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1. 发明申请

US20080253966A1 Diagnostic, Prognostic, and Therapeutic Factor Smac/Diablo in Human Cancer 审中-公开
标题翻译：诊断，预后和治疗因子Smac / Diablo在人类癌症
公开(公告)号：US20080253966A1
公开(公告)日：2008-10-16
申请号：US11667514
申请日：2005-11-18
申请人： Benjamin Bonavida , Tsuneharu Miki , Yoichi Mizutani
发明人： Benjamin Bonavida , Tsuneharu Miki , Yoichi Mizutani
IPC分类号： A61K49/00 , G01N33/574 , C12Q1/02 , C07H21/04 , A61K31/70 , A61P43/00
CPC分类号： G01N33/57496 , G01N33/5011
摘要： The present invention provides, for the first time, the finding that Smac/DIABLO is underexpressed in cancers such as renal cell carcinoma. In particular, the present invention provides methods of diagnosing and providing a prognosis for cancers that underexpress Smac/DIABLO, as well as methods of drug discovery to identify therapeutics useful when used alone or in combination with other cancer therapeutics. The present invention also provides methods of treating or inhibiting cancers that underexpresses Smac/DIABLO, in which potentiation of Smac/DIABLO expression and/or activity sensitizes resistant tumor cells to cytotoxic treatments including chemotherapy, radiation therapy, hormonal therapy, and immunotherapy. Compositions, kits, and integrated systems for carrying out the diagnostic, prognostic, and therapeutic methods of the present invention are also provided.
摘要翻译：本发明首次提供Smac / DIABLO在诸如肾细胞癌的癌症中不显着的发现。特别地，本发明提供了用于诊断并降低对于Smac / DIABLO不降低的癌症的预后的方法，以及用于鉴定当单独使用或与其它癌症治疗剂组合使用时有用的治疗剂的药物发现方法。本发明还提供治疗或抑制Smex / DIABLO不显着的癌症的方法，其中增强Smac / DIABLO表达和/或活性使抗肿瘤细胞对包括化学疗法，放射疗法，激素治疗和免疫治疗在内的细胞毒性治疗敏感。还提供了用于实施本发明的诊断，预后和治疗方法的组合物，试剂盒和综合系统。

2. 发明授权

US09536272B2 Information processing apparatus, method and computer-readable medium 有权
标题翻译：信息处理装置，方法和计算机可读介质
公开(公告)号：US09536272B2
公开(公告)日：2017-01-03
申请号：US12899693
申请日：2010-10-07
申请人： Shigeatsu Yoshioka , Yoichi Mizutani
发明人： Shigeatsu Yoshioka , Yoichi Mizutani
IPC分类号： H04N9/07 , G06T1/00 , G06F3/0354 , G06F3/0484 , G06F3/0485
CPC分类号： G06F3/03543 , G06F3/04845 , G06F3/0485 , G06F2203/04806 , G06T1/00
摘要： In one example embodiment, an information processing apparatus causes a display device to display a first image in a display range. In this embodiment, the first image is from images associated with an observation target object. The images include a first image, a second image, and a third image. In response to a request to change the display range, the information processing apparatus changes the display range at a first speed, and causes the display range to display the second image. In response to a request to terminate the change of the display range, the information processing apparatus changes the display range at a deceleration speed, and causes the display range to display the third image.
摘要翻译：在一个示例性实施例中，信息处理设备使显示设备在显示范围内显示第一图像。在本实施例中，第一图像来自与观察目标对象相关联的图像。图像包括第一图像，第二图像和第三图像。响应于改变显示范围的请求，信息处理设备以第一速度改变显示范围，并使显示范围显示第二图像。响应于终止显示范围的改变的请求，信息处理设备以减速速度改变显示范围，并使显示范围显示第三图像。

3. 发明授权

US08934699B2 Information processing apparatus, information processing method, program, and recording medium 有权
标题翻译：信息处理装置，信息处理方法，程序和记录介质
公开(公告)号：US08934699B2
公开(公告)日：2015-01-13
申请号：US13610442
申请日：2012-09-11
申请人： Kenji Yamane , Masahiro Takahashi , Shinji Watanabe , Yoichi Mizutani , Yutaka Hasegawa , Hiroshi Kyusojin
发明人： Kenji Yamane , Masahiro Takahashi , Shinji Watanabe , Yoichi Mizutani , Yutaka Hasegawa , Hiroshi Kyusojin
IPC分类号： G06K9/00 , G02B21/36 , G06T7/00 , G02B21/00
CPC分类号： G02B21/367 , G02B21/0004 , G06T7/0012
摘要： An information processing apparatus includes a memory and a control unit. The memory stores a first image. The control unit divides the first image into a plurality of regions. Further, the control unit calculates a likelihood of an existence of a sample in the plurality of regions thus divided for each of the plurality of regions. Further, the control unit generates an existence map based on the calculated likelihood, the existence map having the plurality of regions classified into first regions, second regions, and third regions. Further, the control unit generates imaging sequence information based on the generated existence map, the imaging sequence information indicating imaging sequences such that the first regions are imaged prior to the second regions and a total movement distance of a stage for imaging the first and second regions becomes minimum.
摘要翻译：信息处理装置包括存储器和控制单元。存储器存储第一图像。控制单元将第一图像划分成多个区域。此外，控制单元计算对于多个区域中的每一个而对这样划分的多个区域中的样本的存在的可能性。此外，控制单元基于计算出的可能性生成存在图，该存在图具有分为第一区域，第二区域和第三区域的多个区域。此外，控制单元基于生成的存在图来生成成像序列信息，指示成像序列的成像序列信息，使得第一区域在第二区域之前被成像，以及用于对第一和第二区域进行成像的载物台的总移动距离变得最小。

4. 发明授权

US6144407A Image pickup apparatus which enables a light receiving period to commence within a relatively small amount of time after a shutter signal 失效
标题翻译：能够在快门信号之后的相对较短的时间内开始光接收期间的摄像装置
公开(公告)号：US6144407A
公开(公告)日：2000-11-07
申请号：US810339
申请日：1997-02-27
申请人： Yoichi Mizutani , Akihiro Kikuchi , Junichi Sakagami
发明人： Yoichi Mizutani , Akihiro Kikuchi , Junichi Sakagami
IPC分类号： H04N5/235 , H04N5/335 , H04N5/341 , H04N5/347 , H04N5/353 , H04N5/372 , H04N5/378 , H04N5/225 , H04N3/14
CPC分类号： H04N5/353 , H04N5/2353 , H04N5/372
摘要： An image pickup apparatus comprises a solid-state image pickup device including a plurality of light receiving areas, charge transfer areas, charge-reading gate areas and an output portion, a synchronous signal generator for producing line and frame synchronous signals, a timing signal generator for producing selectively a first internal frame synchronous signal in synchronism with the frame synchronous signal and a second internal frame synchronous signal asynchronous with the frame synchronous signal and for forwarding a charge-reading timing signal and a charge-transfer timing signal each synchronizing with the first or second internal frame synchronous signal, a driving signal generator for producing a gate driving signal and a charge-transfer driving signal in response to the charge-reading timing signal and the charge-transfer timing signal, respectively, and for supplying charge-reading gate areas and charge transfer areas with the gate driving signal and the charge-transfer driving signal, respectively, and a control unit operative, in response to a light-receiving command signal supplied thereto, to cause the timing signal generator to forward the charge-reading timing signal and the charge-transfer timing signal each synchronizing with the second internal frame synchronous signal during a predetermined period so that a light receiving period for the solid-state image pickup device is determined in response to the second internal frame synchronous signal.
摘要翻译：图像拾取装置包括：固态图像拾取装置，包括多个光接收区域，电荷转移区域，电荷读取栅极区域和输出部分，用于产生线和帧同步信号的同步信号发生器，定时信号发生器用于与帧同步信号同步选择性地产生第一内部帧同步信号和与帧同步信号异步的第二内部帧同步信号，并且用于转发与第一个同步信号同步的电荷读取定时信号和电荷转移定时信号或第二内部帧同步信号，驱动信号发生器，分别响应于所述充电读取定时信号和所述电荷转移定时信号而产生栅极驱动信号和电荷转移驱动信号，并用于提供电荷读取栅极区域和电荷转移区域，具有门驱动信号和电荷转移驱动并且控制单元响应于提供给其的光接收命令信号而工作，以使定时信号发生器转发与第二内部同步的充电读取定时信号和电荷转移定时信号在预定时段期间，以便根据第二内部帧同步信号来确定固态图像拾取装置的光接收周期。

5. 发明申请

US20130208078A1 INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING SYSTEM, METHOD OF PROCESSING INFORMATION, AND PROGRAM 有权
标题翻译：信息处理装置，信息处理系统，处理信息的方法和程序
公开(公告)号：US20130208078A1
公开(公告)日：2013-08-15
申请号：US13880267
申请日：2012-07-10
申请人： Hiroshi Kyusojin , Yoichi Mizutani , Yutaka Hasegawa , Masahiro Takahashi
发明人： Hiroshi Kyusojin , Yoichi Mizutani , Yutaka Hasegawa , Masahiro Takahashi
IPC分类号： H04N5/265
CPC分类号： H04N5/265 , G06F19/00 , G06F19/321 , G16H80/00 , H04L12/1827 , H04M3/567 , H04N7/15
摘要： An information processing apparatus, an information processing system, and a method of processing information are provided. In one embodiment, the information processing apparatus includes a processor, and a memory device storing instructions. When executed by the processor, the instructions cause the processor to receive, from a first information processing apparatus, area specifying information and location information, the area specifying information specifying a display area in an image, the display area including a plurality of partial images, the location information indicating at least one location of the plurality of partial images. The instructions further cause the processor to transmit, to a second information processing apparatus, the area specifying information and the location information.
摘要翻译：提供信息处理装置，信息处理系统和处理信息的方法。在一个实施例中，信息处理设备包括处理器和存储指令的存储器件。当处理器执行时，指令使得处理器从第一信息处理设备接收区域指定信息和位置信息，区域指定信息指定图像中的显示区域，显示区域包括多个部分图像，所述位置信息指示所述多个部分图像中的至少一个位置。所述指令还使所述处理器向所述第二信息处理设备发送所述区域指定信息和所述位置信息。

6. 发明申请

US20130070970A1 INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, PROGRAM, AND RECORDING MEDIUM 有权
标题翻译：信息处理装置，信息处理方法，程序和记录介质
公开(公告)号：US20130070970A1
公开(公告)日：2013-03-21
申请号：US13610442
申请日：2012-09-11
申请人： Kenji Yamane , Masahiro Takahashi , Shinji Watanabe , Yoichi Mizutani , Yutaka Hasegawa , Hiroshi Kyusojin
发明人： Kenji Yamane , Masahiro Takahashi , Shinji Watanabe , Yoichi Mizutani , Yutaka Hasegawa , Hiroshi Kyusojin
IPC分类号： G06T7/00
CPC分类号： G02B21/367 , G02B21/0004 , G06T7/0012
摘要： An information processing apparatus includes a memory and a control unit. The memory stores a first image. The control unit divides the first image into a plurality of regions. Further, the control unit calculates a likelihood of an existence of a sample in the plurality of regions thus divided for each of the plurality of regions. Further, the control unit generates an existence map based on the calculated likelihood, the existence map having the plurality of regions classified into first regions, second regions, and third regions. Further, the control unit generates imaging sequence information based on the generated existence map, the imaging sequence information indicating imaging sequences such that the first regions are imaged prior to the second regions and a total movement distance of a stage for imaging the first and second regions becomes minimum.
摘要翻译：信息处理装置包括存储器和控制单元。存储器存储第一图像。控制单元将第一图像划分成多个区域。此外，控制单元计算对于多个区域中的每一个而对这样划分的多个区域中的样本的存在的可能性。此外，控制单元基于计算出的可能性生成存在图，该存在图具有分为第一区域，第二区域和第三区域的多个区域。此外，控制单元基于生成的存在图来生成成像序列信息，指示成像序列的成像序列信息，使得第一区域在第二区域之前被成像，以及用于对第一和第二区域进行成像的载物台的总移动距离变得最小。

7. 发明授权

US08248506B2 Imaging apparatus 有权
标题翻译：成像设备
公开(公告)号：US08248506B2
公开(公告)日：2012-08-21
申请号：US12894622
申请日：2010-09-30
申请人： Yoichi Mizutani , Masayuki Takezawa , Hideki Matsumoto , Ken Nakajima , Toshihisa Yamamoto
发明人： Yoichi Mizutani , Masayuki Takezawa , Hideki Matsumoto , Ken Nakajima , Toshihisa Yamamoto
IPC分类号： H04N5/225
CPC分类号： H04N5/23245 , H04N1/2137 , H04N5/23293 , H04N5/343 , H04N5/372 , H04N5/378
摘要： An imaging apparatus for performing efficient signal processing depending on the operational mode. In the finder mode, a CCD interface 21a decimates horizontal components of image data supplied from an image generating unit 10 to one-third and moreover processes the decimated image data with data conversion and resolution conversion to produce Y, Cb and Cr image data which are routed to and written in an image memory 32 over a memory controller 22. In the recording mode, the CCD interface 21a causes the image data from the image generating unit 10 to be written in the image memory 32 via memory controller 22 after decimation and gamma correction etc. The camera DSP 21c reads out the image data via memory controller 22 from the image memory 32 to effect data conversion for writing the resulting data via memory controller 22 in the image memory 32.
摘要翻译：一种用于根据操作模式执行有效信号处理的成像装置。在取景器模式中，CCD接口21a将从图像生成单元10提供的图像数据的水平分量抽取到三分之一，并且用数据转换和分辨率转换处理抽取的图像数据，以产生Y，Cb和Cr图像数据，在存储器控制器22上被路由到和写入图像存储器32中。在记录模式中，CCD接口21a使来自图像生成单元10的图像数据经抽取后的存储器控制器22写入图像存储器32中，并且伽玛校正等。相机DSP 21c经由存储器控制器22从图像存储器32读出图像数据，以进行用于经由存储器控制器22将得到的数据写入图像存储器32中的数据转换。

8. 发明申请

US20090049225A1 Information processing apparatus, information processing method, program for executing the information processing method, storage medium storing the program, DMA controller, DMA transfer method, program for executing the DMA transfer method, and storage medium storing the program 失效
标题翻译：信息处理装置，信息处理方法，执行信息处理方法的程序，存储程序的存储介质，DMA控制器，DMA传送方法，用于执行DMA传送方法的程序以及存储程序的存储介质
公开(公告)号：US20090049225A1
公开(公告)日：2009-02-19
申请号：US12218179
申请日：2008-07-10
申请人： Tsuyoshi Kano , Mitsuki Hinosugi , Masato Kajimoto , Yoichi Mizutani
发明人： Tsuyoshi Kano , Mitsuki Hinosugi , Masato Kajimoto , Yoichi Mizutani
IPC分类号： G06F13/28
CPC分类号： G06F13/28
摘要： Disclosed herein is an information processing apparatus that transfers information, using direct memory access (DMA), between a first storage section in an information processing system and a second storage section in an information transfer system. The information processing system includes the first storage section for storing the information, and a control section. The information transfer system includes: the second storage section for storing descriptor information indicating the location at which the information is stored in the first storage section and the size of the information; and a DMA transfer section for DMA transferring the information between the first storage section and the second storage section based on the descriptor information. The DMA transfer section DMA transfers the descriptor information concerning the DMA transferred information from the second storage section to the first storage section. The control section loads the descriptor information from the first storage section.
摘要翻译：这里公开了一种信息处理装置，其在信息处理系统中的第一存储部分和信息传送系统中的第二存储部分之间传送使用直接存储器访问（DMA）的信息。信息处理系统包括用于存储信息的第一存储部分和控制部分。信息传送系统包括：第二存储部分，用于存储指示信息存储在第一存储部分中的位置的描述符信息和信息的大小; 以及DMA传送部分，用于基于描述符信息在第一存储部分和第二存储部分之间传送信息。 DMA传送部分DMA将关于DMA传送信息的描述符信息从第二存储部分传送到第一存储部分。控制部分加载来自第一存储部分的描述符信息。

9. 发明授权

US07349012B2 Imaging apparatus with higher and lower resolution converters and a compression unit to compress decreased resolution image data 无效
标题翻译：具有较高和较低分辨率转换器的成像设备和用于压缩分辨率降低的图像数据的压缩单元
公开(公告)号：US07349012B2
公开(公告)日：2008-03-25
申请号：US10650021
申请日：2003-08-26
申请人： Masayuki Takezawa , Yoichi Mizutani , Hideki Matsumoto , Ken Nakajima , Toshihisa Yamamoto
发明人： Masayuki Takezawa , Yoichi Mizutani , Hideki Matsumoto , Ken Nakajima , Toshihisa Yamamoto
IPC分类号： H04N5/228
CPC分类号： H04N9/045 , H04N5/23232 , H04N5/23245 , H04N5/23293 , H04N5/772
摘要： In an imaging apparatus, an image is to be displayed in real-time on a finder. In the finder mode, a CCD interface 21a thins out horizontal components of image data supplied from an image generating unit 10 to one-third and also effects gamma correction etc to send the resulting image data to a camera DSP 21c. The camera DSP 21c effects data conversion and resolution conversion on the image data resulting from the thinning to convert the data into Y, Cb and Cr image data which is routed to a memory controller 22. The memory controller 22 writes the image data in the image memory 32 and reads out the data from the memory controller 22 to route the read-out data over an image data bus 33 to an NTSC/PAL encoder 23. The NTSC/PAL encoder 23 converts the image data in resolution and further converts the image data into data of the NTSC or PAL system to route the resulting data to a finder.
摘要翻译：在成像装置中，要在取景器上实时地显示图像。在取景器模式中，CCD接口21a将从图像生成单元10提供的图像数据的水平分量从三分之一消除，并且还进行伽马校正等，以将得到的图像数据发送到相机DSP21c。摄像机DSP21c对由间隔产生的图像数据进行数据转换和分辨率转换，以将数据转换成被路由到存储器控制器22的Y，Cb和Cr图像数据。存储器控制器22将图像数据写入图像存储器32，并从存储器控制器22中读出数据，以将图像数据总线33上的读出数据路由到NTSC / PAL编码器23。 NTSC / PAL编码器23以分辨率转换图像数据，并且将图像数据进一步转换为NTSC或PAL系统的数据，以将得到的数据路由到取景器。

10. 发明申请

US20130019188A1 INFORMATION PROCESSING METHOD AND INFORMATION PROCESSING SYSTEM 有权
标题翻译：信息处理方法和信息处理系统
公开(公告)号：US20130019188A1
公开(公告)日：2013-01-17
申请号：US13538560
申请日：2012-06-29
申请人： Yutaka Hasegawa , Yoichi Mizutani , Masato Kajimoto , Masahiro Takahashi , Hiroshi Kyusojin
发明人： Yutaka Hasegawa , Yoichi Mizutani , Masato Kajimoto , Masahiro Takahashi , Hiroshi Kyusojin
IPC分类号： G06F3/048
CPC分类号： G06F3/04845 , G06F3/1454 , G06F17/30056 , G06F2203/04803 , G06F2203/04806 , G06Q10/10 , H04L12/1813 , H04L12/1822 , H04L12/1827 , H04L65/403 , H04M2250/62 , H04N7/15
摘要： An information processing system and a method for operating same are provided. The information processing system includes a first information processing apparatus and a second information processing apparatus. The first information processing apparatus is configured to display a first synchronous image in a first window, the first window having an operation right. The second information processing apparatus has a synchronous state or an asynchronous state. The second information processing apparatus is configured to: display a second synchronous image; in response to a first request, switch from the synchronous state to the asynchronous state; and in response to a second request, switch from the asynchronous state to the synchronous state.
摘要翻译：提供了一种信息处理系统及其操作方法。信息处理系统包括第一信息处理装置和第二信息处理装置。第一信息处理装置被配置为在第一窗口中显示第一同步图像，第一窗口具有操作权。第二信息处理装置具有同步状态或异步状态。第二信息处理装置被配置为：显示第二同步图像; 响应于第一个请求，从同步状态切换到异步状态; 并且响应于第二请求，从异步状态切换到同步状态。

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