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1. 发明授权

US09895334B2 Treatment of virally induced lesions 有权
公开(公告)号：US09895334B2
公开(公告)日：2018-02-20
申请号：US12598102
申请日：2008-04-30
申请人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
发明人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
IPC分类号： A61K31/22 , A61K31/12 , A61K31/216 , A61K31/222 , A61K47/10 , A61K47/12 , A61K9/06 , A61K47/38 , A61K9/00
CPC分类号： A61K31/216 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/22 , A61K31/222 , A61K47/10 , A61K47/12 , A61K47/38
摘要： The present invention relates generally to the treatment of cutaneous lesions containing cells infected by a virus, as well as compositions for the treatment of such lesions. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating lesions caused by infection with a papilloma virus, such as a mammalian papilloma virus, in particular a Human Papilloma Virus.

2. 发明申请

US20100204318A1 TREATMENT OF VIRALLY INDUCED LESIONS 有权
标题翻译：治疗病毒性感染
公开(公告)号：US20100204318A1
公开(公告)日：2010-08-12
申请号：US12598102
申请日：2008-04-30
申请人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
发明人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
IPC分类号： A61K31/22 , A61P31/20
CPC分类号： A61K31/216 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/22 , A61K31/222 , A61K47/10 , A61K47/12 , A61K47/38
摘要： The present invention relates generally to the treatment of cutaneous lesions containing cells infected by a virus, as well as compositions for the treatment of such lesions. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating lesions caused by infection with a papilloma virus, such as a mammalian papilloma virus, in particular a Human Papilloma Virus.
摘要翻译：本发明一般涉及治疗含病毒感染细胞的皮肤病变，以及用于治疗这种病变的组合物。更具体地说，本发明涉及使用细胞因子化合物，特别是西诺芬当归，用于治疗由乳头瘤病毒感染引起的损伤，例如哺乳动物乳头状瘤病毒，特别是人乳头状瘤病毒。

3. 发明授权

US10143638B2 Method of treating skin with ingenol mebutate 有权
公开(公告)号：US10143638B2
公开(公告)日：2018-12-04
申请号：US13201331
申请日：2010-02-12
申请人： Steven Martin Ogbourne , David Thomas , Ryan Moseley , James Harrison Aylward
发明人： Steven Martin Ogbourne , David Thomas , Ryan Moseley , James Harrison Aylward
IPC分类号： A61K31/22 , A61P17/00 , A61K31/12 , A61K8/37 , A61Q19/08 , A61Q17/04
摘要： The present invention relates generally to the cosmetic treatment of aged skin. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating photo-aged and/or chronologically-aged skin.

4. 发明申请

US20120041064A1 SKIN TREATMENT 审中-公开
标题翻译：皮肤治疗
公开(公告)号：US20120041064A1
公开(公告)日：2012-02-16
申请号：US13201331
申请日：2010-02-12
申请人： Steven Martin Ogbourne , David Thomas , Ryan Moseley , James Harrison Aylward
发明人： Steven Martin Ogbourne , David Thomas , Ryan Moseley , James Harrison Aylward
IPC分类号： A61K31/22 , A61P17/00 , A61K31/12
CPC分类号： A61K8/375 , A61Q17/04 , A61Q19/08
摘要： The present invention relates generally to the cosmetic treatment of aged skin. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating photo-aged and/or chronologically-aged skin.
摘要翻译：本发明一般涉及老化皮肤的美容治疗。更具体地，本发明涉及使用内酯化合物，特别是当归酸烯雌酚，用于治疗光老化和/或按时间顺序老化的皮肤。

5. 发明申请

US20120276045A1 TREATMENT OF SOLID CANCERS 审中-公开
标题翻译：治疗实体癌
公开(公告)号：US20120276045A1
公开(公告)日：2012-11-01
申请号：US13360914
申请日：2012-01-30
申请人： Steven Martin Ogbourne , Andreas Suhrbier
发明人： Steven Martin Ogbourne , Andreas Suhrbier
IPC分类号： A61K31/22 , A61P37/04 , A61K39/00 , A61P35/00 , A61K38/20
CPC分类号： A61K31/22 , A61K9/0019 , A61K36/47 , A61K2300/00
摘要： The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors, and the prevention or reduction of cancer metastasis, by chemoablation of cancer cells by an agent which also stimulates the generation of cancer-specific T-cells, a process referred to herein as immunostimulatory chemoablation. The present invention further contemplates combination therapy comprising immunostimulatory chemoablation and one or more other therapeutic regimens, which enhance, co-operate and/or synergize with the cancer-specific T-cells induced by the chemoablation. The present invention also relates to pharmaceutical compositions for use in treating cancers.
摘要翻译：本发明一般涉及包括肿瘤治疗在内的癌症领域。更具体地说，本发明涉及通过也刺激癌细胞特异性T细胞产生的药物化学消除癌细胞来治疗包括实体瘤在内的固体癌症以及预防或减少癌症转移的过程本文称为免疫刺激化学消炎。本发明进一步考虑了包括免疫刺激化学消炎和一种或多种其它治疗方案的组合疗法，其增强，协同和/或与由化学消炎诱导的癌症特异性T细胞协同作用。本发明还涉及用于治疗癌症的药物组合物。

6. 发明授权

US08106092B2 Treatment of solid cancers 有权
标题翻译：治疗固体癌
公开(公告)号：US08106092B2
公开(公告)日：2012-01-31
申请号：US11792264
申请日：2005-12-02
申请人： Steven Martin Ogbourne , Andreas Suhrbier
发明人： Steven Martin Ogbourne , Andreas Suhrbier
IPC分类号： A01N37/00
CPC分类号： A61K31/22 , A61K9/0019 , A61K36/47 , A61K2300/00
摘要： The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors, and the prevention or reduction of cancer metastasis, by chemoablation of cancer cells by an agent which also stimulates the generation of cancer-specific T-cells, a process referred to herein as immunostimulatory chemoablation. The present invention further contemplates combination therapy comprising immunostimulatory chemoablation and one or more other therapeutic regimens, which enhance, co-operate and/or synergize with the cancer-specific T-cells induced by the chemoablation. The present invention also relates to pharmaceutical compositions for use in treating cancers.
摘要翻译：本发明一般涉及包括肿瘤治疗在内的癌症领域。更具体地说，本发明涉及通过也刺激癌细胞特异性T细胞产生的药物化学消除癌细胞来治疗包括实体瘤在内的固体癌症以及预防或减少癌症转移的过程本文称为免疫刺激化学消炎。本发明进一步考虑了包括免疫刺激化学消炎和一种或多种其它治疗方案的组合疗法，其增强，协同和/或与由化学消炎诱导的癌症特异性T细胞协同作用。本发明还涉及用于治疗癌症的药物组合物。

7. 发明申请

US20080187513A1 Treatment of Solid Cancers 有权
标题翻译：实体癌的治疗
公开(公告)号：US20080187513A1
公开(公告)日：2008-08-07
申请号：US11792264
申请日：2005-12-02
申请人： Steven Martin Ogbourne , Andreas Suhrbier
发明人： Steven Martin Ogbourne , Andreas Suhrbier
IPC分类号： A61K38/20 , A61K31/216 , A61P35/00 , A61K39/00
CPC分类号： A61K31/22 , A61K9/0019 , A61K36/47 , A61K2300/00
摘要： The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors, and the prevention or reduction of cancer metastasis, by chemoablation of cancer cells by an agent which also stimulates the generation of cancer-specific T-cells, a process referred to herein as immunostimulatory chemoablation. The present invention further contemplates combination therapy comprising immunostimulatory chemoablation and one or more other therapeutic regimens, which enhance, co-operate and/or synergize with the cancer-specific T-cells induced by the chemoablation. The present invention also relates to pharmaceutical compositions for use in treating cancers.
摘要翻译：本发明一般涉及包括肿瘤治疗在内的癌症领域。更具体地说，本发明涉及通过也刺激癌细胞特异性T细胞产生的药物化学消除癌细胞来治疗包括实体瘤在内的固体癌症以及预防或减少癌症转移的过程本文称为免疫刺激化学消炎。本发明进一步考虑了包括免疫刺激化学消炎和一种或多种其它治疗方案的组合疗法，其增强，协同和/或与由化学消炎诱导的癌症特异性T细胞协同作用。本发明还涉及用于治疗癌症的药物组合物。

8. 发明授权

US08653133B2 Crystalline ingenol mebutate 有权
标题翻译：结晶西葫芦mebutate
公开(公告)号：US08653133B2
公开(公告)日：2014-02-18
申请号：US13088910
申请日：2011-04-18
申请人： Steven Martin Ogbourne
发明人： Steven Martin Ogbourne
IPC分类号： A61K31/22 , A61P17/12 , A61P35/00 , C07C69/56
CPC分类号： C07C67/52 , A61K9/0014 , A61K9/0034 , A61K9/06 , C07B2200/13 , C07C69/533 , C07C2603/86 , Y02A50/463
摘要： The present invention relates to a novel crystalline form of ingenol mebutate, methods of preparation thereof, and to its use. More specifically, the invention relates to the conversion of amorphous ingenol mebutate (ingenol-3-angelate, PEP005) to a crystalline form, which was characterized by single crystal X-Ray crystallography (XRC), attenuated total reflectance Fourier transform infrared (FTIR-ATR) spectroscopy and Differential Scanning calorimetry (DSC).
摘要翻译：本发明涉及新戊烯酮甲酸酯的结晶形式，其制备方法及其用途。更具体地说，本发明涉及以单结晶X射线晶体学（XRC），衰减全反射傅立叶变换红外（FTIR-3）为特征的无定形内酯酚酸酯（茚满醇-3-当归，PEP005）转化为结晶形式， ATR）光谱和差示扫描量热法（DSC）。

9. 发明申请

US20090215884A1 METHOD FOR WOUND HEALING 审中-公开
标题翻译：治疗方法
公开(公告)号：US20090215884A1
公开(公告)日：2009-08-27
申请号：US12094713
申请日：2006-11-24
申请人： Steven Martin Ogbourne , David Thomas , Ryan Moseley
发明人： Steven Martin Ogbourne , David Thomas , Ryan Moseley
IPC分类号： A61K31/335 , A61P17/02
CPC分类号： A61K31/22 , A61K31/222 , A61K31/235
摘要： The present invention relates generally to methods and compositions for promoting wound healing in a subject. In particular, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in wound healing and compositions therefor which contain such compounds.
摘要翻译：本发明一般涉及用于促进受试者中伤口愈合的方法和组合物。特别地，本发明涉及在含有这些化合物的伤口愈合及其组合物中使用美烯酸酯化合物，特别是当归酸烯雌酚。

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