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1. 发明申请

WO2010124049A2 ENDOPROSTHESIS WITH SELECTIVE DRUG COATINGS 审中-公开
标题翻译：与选择性药物涂层结合
公开(公告)号：WO2010124049A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/031990
申请日：2010-04-22
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KUEHLING, Michael , SCHEUERMANN, Torsten , WEBER, Jan , XU, Yixin
发明人： KUEHLING, Michael , SCHEUERMANN, Torsten , WEBER, Jan , XU, Yixin
IPC分类号： A61L31/08
CPC分类号： A61L31/10 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/61
摘要： An endoprosthesis such as a coronary stent includes a luminal surface, at least a portion of which is covered with a first coating including a first drug, and an ab luminal surface, at least a portion of which is covered with a second coating including a second drug. The first drug has a first eluting profile based on the first coating, and the second drug has a second eluting profile based on the second coating, the first eluting profile being different from the second eluting profile. Methods of making the same are also provided.
摘要翻译：诸如冠状动脉支架的内假体包括腔表面，其至少一部分被第一涂层覆盖，第一涂层包括第一药物和至少一部分覆盖有第二涂层的第二涂层，所述第二涂层包括第二涂层药物。第一种药物基于第一种涂层具有第一洗脱分布，第二种药物基于第二种涂层具有第二种洗脱分布，第一种洗脱分布与第二种洗脱分布不同。还提供了制备其的方法。

2. 发明申请

WO2008134493A1 MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：用于释放治疗药物的医疗装置及其制备方法
公开(公告)号：WO2008134493A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061538
申请日：2008-04-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Aiden , HERRMANN, Robert , MERDAN, Ken , KUEHLING, Michael , O'BRIEN, Barry , RADHAKISHNAN, Rajesh , SCHEUERMANN, Torsten , SCHEWE, Scott , SINGHAI, Anurag , SONG, Young-Ho , TIMM, Mary Joe , WEBER, Jan , XU, Yixin
发明人： FLANAGAN, Aiden , HERRMANN, Robert , MERDAN, Ken , KUEHLING, Michael , O'BRIEN, Barry , RADHAKISHNAN, Rajesh , SCHEUERMANN, Torsten , SCHEWE, Scott , SINGHAI, Anurag , SONG, Young-Ho , TIMM, Mary Joe , WEBER, Jan , XU, Yixin
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device (114) for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures (130) disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置（114）和设置在身体表面上的多个储存器限定结构（130）。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

3. 发明申请

WO2010027678A2 MEDICAL DEVICES HAVING INORGANIC COATINGS FOR THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：具有用于治疗剂递送的无机涂层的医疗设备
公开(公告)号：WO2010027678A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/054394
申请日：2009-08-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , SCHEUERMANN, Torsten , O'BRIEN, Barry, J. , XU, Yixin , FORSYTH, Bruce
发明人： WEBER, Jan , SCHEUERMANN, Torsten , O'BRIEN, Barry, J. , XU, Yixin , FORSYTH, Bruce
IPC分类号： A61L27/30
CPC分类号： A61L27/30 , A61L27/54 , A61L27/56 , A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/608
摘要： According to an aspect of the invention, medical devices are provided that comprise a substrate, at least one therapeutic agent disposed over or in the substrate, and at least one inorganic layer disposed over the therapeutic agent and the substrate, wherein the inorganic layer is either a porous inorganic layer or is a non-porous layer that becomes a porous inorganic layer in vivo. Other aspects of the invention comprise methods for forming medical devices.
摘要翻译：根据本发明的一个方面，提供了医疗装置，其包括基底，设置在基底上或基底内的至少一种治疗剂，以及设置在治疗剂上的至少一个无机层，并且其中所述无机层是多孔无机层或是在体内成为多孔无机层的无孔层。本发明的其它方面包括用于形成医疗装置的方法。

4. 发明申请

WO2009132176A2 MEDICAL DEVICES HAVING INORGANIC PARTICLE LAYERS 审中-公开
标题翻译：具有无机颗粒层的医疗器械
公开(公告)号：WO2009132176A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041520
申请日：2009-04-23
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KUEHLING, Michael , SEIDEL, Dominique , SCHEUERMANN, Torsten , WEBER, Jan
发明人： KUEHLING, Michael , SEIDEL, Dominique , SCHEUERMANN, Torsten , WEBER, Jan
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/61 , A61L2300/62 , A61L2420/02
摘要： An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.
摘要翻译：一种可膨胀医疗装置，其具有设置在含有治疗剂的贮器上方的颗粒层。当医疗装置处于未膨胀构型时，颗粒层具有第一孔隙度，并且当医疗装置处于膨胀构型时具有第二孔隙率。颗粒层包含多个微米级或纳米尺寸的颗粒。在某些实施方案中，颗粒彼此不连接，因此，当医疗装置膨胀/未膨胀时，由颗粒之间的间隔的变化提供不同的孔隙度。还公开了具有颗粒层的医疗装置，其中所述颗粒层包含多个包封的颗粒，以及用颗粒涂覆医疗装置的方法。

5. 发明申请

WO2008061017A1 ENDOPROSTHESIS WITH COATINGS 审中-公开
标题翻译：含涂层的内含物
公开(公告)号：WO2008061017A1
公开(公告)日：2008-05-22
申请号：PCT/US2007/084286
申请日：2007-11-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , XU, Yixin , SCHEUERMANN, Torsten , WEBER, Jan
发明人： XU, Yixin , SCHEUERMANN, Torsten , WEBER, Jan
IPC分类号： A61F2/82
CPC分类号： C23C14/12 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61L31/082 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/608 , A61L2420/08 , C23C14/06 , C23C14/28
摘要： An endoprosthesis such as a coronary stent includes a polymeric reservoir of drug and an over coating formed of ceramic or metal for controlling elution of drug from the reservoir.
摘要翻译：诸如冠状动脉支架的内假体包括药物的聚合物储存器和由陶瓷或金属形成的过涂层，用于控制药物从储存器的洗脱。

6. 发明申请

WO2009131911A3 MEDICAL DEVICES HAVING A COATING OF INORGANIC MATERIAL 审中-公开
公开(公告)号：WO2009131911A3
公开(公告)日：2009-10-29
申请号：PCT/US2009/040964
申请日：2009-04-17
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Aiden , KILCOOLEY, John , O'CONNOR, Tim , O'BRIEN, Barry , SEIDEL, Dominique , KUEHLING, Michael , SCHEUERMANN, Torsten , WEBER, Jan
发明人： FLANAGAN, Aiden , KILCOOLEY, John , O'CONNOR, Tim , O'BRIEN, Barry , SEIDEL, Dominique , KUEHLING, Michael , SCHEUERMANN, Torsten , WEBER, Jan
IPC分类号： A61L31/08 , A61L31/16
摘要： In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.

7. 发明申请

WO2010011515A2 MEDICAL DEVICES HAVING INORGANIC BARRIER COATINGS 审中-公开
标题翻译：具有无机屏障涂层的医疗器械
公开(公告)号：WO2010011515A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/050365
申请日：2009-07-13
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEUERMANN, Torsten , KUEHLING, Michael , WEBER, Jan , SEIDEL, Dominique
发明人： SCHEUERMANN, Torsten , KUEHLING, Michael , WEBER, Jan , SEIDEL, Dominique
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/082 , A61L31/146 , A61L2300/608 , A61L2420/08
摘要： Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.
摘要翻译：具有包含无机材料的阻挡层的医疗装置。医疗装置具有含有治疗剂的储液器，并且阻挡层设置在贮存器的上方。在一个方面，阻挡层在医疗装置的一部分处具有对治疗剂的一种渗透性，并且在医疗装置的另一部分具有不同的渗透性。另一方面，医疗器械的一部分处的储存器中的治疗剂的剂量与医疗器械的另一部分处的储存器中的治疗剂的剂量不同。在另一方面，生物可再吸收层设置在医疗装置的一个或多个部分的阻挡层之上，其中生物可再吸收层包括生物可再吸收材料。此外，公开了涂覆医疗装置的方法，其中使用光刻蚀刻工艺形成医疗装置上的阻挡层，其中多个颗粒用作蚀刻掩模。

8. 发明申请

WO2010096516A3 BIOERODIBLE ENDOPROSTHESIS 审中-公开
公开(公告)号：WO2010096516A3
公开(公告)日：2010-08-26
申请号：PCT/US2010/024520
申请日：2010-02-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEUERMANN, Torsten , WEBER, Jan , ALBRECHT, Peter
发明人： SCHEUERMANN, Torsten , WEBER, Jan , ALBRECHT, Peter
IPC分类号： A61L29/02 , A61L29/14 , A61L31/02 , A61L31/14 , C22C38/04 , C22C38/02
摘要： A bioerodible stent, having a composition comprising Fe, Mn, Si and C has desirable mechanical, erosion, and physiological characteristics.

9. 发明申请

WO2011126708A1 ENDOPROSTHESIS 审中-公开
标题翻译：内置假体
公开(公告)号：WO2011126708A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/029002
申请日：2011-03-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , ATANASOSKA, Liliana , SHIPPY III, James Lee , SCHEUERMANN, Torsten , GREGORICH, Daniel J. , MEYER, Michael P.
发明人： WEBER, Jan , ATANASOSKA, Liliana , SHIPPY III, James Lee , SCHEUERMANN, Torsten , GREGORICH, Daniel J. , MEYER, Michael P.
IPC分类号： A61L31/08 , A61L31/14
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译：除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）芯的表面的至少一部分上的生物可侵蚀金属，其中生物可蚀刻金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。

10. 发明申请

WO2011011531A2 BIOERODIBLE MEDICAL IMPLANTS 审中-公开
标题翻译：生物医学植入物
公开(公告)号：WO2011011531A2
公开(公告)日：2011-01-27
申请号：PCT/US2010/042772
申请日：2010-07-21
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , STINSON, Jonathan, S. , DENG, Charles , BOISMIER, Dennis, A. , WEBER, Jan , SCHEUERMANN, Torsten
发明人： ATANASOSKA, Liliana , STINSON, Jonathan, S. , DENG, Charles , BOISMIER, Dennis, A. , WEBER, Jan , SCHEUERMANN, Torsten
IPC分类号： A61L31/02
CPC分类号： A61L31/022 , A61L31/124 , A61L31/127 , A61L31/148
摘要： A medical implant includes a bioerodible portion adapted to degrade under physiological conditions. The bioerodible portion includes a bioerodible metal matrix and a salt or clay within the bioerodible metal matrix.
摘要翻译：医疗植入物包括适于在生理条件下降解的生物可蚀解部分。生物可蚀解部分包括生物蚀解性金属基质和生物蚀解性金属基质内的盐或粘土。

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