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1. 发明授权

US09403884B2 Peptides useful as cell-penetrating peptides 有权
标题翻译：可用作细胞穿透肽的肽
公开(公告)号：US09403884B2
公开(公告)日：2016-08-02
申请号：US13557706
申请日：2012-07-25
申请人： Roland Brock , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
发明人： Roland Brock , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
IPC分类号： A61K38/17 , C07K14/47 , C07K14/79
CPC分类号： C07K14/47 , A61K31/713 , A61K39/385 , A61K47/644 , A61K51/088 , A61K2039/53 , C07K14/79
摘要： A peptide having an amino acid sequence containing at least eight consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein. The peptide is suitable as a cell-penetrating peptide. A complex of the peptide and a cargo molecule non-covalently bound to the peptide. The cargo molecule may be a nucleic acid, an amino acid, a peptide, a protein, a carbohydrate, a lipid, or a small molecule. A method of penetrating or transfecting a cell using the complex.
摘要翻译：具有含有人乳铁蛋白蛋白质或牛乳铁蛋白蛋白质的至少8个连续氨基酸的氨基酸序列的肽。该肽适合作为细胞穿透肽。肽和与肽共价结合的货物分子的复合物。货物分子可以是核酸，氨基酸，肽，蛋白质，碳水化合物，脂质或小分子。使用复合物渗透或转染细胞的方法。

2. 发明申请

US20130259879A1 VACCINE COMPOSITION COMPRISING COMPLEXED IMMUNOSTIMULATORY NUCLEIC ACIDS AND ANTIGENS PACKAGED WITH DISULFIDE-LINKED POLYETHYLENEGLYCOL/PEPTIDE CONJUGATES 有权
标题翻译：包含复合免疫细胞核酸的疫苗组合物和用分离的聚乙二醇/肽结合物包装的抗体
公开(公告)号：US20130259879A1
公开(公告)日：2013-10-03
申请号：US13824449
申请日：2012-02-10
申请人： Patrick Baumhof , Karl-Josef Kallen , Mariola Fotin-Mleczek
发明人： Patrick Baumhof , Karl-Josef Kallen , Mariola Fotin-Mleczek
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K39/0011 , A61K47/48092 , A61K47/481 , A61K47/48215 , A61K47/48323 , A61K47/549 , A61K47/55 , A61K47/60 , A61K47/6455 , A61K2039/53 , A61K2039/55561 , A61K2039/57 , A61K2039/575
摘要： The present invention is directed to an inventive composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence, complexed with a complexing agent; b) an antigen, preferably a protein or peptide antigen and/or a nucleic acid sequence encoding said antigen; and c) a carrier molecule for combined packaging the adjuvant component and the antigen. The present invention is also directed to the first medical use of such an inventive composition or vaccine composition and to the second medical use of such an inventive composition or vaccine composition or components thereof for the treatment of diseases, such as infectious or cancer or tumour diseases as defined herein. The present invention furthermore discloses kits comprising such a composition or vaccine composition.
摘要翻译：本发明涉及本发明的组合物或疫苗组合物，其包含a）包含或与由络合剂络合的至少一种免疫刺激核酸序列组成的佐剂组分; b）抗原，优选蛋白质或肽抗原和/或编码所述抗原的核酸序列; 和c）用于将佐剂组分和抗原组合包装的载体分子。本发明还涉及这种本发明的组合物或疫苗组合物的第一医疗用途以及这种本发明组合物或疫苗组合物或其组合物用于治疗疾病如感染性或癌症或肿瘤疾病的第二医疗用途如本文所定义。本发明还公开了包含这种组合物或疫苗组合物的试剂盒。

3. 发明授权

US09421255B2 Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates 有权
标题翻译：疫苗组合物包含与二硫键连接的聚乙二醇/肽缀合物包装的复合免疫刺激核酸和抗原
公开(公告)号：US09421255B2
公开(公告)日：2016-08-23
申请号：US13824449
申请日：2012-02-10
申请人： Patrick Baumhof , Karl-Josef Kallen , Mariola Fotin-Mleczek
发明人： Patrick Baumhof , Karl-Josef Kallen , Mariola Fotin-Mleczek
IPC分类号： A61K39/39 , A61K39/00 , A61K47/48
CPC分类号： A61K39/39 , A61K39/0011 , A61K47/48092 , A61K47/481 , A61K47/48215 , A61K47/48323 , A61K47/549 , A61K47/55 , A61K47/60 , A61K47/6455 , A61K2039/53 , A61K2039/55561 , A61K2039/57 , A61K2039/575
摘要： The present invention is directed to an inventive composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence, complexed with a complexing agent; b) an antigen, preferably a protein or peptide antigen and/or a nucleic acid sequence encoding said antigen; and c) a carrier molecule for combined packaging the adjuvant component and the antigen. The present invention is also directed to the first medical use of such an inventive composition or vaccine composition and to the second medical use of such an inventive composition or vaccine composition or components thereof for the treatment of diseases, such as infectious or cancer or tumor diseases as defined herein. The present invention furthermore discloses kits comprising such a composition or vaccine composition.
摘要翻译：本发明涉及本发明的组合物或疫苗组合物，其包含a）包含或与由络合剂复合的至少一种免疫刺激核酸序列组成的佐剂组分; b）抗原，优选蛋白质或肽抗原和/或编码所述抗原的核酸序列; 和c）用于将佐剂组分和抗原组合包装的载体分子。本发明还涉及这种本发明的组合物或疫苗组合物的第一医疗用途以及这种本发明组合物或疫苗组合物或其组合物用于治疗疾病如感染性或癌症或肿瘤疾病的第二医疗用途如本文所定义。本发明还公开了包含这种组合物或疫苗组合物的试剂盒。

4. 发明申请

US20100203076A1 COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION 审中-公开
标题翻译： RNA和阳离子肽的复制用于转移和免疫
公开(公告)号：US20100203076A1
公开(公告)日：2010-08-12
申请号：US12676015
申请日：2008-09-04
申请人： Mariola Fotin-Mleczek , Patrick Baumhof
发明人： Mariola Fotin-Mleczek , Patrick Baumhof
IPC分类号： A61K39/385 , C07K9/00 , A61K38/10 , C12N5/02
CPC分类号： A61K48/005 , A61K9/0019 , A61K38/45 , A61K38/4846 , A61K39/00 , A61K47/61 , A61K47/6455 , A61K48/0033 , A61K48/0041 , A61K48/0066 , A61K48/0075 , A61K2039/53 , C07K19/00 , C12N9/0069 , C12N15/87 , C12Y113/12007 , C12Y204/01007 , C12Y304/21022
摘要： The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the function of cell-penetrating peptide (CPP), has a length of 8 to 15 amino acids and has the empirical formula (Arg)l; (Lys)m; (His)n; (Orn)o; (Xaa)x with the majority of residues being selected from Arg, Lys, His, Orn. The invention further relates to a method for transfecting a cell or an organism, thereby applying the inventive complexed RNA. Additionally, pharmaceutical compositions and kits comprising the inventive complexed RNA, as well as the use of the inventive complexed RNA for transfecting a cell, tissue or an organism and/or for modulating, preferably inducing or enhancing, an immune response are disclosed herein.
摘要翻译：本发明涉及复合RNA，其包含与一种或多种寡肽复合的至少一种RNA，其中具有细胞穿透肽（CPP）功能的寡肽具有8至15个氨基酸的长度，并且具有经验公式（Arg）l; （Lys）m; （他）n （或没有; （Xaa）x，大部分残基选自Arg，Lys，His，Orn。本发明还涉及用于转染细胞或生物体的方法，从而应用本发明的复合RNA。此外，本文公开了包含本发明的复合RNA的药物组合物和试剂盒，以及本发明的复合RNA用于转染细胞，组织或生物体和/或用于调节，优选诱导或增强免疫应答的用途。

5. 发明申请

US20100061932A1 PEPTIDES USEFUL AS CELL-PENETRATING PEPTIDES 审中-公开
标题翻译：肽可用作细胞穿刺肽
公开(公告)号：US20100061932A1
公开(公告)日：2010-03-11
申请号：US12159226
申请日：2006-10-25
申请人： Roland Brock , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
发明人： Roland Brock , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
IPC分类号： A61K49/00 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/00 , A61K38/16 , C07H21/04 , A61K31/7088 , A61P35/00
CPC分类号： C07K14/47 , A61K31/713 , A61K39/385 , A61K47/644 , A61K51/088 , A61K2039/53 , C07K14/79
摘要： The present invention is related to a peptide having an amino acid sequence comprising at least 8 consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein, whereby the peptide is suitable to act as a cell-penetrating peptide.
摘要翻译：本发明涉及具有包含人乳铁蛋白蛋白质或牛乳铁蛋白蛋白质的至少8个连续氨基酸的氨基酸序列的肽，由此该肽适合用作细胞穿透肽。

6. 发明申请

US20130280283A1 COMBINATION OF VACCINATION AND INHIBITION OF MHC CLASS I RESTRICTED ANTIGEN PRESENTATION 有权
标题翻译： MHC类限制性抗原呈递的组合和抑制
公开(公告)号：US20130280283A1
公开(公告)日：2013-10-24
申请号：US13824502
申请日：2011-12-27
申请人： Christina Lorenz , Mariola Fotin-Mleczek , Karl-Josef Kallen
发明人： Christina Lorenz , Mariola Fotin-Mleczek , Karl-Josef Kallen
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/545 , A61K2039/55516
摘要： The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex (MHC) class I restricted antigen presentation. The present invention furthermore relates to a method of vaccination of a mammal using the inventive vaccine/inhibitor combination. The present invention also provides kit of parts comprising the inventive vaccine/inhibitor combination, preferably in different parts of the kit, e.g. for prior, concurrent or subsequent administration of the different parts. Additionally the invention relates to a pharmaceutical composition comprising the inventive vaccine/inhibitor combination to further improve the immune response against tumour cells and infected cells having lost the capability of MHC class I restricted antigen presentation.
摘要翻译：本发明涉及疫苗/抑制剂组合，其包含作为至少一种抗原的疫苗和作为主要组织相容性复合物（MHC）I类限制性抗原呈递的至少一种抑制剂的抑制剂。本发明还涉及使用本发明的疫苗/抑制剂组合接种哺乳动物的方法。本发明还提供了包含本发明的疫苗/抑制剂组合的部分试剂盒，优选在试剂盒的不同部分，例如，用于先前，并发或后续管理不同部件。另外，本发明涉及包含本发明的疫苗/抑制剂组合的药物组合物，以进一步改善针对肿瘤细胞的免疫应答和已失去MHC I类限制性抗原呈递能力的感染细胞。

7. 发明申请

US20130108662A1 PEPTIDES USEFUL AS CELL-PENETRATING PEPTIDES 审中-公开
标题翻译：肽可用作细胞穿刺肽
公开(公告)号：US20130108662A1
公开(公告)日：2013-05-02
申请号：US13557706
申请日：2012-07-25
申请人： Roland Brock , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
发明人： Roland Brock , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K31/713 , A61K39/385 , A61K47/644 , A61K51/088 , A61K2039/53 , C07K14/79
摘要： A peptide having an amino acid sequence containing at least eight consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein. The peptide is suitable as a cell-penetrating peptide. A complex of the peptide and a cargo molecule non-covalently bound to the peptide. The cargo molecule may be a nucleic acid, an amino acid, a peptide, a protein, a carbohydrate, a lipid, or a small molecule. A method of penetrating or transfecting a cell using the complex.
摘要翻译：具有含有人乳铁蛋白蛋白质或牛乳铁蛋白蛋白质的至少8个连续氨基酸的氨基酸序列的肽。该肽适合作为细胞穿透肽。肽和与肽共价结合的货物分子的复合物。载体分子可以是核酸，氨基酸，肽，蛋白质，碳水化合物，脂质或小分子。使用复合物渗透或转染细胞的方法。

8. 发明授权

US09737595B2 Combination of vaccination and inhibition of MHC class I restricted antigen presentation 有权
公开(公告)号：US09737595B2
公开(公告)日：2017-08-22
申请号：US13824502
申请日：2011-12-27
申请人： Christina Lorenz , Mariola Fotin-Mleczek , Karl-Josef Kallen
发明人： Christina Lorenz , Mariola Fotin-Mleczek , Karl-Josef Kallen
IPC分类号： A61K39/00 , C07K14/74
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/545 , A61K2039/55516
摘要： The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex (MHC) class I restricted antigen presentation. The present invention furthermore relates to a method of vaccination of a mammal using the inventive vaccine/inhibitor combination. The present invention also provides kit of parts comprising the inventive vaccine/inhibitor combination, preferably in different parts of the kit, e.g. for prior, concurrent or subsequent administration of the different parts. Additionally the invention relates to a pharmaceutical composition comprising the inventive vaccine/inhibitor combination to further improve the immune response against tumor cells and infected cells having lost the capability of MHC class I restricted antigen presentation.

9. 发明授权

US09572874B2 Composition comprising a complexed (M)RNA and a naked mRNA for providing or enhancing an immunostimulatory response in a mammal and uses thereof 有权
标题翻译：包含复合（M）RNA和裸mRNA的组合物，用于在哺乳动物中提供或增强免疫刺激反应及其用途
公开(公告)号：US09572874B2
公开(公告)日：2017-02-21
申请号：US12994407
申请日：2009-09-30
申请人： Mariola Fotin-Mleczek , Söhnke Voss
发明人： Mariola Fotin-Mleczek , Söhnke Voss
IPC分类号： A61K48/00 , A61K47/06 , A61K39/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/53 , A61K2039/55511 , Y02A50/491
摘要： The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound, and b) at least one free mRNA, encoding at least one therapeutically active protein, antigen, allergen and/or antibody, wherein the immunostimulatory composition is capable to elicit or enhance an innate and optionally an adaptive immune response in a mammal. The inventive immunostimulatory composition may be a pharmaceutical composition or a vaccine. The invention furthermore relates to a method of preparation of the inventive immunostimulatory composition. The invention also relates to the use of the inventive immunostimulatory composition or its components (for the preparation of a pharmaceutical composition or a vaccine) for the treatment of various diseases. Finally, the invention relates to kits containing the inventive immunostimulatory composition, its components and/or the pharmaceutical composition or vaccine.
摘要翻译：本发明涉及免疫刺激组合物，其包含a）佐剂组分，其包含或与由阳离子或聚阳离子化合物络合的至少一种（m）RNA组成，和b）至少一种游离mRNA，其编码至少一种治疗活性蛋白质，抗原，变应原和/或抗体，其中所述免疫刺激组合物能够引发或增强哺乳动物中的先天和任选的适应性免疫应答。本发明的免疫刺激组合物可以是药物组合物或疫苗。本发明还涉及本发明的免疫刺激组合物的制备方法。本发明还涉及本发明的免疫刺激组合物或其组分（用于制备药物组合物或疫苗）用于治疗各种疾病的用途。最后，本发明涉及包含本发明的免疫刺激组合物，其组分和/或药物组合物或疫苗的试剂盒。

10. 发明申请

US20160151504A1 PEPTIDES USEFUL AS CELL-PENETRATING PEPTIDES 审中-公开
标题翻译：肽可用作细胞穿刺肽
公开(公告)号：US20160151504A1
公开(公告)日：2016-06-02
申请号：US14955696
申请日：2015-12-01
申请人： Roland BROCK , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
发明人： Roland BROCK , Rainer Fischer , Mariola Fotin-Mleczek , Hansjoerg Hufnagel , Norbert Windhab
IPC分类号： A61K47/48 , C07K14/79 , A61K51/08 , A61K31/713 , A61K39/385
CPC分类号： C07K14/47 , A61K31/713 , A61K39/385 , A61K47/644 , A61K51/088 , A61K2039/53 , C07K14/79
摘要： A method of penetrating a cell where the cell is contacted with a complex that includes (A) a peptide comprising at least 8 consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein; and (B) a cargo molecule bound to the peptide.
摘要翻译：穿透细胞的方法，其中细胞与复合物接触，所述复合物包括（A）包含人乳铁蛋白蛋白或牛乳铁蛋白的至少8个连续氨基酸的肽; 和（B）结合肽的货物分子。

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