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1. 发明授权

US08021869B2 Method of cell storage in a delivery system comprising a fibrous matrix 有权
标题翻译：包含纤维基质的递送系统中的细胞储存方法
公开(公告)号：US08021869B2
公开(公告)日：2011-09-20
申请号：US11986107
申请日：2007-11-20
申请人： Benjamin Chu , Benjamin S. Hsiao , Michael Hadjiargyrou , Dufei Fang , Xinhua Zong , Kwangsok Kim
发明人： Benjamin Chu , Benjamin S. Hsiao , Michael Hadjiargyrou , Dufei Fang , Xinhua Zong , Kwangsok Kim
IPC分类号： C12N1/04 , C12N11/08 , C12N11/04 , C12N5/00 , C12N5/07 , A61F2/00
CPC分类号： G06Q30/02 , A61F2/28 , A61F2/30756 , A61K9/70 , A61K35/32 , C12N5/0068 , C12N2533/40
摘要： Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable fibrous matrix physically associated with viable cells to contain and release the cells at a controlled rate. The biodegradable and/or bioabsorbable matrix can be formed by electrospinning fibers of biodegradable and/or bioabsorbable fiberizable material. The methods include methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system.
摘要翻译：公开了用于向哺乳动物存储和递送活细胞的细胞储存和递送系统和方法。细胞储存和递送系统包括与活细胞物理相关的可生物降解和/或生物可吸收的纤维基质，以受控的速率含有和释放细胞。可生物降解和/或生物可吸收的基质可以通过静电纺丝的可生物降解和/或生物可吸收的可纤化材料的纤维形成。所述方法包括用于储存活细胞并使用细胞储存和递送系统向哺乳动物递送活细胞的方法。

2. 发明授权

US07172765B2 Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications 有权
标题翻译：可生物降解和/或生物可吸收的纤维制品和用于医疗应用的制品的方法
公开(公告)号：US07172765B2
公开(公告)日：2007-02-06
申请号：US10719290
申请日：2003-11-21
申请人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Collin Brathwaite
发明人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Collin Brathwaite
IPC分类号： A61F2/02
CPC分类号： B32B27/12 , A61K9/0024 , A61K9/70 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , B32B27/18 , B32B27/28 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2307/7163 , B32B2535/00 , Y10T442/2525 , Y10T442/614 , Y10T442/619 , Y10T442/696 , C08L67/04
摘要： Biodegradable and/or bioabsorable fibrous articles and methods for using the articles in medical applications are disclosed. The biodegradable and/or bioabsorable fibrous articles, which are formed by elctrospinning fibers of biodegradable and/or bioabsorbable fiberizable material, comprise a composite (or asymmetric composite) of different biodegradable and/or bioabsorbable fibers. Articles having specific medical uses include an adhesion-reducing barrier and a controlled delivery system. The methods include methods for reducing surgical adhesions, controlled delivery of a medicinal agent and providing controlled tissue healing.
摘要翻译：公开了可生物降解和/或生物可吸收的纤维制品以及在医疗应用中使用制品的方法。可生物降解和/或生物可吸收的纤维制品由可生物降解和/或生物可吸收的可纤化材料的光纤纺丝形成，包括不同的可生物降解和/或生物可吸收的纤维的复合材料（或不对称的复合材料）。具有特定医疗用途的制品包括减粘屏障和受控递送系统。所述方法包括减少手术粘连，药物的受控输送和提供受控组织愈合的方法。

3. 发明授权

US07934917B2 Apparatus for electro-blowing or blowing-assisted electro-spinning technology 有权
标题翻译：电喷或吹塑辅助电纺技术的设备
公开(公告)号：US07934917B2
公开(公告)日：2011-05-03
申请号：US12235996
申请日：2008-09-23
申请人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang
发明人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang
IPC分类号： D01D7/00
CPC分类号： D01D5/0092 , D01D4/04 , D01D5/0069
摘要： A spinneret format, an electric-field reversal format and a process for post-treatment of membranes formed from electro-spinning or electro-blowing are provided, including a cleaning method and apparatus for electro-blowing or blowing-assisted electro-spinning technology.
摘要翻译：提供喷丝头形式，电场反转格式以及由电纺或电吹制成的膜后处理方法，其包括电喷或吹塑辅助电纺技术的清洗方法和设备。

4. 发明授权

US07662332B2 Electro-blowing technology for fabrication of fibrous articles and its applications of hyaluronan 有权
标题翻译：用于制造纤维制品的电喷技术及其在透明质酸中的应用
公开(公告)号：US07662332B2
公开(公告)日：2010-02-16
申请号：US10674464
申请日：2003-10-01
申请人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Akio Okamoto
发明人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Akio Okamoto
IPC分类号： D01D5/08 , D01D5/098 , H05B7/00
CPC分类号： D01D5/0069 , D01F9/00
摘要： A method for electroblowing fibers is provided which involves the steps of: forcing a polymer fluid through a spinneret in a first direction towards a collector located a first distance from the spinneret, while simultaneously blowing a gas through an orifice that is substantially concentrically arranged around the spinneret, wherein the gas is blown substantially in the first direction; wherein an electrostatic differential is generated between the spinneret and the collector; and collecting the fibers, and its use in preparing submicron scale fibers of various types, particularly hyaluronan fibers, and the hyaluronan nanofibers thus formed.
摘要翻译：提供了一种用于电纺纤维的方法，其包括以下步骤：将聚合物流体沿着第一方向通过喷丝板朝向位于离喷丝头第一距离的收集器，同时通过基本上同心地布置在喷丝板周围的孔口喷丝头，其中所述气体基本上在所述第一方向上吹送; 其中在所述喷丝头和所述收集器之间产生静电差异; 并收集纤维，以及其在制备各种类型的亚微米级纤维，特别是透明质酸纤维和由此形成的透明质酸纳米纤维中的用途。

5. 发明授权

US06689374B2 Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications 失效
公开(公告)号：US06689374B2
公开(公告)日：2004-02-10
申请号：US10375329
申请日：2003-02-27
申请人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Collin Brathwaite
发明人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Collin Brathwaite
IPC分类号： A61F202
CPC分类号： B32B27/12 , A61K9/0024 , A61K9/70 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , B32B27/18 , B32B27/28 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2307/7163 , B32B2535/00 , Y10T442/2525 , Y10T442/614 , Y10T442/619 , Y10T442/696 , C08L67/04
摘要： Biodegradable and/or bioabsorable fibrous articles and methods for using the articles in medical applications are disclosed. The biodegradable and/or bioabsorable fibrous articles, which are formed by elctrospinning fibers of biodegradable and/or bioabsorbable fiberizable material, comprise a composite (or asymmetric composite) of different biodegradable and/or bioabsorbable fibers. Articles having specific medical uses include an adhesion-reducing barrier and a controlled delivery system. The methods include methods for reducing surgical adhesions, controlled delivery of a medicinal agent and providing controlled tissue healing.

6. 发明申请

US20090155340A1 Method of cell storage in a delivery system 有权
标题翻译：递送系统中的细胞储存方法
公开(公告)号：US20090155340A1
公开(公告)日：2009-06-18
申请号：US11986107
申请日：2007-11-20
申请人： Benjamin Chu , Benjamin S. Hsiao , Michael Hadjiargyrou , Dufei Fang , Xinhua Zong , Kwangsok Kim
发明人： Benjamin Chu , Benjamin S. Hsiao , Michael Hadjiargyrou , Dufei Fang , Xinhua Zong , Kwangsok Kim
IPC分类号： A61L15/16 , A61K35/12 , C12N5/06
CPC分类号： G06Q30/02 , A61F2/28 , A61F2/30756 , A61K9/70 , A61K35/32 , C12N5/0068 , C12N2533/40
摘要： Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable fibrous matrix physically associated with viable cells to contain and release the cells at a controlled rate. The biodegradable and/or bioabsorbable matrix can be formed by electrospinning fibers of biodegradable and/or bioabsorbable fiberizable material. The methods include methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system.
摘要翻译：公开了用于向哺乳动物存储和递送活细胞的细胞储存和递送系统和方法。细胞储存和递送系统包括与活细胞物理相关的可生物降解和/或生物可吸收的纤维基质，以受控的速率含有和释放细胞。可生物降解和/或生物可吸收的基质可以通过静电纺丝的可生物降解和/或生物可吸收的可纤化材料的纤维形成。所述方法包括用于储存活细胞并使用细胞储存和递送系统向哺乳动物递送活细胞的方法。

7. 发明授权

US06713011B2 Apparatus and methods for electrospinning polymeric fibers and membranes 有权
标题翻译：用于静电纺丝聚合物纤维和膜的装置和方法
公开(公告)号：US06713011B2
公开(公告)日：2004-03-30
申请号：US09859004
申请日：2001-05-16
申请人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang
发明人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang
IPC分类号： D01D500
CPC分类号： D01D5/0092 , D04H1/728
摘要： An apparatus and method for electrospinning polymer fibers and membranes. The method includes electrospinning a polymer fiber from a conducting fluid in the presence of a first electric field established between a conducting fluid introduction device and a ground source and modifying the first electric field with a second electric field to form a jet stream of the conducting fluid. The method also includes electrically controlling the flow characteristics of the jet stream, forming a plurality of electrospinning jet streams and independently controlling the flow characteristics of at least one of the jet streams. The apparatus for electrospinning includes a conducting fluid introduction device containing a plurality of electrospinning spinnerets, a ground member positioned adjacent to the spinnerets, a support member disposed between the spinnerets and the ground member and movable to receive fibers formed from the conducting fluid, and a component for controlling the flow characteristics of conducting fluid from at least one spinneret independently from another spinneret.
摘要翻译：一种用于静电纺丝聚合物纤维和膜的设备和方法。该方法包括在导电流体引入装置和接地源之间建立的第一电场的存在下，从导电流体中电纺聚合物纤维，并用第二电场修改第一电场以形成导电流体的射流。该方法还包括电控制喷射流的流动特性，形成多个静电纺丝射流并且独立地控制至少一个射流的流动特性。用于静电纺丝的装置包括：导电流体引入装置，其包含多个静电纺丝喷丝头;与喷丝板相邻定位的接地部件;设置在喷丝板和接地部件之间并可移动以接收由导电流体形成的纤维的支撑部件，用于控制来自至少一个喷丝板的导电流体的流动特性的组件，其独立于另一个喷丝头。

8. 发明授权

US06685956B2 Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications 失效
标题翻译：可生物降解和/或生物可吸收的纤维制品和用于医疗应用的制品的方法
公开(公告)号：US06685956B2
公开(公告)日：2004-02-03
申请号：US09859007
申请日：2001-05-16
申请人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Collin Brathwaite
发明人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Collin Brathwaite
IPC分类号： A61F202
CPC分类号： B32B27/12 , A61K9/0024 , A61K9/70 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , B32B27/18 , B32B27/28 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2307/7163 , B32B2535/00 , Y10T442/2525 , Y10T442/614 , Y10T442/619 , Y10T442/696 , C08L67/04
摘要： Biodegradable and/or bioabsorable fibrous articles and methods for using the articles in medical applications are disclosed. The biodegradable and/or bioabsorable fibrous articles, which are formed by elctrospinning fibers of biodegradable and/or bioabsorbable fiberizable material, comprise a composite (or asymmetric composite) of different biodegradable and/or bioabsorbable fibers. Articles having specific medical uses include an adhesion-reducing barrier and a controlled delivery system. The methods include methods for reducing surgical adhesions, controlled delivery of a medicinal agent and providing controlled tissue healing.
摘要翻译：公开了可生物降解和/或生物可吸收的纤维制品以及在医疗应用中使用制品的方法。可生物降解和/或生物可吸收的纤维制品由可生物降解和/或生物可吸收的可纤化材料的光纤纺丝形成，包括不同的可生物降解和/或生物可吸收的纤维的复合材料（或不对称的复合材料）。具有特定医疗用途的制品包括减粘屏障和受控递送系统。所述方法包括减少手术粘连，药物的受控输送和提供受控组织愈合的方法。

9. 发明授权

US08222166B2 High flux and low fouling filtration media 有权
标题翻译：高通量和低污垢的过滤介质
公开(公告)号：US08222166B2
公开(公告)日：2012-07-17
申请号：US11664650
申请日：2005-10-05
申请人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Kwang-Sok Kim
发明人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Kwang-Sok Kim
IPC分类号： B32B9/04 , B32B19/00 , B32B5/02 , B32B5/16 , B32B5/26
CPC分类号： B01D69/12 , B01D65/08 , B01D69/141 , B01D71/08 , B01D2321/168 , B01D2323/38 , B01D2323/39 , B01D2325/022 , Y10T428/249921 , Y10T428/25 , Y10T428/256 , Y10T428/259 , Y10T428/29 , Y10T428/2913 , Y10T428/2915 , Y10T428/2944 , Y10T428/298 , Y10T442/20 , Y10T442/2033 , Y10T442/277 , Y10T442/2861 , Y10T442/2885 , Y10T442/2893 , Y10T442/291 , Y10T442/2918 , Y10T442/659
摘要： Membranes suitable for microfiltration, ultrafiltration (UF) and nanofiltration (NF) filters are provided. Such membranes may include a nanofibrous scaffold, optionally in combination with a non-woven substrate and/or a coating of a polymer and a functionalized nanofiller. Suitable membranes may also include a coating of a polymer and a functionalized nanofiller on a substrate, which can include a non-woven membrane, a nanofibrous scaffold, or both.
摘要翻译：提供适用于微滤，超滤（UF）和纳滤（NF）过滤器的膜。这种膜可以包括纳米纤维支架，任选地与无纺基底和/或聚合物和官能化纳米填料的涂层组合。合适的膜还可以包括在基底上的聚合物和功能化纳米填料的涂层，其可以包括无纺膜，纳米纤维支架或两者。

10. 发明申请

US20100323573A1 High flux and low fouling filtration media 有权
标题翻译：高通量和低污垢的过滤介质
公开(公告)号：US20100323573A1
公开(公告)日：2010-12-23
申请号：US11664650
申请日：2005-10-05
申请人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Kwang-sok Kim
发明人： Benjamin Chu , Benjamin S. Hsiao , Dufei Fang , Kwang-sok Kim
IPC分类号： B32B5/02 , B32B5/16 , B32B5/26
CPC分类号： B01D69/12 , B01D65/08 , B01D69/141 , B01D71/08 , B01D2321/168 , B01D2323/38 , B01D2323/39 , B01D2325/022 , Y10T428/249921 , Y10T428/25 , Y10T428/256 , Y10T428/259 , Y10T428/29 , Y10T428/2913 , Y10T428/2915 , Y10T428/2944 , Y10T428/298 , Y10T442/20 , Y10T442/2033 , Y10T442/277 , Y10T442/2861 , Y10T442/2885 , Y10T442/2893 , Y10T442/291 , Y10T442/2918 , Y10T442/659
摘要： Membranes suitable for microfiltration, ultrafiltration (UF) and nanofiltration (NF) filters are provided. Such membranes may include a nanofibrous scaffold, optionally in combination with a non-woven substrate and/or a coating of a polymer and a functionalized nanofiller. Suitable membranes may also include a coating of a polymer and a functionalized nanofiller on a substrate, which can include a non-woven membrane, a nanofibrous scaffold, or both.
摘要翻译：提供适用于微滤，超滤（UF）和纳滤（NF）过滤器的膜。这种膜可以包括纳米纤维支架，任选地与无纺基底和/或聚合物和官能化纳米填料的涂层组合。合适的膜还可以包括在基底上的聚合物和功能化纳米填料的涂层，其可以包括无纺膜，纳米纤维支架或两者。

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