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1. 发明申请

WO2012048171A9 VARIANT CBH I POLYPEPTIDES WITH REDUCED PRODUCT INHIBITION 审中-公开
标题翻译：具有减少产品抑制性能的多种CBH I多糖
公开(公告)号：WO2012048171A9
公开(公告)日：2012-08-30
申请号：PCT/US2011055181
申请日：2011-10-06
申请人： BP CORP NORTH AMERICA INC , STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBUHL PETER
发明人： STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBUHL PETER
IPC分类号： C12N9/42 , C07K14/47 , C12N9/00
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.
摘要翻译：本公开涉及具有降低的产物抑制的变体CBH I多肽，以及包含变体CBH I多肽的组合物，例如纤维素酶组合物。变体CBH I多肽和相关组合物可用于各种农业和工业应用。本公开还涉及编码变体CBH I多肽的核酸和重组表达变体CBH I多肽的宿主细胞。

2. 发明申请

WO2012048171A3 VARIANT CBH I POLYPEPTIDES WITH REDUCED PRODUCT INHIBITION 审中-公开
标题翻译：变体CBH I多肽与减少产品抑制作用
公开(公告)号：WO2012048171A3
公开(公告)日：2012-07-19
申请号：PCT/US2011055181
申请日：2011-10-06
申请人： BP CORP NORTH AMERICA INC , STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBUHL PETER
发明人： STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBUHL PETER
IPC分类号： C12N9/42 , C07K14/47 , C12N9/00
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.
摘要翻译：本公开涉及具有降低的产物抑制的变体CBH1多肽和包含变体CBH1多肽的组合物，例如纤维素酶组合物。变体CBH I多肽和相关组合物可以用于各种农业和工业应用。本公开还涉及编码变体CBH1多肽的核酸和重组表达变体CBH1多肽的宿主细胞。

3. 发明申请

WO2012051055A3 VARIANT CBH I POLYPEPTIDES 审中-公开
标题翻译：变种CBH多糖
公开(公告)号：WO2012051055A3
公开(公告)日：2012-06-28
申请号：PCT/US2011055180
申请日：2011-10-06
申请人： BP CORP NORTH AMERICA INC , STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBUHL PETER
发明人： STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBUHL PETER
IPC分类号： C12N9/42 , C07K14/47 , C12N9/00
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbh1) (e.g., an exo-cellobiohydrolase, e.g., having an "exo" activity that can processively release cellobiose units ß-1,4 glucose - glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a ß- xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.
摘要翻译：在替代实施方案中，本发明提供了具有木质纤维素分解（木质纤维素）活性的多肽，例如木质素分解和纤维素分解活性，包括例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶（cbh1）（例如外切纤维二糖水解酶例如具有可以逐步释放纤维二糖单位β-1,4葡萄糖 - 葡萄糖二糖的“外部”活性，β-葡糖苷酶，木聚糖酶，甘露聚糖，木糖苷酶（例如β-木糖苷酶）和/或阿拉伯呋喃糖苷酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个实施方案中，本发明提供本发明的多肽的耐热性和耐热性形式。本发明的多肽和核酸用于各种药物，农业和工业环境中; 例如，作为用于将生物质例如木质纤维素残基生物转化为可发酵糖的酶，其中在一方面，这些糖用作生产乙醇和燃料的化学原料，例如生物燃料，例如合成液体或气体燃料，包括乙醇，甲醇等。

4. 发明申请

WO2013082616A3 COMPOSITIONS AND METHODS FOR BIOMASS LIQUEFACTION 审中-公开
标题翻译：用于生物质液化的组合物和方法
公开(公告)号：WO2013082616A3
公开(公告)日：2014-01-16
申请号：PCT/US2012067637
申请日：2012-12-03
申请人： BP CORP NORTH AMERICA INC , GARRETT JAMES B , STEGE JUSTIN T , LAFFERTY WILLIAM M , SLOBAK ARNE I , HANSON SARAH RICHARDSON , POLAND JOHN
发明人： GARRETT JAMES B , STEGE JUSTIN T , LAFFERTY WILLIAM M , SLOBAK ARNE I , HANSON SARAH RICHARDSON , POLAND JOHN
IPC分类号： C12P19/14 , C13K1/02
CPC分类号： C12P19/14 , C12M27/02 , C12M27/20 , C12P19/02 , C12P2201/00 , C13K1/02 , C13K13/002
摘要： The present disclosure relates methods and compositions for pretreatment of biomass, for example to form a biomass slurry suitable for downstream processing (e.g., saccharification, fermentation, etc.). The present methods provide several advantages in industrial operations, such as better heat exchange, reduced power and water usage, and the ability to carry out reactions continuously due to the reduced requirement for cleaning reaction vessels.
摘要翻译：本公开涉及用于预处理生物质的方法和组合物，例如形成适于下游处理（例如糖化，发酵等）的生物质浆料。本方法在工业操作中提供了几个优点，例如更好的热交换，功率降低和使用水量，以及由于对清洁反应容器的要求减少而连续进行反应的能力。

5. 发明申请

WO2008095033A8 ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于治疗细胞凋亡的酶，编码其核酸的酶及其制备和使用它们的方法
公开(公告)号：WO2008095033A8
公开(公告)日：2009-09-03
申请号：PCT/US2008052517
申请日：2008-01-30
申请人： VERENIUM CORP , SYNGENTA PARTICIPATIONS AG , STEGE JUSTIN T , CHANG CATHY , ABOUSHADI NAHLA , DJORDJEVIC GORDANA , BURKE ELLEN , LUGINBUHL PETER , DYCAICO MARK , RICHARDSON TOBY , POLAND JOHN , HEFNER YING , MILES STACY MARIE
发明人： STEGE JUSTIN T , CHANG CATHY , ABOUSHADI NAHLA , DJORDJEVIC GORDANA , BURKE ELLEN , LUGINBUHL PETER , DYCAICO MARK , RICHARDSON TOBY , POLAND JOHN , HEFNER YING , MILES STACY MARIE
IPC分类号： C07K5/00 , A61K48/00 , C12N9/00
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/2445 , C12P7/04 , C12P19/02 , C12Y302/01021 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta- glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a ß- xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts; for example, the invention provides a multi-enzyme system that can hydrolyze polysaccharides in a bagasse component of sugarcane processed in sugar mills. The invention provides enzymes for the bioconversion of lignocellulosic residues into fermentable sugars; and these sugars can be used as a chemical feedstock for the production of ethanol and fuels, including biofuels such as bioethanol, biopropanol, biobutanol and biodiesels.
摘要翻译：本发明提供具有木质纤维素分解活性的多肽，例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖，木糖苷酶（例如β-木糖苷酶），阿拉伯呋喃糖苷酶和 /或葡萄糖氧化酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明提供了可以酶促加工（水解）甘蔗渣，即甘蔗渣降解或用于生物量加工的多肽，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。在一个实施方案中，本发明提供本发明的多肽的耐热性和耐热性形式。本发明的多肽可用于各种药物，农业和工业环境; 例如，本发明提供了一种可以在糖厂加工的甘蔗的蔗渣组分中水解多糖的多酶体系。本发明提供用于将木质纤维素残基生物转化成可发酵糖的酶; 并且这些糖可以用作生产乙醇和燃料的化学原料，包括生物燃料如生物乙醇，生物丙醇，生物丁醇和生物柴油。

6. 发明申请

WO2008095033A3 ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于治疗细胞凋亡的酶，编码其核酸的酶及其制备和使用它们的方法
公开(公告)号：WO2008095033A3
公开(公告)日：2008-09-18
申请号：PCT/US2008052517
申请日：2008-01-30
申请人： VERENIUM CORP , SYNGENTA PARTICIPATIONS AG , CHANG CATHY , STEGE JUSTIN T , ABOUSHADI NAHLA , DJORDJEVIC GORDANA , BURKE ELLEN , LUGINBUHL PETER , DYCAICO MARK , RICHARDSON TOBY , POLAND JOHN , HEFNER YING , MILES STACY MARIE
发明人： STEGE JUSTIN T , ABOUSHADI NAHLA , DJORDJEVIC GORDANA , BURKE ELLEN , LUGINBUHL PETER , DYCAICO MARK , RICHARDSON TOBY , POLAND JOHN , HEFNER YING , MILES STACY MARIE
IPC分类号： C07K5/00 , A61K48/00 , C12N9/00
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/2445 , C12P7/04 , C12P19/02 , C12Y302/01021 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta- glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a ß- xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts; for example, the invention provides a multi-enzyme system that can hydrolyze polysaccharides in a bagasse component of sugarcane processed in sugar mills. The invention provides enzymes for the bioconversion of lignocellulosic residues into fermentable sugars; and these sugars can be used as a chemical feedstock for the production of ethanol and fuels, including biofuels such as bioethanol, biopropanol, biobutanol and biodiesels.
摘要翻译：本发明提供具有木质纤维素分解活性的多肽，例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖，木糖苷酶（例如β-木糖苷酶），阿拉伯呋喃糖苷酶和 /或葡萄糖氧化酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明提供了可以酶促加工（水解）甘蔗渣，即甘蔗渣降解或用于生物量加工的多肽，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。在一个实施方案中，本发明提供本发明的多肽的耐热性和耐热性形式。本发明的多肽可用于各种药物，农业和工业环境; 例如，本发明提供了一种可以在糖厂加工的甘蔗的蔗渣组分中水解多糖的多酶体系。本发明提供用于将木质纤维素残基生物转化成可发酵糖的酶; 并且这些糖可以用作生产乙醇和燃料的化学原料，包括生物燃料如生物乙醇，生物丙醇，生物丁醇和生物柴油。

7. 发明专利

BR112013008347A2 polipeptídeos de variantes cbh i 未知
公开(公告)号：BR112013008347A2
公开(公告)日：2016-06-14
申请号：BR112013008347
申请日：2011-10-06
申请人： BP CORP NORTH AMERICA INC
发明人： VARVAK ALEXANDER , LYON CHRIS S , POLAND JOHN , STEGE JUSTIN T , LUGINBUHL PETER , HEALEY SHAUN
IPC分类号： C07K14/47 , C12N9/00 , C12N9/42

8. 发明专利

CA2811787A1 VARIANT CBH I POLYPEPTIDES 未知
公开(公告)号：CA2811787A1
公开(公告)日：2012-04-19
申请号：CA2811787
申请日：2011-10-06
申请人： BP CORP NORTH AMERICA INC
发明人： STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBUHL PETER
IPC分类号： C12N9/42 , C07K14/47 , C12N9/00
摘要： In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbh1) (e.g., an exo-cellobiohydrolase, e.g., having an "exo" activity that can processively release cellobiose units ß-1,4 glucose - glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a ß- xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.

9. 发明专利

CA2811789A1 VARIANT CBH I POLYPEPTIDES WITH REDUCED PRODUCT INHIBITION 未知
公开(公告)号：CA2811789A1
公开(公告)日：2012-04-12
申请号：CA2811789
申请日：2011-10-06
申请人： BP CORP NORTH AMERICA INC
发明人： STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBUHL PETER
IPC分类号： C07K14/435 , C07K14/47 , C12N9/00
摘要： The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.

10. 发明专利

AR083354A1 POLIPEPTIDOS VARIANTES CBH I (CELOBIOHIDROLASAS I) CON REDUCIDA INHIBICION DE PRODUCTO 未知
公开(公告)号：AR083354A1
公开(公告)日：2013-02-21
申请号：ARP110103718
申请日：2011-10-06
申请人： BP CORP NORTH AMERICA INC
发明人： STEGE JUSTIN T , VARVAK ALEXANDER , POLAND JOHN , LYON CHRIS S , HEALEY SHAUN , LUGINBHL PETER
IPC分类号： C07K14/415 , C12N1/19 , C12N1/21 , C12N15/29 , C12N15/63 , C12P7/06 , C12P19/00
摘要： Una composición que lo comprende, un método para producir etanol, el vector que lo comprende, una célula recombinante manipulada para expresar el ácido nucleico divulgado.Reivindicación 1: Un polipéptido que comprende un dominio catalítico de celobiohidrolasa I (“CBH I”) variante en comparación con un dominio catalítico CBH I de referencia, que comprende: (a) una sustitución en la posición del aminoácido correspondiente a R268 de T. reesei CBH I (“sustitución de R268”); (b) una sustitución en la posición del aminoácido correspondiente a R411 de T. reesei CBH I (“sustitución de R411”); o (c) tanto una sustitución de R268 como una sustitución de R411, en donde una o ambas de dichas sustituciones dan como resultado una inhibición reducida del producto en comparación con el dominio catalítico CBH I de referencia. Reivindicación 47: Un método para sacarificar la biomasa, que comprende: tratamiento de la biomasa con una composición de acuerdo con cualquiera de las reivindicaciones 37 a 43 o con un caldo de cultivo de acuerdo con cualquiera de las reivindicaciones 44 a 46. Reivindicación 55: Un ácido nucleico que comprende una secuencia de nucleótidos que codifica el polipéptido de acuerdo con cualquiera de las reivindicaciones 1 a 36. Reivindicación 74: Un método de producción de un polipéptido de acuerdo con cualquiera de las reivindicaciones 1 a 36, que comprende el cultivo de la célula recombinante manipulada por ingeniería para expresar dicho polipéptido en condiciones en las que se expresa el polipéptido.

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