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1. 发明申请

US20120189720A1 METHOD FOR TREATMENT OF DIARRHEA-PREDOMINANT IRRITABLE BOWEL SYNDROME 有权
标题翻译：用于治疗腹泻 - 可预防性胆固醇的综合症的方法
公开(公告)号：US20120189720A1
公开(公告)日：2012-07-26
申请号：US13304604
申请日：2011-11-25
申请人： Barry D. Quart , David P. Rosenbaum , Thomas X. Neenan , Robert C. Blanks
发明人： Barry D. Quart , David P. Rosenbaum , Thomas X. Neenan , Robert C. Blanks
IPC分类号： A61K31/353 , A61P1/00 , A61P25/00 , A61K36/185 , A61K36/47
CPC分类号： A61K31/353 , A61K9/28 , A61K31/365 , A61K31/426 , A61K36/38 , A61K36/47
摘要： The present invention provides methods for treating diarrhea-predominant irritable bowel syndrome comprising administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea-predominant irritable bowel syndrome (d-IBS). Treatment of d-IBS includes the treatment of the diarrhea component of d-IBS as well as the pain, abdominal discomfort and other symptoms associated with d-IBS. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.
摘要翻译：本发明提供了治疗腹泻型肠易激综合征综合征的方法，其包括向有需要的患者施用足以治疗腹泻型肠易激综合征（d-IBS）的氯离子转运抑制剂。 d-IBS的治疗包括治疗d-IBS的腹泻成分以及与d-IBS相关的疼痛，腹部不适和其他症状。在一个实施方案中，氯离子转运抑制剂是疏水剂。

2. 发明申请

US20070254050A1 Method for treatment of diarrhea-predominant irritable bowel syndrome 审中-公开
标题翻译：治疗腹泻型肠易激综合征的方法
公开(公告)号：US20070254050A1
公开(公告)日：2007-11-01
申请号：US11510152
申请日：2006-08-24
申请人： Barry D. Quart , David P. Rosenbaum , Thomas X. Neenan , Robert C. Blanks
发明人： Barry D. Quart , David P. Rosenbaum , Thomas X. Neenan , Robert C. Blanks
IPC分类号： A61K36/47 , A61K31/426 , A61K31/365
CPC分类号： A61K31/353 , A61K9/28 , A61K31/365 , A61K31/426 , A61K36/38 , A61K36/47
摘要： The present invention provides methods for treating diarrhea-predominant irritable bowel syndrome comprising administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea-predominant irritable bowel syndrome (d-IBS). Treatment of d-IBS includes the treatment of the diarrhea component of d-IBS as well as the pain, abdominal discomfort and other symptoms associated with d-IBS. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.
摘要翻译：本发明提供了治疗腹泻型肠易激综合征综合征的方法，其包括向有需要的患者施用足以治疗腹泻型肠易激综合征（d-IBS）的氯离子转运抑制剂。 d-IBS的治疗包括治疗d-IBS的腹泻成分以及与d-IBS相关的疼痛，腹部不适和其他症状。在一个实施方案中，氯离子转运抑制剂是疏水剂。

3. 发明授权

US4440921A Coupling of polyorganophosphazenes to carboxylic acid 失效
标题翻译：聚有机膦腈与羧酸的偶联
公开(公告)号：US4440921A
公开(公告)日：1984-04-03
申请号：US390350
申请日：1982-06-21
申请人： Harry R. Allcock , Thomas X. Neenan , Walter C. Kossa
发明人： Harry R. Allcock , Thomas X. Neenan , Walter C. Kossa
IPC分类号： C08G73/00 , C08G79/02
CPC分类号： C08G79/025 , C08G73/00
摘要： A carboxylated phosphazene polymer, comprising a phosphazene polymer backbone covalently coupled to a carboxylate-containing compound through a divalent organic radical attached at one end to the carboxylate by an amide bond formed at a primary aliphatic amino group of the radical and at the other end to a phosphorous of the phosphazene backbone.
摘要翻译：一种羧基化磷腈聚合物，其包含磷腈聚合物主链，其共价连接到含羧酸酯的化合物上，通过二价有机基团，其一端通过在该基团的伯脂肪族氨基上形成的酰胺键连接到羧酸酯上，另一端与磷腈骨架的磷。

4. 发明授权

US06593366B2 Ionic polymers as anti-infective agents 有权
公开(公告)号：US06593366B2
公开(公告)日：2003-07-15
申请号：US10081022
申请日：2002-02-21
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K3122
CPC分类号： A61K31/785 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

5. 发明授权

US5200544A Resist materials 失效
标题翻译：抵抗材料
公开(公告)号：US5200544A
公开(公告)日：1993-04-06
申请号：US825341
申请日：1992-01-24
申请人： Francis M. Houlihan , Thomas X. Neenan , Elsa Reichmanis
发明人： Francis M. Houlihan , Thomas X. Neenan , Elsa Reichmanis
IPC分类号： G03F7/039
CPC分类号： G03F7/039
摘要： A class of resist compositions sensitive to deep ultraviolet radiation includes a resin sensitive to acid and a composition that generates acid upon exposure to such radiation. A group of nitrobenzyl materials is particularly suitable for use as the acid generator.
摘要翻译：一类对深紫外线辐射敏感的抗蚀剂组合物包括对酸敏感的树脂和暴露于这种辐射时产生酸的组合物。一组硝基苄基材料特别适合用作酸产生剂。

6. 发明授权

US4987209A Diethynyl monomers and polymers thereof 失效
标题翻译：二乙炔基单体及其聚合物
公开(公告)号：US4987209A
公开(公告)日：1991-01-22
申请号：US281911
申请日：1988-12-07
申请人： Thomas X. Neenan , George M. Whitesides
发明人： Thomas X. Neenan , George M. Whitesides
IPC分类号： C07C25/24 , C07C33/28 , C07C323/09 , C08F38/00
CPC分类号： C08F38/00 , C07C25/24 , C07C323/09 , C07C33/28
摘要： The compound 1,3-diethynyl tetrafluorobenzene, and compounds having the structure ##STR1## in which ##STR2## represents a perfluorinated benzene ring and X represents oxygen or sulfur, as well as homopolymers and copolymers thereof.
摘要翻译：化合物1,3-二乙炔基四氟苯以及具有“IMAGE”结构的化合物，其中“IMAGE”表示全氟化苯环，X表示氧或硫，以及其均聚物和共聚物。

7. 发明授权

US4451647A Heparinized polyorganophosphazenes 失效
标题翻译：肝素化聚有机磷腈
公开(公告)号：US4451647A
公开(公告)日：1984-05-29
申请号：US390344
申请日：1982-06-21
申请人： Harry R. Allcock , Thomas X. Neenan
发明人： Harry R. Allcock , Thomas X. Neenan
IPC分类号： A61L33/00 , A61L33/06 , C08B37/10 , C08G79/02 , A61K31/725
CPC分类号： A61K31/715 , A61L33/0023 , A61L33/068 , C08B37/0075 , C08G79/025
摘要： A polyphosphazene-bound heparin complex comprising a polymeric phosphozine backbone, a quaternary ammonium ion covalently attached to the backbone through a bivalent organic radical attached at one end to the nitrogen atoms of the ion and at the other end to a phosphorus atoms of the backbone, and heparin ionically bound to said quaternary ammonium ion is disclosed along with methods for preparing such complexes.
摘要翻译：包含聚磷腈结合的肝素复合物，其包含聚合磷酸骨架，季铵离子，其通过一端与离子的氮原子连接并且在另一端与骨架的磷原子共价连接到主链上，并且与所述季铵离子离子键合的肝素与制备这种复合物的方法一起公开。

8. 发明授权

US06482402B1 Antimicrobial compositions and methods 有权
标题翻译：抗微生物组合物和方法
公开(公告)号：US06482402B1
公开(公告)日：2002-11-19
申请号：US09568825
申请日：2000-05-11
申请人： Caroline Kurtz , Thomas X. Neenan
发明人： Caroline Kurtz , Thomas X. Neenan
IPC分类号： A61K3174
CPC分类号： A61K45/06 , A61K31/74 , A61K2300/00
摘要： The present invention relates to antimicrobial compositions including pharmaceutical compositions and treatment regimens for preventing or treating a microbial infection in a mammal, such as a human, by administering to the mammal, a therapeutically effective amount of a polymer and a therapeutically effective amount of an antibacterial agent.
摘要翻译：本发明涉及包含用于预防或治疗哺乳动物（例如人）的微生物感染的药物组合物和治疗方案的抗微生物组合物，其通过向哺乳动物施用治疗有效量的聚合物和治疗有效量的抗菌剂代理商

9. 发明授权

US06187762B1 Polyvalent polymers for the treatment of rotavirus infection 失效
标题翻译：用于治疗轮状病毒感染的多价聚合物
公开(公告)号：US06187762B1
公开(公告)日：2001-02-13
申请号：US09286351
申请日：1999-04-05
申请人： W. Harry Mandeville, III , John S. Petersen , Venkata R. Garigapati , Thomas X. Neenan
发明人： W. Harry Mandeville, III , John S. Petersen , Venkata R. Garigapati , Thomas X. Neenan
IPC分类号： A61K3170
CPC分类号： C07H13/04 , C07D309/10 , C07H15/04 , C08F246/00
摘要： The present invention includes polymerizable monomers comprising a fucoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the fucoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more fucoside moieties, such as pendant fucoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. In another embodiment, the present invention comprises a method for treating a rotavirus infection in a mammal, for example, a human, by administering to the mammal a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties. The glycoside moieties can be, for example, fucoside moieties or sialic acid moieties. The polymer can be a homopolyrner or a co-polymer. In one embodiment, the polymer is a copolymer comprising a glycoside-bearing monomer and a hydrophobic monomer. In another embodiment, the polymer to be administered comprises two or more different glycoside-bearing monomers.
摘要翻译：本发明包括包含岩藻糖苷部分的可聚合单体。在一个实施方案中，单体具有可聚合官能团，例如烯键，通过间隔基团例如亚烷基或其中一个或多个碳原子被杂原子，例如氧，氮或硫原子。本发明还包括包含一种或多种可以抑制或预防哺乳动物轮状病毒感染的岩藻糖苷部分的聚合物，例如侧壁ucoside部分。这样的聚合物可以包括例如本发明的单体。聚合物可以是均聚物或共聚物，并且可以具有例如聚丙烯酰胺，聚丙烯酸酯或聚苯乙烯主链。在另一个实施方案中，本发明包括通过向哺乳动物施用治疗有效量的包含一个或多个糖苷部分的聚合物，例如侧链糖苷部分，来治疗哺乳动物例如人的轮状病毒感染的方法。糖苷部分可以是例如岩藻糖苷部分或唾液酸部分。聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含含糖苷单体和疏水性单体的共聚物。在另一个实施方案中，待施用的聚合物包含两种或更多种不同的含糖苷单体。

10. 发明授权

US6034129A Ionic polymers as anti-infective agents 失效
公开(公告)号：US6034129A
公开(公告)日：2000-03-07
申请号：US670764
申请日：1996-06-24
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K31/785 , A61P31/04 , A61P31/10 , A61P33/00 , A61P33/04 , A61K31/14 , A61K31/16 , A61K31/74
CPC分类号： A61K31/785
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

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