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1. 发明授权

US09724422B2 Human lactoferrin derived peptide for use as an antigen masking agent 有权
公开(公告)号：US09724422B2
公开(公告)日：2017-08-08
申请号：US13988829
申请日：2010-11-26
申请人： Benedikt Hartwig , Juan Tome Alcalde , Norbert Windhab , Maria del Pilar Ansuategui Panzano , Matias Javier Vara Carrera
发明人： Benedikt Hartwig , Juan Tome Alcalde , Norbert Windhab , Maria del Pilar Ansuategui Panzano , Matias Javier Vara Carrera
IPC分类号： C07K14/00 , C07K14/435 , C07K14/79 , A61K38/16 , A61K38/40 , A61K47/42 , A61K47/48 , A61K38/00
CPC分类号： A61K47/42 , A61K38/00 , A61K38/16 , A61K38/40 , A61K47/6811 , C07K14/435 , C07K14/79
摘要： The invention refers to a human lactoferrin derived peptide for use as an antigen masking agent in the production of a pharmaceutical composition for delivery of a biological active substance in a mammalian organism, where the biological active substance is able to induce an undesired immune response by the mammalian organism, where the pharmaceutical composition comprises a supramolecular aggregate of the biological active substance and the human lactoferrin derived peptide, with the effect that after delivery of pharmaceutical composition to the mammalian organism, there is no or only a diminished induction of the undesired immune response against the biological active substance.

2. 发明申请

US20120143039A1 ORAL DOSAGE FORM, COMPRISING AT LEAST ONE BIOLOGICALLY ACTIVE AGENT, FORMULATION AUXILIARY SUBSTANCES AND MAGNETIZABLE PARTICLES 有权
标题翻译：口服剂型，包含至少一种生物活性剂，配方辅助物质和可磁化颗粒
公开(公告)号：US20120143039A1
公开(公告)日：2012-06-07
申请号：US13390353
申请日：2010-08-30
申请人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
发明人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
IPC分类号： A61B5/05 , A61J3/07
CPC分类号： A61K9/2072 , A61K9/0009 , A61K9/0053 , A61K9/2095 , A61K9/2813 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K9/4883 , A61K9/5094
摘要： The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.
摘要翻译：本发明涉及口服剂型，其包含至少一种生物活性剂，制剂辅助物质和可磁化颗粒，其中所述剂型具有至少两相组合物，其中所述相可以在口服给药后溶于体内，因为它们制剂和可磁化颗粒结合在制剂辅助物质中并以磁化状态存在，其中磁化颗粒存在于剂型的至少两个相中并产生磁场，其中这些相在体内不同时间溶解在体内并且其中使用检测系统获取相对于身体中的时间，位置和运动的磁场强度，并且可以使用基于计算机的评估系统进行评估。

3. 发明申请

US20130302342A1 HUMAN LACTOFERRIN DERIVED PEPTIDE FOR USE AS AN ANTIGEN MASKING AGENT 有权
标题翻译：人类LACTOFERRIN衍生肽用作抗原掩蔽剂
公开(公告)号：US20130302342A1
公开(公告)日：2013-11-14
申请号：US13988829
申请日：2010-11-26
申请人： Benedikt Hartwig , Juan Tome Alcalde , Norbert Windhab , María del Pilar Ansuategui Panzano , Matías Javier Vara Carrera
发明人： Benedikt Hartwig , Juan Tome Alcalde , Norbert Windhab , María del Pilar Ansuategui Panzano , Matías Javier Vara Carrera
IPC分类号： A61K47/42 , A61K47/48
CPC分类号： A61K47/42 , A61K38/00 , A61K38/16 , A61K38/40 , A61K47/6811 , C07K14/435 , C07K14/79
摘要： The invention refers to a human lactoferrin derived peptide for use as an antigen masking agent in the production of a pharmaceutical composition for delivery of a biological active substance in a mammalian organism, where the biological active substance is able to induce an undesired immune response by the mammalian organism, where the pharmaceutical composition comprises a supramolecular aggregate of the biological active substance and the human lactoferrin derived peptide, with the effect that after delivery of pharmaceutical composition to the mammalian organism, there is no or only a diminished induction of the undesired immune response against the biological active substance.
摘要翻译：本发明涉及用于制备用于在哺乳动物生物体内递送生物活性物质的药物组合物中用作抗原掩蔽剂的人乳铁蛋白衍生肽，其中生物活性物质能够诱导不希望的免疫应答哺乳动物生物体，其中药物组合物包含生物活性物质和人乳铁蛋白衍生肽的超分子聚集体，其效果是在将药物组合物递送至哺乳动物生物体后，不存在或仅减少不希望的免疫应答的诱导针对生物活性物质。

4. 发明授权

US09050256B2 Oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles 有权
标题翻译：口服剂型，包含至少一种生物活性剂，制剂辅助物质和可磁化颗粒
公开(公告)号：US09050256B2
公开(公告)日：2015-06-09
申请号：US13390353
申请日：2010-08-30
申请人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
发明人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
IPC分类号： A61B5/055 , A61K9/20 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/00
CPC分类号： A61K9/2072 , A61K9/0009 , A61K9/0053 , A61K9/2095 , A61K9/2813 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K9/4883 , A61K9/5094
摘要： The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.
摘要翻译：本发明涉及口服剂型，其包含至少一种生物活性剂，制剂辅助物质和可磁化颗粒，其中所述剂型具有至少两相组合物，其中所述相可以在口服给药后溶于体内，因为它们制剂和可磁化颗粒结合在制剂辅助物质中并以磁化状态存在，其中磁化颗粒存在于剂型的至少两个相中并产生磁场，其中这些相在体内不同时间溶解在体内并且其中使用检测系统获取相对于身体中的时间，位置和运动的磁场强度，并且可以使用基于计算机的评估系统进行评估。

5. 发明申请

US20150008914A1 DETECTION SYSTEM FOR DETECTING MAGNETIC OBJECTS IN THE HUMAN ORGANISM 有权
标题翻译：用于检测人体中磁性物体的检测系统
公开(公告)号：US20150008914A1
公开(公告)日：2015-01-08
申请号：US14367682
申请日：2012-01-09
申请人： Benedikt Hartwig , Peter Niepoth , Steffen Junginger , Hans-Joachim Stiller , Norbert Windhab , Gerhard Geipel
发明人： Benedikt Hartwig , Peter Niepoth , Steffen Junginger , Hans-Joachim Stiller , Norbert Windhab , Gerhard Geipel
IPC分类号： G01N27/72 , A61B5/07 , A61B5/05
CPC分类号： G01N27/72 , A61B1/041 , A61B5/0515 , A61B5/062 , A61B5/073 , G01R33/028 , G01R33/096 , G01R33/10
摘要： The subject matter of the invention is a detector system for detecting magnetic bodies in the human organism, which comprises at least two sensor assemblies, wherein each sensor assembly has one, two or three anisotropic magnetic resistance sensors, of which the axes of weak magnetisation point in different directions in pairs, and each sensor assembly has a spacing of 0.5 to 50 cm from the sensor assembly or the other sensor assemblies, and at least two sensor assemblies are tilted at an angle of 0 to 45° with respect to one another, and in addition a method for detecting the magnetic flux produced by a magnetic body in the human organism, and the use of the detector system according to the invention for detecting swallowed magnetic bodies and the disintegration of the same in the digestive system.
摘要翻译：本发明的主题是用于检测人体中的磁体的检测器系统，其包括至少两个传感器组件，其中每个传感器组件具有一个，两个或三个各向异性磁阻传感器，其中弱磁化点的轴并且每个传感器组件具有距离传感器组件或其它传感器组件0.5至50cm的间隔，并且至少两个传感器组件相对于彼此以0至45°的角度倾斜，以及用于检测由人体中的磁体产生的磁通量的方法，以及使用根据本发明的检测器系统来检测吞咽的磁体并将其在消化系统中的分解。

6. 发明授权

US09696279B2 Detection system for detecting magnetic objects in the human organism 有权
公开(公告)号：US09696279B2
公开(公告)日：2017-07-04
申请号：US14367682
申请日：2012-01-09
申请人： Benedikt Hartwig , Peter Niepoth , Steffen Junginger , Hans-Joachim Stiller , Norbert Windhab , Gerhard Geipel
发明人： Benedikt Hartwig , Peter Niepoth , Steffen Junginger , Hans-Joachim Stiller , Norbert Windhab , Gerhard Geipel
IPC分类号： A61B5/05 , G01N27/72 , A61B1/04 , A61B5/06 , G01R33/09 , G01R33/028 , G01R33/10 , A61B5/07
CPC分类号： G01N27/72 , A61B1/041 , A61B5/0515 , A61B5/062 , A61B5/073 , G01R33/028 , G01R33/096 , G01R33/10
摘要： The subject matter of the invention is a detector system for detecting magnetic bodies in the human organism, which comprises at least two sensor assemblies, wherein each sensor assembly has one, two or three anisotropic magnetic resistance sensors, of which the axes of weak magnetization point in different directions in pairs, and each sensor assembly has a spacing of 0.5 to 50 cm from the sensor assembly or the other sensor assemblies, and at least two sensor assemblies are tilted at an angle of 0 to 45° with respect to one another, and in addition a method for detecting the magnetic flux produced by a magnetic body in the human organism, and the use of the detector system according to the invention for detecting swallowed magnetic bodies and the disintegration of the same in the digestive system.

7. 发明申请

US20100061932A1 PEPTIDES USEFUL AS CELL-PENETRATING PEPTIDES 审中-公开
标题翻译：肽可用作细胞穿刺肽
公开(公告)号：US20100061932A1
公开(公告)日：2010-03-11
申请号：US12159226
申请日：2006-10-25
申请人： Roland Brock , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
发明人： Roland Brock , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
IPC分类号： A61K49/00 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/00 , A61K38/16 , C07H21/04 , A61K31/7088 , A61P35/00
CPC分类号： C07K14/47 , A61K31/713 , A61K39/385 , A61K47/644 , A61K51/088 , A61K2039/53 , C07K14/79
摘要： The present invention is related to a peptide having an amino acid sequence comprising at least 8 consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein, whereby the peptide is suitable to act as a cell-penetrating peptide.
摘要翻译：本发明涉及具有包含人乳铁蛋白蛋白质或牛乳铁蛋白蛋白质的至少8个连续氨基酸的氨基酸序列的肽，由此该肽适合用作细胞穿透肽。

8. 发明授权

US07315784B2 Network for evaluating data obtained in a biochip measurement device 失效
标题翻译：用于评估在生物芯片测量装置中获得的数据的网络
公开(公告)号：US07315784B2
公开(公告)日：2008-01-01
申请号：US09784720
申请日：2001-02-15
申请人： Klaus Abraham-Fuchs , Arne Hengerer , Norbert Windhab , Kieran T. Gallahue , James P. O'Connell , Greg Gosch
发明人： Klaus Abraham-Fuchs , Arne Hengerer , Norbert Windhab , Kieran T. Gallahue , James P. O'Connell , Greg Gosch
IPC分类号： G06F19/00 , G01N33/48 , A61B5/00 , C12Q1/00
CPC分类号： G06F19/28 , G06F19/24 , G16H10/20
摘要： In a method and a network for evaluating medical data in a clinical study, biochips containing patient samples with multiple biomolecular markers are tested in a number of point of care test devices respectively at point of care sites. Each test of each biochip sample produces a diagnostic result, which is entered into the electronic patient record for the patient who produced the sample. A follow-up examination is subsequently conducted for each patient, and the results of the follow-up examination are also entered into that patient's electronic patient record. The follow-up results indicate whether the diagnostic test result was a false positive, a false negative or correct. The follow-up data and the original diagnostic results from all point of care sites are electronically transmitted to a remote server, which has access to an expert system which uses the test results and the follow-up data to automatically devise a measurement protocol for a selected pathology.
摘要翻译：在临床研究中用于评估医学数据的方法和网络中，分别在护理部位的许多点护理测试装置中测试含有具有多个生物分子标记的患者样品的生物芯片。每个生物芯片样品的每个测试产生诊断结果，其被输入到生产样品的患者的电子病人记录中。随后对每名患者进行随访检查，随访检查结果也纳入该患者的电子病历。随访结果表明诊断检查结果是假阳性，假阴性或正确。来自所有护理点的后续数据和原始诊断结果被电子传输到远程服务器，该远程服务器可以访问使用测试结果的专家系统和后续数据来自动设计测量协议选择病理学。

9. 发明授权

US06696555B1 3'-Desoxypentopyranosyl nucleic acid, its production and its use 失效
标题翻译： 3'-脱氧吡喃糖基核酸，其生产及其用途
公开(公告)号：US06696555B1
公开(公告)日：2004-02-24
申请号：US09762977
申请日：2001-04-19
申请人： Christian Miculka , Thomas Wagner , Norbert Windhab
发明人： Christian Miculka , Thomas Wagner , Norbert Windhab
IPC分类号： C07H2100
CPC分类号： C07H21/02 , C07H19/04 , C07H21/00 , F16H15/42 , Y02P20/55
摘要： The invention relates to a 3′-deoxypentopyranosylnucleic acid consisting essentially of 3′-deoxypentopyranosylnucleosides of the formulae (I) or of the formulae (II) their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.
摘要翻译：本发明涉及基本上由式（I）或式（II）的3'-脱氧吡喃半乳糖基核苷组成的3'-脱氧吡喃糖基核酸，其制备和用于制备治疗，诊断和/或电子成分的方法。

10. 发明授权

US07833715B1 Biomolecules having multiple attachment moieties for binding to a substrate surface 有权
标题翻译：具有多个附着部分的生物分子用于结合底物表面
公开(公告)号：US07833715B1
公开(公告)日：2010-11-16
申请号：US11655009
申请日：2007-01-18
申请人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
发明人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02
CPC分类号： C07H19/04 , C07H21/00 , C12Q1/68 , G01N33/54353
摘要： Methods of binding biomolecules to a substrate are provided that include contacting the biomolecule with a branched linking moiety to form a branched linking structure. The branched linking structure is then contacted with a binding moiety on the substrate to form a coupled substrate binding structure, thereby binding the biomolecule to the substrate. The biomolecule may contain a Lewis base or a nucleophile to react with a Lewis acid or electrophile in the branched linking moiety. Alternatively, the biomolecule may contain a Lewis acid or electrophile that can react with a Lewis base or nucleophile in the branched linking moiety. Additionally, the biomolecule can be bound to the substrate through a covalent or non-covalent bond.
摘要翻译：提供了将生物分子与底物结合的方法，包括使生物分子与支链连接部分接触以形成支链结构。然后将支链连接结构与基底上的结合部分接触以形成偶联的底物结合结构，从而将生物分子结合到底物上。生物分子可以含有路易斯碱或亲核试剂以与支链连接部分中的路易斯酸或亲电子试剂反应。或者，生物分子可以含有路易斯酸或亲电子试剂，其可以与支链连接部分中的路易斯碱或亲核试剂反应。此外，生物分子可以通过共价或非共价键与底物结合。

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