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1. 发明申请

WO2010126163A1 HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE 审中-公开
标题翻译：异丁基二甲基吡啶衍生物
公开(公告)号：WO2010126163A1
公开(公告)日：2010-11-04
申请号：PCT/JP2010/057847
申请日：2010-04-27
申请人： BANYU PHARMACEUTICAL CO.,LTD. , KAMEDA, Minoru , KOBAYASHI, Kensuke , NAKAMA, Chisato , ANDO, Makoto , SATO, Nagaaki
发明人： KAMEDA, Minoru , KOBAYASHI, Kensuke , NAKAMA, Chisato , ANDO, Makoto , SATO, Nagaaki
IPC分类号： C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/541 , A61P3/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/02 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D413/14 , C07D417/14 , C07D451/04
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D451/04
摘要： The present invention relates to a compound represented by a formula (I): wherein X is a group represented by or the like; Y is a group represented by or the like; and Ar 1 is a group represented by or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由式（I）表示的化合物：其中X是由等表示的基团; Y是由等表示的基团; 和Ar 1是由其表示的基团或其药学上可接受的盐。

2. 发明申请

WO2004031175A2 N-SUBSTITUTE-2-OXODIHYDROPYRIDINE DERIVATES 审中-公开
标题翻译： N-取代-2-氧代二氢吡啶衍生物
公开(公告)号：WO2004031175A2
公开(公告)日：2004-04-15
申请号：PCT/JP2003/012290
申请日：2003-09-25
申请人： BANYU PHARMACEUTICAL CO., LTD. , SATO, Nagaaki , ANDO, Makoto , ISHIKAWA, Shiho , NAGASE, Tsuyoshi , NAGAI, Keita , KANATANI, Akio
发明人： SATO, Nagaaki , ANDO, Makoto , ISHIKAWA, Shiho , NAGASE, Tsuyoshi , NAGAI, Keita , KANATANI, Akio
IPC分类号： C07D401/14
CPC分类号： C07D213/80 , C07D401/04 , C07D401/14
摘要： A compound of the formula (I): (wherein Ar 1l and Ar 2 are independently aryl or heteroaryl, any of which is optionally substituted by a substituent selected from the group consisting of cyano, halogen, nitro, lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, cyclo-lower alkyl, cyclo(lower alkyl) -lower alkyl, lower alkenyl, lower alkylamino, di-lower alkylamino, lower alkanoylamino, lower alkylsulfonylamino, arylsulfonylamino, hydroxy, lower alkoxy, halo-lower alkoxy, aryloxy, heteroaryloxy, lower alkylthio, carboxyl, formyl, lower alkanoyl, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, di-lower alkylcarbamoyl, lower alkylsulfonyl, arylsulfonyl, aryl and heteroaryl; R 1 and R 2 are independently lower alkyl, cyclo-lower alkyl, cyclo(lower alkyl)-lower alkyl or lower alkoxy, any of which is optionally substituted by a substituent selected from the group consisting of halogen, lower alkylamino, di-lower alkylamino, lower alkanoylamino, hydroxy, lower alkoxy, f ormyl, lower alkoxycarbonyl, lower alkylcarbamoyl and di-lower alkylcarbamoyl; R 1 , R 4 and R 5 are independently hydrogen, cyano, halogen hydroxy, or lower alkyl, lower alkoxy or lower alkylthio, the last three groups being optionally substituted by a substituent selected from the group consisting of halogen, lower alkylamino, di -lower alkylamino, lower alkanoylamino, hydroxy, lower alkoxy, formyl, lower alkoxycarbonyl, lower alkylcarbamoyl and di-lower alkylcarbamoyl), or a salt or ester thereof is useful as a neuropeptide Y receptor antagonist agent and is also useful as an agent for the treatment of bulimia, obesity or diabetes.
摘要翻译：式（I）的化合物：其中Ar 11和Ar 2独立地为芳基或杂芳基，其中任何一个任选被选自氰基，卤素，硝基，低级烷基，卤代低级烷基，羟基 - 低级烷基，环 - 低级烷基，环（低级烷基） - 低级烷基，低级烯基，低级烷基氨基，二低级烷基氨基，低级烷酰基氨基，低级烷基磺酰基氨基，芳基磺酰基氨基，羟基，低级烷氧基，低级烷氧基，芳氧基，杂芳氧基，低级烷硫基，羧基，甲酰基，低级烷酰基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基，二低级烷基氨基甲酰基，低级烷基磺酰基，芳基磺酰基，芳基和杂芳基; R 1和R 2独立地为低级烷基，环 - 低级烷基，环（低级烷基） - 低级烷基或低级烷氧基，其中任何一个任选被选自卤素，低级烷基氨基，二低级烷基氨基，低级烷酰氨基，羟基，低级烷氧基，芳基，低级低级烷基氨基甲酰基和二低级烷基氨基甲酰基; R 1，R 4和R 5独立地是氢，氰基，卤素羟基或低级烷基，低级烷氧基或低级烷硫基，最后三个基团任选被选自以下的取代基取代：卤素低级烷基氨基，二低级烷基氨基，低级烷酰基氨基，羟基，低级烷氧基，甲酰基，低级烷氧基羰基，低级烷基氨基甲酰基和二低级烷基氨基甲酰基）或其盐或酯可用作神经肽Y受体拮抗剂，也可用作为治疗贪食症，肥胖症或糖尿病的药物。

3. 发明公开

EP2264026A1 ALKYLAMINOPYRIDINE DERIVATIVE 审中-公开
标题翻译：烷基氨基吡啶衍生物
公开(公告)号：EP2264026A1
公开(公告)日：2010-12-22
申请号：EP09718266.1
申请日：2009-03-04
申请人： Banyu Pharmaceutical Co., Ltd.
发明人： ANDO, Makoto , ITO, Hirokatsu , KAMEDA, Minoru , KAWAMOTO, Hiroshi , KOBAYASHI, Kensuke , MIYAZOE, Hiroshi , NAKAMA, Chisato , SATO, Nagaaki , TSUJINO, ToshiakI
IPC分类号： C07D401/14 , A61K31/4545 , A61K31/46 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61P3/04 , A61P3/10 , A61P43/00 , C07D413/14 , C07D417/14 , C07D451/02 , C07D498/08
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D498/08
摘要： The present invention relates to a compound that is useful for treatment of, for example, hypertension, arteriosclerosis, bulimia and obesity because of having an antagonistic action to a neuropeptide Y receptor and is represented by formula (I)

[wherein R 1 represents hydrogen, cyano, or the like;
R represents a group represented by formula (II);

X 1 represents C 1-4 lower alkylene or the like; X 2 represents lower alkylene or the like; and Het represents a 5-membered heteroaromatic ring that has at least one nitrogen atom and, in addition, one or two hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms]
or to a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由于具有对神经肽Y受体的拮抗作用而用于治疗例如高血压，动脉硬化，贪食症和肥胖症的化合物，并由式（I）表示[其中R 1表示氢，氰基或类似的; R表示由式（II）表示的基团; X1代表C1-4低级亚烷基等; X2代表低级亚烷基等; 并且Het表示具有至少一个氮原子并且另外具有一个或两个选自氮，硫和氧原子的杂原子的5-元杂芳环]或其药学上可接受的盐。

4. 发明公开

EP2072519A1 DIARYL KETIMINE DERIVATIVE 审中-公开
公开(公告)号：EP2072519A1
公开(公告)日：2009-06-24
申请号：EP07828506.1
申请日：2007-09-27
申请人： BANYU PHARMACEUTICAL CO., LTD.
发明人： SUZUKI, Takao , ANDO, Makoto , MIYAZOE, Hiroshi , KAMEDA, Minoru , SEKINO, Etsuko , MORIYA, Minoru
IPC分类号： C07D491/20 , A61K31/438 , A61K31/444 , A61K31/497 , A61K31/506 , A61P1/00 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/06 , A61P15/10 , A61P17/00 , A61P19/06
CPC分类号： C07D491/20
摘要： Provided is a compound of a formula (I):

[wherein R 1a and R 1b are the same or different, representing a hydrogen atom, etc.; R 2a and R 2b are the same or different, representing a hydrogen atom, etc., or R 2a and R 2b , taken together, form -CH 2 CH 2 -, R 3a and R 3b are the same or different, representing a hydrogen atom, etc.; or R 3a and R 3b , taken together, form - CH 2 CH 2 -etc.; Y 1 and Y 2 represent -C(R) 2 -, etc.; Z represents OR, NR 2 , etc.; R represents a hydrogen atom, a C 1-6 alkyl group, etc.; Ar 1 represents a 6-membered aromatic carbocyclic group, etc.; Ar 2 represents a 6-membered aromatic carbocyclic group, etc; A 3 represents a 6-membered aromatic carbocyclic group etc.]. The compound is useful as a medicine for central disorders, cardiovascular disorders, metabolic disorders.
摘要翻译：提供了式（I）的化合物：[其中R1a和R1b相同或不同，代表氢原子等; R 2a和R 2b相同或不同，代表氢原子等，或者R 2a和R 2b一起形成-CH 2 CH 2 - ，R 3a和R 3b相同或不同，代表氢原子等。或者R3a和R3b一起形成-CH2CH2-等; Y1和Y2表示-C（R）2 - 等; Z代表OR，NR2等; R表示氢原子，C1-6烷基等; Ar1表示6元芳族碳环基等; Ar2表示6元芳族碳环基团等; A3表示6元芳族碳环基团等]。该化合物可用作中枢疾病，心血管疾病，代谢疾病的药物。

5. 发明公开

EP1916239A1 PYRIDONE COMPOUND 审中-公开
标题翻译：吡啶酮化合物
公开(公告)号：EP1916239A1
公开(公告)日：2008-04-30
申请号：EP06782591.9
申请日：2006-08-03
申请人： BANYU PHARMACEUTICAL CO., LTD.
发明人： ANDO, Makoto , SEKINO, Etsuko , HAGA, Yuji , OTAKE, Norikazu , MORIYA, Minoru
IPC分类号： C07D213/64 , A61P1/16
CPC分类号： C07D213/69 , C07D213/64 , C07D213/89 , C07D239/52 , C07D401/10 , C07D401/14 , C07D405/10 , C07D487/08
摘要： An active ingredient is a compound represented by the general formula [I]:

[wherein R 1 and R 2 represent a lower alkyl group, a C 3-6 cycloalkyl group or the like, X 1 and X 2 represent methine, an Ar-Y 1 -Y 2 -Y 3 -substituted methine or the like, however either of them is an Ar-Y 1 -Y 2 -Y 3 -substituted methine, X 3 to X 8 represent methine, -N- or the like, Y 1 and Y 3 represent a single bond, -O- or the like, Y 2 represent a single bond, a lower alkylene group or the like, W represent -(O)-(CH 2 )n-(O)- or the like, n represents an integer of 1 to 4, L and Z 2 represent a single bond or a methylene group, Z 1 represents a single bond, a C 1-4 alkylene group or the like, and Ar represents an aromatic carbocyclic group or the like]. The compound acts as a melanin-concentrating hormone receptor antagonist and useful as a therapeutic agent for obesity or the like.
摘要翻译：活性成分是由通式[I]表示的化合物：[其中R1和R2代表低级烷基，C3-6环烷基等，X1和X2代表次甲基，Ar-Y1-Y2-Y3 取代的次甲基等，然而它们中的任一个都是Ar-Y1-Y2-Y3-取代的次甲基，X3至X8代表次甲基，N-等，Y1和Y3代表单键，-O-或 Y 2表示单键，低级亚烷基等，W表示 - （O） - （CH 2）n - （O） - 等，n表示1至4的整数，L和Z 2表示单键或亚甲基，Z 1表示单键，C 1-4亚烷基等，Ar表示芳香族碳环基等]。该化合物作为黑色素浓缩激素受体拮抗剂发挥作用，可用作肥胖症等的治疗剂。

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