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1. 发明申请

US20070072856A1 LPAAT-beta inhibitors and uses thereof 失效
标题翻译： LPAAT-β抑制剂及其用途
公开(公告)号：US20070072856A1
公开(公告)日：2007-03-29
申请号：US11601513
申请日：2006-11-16
申请人： Baoqing Gong , John Tulinsky , Lynn Bonham , J. Klein , Robert Finney , David Hollenback , Scott Shaffer , Norina Tang , Thayer White , David Leung
发明人： Baoqing Gong , John Tulinsky , Lynn Bonham , J. Klein , Robert Finney , David Hollenback , Scott Shaffer , Norina Tang , Thayer White , David Leung
IPC分类号： A61K31/5377 , A61K31/53 , C07D413/02 , C07D251/48
CPC分类号： C07D251/70 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/58
摘要： The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.
摘要翻译：本发明涉及三嗪及其用于抑制溶血磷脂酰基转移酶β（LPAAT-β）活性的用途。本发明还涉及使用所述三嗪治疗癌症的方法。本发明还涉及用于筛选LPAAT-β活性的方法。

2. 发明申请

US20060035896A1 LPAAT-beta inhibitors and uses thereof 失效
标题翻译： LPAAT-β抑制剂及其用途
公开(公告)号：US20060035896A1
公开(公告)日：2006-02-16
申请号：US11224340
申请日：2005-09-12
申请人： Lynn Bonham , J. Klein , Robert Finney , David Hollenback , Scott Shaffer , Norina Tang , Thayer White , David Leung , Baoqing Gong , John Tulinsky
发明人： Lynn Bonham , J. Klein , Robert Finney , David Hollenback , Scott Shaffer , Norina Tang , Thayer White , David Leung , Baoqing Gong , John Tulinsky
IPC分类号： A61K31/5377 , A61K31/53 , C07D413/02 , C07D403/02
CPC分类号： C07D251/70 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/58
摘要： The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPMT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.
摘要翻译：本发明涉及三嗪及其用于抑制溶血磷脂酰基转移酶β（LPMT-β）活性的用途。本发明还涉及使用所述三嗪治疗癌症的方法。本发明还涉及用于筛选LPAAT-β活性的方法。

3. 发明申请

US20060211102A1 Human lysophosphatidic acid acyltransferase gamma-1 polypeptide 审中-公开
标题翻译：人溶血磷脂酸酰基转移酶γ-1多肽
公开(公告)号：US20060211102A1
公开(公告)日：2006-09-21
申请号：US11440015
申请日：2006-05-25
申请人： David Leung , Daniel Adourel , David Hollenback
发明人： David Leung , Daniel Adourel , David Hollenback
IPC分类号： C12N9/10
CPC分类号： C12N9/1029
摘要： Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
摘要翻译：多肽例如通过编码cDNA序列的表达获得，其具有酶溶血磷脂酸酰基转移酶（LPAAT）的活性，也称为1-酰基sn-甘油-3-磷酸酰基转移酶。

4. 发明授权

US08748577B2 Conjugates of biologically active polypeptides having an increased in vivo half-life 失效
标题翻译：具有增加的体内半衰期的生物活性多肽的缀合物
公开(公告)号：US08748577B2
公开(公告)日：2014-06-10
申请号：US13363278
申请日：2012-01-31
申请人： Marc Besman , Stewart Chipman , David Leung , Jack Singer
发明人： Marc Besman , Stewart Chipman , David Leung , Jack Singer
IPC分类号： C07K14/00 , A61K38/16 , A61K38/14
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/409 , Y02A50/473
摘要： Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.
摘要翻译：公开了生物活性蛋白质缀合物，其包含通过肽键与多肽偶联的生物活性多肽，所述多肽包含2至约500个单位的重复肽基序，其中所述生物活性蛋白质缀合物与内在的未缀合的生物活性多肽或蛋白质的半衰期。还公开了制备和使用共轭蛋白的方法，以及用于确定给定缀合物相对于未缀合多肽的固有半衰期显示修饰的半衰期的方法。

5. 外观设计

USD652821S1 Headphone 有权
公开(公告)号：USD652821S1
公开(公告)日：2012-01-24
申请号：US29382413
申请日：2011-01-03
申请人： Noel Lee , Jacky Hsiung , David Leung , Einstein Galang
设计人： Noel Lee , Jacky Hsiung , David Leung , Einstein Galang

6. 发明申请

US20090298762A1 CONJUGATES OF BIOLOGICALLY ACTIVE PROTEINS HAVING A MODIFIED IN VIVO HALF-LIFE 有权
标题翻译：生物活性蛋白质与血液中的生物活性蛋白的结合
公开(公告)号：US20090298762A1
公开(公告)日：2009-12-03
申请号：US12251324
申请日：2008-10-14
申请人： Marc Besman , Stewart Chipman , David Leung , Jack Singer
发明人： Marc Besman , Stewart Chipman , David Leung , Jack Singer
IPC分类号： A61K38/16 , C07K14/745 , C07K14/61 , C07K14/54 , C07K14/52 , C07K16/18 , C07K14/00 , C07K7/08 , C07K7/06 , C07K7/00 , C07K5/00 , C12N9/50 , C12N9/00 , C07K14/555 , C07K14/575 , A61K38/10 , A61K38/08 , A61K38/07 , A61K38/06 , A61K38/05 , C07H21/00 , C12N15/74 , C12N5/06 , C12N1/21 , C12N1/16 , C12P21/02 , G01N33/48 , A61P43/00
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/409 , Y02A50/473
摘要： Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.
摘要翻译：公开了生物活性蛋白质缀合物，其包含通过肽键与多肽偶联的生物活性多肽，所述多肽包含2至约500个单位的重复肽基序，其中所述生物活性蛋白质缀合物与内在的未缀合的生物活性多肽或蛋白质的半衰期。还公开了制备和使用共轭蛋白的方法，以及用于确定给定缀合物相对于未缀合多肽的固有半衰期显示修饰的半衰期的方法。

7. 发明授权

US6111397A Temperature-compensated reference voltage generator and method therefor 失效
标题翻译：温度补偿参考电压发生器及其方法
公开(公告)号：US6111397A
公开(公告)日：2000-08-29
申请号：US120622
申请日：1998-07-22
申请人： David Leung
发明人： David Leung
IPC分类号： G05F3/24 , G05F3/26 , G05F3/16
CPC分类号： G05F3/245 , G05F3/262 , Y10S323/907
摘要： A reference voltage generator for producing a regulated, temperature-compensated output voltage from an unregulated power supply voltage is provided herein. The reference voltage generator includes a pre-regulating circuit and a temperature-compensating circuit. The temperature compensating circuit includes a first series path comprising a first cascode current sources and a first resistor; a second series path comprising a second cascode current source, a first field effect transistor and a first diode; and a third series path comprising a third cascode current source, a second field effect transistor, a second resistor and a second diode. The first series path being connected to the second series path between the first field resistor and the first diode. The current produced by the first current source, develops a voltage across the first resistor, which varies at least as a function of the ratio of the first and second resistors, the ratio of the diode junction areas, the dimensions of the first and second field effect transistors, and the first diode thermal voltage which has a positive temperature coefficient. The voltage across the first diode has a negative temperature coefficient. The output voltage taken across both the first resistor and first diode can be made substantially temperature invariant if the resistor ratio is selected such that it amplifies the temperature coefficient of the thermal voltage so that it is substantially equal and opposite to the temperature coefficient of the first diode voltage.
摘要翻译：本文提供了一种用于从未调节的电源电压产生调节温度补偿的输出电压的参考电压发生器。参考电压发生器包括预调节电路和温度补偿电路。温度补偿电路包括第一串联路径，其包括第一共源共栅电流源和第一电阻器; 第二串联路径，包括第二共源共栅电流源，第一场效应晶体管和第一二极管; 以及包括第三共源共栅电流源，第二场效应晶体管，第二电阻和第二二极管的第三串联路径。第一串联路径连接到第一场电阻器和第一二极管之间的第二串联路径。由第一电流源产生的电流产生跨越第一电阻器的电压，其至少与第一和第二电阻器的比率，二极管接合面积的比率，第一和第二场域的尺寸，效应晶体管，以及具有正温度系数的第一二极管热电压。第一二极管两端的电压具有负温度系数。如果选择电阻比使得其放大热电压的温度系数使得其基本上等于并与第一电阻和第一二极管的温度系数相反，则可以使第一电阻器和第一二极管两端的输出电压基本上是温度不变的二极管电压。

8. 发明申请

US20140051279A1 Posable Strain Relief for a Cable 有权
标题翻译：电缆应力消除
公开(公告)号：US20140051279A1
公开(公告)日：2014-02-20
申请号：US13587860
申请日：2012-08-16
申请人： Noel Lee , Kendrew Lee , Jacky Hsiung , David Leung
发明人： Noel Lee , Kendrew Lee , Jacky Hsiung , David Leung
IPC分类号： H01R13/56
CPC分类号： H01R13/562 , H01R13/567 , H01R13/5833 , H01R13/5841
摘要： A possible strain relief for use with a cable which can he bent into a particular shape by the user, and which retains that shape, thus allowing modification to suit a specific environment or use.
摘要翻译：用于电缆的可能的应变消除，其可以由使用者弯曲成特定形状，并且保持该形状，从而允许修改以适应特定环境或使用。

9. 发明授权

US08129348B2 Conjugates of biologically active proteins having a modified in vivo half-life 有权
标题翻译：具有改变的体内半衰期的生物活性蛋白质的缀合物
公开(公告)号：US08129348B2
公开(公告)日：2012-03-06
申请号：US12251324
申请日：2008-10-14
申请人： Marc Besman , Stewart Chipman , David Leung , Jack Singer
发明人： Marc Besman , Stewart Chipman , David Leung , Jack Singer
IPC分类号： A61K38/16 , A61K38/14 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/409 , Y02A50/473
摘要： Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.
摘要翻译：公开了生物活性蛋白质缀合物，其包含通过肽键与多肽偶联的生物活性多肽，所述多肽包含2至约500个单位的重复肽基序，其中所述生物活性蛋白质缀合物与内在的未缀合的生物活性多肽或蛋白质的半衰期。还公开了制备和使用共轭蛋白的方法，以及用于确定给定缀合物相对于未缀合多肽的固有半衰期显示修饰的半衰期的方法。

10. 发明授权

US07280999B2 Network address server 有权
标题翻译：网络地址服务器
公开(公告)号：US07280999B2
公开(公告)日：2007-10-09
申请号：US10155225
申请日：2002-05-28
申请人： Edmon Chung , David Leung
发明人： Edmon Chung , David Leung
IPC分类号： G06F17/30 , G06F7/00 , G06F12/00
CPC分类号： H04L29/12132 , H04L29/12594 , H04L61/1552 , H04L61/3035 , Y10S707/99932
摘要： A network address server is configured to resolve a target network address name label with a network address, with the target address name label defining a branch of one level of a multi-level network address name space. The network address server is one of a plurality of network address servers each being uniquely associated with a respective region of the address name space level. The network server includes an address name database, and an address name processor in communication with the address name database for providing a response to a query for the network address corresponding to the target address name label. The address name database includes a number of database records, each identifying a unique address name label and a network address uniquely associated with the address name label. The address name processor includes a correlation processor, a correlation transceiver in communication with the correlation processor, and a response processor in communication with the correlation processor and the correlation transceiver. The correlation processor is configured to determine a correlation between the target address name label and the respective unique address name region. The correlation transceiver is configured to provide the other network address servers with a respective indication of the determined correlation and for receiving a corresponding correlation indication from at least one of the other network address servers. The response processor is configured to provide a response to the query in accordance with the correlation indications.
摘要翻译：网络地址服务器被配置为使用网络地址来解析目标网络地址名称标签，目标地址名称标签定义多级网络地址名称空间的一级分支。网络地址服务器是多个网络地址服务器之一，每个网络地址服务器与地址名称空间级别的相应区域唯一地相关联。网络服务器包括地址名称数据库和与地址名称数据库通信的地址名称处理器，用于向对应于目标地址名称标签的网络地址的查询提供响应。地址名称数据库包括多个数据库记录，每个数据库记录标识唯一地址名称标签和与地址名称标签唯一相关联的网络地址。地址名称处理器包括相关处理器，与相关处理器通信的相关收发器以及与相关处理器和相关收发器通信的响应处理器。相关处理器被配置为确定目标地址名称标签和相应的唯一地址名称区域之间的相关性。相关收发器被配置为向其他网络地址服务器提供所确定的相关性的相应指示，并且用于从至少一个其他网络地址服务器接收相应的相关指示。响应处理器被配置为根据相关指示向查询提供响应。

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