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1. 发明申请

WO2004020034A2 MICROABRADER WITH CONTROLLED ABRASION FEATURES 审中-公开
标题翻译：具有可控磨损特性的微型控制器
公开(公告)号：WO2004020034A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/026811
申请日：2003-08-27
申请人： BECTON DICKINSON AND COMPANY , LASTOVICH, Alexander, G. , MARTIN, Frank, E. , HAIDER, Ishaq, M. , CLARKE, Richard, P. , ALARCON, Jason, B.
发明人： LASTOVICH, Alexander, G. , MARTIN, Frank, E. , HAIDER, Ishaq, M. , CLARKE, Richard, P. , ALARCON, Jason, B.
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed, in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.
摘要翻译：用于通过研磨过程将物质递送到皮肤中的研磨装置包括适于在期望的递送部位压靠皮肤的壳体，布置在壳体的上部开口中的施用器头和可移动穿过壳体的下开口以在至少一个沟槽中研磨递送位置，并且研磨表面附接至施加器头部，由此壳体在壳体的递送部位和结构处保持牢固且静止，并且施加器头部控制参数的磨损过程。具体而言，控制施加到研磨表面的力或压力的量，研磨表面在皮肤上移动的速度和研磨表面跨过皮肤的横向通过的次数，使得研磨装置提供犁沟长度基本上相同的深度，从而提供可重复的结果，即使不同的技术人员将研磨装置应用于患者的皮肤。

2. 发明申请

WO2004024219A1 METHOD AND APPARATUS FOR EPIDERMAL DELIVERY OF A SUBSTANCE 审中-公开
标题翻译：用于物质输送的方法和装置
公开(公告)号：WO2004024219A1
公开(公告)日：2004-03-25
申请号：PCT/US2003/028273
申请日：2003-09-10
申请人： BECTON DICKINSON AND COMPANY , HAIDER, M., Ishaq , CLARKE, Richard, P. , FENTRESS, James, K. , MIKSZTA, John, A. , MARTIN, Frank, E.
发明人： HAIDER, M., Ishaq , CLARKE, Richard, P. , FENTRESS, James, K. , MIKSZTA, John, A. , MARTIN, Frank, E.
IPC分类号： A61M5/32
CPC分类号： A61M5/3291 , A61M5/14244 , A61M5/14248 , A61M5/148 , A61M5/158 , A61M5/46 , A61M2005/14208 , A61M2005/1581
摘要： A methbd and apparatus for epidermal and/or intradermal delivery of a substance is provided. A needle having at least one side port is used to penetrate the skin of a subject. The needle may be of any size. A substance is delivered through the side port and into the skin. The side port can be of any size or shape and be arranged at any location on the needle.
摘要翻译：提供了用于表皮和/或皮内递送物质的方法和装置。具有至少一个侧端口的针头用于穿透受试者的皮肤。针可以是任何尺寸的。物质通过侧端口进入皮肤。侧端口可以是任何尺寸或形状，并且布置在针上的任何位置。

3. 发明申请

WO2005091922A2 METHODS AND DEVICES FOR IMPROVING DELIVERY OF A SUBSTANCE TO SKIN 审中-公开
标题翻译：改善皮肤物质输送的方法和装置
公开(公告)号：WO2005091922A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/006660
申请日：2005-03-03
申请人： BECTON, DICKINSON AND COMPANY , PETTITS, Ronald, J. , SUTTER, Diane, E. , CLARKE, Richard, P.
发明人： PETTITS, Ronald, J. , SUTTER, Diane, E. , CLARKE, Richard, P.
IPC分类号： A61M5/145 , A61M5/46 , A61M5/48 , A61M31/00
CPC分类号： A61M5/46 , A61M5/1452 , A61M5/484 , A61M2205/3351
摘要： A method of delivery of a substance to a human subject’s skin comprising deposition into a specific compartment of the skin, wherein the delivery occurs at a controlled rate and pressure. The methods of the invention provide accurate deposition of pre-selected volume of the substance e.g., greater than 90% of the pre-selected volume. The methods of the invention encompass varying one or more parameters including but not limited to configurations of the delivery device, volume, pressure, and flow rate of delivery, to enhance the efficacy of delivery of the substance to the human skin. Substances delivered in accordance with the methods of the invention result to the human skin. Substances delivered in accordance with the methods of the invention result in a more efficacious deposition of the substance into the targeted compartment, improved delivery performance, i.e., completeness of delivery as measured by quantification of the substance not delivered or the amount of the substance leaked out from the injection site, and enhanced safety as measured by the occurrence of minimal adverse cutaneous events at the site of injection.
摘要翻译：将物质递送至人受试者的皮肤的方法，包括沉积到皮肤的特定隔室中，其中递送以受控的速率和压力发生。本发明的方法提供物质的预选体积的精确沉积，例如大于预选体积的90％。本发明的方法包括改变一个或多个参数，包括但不限于递送装置的配置，体积，压力和输送流速，以增强物质递送至人皮肤的功效。根据本发明的方法输送的物质导致人的皮肤。根据本发明的方法递送的物质导致物质进入目标隔室的更有效的沉积，改善的输送性能，即通过定量未输送的物质或泄露的物质的量测量的输送的完整性从注射部位，并通过在注射部位的最小不良皮肤事件的发生所测量的增强的安全性。

4. 发明申请

WO2004031266A2 CELL ADHESION RESISTING SURFACES 审中-公开
标题翻译：细胞粘附抗表面
公开(公告)号：WO2004031266A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/030479
申请日：2003-09-29
申请人： BECTON, DICKINSON AND COMPANY , LIEBMANN-VINSON, Andrea , CLARKE, Richard, P. , XU, Ruiling , HEIDARAN, Mohammad, A.
发明人： LIEBMANN-VINSON, Andrea , CLARKE, Richard, P. , XU, Ruiling , HEIDARAN, Mohammad, A.
IPC分类号： C08J
CPC分类号： C12N5/0068 , C12N2533/80 , Y10T428/13 , Y10T428/1352
摘要： A coated surface that resists cell adhesion comprising hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).
摘要翻译：耐受细胞粘附的包被表面包含透明质酸，其直接结合等离子体处理的聚合物表面。公开了生产涂覆表面的方法，以及透明质酸通过连接配体结合多肽（抗体或抗体结合蛋白）的进一步修饰。

5. 发明授权

EP1539281B1 METHOD AND APPARATUS FOR EPIDERMAL DELIVERY OF A SUBSTANCE 有权
标题翻译：方法和设备给人一种表皮物质
公开(公告)号：EP1539281B1
公开(公告)日：2007-05-30
申请号：EP03755805.3
申请日：2003-09-10
申请人： Becton Dickinson and Company
发明人： HAIDER, M., Ishaq , CLARKE, Richard, P. , FENTRESS, James, K. , MIKSZTA, John, A. , MARTIN, Frank, E.
IPC分类号： A61M5/32
CPC分类号： A61M5/3291 , A61M5/14244 , A61M5/14248 , A61M5/148 , A61M5/158 , A61M5/46 , A61M2005/14208 , A61M2005/1581
摘要： A methbd and apparatus for epidermal and/or intradermal delivery of a substance is provided. A needle having at least one side port is used to penetrate the skin of a subject. The needle may be of any size. A substance is delivered through the side port and into the skin. The side port can be of any size or shape and be arranged at any location on the needle.

6. 发明授权

EP1531895B1 MICROABRADER WITH CONTROLLED ABRASION FEATURES 有权
标题翻译：具有受控磨砂打磨特性的微型器件
公开(公告)号：EP1531895B1
公开(公告)日：2015-02-25
申请号：EP03749156.0
申请日：2003-08-27
申请人： Becton Dickinson and Company
发明人： LASTOVICH, Alexander, G. , MARTIN, Frank, E. , HAIDER, Ishaq, M. , CLARKE, Richard, P. , ALARCON, Jason, B. , DEKKER, John, P., III , MIKSZTA, John, A. , HARDING, Weston
IPC分类号： A61M37/00 , A61B17/20
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053

7. 发明公开

EP1547451A2 CELL ADHESION RESISTING SURFACES 审中-公开
标题翻译：细胞责任反对常设曲面
公开(公告)号：EP1547451A2
公开(公告)日：2005-06-29
申请号：EP03770507.6
申请日：2003-09-29
申请人： Becton Dickinson and Company
发明人： LIEBMANN-VINSON, Andrea , CLARKE, Richard, P. , XU, Ruiling , HEIDARAN, Mohammad, A.
IPC分类号： H05H1/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00
CPC分类号： C12N5/0068 , C12N2533/80 , Y10T428/13 , Y10T428/1352
摘要： A coated surface that resists cell adhesion comprising hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).

8. 发明公开

EP1539281A1 METHOD AND APPARATUS FOR EPIDERMAL DELIVERY OF A SUBSTANCE 有权
标题翻译：方法和设备给人一种表皮物质
公开(公告)号：EP1539281A1
公开(公告)日：2005-06-15
申请号：EP03755805.3
申请日：2003-09-10
申请人： Becton Dickinson and Company
发明人： HAIDER, M., Ishaq , CLARKE, Richard, P. , FENTRESS, James, K. , MIKSZTA, John, A. , MARTIN, Frank, E.
IPC分类号： A61M5/32
CPC分类号： A61M5/3291 , A61M5/14244 , A61M5/14248 , A61M5/148 , A61M5/158 , A61M5/46 , A61M2005/14208 , A61M2005/1581
摘要： A methbd and apparatus for epidermal and/or intradermal delivery of a substance is provided. A needle having at least one side port is used to penetrate the skin of a subject. The needle may be of any size. A substance is delivered through the side port and into the skin. The side port can be of any size or shape and be arranged at any location on the needle.

9. 发明公开

EP1531895A2 MICROABRADER WITH CONTROLLED ABRASION FEATURES 有权
标题翻译：具有受控磨砂打磨特性的微型器件
公开(公告)号：EP1531895A2
公开(公告)日：2005-05-25
申请号：EP03749156.0
申请日：2003-08-27
申请人： Becton Dickinson and Company
发明人： LASTOVICH, Alexander, G. , MARTIN, Frank, E. , HAIDER, Ishaq, M. , CLARKE, Richard, P. , ALARCON, Jason, B. , DEKKER, John, P., III
IPC分类号： A61M37/00 , A61B17/20
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed, in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.

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