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1. 发明授权

US07225029B2 Implantable cardiac therapy device with dual chamber can to isolate high-frequency circuitry 失效
标题翻译：具有双室的植入式心脏治疗装置可以隔离高频电路
公开(公告)号：US07225029B2
公开(公告)日：2007-05-29
申请号：US10039743
申请日：2001-10-26
申请人： Balakrishnan Shankar , Matthew Whitlock , Mark W. Kroll
发明人： Balakrishnan Shankar , Matthew Whitlock , Mark W. Kroll
IPC分类号： A61N1/375
CPC分类号： A61N1/37211 , A61N1/3718 , A61N1/37282 , A61N1/375 , Y10S128/903
摘要： An implantable cardiac therapy device is constructed with a housing that defines first and second chambers. The first chamber holds cardiac therapy circuitry, such as sensing and/or stimulation circuitry. The second chamber holds high-frequency circuitry that transmits and receives high-frequency signals used in communication with external devices. The dual-chamber housing allows the implantable cardiac therapy device to handle high-frequency signals in an isolated environment, thereby enabling longer range telemetry, without interfering with the cardiac therapy circuitry. The implantable cardiac therapy device can be linked to a cardiac network of knowledge workers that evaluate the data generated by the device and provide instructions to remotely program the device.
摘要翻译：可植入心脏治疗装置构造有限定第一和第二腔室的壳体。第一个房间容纳心脏治疗电路，例如感测和/或刺激电路。第二室保持高频电路，发送和接收与外部设备通信使用的高频信号。双室壳体允许可植入心脏治疗装置在隔离环境中处理高频信号，从而实现更长距离的遥测，而不干扰心脏治疗电路。可植入心脏治疗装置可以连接到知识工作者的心脏网络，其评估由装置产生的数据并提供远程编程装置的指令。

2. 发明授权

US06442428B1 Implantable cardiac stimulation device having a programmable reconfigurable sequencer 失效
公开(公告)号：US06442428B1
公开(公告)日：2002-08-27
申请号：US09805671
申请日：2001-03-13
申请人： Balakrishnan Shankar , Kenneth R. McNeil, II
发明人： Balakrishnan Shankar , Kenneth R. McNeil, II
IPC分类号： A61N136
CPC分类号： A61N1/37229 , A61N1/025 , A61N1/362
摘要： A pacemaker or implantable cardioverter defibrillator is provided with a microcontroller having a general purpose microprocessor for performing high-level device functions and a sequencer for performing routine pacing functions. The general purpose microprocessor is programmed using an instruction set capable of general programming applications. The sequencer is programmed using a very simple instruction set having instructions selected only for performing routine pacing functions. The sequencer may be, for example, a programmable state machine. By providing a programmable sequencer for controlling routine pacing operations, the microprocessor is thereby free to devote its resources to performing high-level functions. Hence, the microprocessor may be operated at a lower clock frequency than would otherwise be needed if the microprocessor were also required to perform routine pacing functions and power savings are thereby achieved. By controlling all routine pacing operations using the programmable sequencer, the routine operations are thereby more expediently and reliably performed. Also, because software for the sequencer is developed using only the simple instruction set associated therewith, pacing software is quickly and reliably developed. Additional benefits are gained by isolating the pacing software from the high-level functional software to permit, for example, the microprocessor software to be replaced without affecting the sequencer software, and vice versa. Also, a method is described for generating an integrated circuit having a configuration optimized based upon predetermined software requirements. The method may be used to design the sequencer.

3. 发明授权

US06430440B1 Magnetoresistive-based position sensor for use in an implantable electrical device 失效
标题翻译：用于可植入电气设备的基于磁阻的位置传感器
公开(公告)号：US06430440B1
公开(公告)日：2002-08-06
申请号：US09457194
申请日：1999-12-08
申请人： Kenneth R. McNeil, II , Balakrishnan Shankar , Alan B. Vogel , Scott Gibson
发明人： Kenneth R. McNeil, II , Balakrishnan Shankar , Alan B. Vogel , Scott Gibson
IPC分类号： A61N118
CPC分类号： A61N1/36542 , A61B5/11
摘要： An implantable cardiac stimulation device including an activity/position sensor that incorporates a magnetoresistive sensor and a magnet that are positioned so as to move relative to each other in response to activity and the body position of the patient when the device is implanted in the body of the patient. In one embodiment, the sensor includes a magnetoresistive sensor that is made from giant magnetoresistive (GMR) materials. Preferably, a magnet is positioned on a flexible cantilevered beam so as to be positioned adjacent the magnetoresistive sensor. Movement of the patient results in relative movement of the magnet with respect to the magnetoresistive sensor and generates a signal having an AC component corresponding to a patient's activity and a DC component corresponding to the patient's body position. The signal can be used by the implantable cardiac stimulation device's processor for adjusting the delivery of therapeutic electrical stimulation such as by adjusting the pacing rate of pacing pulses being delivered to the patient's heart.
摘要翻译：一种植入式心脏刺激装置，包括活动/位置传感器，其包括磁阻传感器和磁体，所述活动/位置传感器被定位成响应于患者的活动和身体位置而相对于彼此移动，当该装置被植入体内时患者。在一个实施例中，传感器包括由巨磁阻（GMR）材料制成的磁阻传感器。优选地，磁体定位在柔性悬臂梁上，以便邻近磁阻传感器定位。患者的移动导致磁体相对于磁阻传感器的相对移动，并且产生具有对应于患者活动的AC分量的信号和对应于患者身体位置的DC分量。该信号可被可植入心脏刺激装置的处理器用于调节治疗性电刺激的递送，例如通过调节递送至患者心脏的起搏脉冲的起搏速率。

4. 发明授权

US07031773B1 Implantable cardiac stimulation system providing autocapture and lead impedance assessment and method 失效
标题翻译：可植入式心脏刺激系统，提供自体电位和引线阻抗评估及方法
公开(公告)号：US07031773B1
公开(公告)日：2006-04-18
申请号：US10340099
申请日：2003-01-10
申请人： Paul A. Levine , Balakrishnan Shankar , Kenneth R. McNeil, II , Joseph J. Florio
发明人： Paul A. Levine , Balakrishnan Shankar , Kenneth R. McNeil, II , Joseph J. Florio
IPC分类号： A61N1/362
CPC分类号： A61N1/3686 , A61N1/3712
摘要： An implantable cardiac stimulation system provides autocapture assessment and lead impedance surveillance. The system includes a pulse generator that provides pacing stimulation pulses and a lead system including a plurality of electrodes that provide a plurality of different electrode configurations. The system further includes a switch that selectively couples the pulse generator to any one of the plurality of pacing electrode configurations and an autocapture circuit that performs autocapture tests with the pulse generator. The autocapture circuit includes a capture detector that detects evoked responses with an evoked response electrode configuration. When there is a failure to detect an evoked response, an impedance measuring circuit measures the lead impedance of the evoked response electrode configuration. If the measured lead impedance is outside of a given range, the switch couples the pulse generator to an electrode configuration other than the evoked response electrode configuration. Thereafter, the autocapture circuit performs a further autocapture and impedance measuring test or sets the pacing output to a level which assures capture.
摘要翻译：可植入心脏刺激系统提供自体电位评估和引线阻抗监测。该系统包括提供起搏刺激脉冲的脉冲发生器和包括提供多个不同电极配置的多个电极的引导系统。所述系统还包括将所述脉冲发生器选择性地耦合到所述多个起搏电极配置中的任一个的开关和使用所述脉冲发生器进行自动俘获测试的自动俘获电路。自动俘获电路包括捕获检测器，其通过诱发的响应电极配置来检测诱发的反应。当无法检测到诱发反应时，阻抗测量电路测量诱发响应电极配置的引线阻抗。如果测量的引线阻抗在给定范围之外，则开关将脉冲发生器耦合到除了诱发响应电极配置之外的电极配置。此后，自动捕获电路进一步进行自动捕获和阻抗测量测试，或将起搏输出设置为确保捕获的水平。

5. 发明申请

US20050222631A1 Hierarchical data storage and analysis system for implantable medical devices 审中-公开
标题翻译：可植入医疗器械的分层数据存储和分析系统
公开(公告)号：US20050222631A1
公开(公告)日：2005-10-06
申请号：US10819400
申请日：2004-04-06
申请人： Nirav Dalal , Balakrishnan Shankar
发明人： Nirav Dalal , Balakrishnan Shankar
IPC分类号： A61B5/00 , A61N1/372 , A61N1/37
CPC分类号： A61N1/37282 , A61N1/37252 , G06F19/3418
摘要： A hierarchical data storage and analysis system for implantable medical devices is described. In an implementation, a method includes analyzing data collected by an implantable medical device (IMD) by utilizing a set of analytical capabilities. A determination is made, from the analyzing, whether to communicate the data to a computing device having additional analytical capabilities and storage space that are not available at the IMD.
摘要翻译：描述了用于可植入医疗装置的分级数据存储和分析系统。在实现中，一种方法包括通过利用一组分析能力来分析由可植入医疗装置（IMD）收集的数据。从分析中确定是否将数据传送到具有额外分析能力的计算设备和在IMD上不可用的存储空间。

6. 发明授权

US06625488B2 Implantable cardiac stimulation device having a programmable reconfigurable sequencer 失效
公开(公告)号：US06625488B2
公开(公告)日：2003-09-23
申请号：US09805666
申请日：2001-03-13
申请人： John W. Poore , Balakrishnan Shankar , Kenneth R. McNeil, II
发明人： John W. Poore , Balakrishnan Shankar , Kenneth R. McNeil, II
IPC分类号： A61N1362
CPC分类号： A61N1/37229 , A61N1/025 , A61N1/372
摘要： A pacemaker or implantable cardioverter defibrillator is provided with a microcontroller having a general purpose microprocessor for performing high-level device functions and a sequencer for performing routine pacing functions. The general purpose microprocessor is programmed using an instruction set capable of general programming applications. The sequencer is programmed using a very simple instruction set having instructions selected only for performing routine pacing functions. The sequencer may be, for example, a programmable state machine. By providing a programmable sequencer for controlling routine pacing operations, the microprocessor is thereby free to devote its resources to performing high-level functions. Hence, the microprocessor may be operated at a lower clock frequency than would otherwise be needed if the microprocessor were also required to perform routine pacing functions and power savings are thereby achieved. By controlling all routine pacing operations using the programmable sequencer, the routine operations are thereby more expediently and reliably performed. Also, because software for the sequencer is developed using only the simple instruction set associated therewith, pacing software is quickly and reliably developed. Additional benefits are gained by isolating the pacing software from the high-level functional software to permit, for example, the microprocessor software to be replaced without affecting the sequencer software, and vice versa. Also, a method is described for generating an integrated circuit having a configuration optimized based upon predetermined software requirements. The method may be used to design the sequencer.

7. 发明授权

US5370669A Implantable cardiac defibrillator with layered package 失效
标题翻译：植入式心脏除颤器，分层包装
公开(公告)号：US5370669A
公开(公告)日：1994-12-06
申请号：US154211
申请日：1993-11-17
申请人： Terry D. Daglow , Kenneth R. McNeil, II , Balakrishnan Shankar
发明人： Terry D. Daglow , Kenneth R. McNeil, II , Balakrishnan Shankar
IPC分类号： A61N1/39 , H01M2/10 , H01M10/42 , A61N1/375
CPC分类号： A61N1/3956 , H01M10/4264 , H01M2/1066
摘要： An implantable medical device, and more particularly a fully implantable defibrillator which may also include bradycardia and cardioversion pacing, in which the components of the device are housed within an implantable casing having three orthogonal dimensions of height, width and thickness. The height and width are substantially greater than the thickness. The implantable device comprises three major sub-systems, specifically, the batteries, the power capacitors, and the electronics. Each of the three sub-systems lie in parallel height-width planes, each plane being adjacent another in the thickness dimension.
摘要翻译：更具体地，可植入式除颤器，其还可以包括心动过缓和心脏复律起搏，其中装置的部件容纳在具有三个正交尺寸的高度，宽度和厚度的可植入壳体内。高度和宽度明显大于厚度。该可植入装置包括三个主要子系统，特别是电池，功率电容器和电子装置。三个子系统中的每一个都位于平行的高度 - 高度平面中，每个平面在厚度尺寸上相邻。

8. 发明授权

US06963779B1 System for the selective activation of functions in an implantable device by a magnetic field 有权
标题翻译：用于通过磁场选择性地激活可植入装置中的功能的系统
公开(公告)号：US06963779B1
公开(公告)日：2005-11-08
申请号：US10157573
申请日：2002-05-28
申请人： Balakrishnan Shankar
发明人： Balakrishnan Shankar
IPC分类号： A61N1/37 , A61N1/372
CPC分类号： A61N1/37217
摘要： An implantable medical device that includes a magnetic sensor circuit that senses the presence of an external magnetic field and provides a signal that is proportionate to the strength of the magnetic field. The implantable medical device uses the variable signal to determine whether a magnetic field is being applied that is selected to activate a preselected function. In one implementation, the preselected function is a power up sequence.
摘要翻译：一种可植入医疗装置，其包括检测外部磁场的存在并提供与磁场强度成比例的信号的磁传感器电路。可植入医疗装置使用可变信号来确定是否施加被选择以激活预选功能的磁场。在一个实现中，预选功能是上电序列。

9. 发明授权

US06411849B1 Implatable electrical device incorporating a magnetoresistive-based motion sensor 失效
标题翻译：包含基于磁阻的运动传感器的可插入电气装置
公开(公告)号：US06411849B1
公开(公告)日：2002-06-25
申请号：US09457279
申请日：1999-12-08
申请人： Balakrishnan Shankar , Kenneth R. McNeil, II , Alan B. Vogel , Scott Gibson
发明人： Balakrishnan Shankar , Kenneth R. McNeil, II , Alan B. Vogel , Scott Gibson
IPC分类号： A61N118
CPC分类号： A61N1/36542
摘要： An implantable cardiac device including an activity sensor that incorporates a magnetoresistive sensor and a magnet that are positioned so as to move relative to each other in response to activity of the patient when the device is implanted in the body of the patient. In one embodiment, the sensor includes a magnetoresistive sensor that is made from giant magnetoresistive (GMR) materials. In another embodiment, a magnet is positioned on a flexible cantilevered beam so as to be positioned adjacent the magnetoresistive sensor. Movement of the patient results in relative movement of the magnet with respect to the magnetoresistive sensor. The signal can be used by the implantable cardiac device's processor for adjusting the delivery of therapeutic electrical stimulation such as by adjusting the pacing rate of pacing pulses being delivered to the patient's heart.
摘要翻译：一种可植入心脏装置，其包括活动传感器，该活动传感器包括磁阻传感器和磁体，所述活动传感器定位成当所述装置植入患者体内时响应于患者的活动而相对于彼此移动。在一个实施例中，传感器包括由巨磁阻（GMR）材料制成的磁阻传感器。在另一个实施例中，磁体被定位在柔性悬臂梁上，以便被定位成邻近磁阻传感器。患者的运动导致磁体相对于磁阻传感器的相对运动。该信号可被可植入的心脏设备的处理器用于调节治疗性电刺激的递送，例如通过调节递送给患者心脏的起搏脉冲的起搏速率。

10. 发明授权

US5571141A Device and method for cardiac arrhythmia therapy with failure detection and backup 失效
标题翻译：心律失常治疗的故障检测和备份的装置和方法
公开(公告)号：US5571141A
公开(公告)日：1996-11-05
申请号：US316254
申请日：1994-09-30
申请人： Ken R. McNeil , Lee A. Cantrell , Balakrishnan Shankar
发明人： Ken R. McNeil , Lee A. Cantrell , Balakrishnan Shankar
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3931 , A61N1/3706
摘要： An implantable automatic cardioverter/defibrillator device for a cardiac patient has a primary control mode for a defibrillation therapy delivery system. The primary control mode is responsive to detection of fibrillation of the patient's heart for causing the delivery of a preselected electrical waveform therapy to the heart. The device also has a secondary control mode which is enabled by detecting a predetermined failure mechanism that causes malfunctioning of the primary mode. The enabled secondary control mode uses at least some of the functional part of the primary mode in responding to fibrillation of the patient's heart to initiate generation of defibrillation therapy for application to the patient's heart.
摘要翻译：用于心脏病患者的可植入式自动心脏复律器/除纤颤器装置具有用于除颤治疗递送系统的主要控制模式。主要控制模式响应于检测患者心脏的原纤维，以使预先选择的电波形治疗递送到心脏。该设备还具有辅助控制模式，其通过检测导致主要模式故障的预定故障机制来启用。启用的次级控制模式使用主要模式的功能部分中的至少一些来响应患者心脏的颤动，以开始产生除颤治疗以应用于患者的心脏。

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