sample is provided. In one exemplary embodiment, the apparatus can include an arrangement which has a specific portion with a plurality of channels. One of channels can facilitate a first radiation of the radiations to be forwarded to the sample that is within an anatomical structure, and another one of the channels can facilitate a second radiation of the radiations to be forwarded to the sample. The first radiation may have a first wavelength band, and the second radiation may have a second wavelength band. The first wavelength band may be substantially different from the second wavelength band. According to another exemplary embodiment, the first radiation can be adapted to be delivered to a first area of the sample, and the second radiation may be capable of being delivered to a second area of the sample. The first area may be substantially enclosed by the second area. According to yet another exemplary embodiment of the present invention, each of the channels can facilitate at least one particular radiation of the radiations to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. Centers of every one of the areas may be provided substantially along a line.
摘要翻译：提供了一种向样品施加多个电磁辐射的装置。在一个示例性实施例中，装置可以包括具有多个通道的特定部分的装置。通道中的一个可以促进要转发到解剖结构内的样品的辐射的第一辐射，并且另一个通道可以促进辐射的第二次辐射以被转发到样品。第一辐射可以具有第一波长带，并且第二辐射可以具有第二波长带。第一波长带可能与第二波长带显着不同。根据另一示例性实施例，第一辐射可以适于被传送到样品的第一区域，并且第二辐射可以能够被传送到样品的第二区域。第一区域可以基本上被第二区域包围。根据本发明的另一个示例性实施例，每个通道可以促进辐射的至少一个特定辐射被转发到样品的解剖结构内的样品，辐射被递送到样品的解剖结构中样品。可以基本沿着一条线提供每个区域的中心。

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