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1. 发明申请

WO1998011828A1 STENT LINING 审中-公开
公开(公告)号：WO1998011828A1
公开(公告)日：1998-03-26
申请号：PCT/US1997016970
申请日：1997-09-19
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , SAHATJIAN, Ronald, A. , BARRY, James, J. , PALASIS, Maria
IPC分类号： A61B17/00
CPC分类号： A61F2/90 , A61F2/0077 , A61F2/958 , A61F2230/0013 , A61F2250/0067 , A61K9/0024 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0011 , A61L33/0023 , A61L33/0029 , A61L33/0047 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61M25/0045 , A61M25/104 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/1093 , A61M2205/0266 , C08L33/02 , C08L35/00
摘要： The invention features a catheter assembly (51) and methods for delivering a hydrogel lines stent (50) to a body lumen, and methods for lining a stent with a hydrogel. The assembly includes a catheter (51) which has a balloon at least a portion of which is coated with a hydrogel, and an expansible stent (50) mounted on the balloon in a contracted condition for passage with the catheter (51) to a site of a body. Expansion of the balloon lodges the stent (50) in the body with hydrogel coated on the inner surfaces of the stent (50) as a lining.
摘要翻译：本发明的特征在于导管组件（51）和用于将水凝胶管支架（50）输送到体腔的方法以及用水凝胶衬里支架的方法。组件包括导管（51），其具有至少一部分涂覆有水凝胶的球囊，以及可膨胀支架（50），其以收缩状态安装在球囊上，用于将导管（51）通向位置的身体气囊的膨胀以支架（50）的内表面上涂覆有水凝胶作为衬里将支架（50）放置在体内。

2. 发明申请

WO1996009086A1 MEDICAL DEVICE WITH LUBRICIOUS COATING 审中-公开
标题翻译：具有润滑涂层的医疗装置
公开(公告)号：WO1996009086A1
公开(公告)日：1996-03-28
申请号：PCT/US1995011948
申请日：1995-09-19
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , FAN, You-Ling , MARLIN, Lawrence , SAHATJIAN, Ronald, A. , SCHULTZ, Steven, A.
IPC分类号： A61M29/00
CPC分类号： A61M25/0045 , A61L29/06 , A61L29/085 , A61M25/104 , A61L29/14 , C08L71/02 , A61L29/148 , C08L67/02
摘要： A medical balloon and catheter in which the balloon (14) is wrapped and folded upon itself tortuously and tightly so outer surfaces (12) contact each other for insertion into the body and in whic the balloon is free of bridging and adhesion between abutting surfaces. The balloon has a base of a continuous polymeric surface (10) expandable from a folded, wrapped configuration with surfaces touching each other into a balloon when inflated. A lubricious, bio-compatible, hydrogel coating (11) is disposed on the polymeric surface and a thin, lubricious, blood-compatible coating (12) is disposed upon the hydrogen coating and adheres to it to prevent abutting surfaces of the folded polymeric surfaces from adhering to each other during inflation and to prevent delamination of the hydrogel coating and/or rupture of the balloon. Preferably the blood-compatible coating (12) is polyethylene glycol, methoxy polyethylene glycol or mixtures thereof having a molecular weight between about 100 and 20,000 grams per gram mole.
摘要翻译：一种医疗气球和导管，其中气囊（14）被折叠地紧密地包裹并折叠，所以外表面（12）彼此接触以插入身体，并且气球在邻接表面之间没有桥接和粘附。气囊具有可从折叠的包裹构造展开的连续聚合物表面（10）的基部，当膨胀时，表面彼此接触成一个气球。将润滑的，生物相容的水凝胶涂层（11）设置在聚合物表面上，并且将薄的，润滑的，兼容血液的涂层（12）设置在氢气涂层上并粘附到其上以防止折叠的聚合物表面的邻接表面在充气期间彼此粘附并防止水凝胶涂层分层和/或气囊破裂。优选地，血液相容性涂层（12）是聚乙二醇，甲氧基聚乙二醇或其分子量为约100至20,000克/克摩尔的其混合物。

3. 发明申请

WO1995017847A1 BODILY SAMPLE COLLECTION 审中-公开
标题翻译： BODILY样品系列
公开(公告)号：WO1995017847A1
公开(公告)日：1995-07-06
申请号：PCT/US1994014456
申请日：1994-12-16
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , SAHATJIAN, Ronald, A.
IPC分类号： A61B05/00
CPC分类号： A61B10/04 , A61M25/10 , A61M29/02 , A61M2025/1072 , A61M2025/1086 , A61M2025/109
摘要： This invention is treating a patient by collecting a bodily sample from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe (2) is provided in the form of an elongate catheter (4) having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a balloon (8) with polymer (16) thereon capable of recieving a substantial amount of bodily sample.
摘要翻译：本发明是通过从患者体内深处收集身体样品并将样品收集在身体外部以便于治疗患者来治疗患者。提供采样探针（2）以细长导管（4）的形式提供，其具有保留在身体外部的近端部分和可位于体内的远端部分。远侧部分包括其上具有聚合物（16）的球囊（8），其能够接收大量的身体样品。

4. 发明申请

WO1997031674A1 IMPROVED BALLOON CATHETER 审中-公开
标题翻译：改进的气球导管
公开(公告)号：WO1997031674A1
公开(公告)日：1997-09-04
申请号：PCT/US1997003200
申请日：1997-02-28
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ABELE, John, E. , SAHATJIAN, Ronald, A.
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61F2/958 , A61M25/0043 , A61M25/1002 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M2025/0047 , A61M2025/1004 , A61M2025/1031 , A61M2025/1086 , A61M2025/1088
摘要： An expansible balloon catheter (10) has at least a first exterior surface (27) with a given coefficent of friction and a second exterior surface (32) with a greater coefficient of friction. In a compact form only the first exterior surface is exposed to produce one coefficient of friction during transfer of the collapsed or uninflated balloon to and across a lesion. When inflated, the second surface dominates the first surface and produces a second coefficient of friction.
摘要翻译：可膨胀气囊导管（10）至少具有一定摩擦系数的第一外表面（27）和具有更大摩擦系数的第二外表面（32）。在紧凑形式中，只有第一外表面暴露以在将塌缩或未膨胀的气囊转移到病变处并穿过病变时产生一个摩擦系数。当膨胀时，第二表面支配第一表面并产生第二摩擦系数。

5. 发明申请

WO1995009667A1 MEDICAL DEVICE BALLOONS CONTAINING THERMOPLASTIC ELASTOMERS 审中-公开
标题翻译：含有热塑性弹性体的医疗器械气囊
公开(公告)号：WO1995009667A1
公开(公告)日：1995-04-13
申请号：PCT/US1994010961
申请日：1994-09-28
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , HAMILTON, Bruce , SAHATJIAN, Ronald, A.
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61L29/049 , A61L29/12 , A61M25/0045 , A61M25/1002 , A61M25/1038 , A61M2025/1075 , C08L67/02 , C08L71/02
摘要： A dilatation balloon and catheter for insertion into a bodily conduit. The catheter (10) includes shaft (12) and a dilatation balloon (24) at the distal end of the shaft. The balloon is inflated via a central lumen (14) in the shaft for delivery of a fluid inflation media. The balloon is fabricated from a combination of a thermoplastic elastomer (TPE), preferably an engineering thermoplastic elastomer (ETE), with a non-compliant structural polymeric material. The combination may be a blend of the non-compliant structural polymer and the TPE. Alternatively, the combination may be a layered balloon having, for example, a non-compliant structural polymer inner layer and a soft, abrasion resistant, elastomeric outer layer. Methods for fabricating the balloon from the combination of a TPE and a non-compliant structural polymer are also disclosed.
摘要翻译：用于插入身体导管的扩张球囊和导管。导管（10）在轴的远端包括轴（12）和膨胀气球（24）。气球通过轴中的中心腔（14）膨胀，用于输送流体充气介质。气球由热塑性弹性体（TPE），优选工程热塑性弹性体（ETE）与非柔顺结构聚合材料的组合制成。该组合可以是不顺应结构聚合物和TPE的混合物。或者，组合可以是具有例如不顺应结构聚合物内层和柔软，耐磨损的弹性体外层的分层气囊。还公开了从TPE和不顺应结构聚合物的组合制造球囊的方法。

6. 发明申请

WO1996019257A1 STENT PLACEMENT DEVICE WITH MEDICATION DISPENSER AND METHOD 审中-公开
标题翻译：具有药物分配器和方法的静置放置装置
公开(公告)号：WO1996019257A1
公开(公告)日：1996-06-27
申请号：PCT/US1995016643
申请日：1995-12-21
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , BARRY, James, J. , NICHOLAS, Peter, M. , SAHATJIAN, Ronald, A.
IPC分类号： A61M29/00
CPC分类号： A61F2/958 , A61F2250/0067 , A61M25/0023 , A61M25/10 , A61M25/10181 , A61M25/1027 , A61M25/1029 , A61M2025/0036 , A61M2025/004 , A61M2025/105 , A61M2025/1086
摘要： An inflatable medical device and method for the placement of a stent in a body passageway by means of a two stage expansion of the stent and for the delivery of medications to precise location in the passageway. The device includes a catheter shaft (14) having a plurality of lumens (13, 22, 28) disposed therein. The catheter shaft has a distal end adapted to be disposed within a vascular passageway. An inflatable balloon is defined by a generally cylindrical wall and is adapted to receive inflation fluids. The balloon is disposed on the distal end of the shaft. An array of circumferentially arranged inflation conduits (40) is disposed in the wall. The conduits (40) are spaced from each other within the wall of the balloon whereby to form an annular array. An array of medication delivering conduits (25) can be disposed within the wall of the balloon. These conduits are adapted to deliver medications to predetermined locations within the body passageway being treated. A stent (30) is removably disposed around the exterior of the wall of the balloon and is expandable radially outwardly from a narrow insertion diameter to a larger second diameter by the expansion of the balloon (16) and then to a still larger third diameter by inflation of the inflation conduits (40) whereby to expand the body passageway and seat the stent.
摘要翻译：一种可膨胀的医疗装置和方法，用于通过支架的两级扩张以及用于将药物递送到通道中的精确位置来将支架放置在身体通道中。该装置包括具有设置在其中的多个管腔（13,22,28）的导管轴（14）。导管轴具有适于设置在血管通路内的远端。可膨胀气囊由大致圆柱形的壁限定，并适于接收充气流体。气球设置在轴的远端。周向布置的充气导管（40）的阵列设置在壁中。导管（40）在球囊的壁内彼此间隔开，从而形成环形阵列。药物输送管道（25）的阵列可以设置在气囊的壁内。这些管道适于将药物递送到正在治疗的身体通道内的预定位置。支架（30）可移除地设置在球囊的壁的外部周围，并且可以通过球囊（16）的膨胀从狭窄的插入直径径向向外扩展到更大的第二直径，然后通过膨胀管道（40）的膨胀，从而膨胀身体通道并对支架进行安置。

7. 发明申请

WO1995026214A1 DRUG TREATMENT OF DISEASED SITES DEEP WITHIN THE BODY 审中-公开
标题翻译：治疗疾病网站深度体内的药物治疗
公开(公告)号：WO1995026214A1
公开(公告)日：1995-10-05
申请号：PCT/US1995003872
申请日：1995-03-29
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , NICHOLAS, Peter, M. , SAHATJIAN, Ronald, A. , BARRY, James, J.
IPC分类号： A61M31/00
CPC分类号： A61M25/104 , A61M37/00 , A61M2025/105 , A61M2025/109
摘要： A diseased site, such as vascular dilatation site (26), is treated by first locally delivering to the site an agent (14) that is effective to localize a desired drug (32) and then systemically administering the drug.
摘要翻译：通过首先将有效定位所需药物（32）然后全身施用该药物的药剂（14）首先局部递送至患部位，例如血管扩张部位（26）。

8. 发明申请

WO1995017849A1 SAMPLE COLLECTION 审中-公开
标题翻译：样品收集
公开(公告)号：WO1995017849A1
公开(公告)日：1995-07-06
申请号：PCT/US1994014790
申请日：1994-12-22
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , SAHATJIAN, Ronald, A.
IPC分类号： A61B05/00
CPC分类号： A61B10/04 , A61M25/10 , A61M29/02 , A61M2025/1072 , A61M2025/1086 , A61M2025/109
摘要： This invention is taking a bodily sample from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter (4) having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a membrane (16) with openings (18) that communicate with space (19) that communicates with a source of suction force (22). The catheter (4) is positioned within the body. The sample is taken by exposing the membrane (16) by placing it in proximity with a desired location so that the bodily sample is received by the membrane (16). The catheter (4) is removed from the patient and the sample is collected outside the body.
摘要翻译：本发明从患者体内的深处取出身体样品，并将样品收集在身体外部，以便于患者的治疗。提供采样探针的形式为细长的导管（4），其具有保留在身体外部的近端部分和可位于体内的远侧部分。远端部分包括具有与空气（19）连通的开口（18）的膜（16），其与吸力源（22）连通。导管（4）位于体内。通过将膜（16）放置在所需位置附近使得膜（16）暴露于样品，使得身体样品被膜（16）接收。将导管（4）从患者身上取出，将样品收集在体外。

9. 发明申请

WO1995003083A1 DRUG DELIVERY 审中-公开
标题翻译：药物递送
公开(公告)号：WO1995003083A1
公开(公告)日：1995-02-02
申请号：PCT/US1994008394
申请日：1994-07-25
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , SAHATJIAN, Ronald, A. , BARRY, James, J.
IPC分类号： A61M31/00
CPC分类号： A61M25/104 , A61F2/90 , A61F2230/0013 , A61F2250/0067 , A61K9/0024 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0023 , A61L33/0029 , A61L2300/256 , A61L2300/258 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M16/0481 , A61M25/0045 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/105 , A61M2025/1086 , A61M2205/0266 , C08L33/02 , C08L35/00
摘要： The invention features a catheter (1) for delivering drugs to tissue at a desired location of the wall of a body lumen (2). The catheter (1) has a catheter shaft (3) and an expandable portion (4) mounted on the catheter shaft (3). The expandable portion (4) is expandable to a controlled pressure to fill the cross section of the body lumen (2) and press against the wall of the body lumen (2). At least a portion of the exterior surface of the expandable portion (4) is defined by a coating (6) of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution (8) of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer (6) and drug (8) are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating (6) during compression of the hydrogel polymer coating (6) against the wall of the lumen (2) when the expandable portion (4) is expanded.
摘要翻译：本发明的特征在于一种用于在体腔（2）的壁的期望位置处将药物递送至组织的导管（1）。导管（1）具有安装在导管轴（3）上的导管轴（3）和可扩张部分（4）。可膨胀部分（4）可膨胀至受控的压力以填充体腔（2）的横截面并压靠身体腔（2）的壁。可膨胀部分（4）的外表面的至少一部分由强力粘附的可溶胀水凝胶聚合物的涂层（6）限定。掺入水凝胶聚合物中的是待递送至组织或斑块的预选药物的水溶液（8）。选择水凝胶聚合物（6）和药物（8）以在将水凝胶聚合物涂层（6）压缩到内腔壁（2）的过程中允许从水凝胶聚合物涂层（6）快速释放所需剂量的药物），当可膨胀部分（4）膨胀时。

10. 发明申请

WO1995005860A1 IMPROVED BALLOON CATHETER 审中-公开
标题翻译：改进的气球导管
公开(公告)号：WO1995005860A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009489
申请日：1994-08-23
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ABELE, John, E. , SAHATJIAN, Ronald, A.
IPC分类号： A61M05/32
CPC分类号： A61M25/104 , A61M25/0043 , A61M25/1002 , A61M25/1029 , A61M25/1038 , A61M2025/0047 , A61M2025/1031 , A61M2025/1086
摘要： An expansible balloon catheter (10, 15) has at least a first exterior surface (27) with a given coefficient of friction and a second exterior surface (32) with a greater coefficient of friction. In a compact form only the first exterior surface is exposed to produce a low coefficient of friction during transfer of the collapsed or unflated balloon to and across a lesion. When inflated, the second surface dominates the first surface and produces an increased coefficient of friction overall thereby to stabilize the balloon in the lesion.
摘要翻译：可膨胀气囊导管（10,15）至少具有给定摩擦系数的第一外表面（27）和具有更大摩擦系数的第二外表面（32）。在紧凑形式中，仅将第一外表面暴露以在将塌缩或未膨胀的气囊转移到病变处和穿过病变处产生低摩擦系数。当膨胀时，第二表面支配第一表面并产生增加的摩擦系数，从而使气囊在病变中稳定。

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