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1. 发明申请

US20070275890A1 Chaperonin 10 Modulation Of Toll-Like Receptor-Inducible Cytokine And Chemokine Secretion 审中-公开
标题翻译：伴侣蛋白10调节Toll样受体诱导的细胞因子和趋化因子分泌
公开(公告)号：US20070275890A1
公开(公告)日：2007-11-29
申请号：US10586143
申请日：2005-01-14
申请人： Barbara Johnson , Andreas Suhrbier , Dean Naylor , Caroline Dobbin , Christopher Howard
发明人： Barbara Johnson , Andreas Suhrbier , Dean Naylor , Caroline Dobbin , Christopher Howard
IPC分类号： A61K38/16 , A61P29/00 , A61P9/00 , C07K17/00 , G01N33/53
CPC分类号： A61K38/1709 , A61K47/62 , A61K2300/00
摘要： Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.
摘要翻译：使用伴侣蛋白10（Cpn10）的方法用于调节Toll样受体信号传导和/或Toll样受体诱导型免疫调节剂分泌。 Cpn10负调节Toll样受体激动剂诱导的促炎细胞因子和趋化因子分泌，分别为IL-6和RANTES。 Cpn10阳性调节Toll样受体激动剂诱导的抗炎细胞因子和趋化因子分泌，一个例子是IL-10。 Cpn10的这些免疫调节活性可用于治疗由过度促炎细胞因子和趋化因子分泌引起的疾病，病症和病症。本发明还涉及根据其调节Toll样受体信号传导和/或Toll样受体诱导型免疫调节剂分泌的能力来产生，设计和/或筛选Cpn10激动剂和拮抗剂。

2. 发明授权

US07776343B1 Immunogenic complexes and methods relating thereto 有权
公开(公告)号：US07776343B1
公开(公告)日：2010-08-17
申请号：US09506011
申请日：2000-02-17
申请人： John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
发明人： John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
IPC分类号： A61K47/00
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/55561 , A61K2039/55572 , A61K2039/55577 , A61K2039/57
摘要： The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen. The complexes of the present invention are useful, inter alia, as therapeutic and/or prophylactic agents for facilitating the induction of a cytotoxic T-lymphocyte response to an antigen.

3. 发明授权

US07449492B2 Therapeutic agents—I 有权
标题翻译：治疗剂 - I
公开(公告)号：US07449492B2
公开(公告)日：2008-11-11
申请号：US10315288
申请日：2002-12-09
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/21
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of infection by pathogenic or potentially pathogenic entities, or entities capable of opportunistic infection in mammals, including humans and primates, non-mammalian animals and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtainable from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of infection by pathogenic entities in mammalian, animal and avian subjects. The present invention further contemplates a method for the prophylaxis and/or treatment in mammalian, animal or avian subjects of infection or potential infection by pathogenic entities by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family of plants or their botanical or horticultural derivatives or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or in the form of a chemical fraction, sub-fraction, preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防致病或潜在致病实体或能够在包括人和灵长类动物，非哺乳动物和禽类物种在内的哺乳动物中机会感染的实体的感染的化学试剂。更具体地说，本发明提供了一种可从植物或植物或园艺亲属的大戟科家族成员获得的大环二萜类化合物或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式在哺乳动物，动物和禽类受试者中感染病原体。本发明进一步考虑了一种通过局部或全身施用可从植物大戟科植物的成员获得的大环二萜在哺乳动物，动物或禽类受试者中预防和/或治疗感染或潜在感染的方法，或其植物或园艺衍生物或衍生物，化学类似物或化学合成形式的药剂。本发明的化学试剂可以是纯化合物的形式，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式 - 植物的分离，制备或提取。

4. 发明授权

US08106092B2 Treatment of solid cancers 有权
标题翻译：治疗固体癌
公开(公告)号：US08106092B2
公开(公告)日：2012-01-31
申请号：US11792264
申请日：2005-12-02
申请人： Steven Martin Ogbourne , Andreas Suhrbier
发明人： Steven Martin Ogbourne , Andreas Suhrbier
IPC分类号： A01N37/00
CPC分类号： A61K31/22 , A61K9/0019 , A61K36/47 , A61K2300/00
摘要： The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors, and the prevention or reduction of cancer metastasis, by chemoablation of cancer cells by an agent which also stimulates the generation of cancer-specific T-cells, a process referred to herein as immunostimulatory chemoablation. The present invention further contemplates combination therapy comprising immunostimulatory chemoablation and one or more other therapeutic regimens, which enhance, co-operate and/or synergize with the cancer-specific T-cells induced by the chemoablation. The present invention also relates to pharmaceutical compositions for use in treating cancers.
摘要翻译：本发明一般涉及包括肿瘤治疗在内的癌症领域。更具体地说，本发明涉及通过也刺激癌细胞特异性T细胞产生的药物化学消除癌细胞来治疗包括实体瘤在内的固体癌症以及预防或减少癌症转移的过程本文称为免疫刺激化学消炎。本发明进一步考虑了包括免疫刺激化学消炎和一种或多种其它治疗方案的组合疗法，其增强，协同和/或与由化学消炎诱导的癌症特异性T细胞协同作用。本发明还涉及用于治疗癌症的药物组合物。

5. 发明申请

US20080187513A1 Treatment of Solid Cancers 有权
标题翻译：实体癌的治疗
公开(公告)号：US20080187513A1
公开(公告)日：2008-08-07
申请号：US11792264
申请日：2005-12-02
申请人： Steven Martin Ogbourne , Andreas Suhrbier
发明人： Steven Martin Ogbourne , Andreas Suhrbier
IPC分类号： A61K38/20 , A61K31/216 , A61P35/00 , A61K39/00
CPC分类号： A61K31/22 , A61K9/0019 , A61K36/47 , A61K2300/00
摘要： The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors, and the prevention or reduction of cancer metastasis, by chemoablation of cancer cells by an agent which also stimulates the generation of cancer-specific T-cells, a process referred to herein as immunostimulatory chemoablation. The present invention further contemplates combination therapy comprising immunostimulatory chemoablation and one or more other therapeutic regimens, which enhance, co-operate and/or synergize with the cancer-specific T-cells induced by the chemoablation. The present invention also relates to pharmaceutical compositions for use in treating cancers.
摘要翻译：本发明一般涉及包括肿瘤治疗在内的癌症领域。更具体地说，本发明涉及通过也刺激癌细胞特异性T细胞产生的药物化学消除癌细胞来治疗包括实体瘤在内的固体癌症以及预防或减少癌症转移的过程本文称为免疫刺激化学消炎。本发明进一步考虑了包括免疫刺激化学消炎和一种或多种其它治疗方案的组合疗法，其增强，协同和/或与由化学消炎诱导的癌症特异性T细胞协同作用。本发明还涉及用于治疗癌症的药物组合物。

6. 发明授权

US09895334B2 Treatment of virally induced lesions 有权
公开(公告)号：US09895334B2
公开(公告)日：2018-02-20
申请号：US12598102
申请日：2008-04-30
申请人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
发明人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
IPC分类号： A61K31/22 , A61K31/12 , A61K31/216 , A61K31/222 , A61K47/10 , A61K47/12 , A61K9/06 , A61K47/38 , A61K9/00
CPC分类号： A61K31/216 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/22 , A61K31/222 , A61K47/10 , A61K47/12 , A61K47/38
摘要： The present invention relates generally to the treatment of cutaneous lesions containing cells infected by a virus, as well as compositions for the treatment of such lesions. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating lesions caused by infection with a papilloma virus, such as a mammalian papilloma virus, in particular a Human Papilloma Virus.

7. 发明授权

US09314458B2 Topical use of ingenol-3-angelate or a salt thereof to treat skin cancer 有权
标题翻译：局部使用美沙芬-3-安息香酸盐或其盐治疗皮肤癌
公开(公告)号：US09314458B2
公开(公告)日：2016-04-19
申请号：US13034172
申请日：2011-02-24
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61P35/00 , A61P17/04 , A61P31/22 , A61K31/455 , A61K31/22 , A61K36/47
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogs or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analog or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防炎性病症或改善由哺乳动物（包括人类和灵长类，非哺乳动物和禽类）物种中的炎性病症引起或促进的症状的化学试剂。更具体地说，本发明提供了从大戟科植物或植物或园艺亲属的成员获得的大环二萜类家族化学试剂或衍生物或化学类似物或用于治疗或预防的药剂的化学合成形式的炎性病症或改善由哺乳动物，动物或禽类物种中的炎性病症引起或促进的症状。本发明进一步考虑了一种用于预防或治疗哺乳动物，动物或禽类受试者的炎症性疾病的方法，包括慢性或短暂性炎性病症或通过局部或全身给予大环二萜来改善炎症状态的症状，所述大环二萜可从大戟科（Euphorbiaceae）家族的成员或植物或园艺亲属或衍生物，化学类似物或化学合成形式的药剂。本发明的化学试剂可以是纯化的化合物，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式，子部分或植物的制备或提取物。

8. 发明申请

US20100010193A1 Immunogenic complexes and methods relating thereto 有权
标题翻译：免疫原性复合物及其相关方法
公开(公告)号：US20100010193A1
公开(公告)日：2010-01-14
申请号：US12458116
申请日：2009-07-01
申请人： John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
发明人： John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
IPC分类号： C07K1/00
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/55561 , A61K2039/55572 , A61K2039/55577 , A61K2039/57
摘要： The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen. The complexes of the present invention are useful, inter alia, as therapeutic and/or prophylactic agents for facilitating the induction of a cytotoxic T-lymphocyte response to an antigen.
摘要翻译：本发明一般涉及包含带电荷的有机载体和带电荷的抗原的免疫原性复合物，更具体地说，涉及带负电荷的有机载体和带正电荷的抗原。本发明的复合物尤其可用作促进诱导对抗原的细胞毒性T淋巴细胞应答的治疗和/或预防剂。

9. 发明申请

US20110213002A1 MACROCYCLIC DITERPENES FOR TREATING CONDITIONS ASSOCIATED WITH PROTEIN KINASE C 有权
标题翻译：用于处理与蛋白激酶C相关的条件的大分子化合物
公开(公告)号：US20110213002A1
公开(公告)日：2011-09-01
申请号：US13034172
申请日：2011-02-24
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/465 , A61K31/22 , A61P11/06 , A61P9/00 , A61P7/00 , A61P25/28 , A61P25/24 , A61P3/10 , A61P25/00 , A61P19/00 , A61P31/12 , A61P17/06 , A61K31/122
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防炎性病症或改善由哺乳动物（包括人类和灵长类，非哺乳动物和禽类）物种中的炎性病症引起或促进的症状的化学试剂。更具体地说，本发明提供从大戟科植物或植物或园艺亲属的成员获得的大环二萜类家族化学试剂或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式的炎性病症或改善由哺乳动物，动物或禽类物种中的炎性病症引起或促进的症状。本发明进一步考虑了一种用于预防或治疗哺乳动物，动物或禽类受试者的炎症性疾病的方法，包括慢性或短暂性炎性病症或通过局部或全身给予大环二萜来改善炎症状态的症状，所述大环二萜可从大戟科的成员或植物或园艺亲属或衍生物，化学类似物或化学合成形式的药剂。本发明的化学试剂可以是纯化的化合物，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式，子部分或植物的制备或提取物。

10. 发明申请

US20100204318A1 TREATMENT OF VIRALLY INDUCED LESIONS 有权
标题翻译：治疗病毒性感染
公开(公告)号：US20100204318A1
公开(公告)日：2010-08-12
申请号：US12598102
申请日：2008-04-30
申请人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
发明人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
IPC分类号： A61K31/22 , A61P31/20
CPC分类号： A61K31/216 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/22 , A61K31/222 , A61K47/10 , A61K47/12 , A61K47/38
摘要： The present invention relates generally to the treatment of cutaneous lesions containing cells infected by a virus, as well as compositions for the treatment of such lesions. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating lesions caused by infection with a papilloma virus, such as a mammalian papilloma virus, in particular a Human Papilloma Virus.
摘要翻译：本发明一般涉及治疗含病毒感染细胞的皮肤病变，以及用于治疗这种病变的组合物。更具体地说，本发明涉及使用细胞因子化合物，特别是西诺芬当归，用于治疗由乳头瘤病毒感染引起的损伤，例如哺乳动物乳头状瘤病毒，特别是人乳头状瘤病毒。

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