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1. 发明申请

WO2010135418A2 IMPLANTABLE MEDICAL DEVICES FOR THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：用于治疗药物递送的可植入医疗装置
公开(公告)号：WO2010135418A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035391
申请日：2010-05-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEWE, Scott , WARNER, Robert, W. , IPPOLITI, J., Thomas , BECKFORD, Hollie
发明人： SCHEWE, Scott , WARNER, Robert, W. , IPPOLITI, J., Thomas , BECKFORD, Hollie
IPC分类号： A61L27/20 , A61L27/54 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/16
CPC分类号： A61L27/54 , A61L27/20 , A61L29/043 , A61L29/16 , A61L31/042 , A61L31/16 , A61L2300/416 , A61L2300/42 , C08L5/08 , C08L5/10
摘要： Various aspects of the invention relate to implantable medical devices, which comprise a layer of material (e.g., in the form of a sheet, tube, etc.) that comprises a bioerodible polymer and a therapeutic agent. Other aspects of the invention relate to methods of forming such devices. Still other aspects of the invention relate to methods of treatment using such devices.
摘要翻译：本发明的各个方面涉及可植入医疗装置，其包括包含生物可腐蚀聚合物和治疗剂的材料层（例如，片状，管状等）。本发明的其它方面涉及形成这种装置的方法。本发明的其它方面涉及使用这种装置的治疗方法。

2. 发明申请

WO2011019952A1 POLYMERS HAVING LIPOPHILIC HYDROCARBON AND BIODEGRADABLE POLYMERIC SEGMENTS 审中-公开
标题翻译：具有脂质烃和可生物降解聚合物部分的聚合物
公开(公告)号：WO2011019952A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045370
申请日：2010-08-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , IPPOLITI, J., Thomas , SPEROS, Joshua , SCHEWE, Scott , WARNER, Robert, W. , EVERSON, Dan
发明人： IPPOLITI, J., Thomas , SPEROS, Joshua , SCHEWE, Scott , WARNER, Robert, W. , EVERSON, Dan
IPC分类号： C08G63/08
CPC分类号： C08G63/08
摘要： The present invention pertains, among other things, to polymers having one or more lipophilic hydrocarbon segments and one or more biodegradable polymeric segments, to methods of making such polymers and to products formed using such polymers.
摘要翻译：本发明尤其涉及具有一个或多个亲油性烃链段和一个或多个可生物降解的聚合物链段的聚合物，制备这种聚合物的方法以及使用这种聚合物形成的产品。

3. 发明申请

WO2009158461A1 MEDICAL COPOLYMERS 审中-公开
标题翻译：医用共聚物
公开(公告)号：WO2009158461A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048597
申请日：2009-06-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , IPPOLITI, J. Thomas , SCHEWE, Scott , WARNER, Robert W. , ZOROMSKI, Michele
发明人： IPPOLITI, J. Thomas , SCHEWE, Scott , WARNER, Robert W. , ZOROMSKI, Michele
IPC分类号： A61L31/06 , A61L31/10 , C08G61/08
CPC分类号： C08G61/08 , A61L31/06 , A61L31/10 , C08G61/12 , C08G2261/147 , C08G2261/3324 , C08G2261/3342 , C08G2261/418
摘要： According to an aspect of the present invention, medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of –C=C– groups within the polymer backbone, (ii) a plurality of–R1– groups within the polymer backbone, wherein R1 comprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of –C=C– groups and a plurality of –R1– groups within the polymer backbone (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Further aspects of the invention, among others, relate to methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products.
摘要翻译：根据本发明的一个方面，提供了医用共聚物，其包含（a）聚合物骨架，其包含（i）聚合物主链内的多个-C = C-基团，（ii）多个R 1基团，聚合物主链，其中R 1包含自由基取代的C 2 -C 10环状或杂环基团，或（iii）聚合物主链（b）中的多个-C = C-基团和多个-R1-基团，多个沿着聚合物主链的烃基侧基包含长度为至少四个碳的饱和或不饱和碳链，以及（c）沿着聚合物主链的多个两性离子侧基，其包含带正电荷的季铵基团和带负电的磷酸基团。本发明的其它方面尤其涉及形成这种共聚物的方法，含有这种共聚物的医药产品，以及制备这种医药产品的方法。

4. 发明申请

WO2008088507A2 BLOOD-CONTACTING MEDICAL DEVICES FOR THE RELEASE OF NITRIC OXIDE AND ANTI-RESTENOTIC AGENTS 审中-公开
标题翻译：用于释放氮氧化物和抗病毒剂的血液接触医疗装置
公开(公告)号：WO2008088507A2
公开(公告)日：2008-07-24
申请号：PCT/US2007/025076
申请日：2007-12-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , IPPOLITI, Thomas, J. , SCHEWE, Scott , ZOROMSKI, Michele , WARNER, Robert, W. , ATANASOSKA, Liliana , WEBER, Jan
发明人： IPPOLITI, Thomas, J. , SCHEWE, Scott , ZOROMSKI, Michele , WARNER, Robert, W. , ATANASOSKA, Liliana , WEBER, Jan
IPC分类号： A61L27/44 , A61L27/54
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/45
摘要： According to an aspect of the present invention, implantable or insertable blood- contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区和一种或多种抗再狭窄剂。释放区域包含一种或多种聚合物组分。释放区域还任选地含有一种或多种无机组分。一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。

5. 发明申请

WO2006086672A1 INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER 审中-公开
标题翻译：用于与电力来源连接的治疗药物的内部医疗装置
公开(公告)号：WO2006086672A1
公开(公告)日：2006-08-17
申请号：PCT/US2006/004808
申请日：2006-02-10
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , HOLMAN, Thomas, J. , WEBER, Jan , WARNER, Robert , SCHEWE, Scott
发明人： ATANASOSKA, Liliana , HOLMAN, Thomas, J. , WEBER, Jan , WARNER, Robert , SCHEWE, Scott
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。

6. 发明申请

WO2007123627A1 MEDICAL BALLOONS 审中-公开
标题翻译：医用气球
公开(公告)号：WO2007123627A1
公开(公告)日：2007-11-01
申请号：PCT/US2007/007433
申请日：2007-03-26
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HORN, Daniel, J. , WEBER, Jan , BLIX, John , TOMASCHKO, Daniel, K. , SCHEWE, Scott , GUNDERSON, Richard, C. , VOLK, Angela, K. , CHEN, John, Jianhua
发明人： HORN, Daniel, J. , WEBER, Jan , BLIX, John , TOMASCHKO, Daniel, K. , SCHEWE, Scott , GUNDERSON, Richard, C. , VOLK, Angela, K. , CHEN, John, Jianhua
IPC分类号： A61M25/10 , A61M29/02 , A61L29/08 , A61L29/12
CPC分类号： A61M25/10 , A61L29/085 , A61L29/123 , A61L29/126 , A61M25/1029 , A61M25/1038 , A61M2025/1031 , A61M2025/1075 , A61M2025/1088
摘要： Described herein are medical balloons which contain one or more material regions that are configured to cause the balloons to preferentially fold into predetermined orientations upon deflation.
摘要翻译：这里描述的是包含一个或多个材料区域的医疗气囊，其被构造成使得气囊在放气时优先折叠成预定取向。

7. 发明申请

WO2012030895A2 HEMOSTATIC COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：嗜热组合物及其制备方法和使用方法
公开(公告)号：WO2012030895A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/049863
申请日：2011-08-31
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEWE, Scott , WARNER, Robert , WEBER, Jan , ARNEY, Michael
发明人： SCHEWE, Scott , WARNER, Robert , WEBER, Jan , ARNEY, Michael
IPC分类号： A61L31/04
CPC分类号： A61L31/125 , A61B17/0057 , A61B2017/00004 , A61B2017/00601 , A61B2017/00654 , A61B2017/00898 , A61K9/70 , A61L15/44 , A61L15/62 , A61L31/042 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/406 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/418 , A61L2300/42 , A61L2400/04
摘要： The disclosure pertains to hemostatic compositions comprising a plurality of nonwoven fibers disposed in a rapidly soluble solid matrix and methods of making and using the same. The compositions may also comprise one or more therapeutic agents.
摘要翻译：本公开涉及包含布置在快速溶解固体基质中的多个非织造纤维的止血组合物及其制备和使用方法。组合物还可以包含一种或多种治疗剂。

8. 发明申请

WO2006135755A2 MEDICAL DEVICES HAVING SUPERHYDROPHOBIC SURFACES,SUPERHYDROPHILIC SURFACES, OR BOTH 审中-公开
标题翻译：具有超级表面的超声波表面或两面的医疗装置
公开(公告)号：WO2006135755A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022497
申请日：2006-06-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , SCHEWE, Scott , BERG, Brian
发明人： WEBER, Jan , SCHEWE, Scott , BERG, Brian
CPC分类号： A61L29/14 , A61M2205/0222 , A61M2205/0238
摘要： According to an aspect of the invention, medical devices are provided, which have the following (a) one or more superhydrophobic surface regions, (b) one or more superhydrophilic surface regions having a durometer of at least 4OA, or (c) a combination of one or more superhydrophobic surface regions and one or more superhydrophilic surface regions having a durometer of at least 4OA. Such surfaces are created, for example, to provide reduced resistance to the movement of adjacent materials, including adjacent fluids and solids. Examples of medical device surface regions benefiting from the present invention include, for example, outside and/or inside (luminal) surfaces of the following: vascular catheters, urinary catheters, hydrolyser catheters, guide wires, pullback sheaths, left ventricular assist devices, endoscopes, airway tubes and injection needles, among many other devices.
摘要翻译：根据本发明的一个方面，提供了医疗装置，其具有以下（a）一个或多个超疏水表面区域，（b）一个或多个具有至少40A的硬度的超亲水性表面区域，或（c）组合的一个或多个超疏水表面区域和一个或多个具有至少40A的硬度的超亲水表面区域。例如，这样的表面被创建以提供对相邻材料，包括相邻流体和固体的运动的降低的阻力。受益于本发明的医疗器械表面区域的实例包括例如以下的外部和/或内部（腔）表面：血管导管，导尿管，水解导管，引导线，回拉鞘，左心室辅助装置，内窥镜，气道管和注射针等。

9. 发明申请

WO2006042260A2 REINFORCED AND DRUG-ELUTING BALLOON CATHETERS AND METHODS FOR MAKING SAME 审中-公开
标题翻译：加强和制造气球导管及其制造方法
公开(公告)号：WO2006042260A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036625
申请日：2005-10-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HOLMAN, Thomas, J. , WEBER, Jan , SCHEWE, Scott
发明人： HOLMAN, Thomas, J. , WEBER, Jan , SCHEWE, Scott
IPC分类号： A61M25/10 , A61M25/00
CPC分类号： A61M25/1029 , A61M25/10 , A61M25/1002 , A61M25/1034 , A61M25/1038 , A61M2025/0058 , A61M2025/1031 , A61M2025/105 , A61M2025/1084
摘要： The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.
摘要翻译：本发明一般涉及血管内医疗装置的领域，更具体地涉及用于治疗和诊断疾病的体内气囊导管和其它类似的诊断或治疗导管领域。特别地，本发明涉及增强气囊导管和药物洗脱球囊导管及其相应的制造方法。

10. 发明申请

WO2008134493A1 MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：用于释放治疗药物的医疗装置及其制备方法
公开(公告)号：WO2008134493A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061538
申请日：2008-04-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Aiden , HERRMANN, Robert , MERDAN, Ken , KUEHLING, Michael , O'BRIEN, Barry , RADHAKISHNAN, Rajesh , SCHEUERMANN, Torsten , SCHEWE, Scott , SINGHAI, Anurag , SONG, Young-Ho , TIMM, Mary Joe , WEBER, Jan , XU, Yixin
发明人： FLANAGAN, Aiden , HERRMANN, Robert , MERDAN, Ken , KUEHLING, Michael , O'BRIEN, Barry , RADHAKISHNAN, Rajesh , SCHEUERMANN, Torsten , SCHEWE, Scott , SINGHAI, Anurag , SONG, Young-Ho , TIMM, Mary Joe , WEBER, Jan , XU, Yixin
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device (114) for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures (130) disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置（114）和设置在身体表面上的多个储存器限定结构（130）。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

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