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1. 发明申请

WO2008134493A1 MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：用于释放治疗药物的医疗装置及其制备方法
公开(公告)号：WO2008134493A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061538
申请日：2008-04-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Aiden , HERRMANN, Robert , MERDAN, Ken , KUEHLING, Michael , O'BRIEN, Barry , RADHAKISHNAN, Rajesh , SCHEUERMANN, Torsten , SCHEWE, Scott , SINGHAI, Anurag , SONG, Young-Ho , TIMM, Mary Joe , WEBER, Jan , XU, Yixin
发明人： FLANAGAN, Aiden , HERRMANN, Robert , MERDAN, Ken , KUEHLING, Michael , O'BRIEN, Barry , RADHAKISHNAN, Rajesh , SCHEUERMANN, Torsten , SCHEWE, Scott , SINGHAI, Anurag , SONG, Young-Ho , TIMM, Mary Joe , WEBER, Jan , XU, Yixin
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device (114) for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures (130) disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置（114）和设置在身体表面上的多个储存器限定结构（130）。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

2. 发明申请

WO2009076592A2 MEDICAL DEVICES HAVING POROUS COMPONENT FOR CONTROLLED DIFFUSION 审中-公开
标题翻译：具有用于控制扩散的多元组件的医疗装置
公开(公告)号：WO2009076592A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/086560
申请日：2008-12-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SINGAL, Anurag , HERRMANN, Robert, A. , XU, Yixin , SONG, Young-Ho
发明人： SINGAL, Anurag , HERRMANN, Robert, A. , XU, Yixin , SONG, Young-Ho
IPC分类号： A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L31/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L29/14 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain the following: (a) substrate having one or more depressions that contain at least one therapeutic agent and (b) a porous membrane disposed over the substrate and the one or more depressions, which regulate transport of chemical species between the therapeutic-agent-containing depressions and the exterior of the device. The substrate and the porous membrane are formed of different materials each with a different thermal expansion coefficient. Moreover, one of the substrate and the porous membrane at least partially surrounds the other. Other aspects of the present invention are directed to methods of making such medical devices, and methods of treatment using such medical devices.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含以下内容：（a）具有一个或多个凹陷的基底，其含有至少一种治疗剂，和（b）设置在基底上的多孔膜，一个或多个凹陷，其调节化学物质在含治疗剂的凹陷和装置的外部之间的运输。基板和多孔膜由各自具有不同热膨胀系数的不同材料形成。此外，衬底和多孔膜中的一个至少部分地围绕另一个。本发明的其他方面涉及制造这种医疗装置的方法，以及使用这种医疗装置的治疗方法。

3. 发明公开

EP2229192A2 MEDICAL DEVICES HAVING POROUS COMPONENT FOR CONTROLLED DIFFUSION 审中-公开
标题翻译：具有多孔部件式医疗设备对于受控扩散
公开(公告)号：EP2229192A2
公开(公告)日：2010-09-22
申请号：EP08859344.7
申请日：2008-12-12
申请人： Boston Scientific Scimed, Inc.
发明人： SINGAL, Anurag , HERRMANN, Robert, A. , XU, Yixin , SONG, Young-Ho
IPC分类号： A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L31/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L29/14 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain the following: (a) substrate having one or more depressions that contain at least one therapeutic agent and (b) a porous membrane disposed over the substrate and the one or more depressions, which regulate transport of chemical species between the therapeutic-agent-containing depressions and the exterior of the device. The substrate and the porous membrane are formed of different materials each with a different thermal expansion coefficient. Moreover, one of the substrate and the porous membrane at least partially surrounds the other. Other aspects of the present invention are directed to methods of making such medical devices, and methods of treatment using such medical devices.

4. 发明公开

EP2152206A1 MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：释的治疗剂和工艺医疗器械用于生产
公开(公告)号：EP2152206A1
公开(公告)日：2010-02-17
申请号：EP08746879.9
申请日：2008-04-25
申请人： Boston Scientific Scimed, Inc.
发明人： FLANAGAN, Aiden , HERRMANN, Robert , MERDAN, Ken , KUEHLING, Michael , O'BRIEN, Barry , RADHAKISHNAN, Rajesh , SCHEUERMANN, Torsten , SCHEWE, Scott , SINGHAI, Anurag , SONG, Young-Ho , TIMM, Mary Joe , WEBER, Jan , XU, Yixin
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device (114) for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures (130) disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.

5. 发明申请

WO2011084513A2 THERAPEUTIC POLYMERIC NANOPARTICLE COMPOSITIONS WITH HIGH GLASS TRANSITION TEMPERATURE OR HIGH MOLECULAR WEIGHT COPOLYMERS 审中-公开
标题翻译：具有高玻璃化转变温度或高分子量共聚物的治疗性聚合纳米微粒组合物
公开(公告)号：WO2011084513A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/060564
申请日：2010-12-15
申请人： BIND BIOSCIENCES, INC. , ALI, Mir, Mukkaram , SABNIS, Abhimanyu , DEWITT, David , TROIANO, Greg , WRIGHT, James , FIGUEIREDO, Maria , FIGA, Michael , VAN GEEN HOVEN, Tina , SONG, Young-Ho , AUER, Jason , CAMPBELL, Tarikh, Christopher
发明人： ALI, Mir, Mukkaram , SABNIS, Abhimanyu , DEWITT, David , TROIANO, Greg , WRIGHT, James , FIGUEIREDO, Maria , FIGA, Michael , VAN GEEN HOVEN, Tina , SONG, Young-Ho , AUER, Jason , CAMPBELL, Tarikh, Christopher
IPC分类号： A61K47/30 , A61K31/337 , A61K9/127 , A61P11/06 , A61P19/10 , A61P29/00
CPC分类号： G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
摘要： The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米粒子的药物组合物。本发明的其他方面包括制造这种纳米颗粒的方法。

6. 发明申请

WO2005018606A1 MEDICAL DEVICES COMPRISING SPRAY DRIED MICROPARTICLES 审中-公开
标题翻译：包含喷雾干燥微生物的医疗装置
公开(公告)号：WO2005018606A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/025925
申请日：2004-08-11
申请人： SCIMED LIFE SYSTEMS, INC. , SONG, Young-Ho
发明人： SONG, Young-Ho
IPC分类号： A61K9/00
CPC分类号： A61L29/16 , A61K9/1647 , A61L27/54 , A61L31/16 , A61L2300/622
摘要： An implantable or insertable medical device which includes (a) a tacky polymeric region and (b) spray dried microparticles, which are adhered to the tacky polymeric region. The present invention is further directed to methods of forming such medical devices, and methods of releasing a therapeutic agent within a patient using such medical devices.
摘要翻译：一种可植入或可插入的医疗装置，其包括（a）粘性聚合物区域和（b）喷雾干燥的微粒，其粘附到粘性聚合物区域。本发明还涉及形成这种医疗装置的方法，以及使用这种医疗装置在患者体内释放治疗剂的方法。

7. 发明申请

WO2005016399A1 MEDICAL DEVICES CONTAINING ANTIOXIDANT AND THERAPEUTIC AGENT 审中-公开
标题翻译：含有抗氧化剂和治疗剂的医疗装置
公开(公告)号：WO2005016399A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/026239
申请日：2004-08-11
申请人： SCIMED LIFE SYSTEMS, INC. , SONG, Young-Ho
发明人： SONG, Young-Ho
IPC分类号： A61L31/04
CPC分类号： A61L31/143 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/802
摘要： An medical device which comprises (a) a medical device substrate and (b) a therapeutic-agent-containing region over the substrate that comprises a therapeutic agent and an antioxidant. Exemplary medical devices are implantable or insertable medical devices, such as catheters, guide wires, balloons, filters, stents, stent grafts, vascular grafts, vascular patches and shunts. Also described are methods of making devices such as those above, which methods comprise: (a) providing a solution comprising (i) solvent, (ii) the therapeutic agent, and (iii) the antioxidant; (b) providing the medical device substrate; (c) contacting the solution with the medical device substrate; and (d) removing the solvent from the solution to form the therapeutic-agent-containing region.
摘要翻译：一种医疗装置，其包括（a）医疗装置基板和（b）包含治疗剂和抗氧化剂的基材上的含治疗剂的区域。示例性医疗装置是可植入或可插入的医疗装置，例如导管，导丝，球囊，过滤器，支架，支架移植物，血管移植物，血管斑块和分流器。还描述了制造诸如上述装置的方法，该方法包括：（a）提供包含（i）溶剂，（ii）治疗剂和（iii）抗氧化剂的溶液; （b）提供医疗装置基板; （c）使溶液与医疗装置基板接触; 和（d）从溶液中除去溶剂以形成含治疗剂的区域。

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