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    • 1. 发明申请
    • METHODS AND DEVICES FOR IMPROVING DELIVERY OF A SUBSTANCE TO SKIN
    • 改善皮肤物质输送的方法和装置
    • WO2005091922A3
    • 2006-06-08
    • PCT/US2005006660
    • 2005-03-03
    • BECTON DICKINSON COPETTITS RONALD JSUTTER DIANE ECLARKE RICHARD P
    • PETTITS RONALD JSUTTER DIANE ECLARKE RICHARD P
    • A61M31/00A61M5/145A61M5/46A61M5/48
    • A61M5/46A61M5/1452A61M5/484A61M2205/3351
    • A method of delivery of a substance to a human subject's skin comprising deposition into a specific compartment of the skin, wherein the delivery occurs at a controlled rate and pressure. The methods of the invention provide accurate deposition of pre-selected volume of the substance e.g., greater than 90% of the pre-selected volume. The methods of the invention encompass varying one or more parameters including but not limited to configurations of the delivery device, volume, pressure, and flow rate of delivery, to enhance the efficacy of delivery of the substance to the human skin. Substances delivered in accordance with the methods of the invention result to the human skin. Substances delivered in accordance with the methods of the invention result in a more efficacious deposition of the substance into the targeted compartment, improved delivery performance, i.e., completeness of delivery as measured by quantification of the substance not delivered or the amount of the substance leaked out from the injection site, and enhanced safety as measured by the occurrence of minimal adverse cutaneous events at the site of injection.
    • 将物质递送至人受试者的皮肤的方法,包括沉积到皮肤的特定隔室中,其中递送以受控的速率和压力发生。 本发明的方法提供物质的预选体积的精确沉积,例如大于预选体积的90%。 本发明的方法包括改变一个或多个参数,包括但不限于递送装置的配置,体积,压力和输送流速,以增强物质递送至人体皮肤的功效。 根据本发明的方法输送的物质导致人的皮肤。 根据本发明的方法输送的物质导致物质进入目标隔室的更有效的沉积,改善的输送性能,即通过定量未输送的物质或泄露的物质的量测量的递送的完整性 从注射部位,并通过在注射部位的最小不良皮肤事件的发生所测量的增强的安全性。
    • 2. 发明申请
    • METHODS AND DEVICES FOR IMPROVING DELIVERY OF A SUBSTANCE TO SKIN
    • 改善皮肤物质输送的方法和装置
    • WO2005091922A2
    • 2005-10-06
    • PCT/US2005/006660
    • 2005-03-03
    • BECTON, DICKINSON AND COMPANYPETTITS, Ronald, J.SUTTER, Diane, E.CLARKE, Richard, P.
    • PETTITS, Ronald, J.SUTTER, Diane, E.CLARKE, Richard, P.
    • A61M5/145A61M5/46A61M5/48A61M31/00
    • A61M5/46A61M5/1452A61M5/484A61M2205/3351
    • A method of delivery of a substance to a human subject’s skin comprising deposition into a specific compartment of the skin, wherein the delivery occurs at a controlled rate and pressure. The methods of the invention provide accurate deposition of pre-selected volume of the substance e.g., greater than 90% of the pre-selected volume. The methods of the invention encompass varying one or more parameters including but not limited to configurations of the delivery device, volume, pressure, and flow rate of delivery, to enhance the efficacy of delivery of the substance to the human skin. Substances delivered in accordance with the methods of the invention result to the human skin. Substances delivered in accordance with the methods of the invention result in a more efficacious deposition of the substance into the targeted compartment, improved delivery performance, i.e., completeness of delivery as measured by quantification of the substance not delivered or the amount of the substance leaked out from the injection site, and enhanced safety as measured by the occurrence of minimal adverse cutaneous events at the site of injection.
    • 将物质递送至人受试者的皮肤的方法,包括沉积到皮肤的特定隔室中,其中递送以受控的速率和压力发生。 本发明的方法提供物质的预选体积的精确沉积,例如大于预选体积的90%。 本发明的方法包括改变一个或多个参数,包括但不限于递送装置的配置,体积,压力和输送流速,以增强物质递送至人皮肤的功效。 根据本发明的方法输送的物质导致人的皮肤。 根据本发明的方法递送的物质导致物质进入目标隔室的更有效的沉积,改善的输送性能,即通过定量未输送的物质或泄露的物质的量测量的输送的完整性 从注射部位,并通过在注射部位的最小不良皮肤事件的发生所测量的增强的安全性。