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1. 发明申请

WO1993017752A1 BIOLOGICAL IN SITU ELECTRICAL CURRENT GENERATING APPARATUS 审中-公开
标题翻译：生物电工电流发生器
公开(公告)号：WO1993017752A1
公开(公告)日：1993-09-16
申请号：PCT/US1993002233
申请日：1993-03-03
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ANDERSEN, Erik
IPC分类号： A61N01/00
CPC分类号： A61N1/05
摘要： An apparatus (20) for the in situ generation of an electrical current in a biological environment characterized by including an electrolytic fluid. The apparatus comprises first (21) and second (23) electrodes of differing electrochemical potentials separated by an insulator (22). The apparatus is adapted to be implanted in the environment. The presence of the electrolytic fluid and formation of a current path by hyperplastic cells bridging the electrodes enables electrolysis to occur and a direct current to pass through the current path to impede hyperplastic cell growth.
摘要翻译：一种用于在生物环境中原位产生电流的设备（20），其特征在于包括电解液。该装置包括由绝缘体（22）分开的不同电化学电位的第一（21）和第二（23）个电极。该装置适于植入环境中。电解液的存在和通过桥接电极的增生细胞形成电流路径使得电解发生，并且直流电流通过电流路径以阻止增生细胞生长。

2. 发明申请

WO1994001056A1 TUBULAR MEDICAL PROSTHESIS 审中-公开
公开(公告)号：WO1994001056A1
公开(公告)日：1994-01-20
申请号：PCT/US1993006529
申请日：1993-07-12
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ANDERSEN, Erik , STRECKER, Ernst, Peter
IPC分类号： A61F02/04
CPC分类号： A61F2/90 , A61F2/04 , A61F2/07 , A61F2/95 , A61F2002/072 , A61F2002/9505 , A61F2002/9511 , A61F2210/0019 , A61F2230/0013 , A61F2230/008 , A61F2250/0048 , A61F2250/0067 , A61L31/005 , A61L31/04 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2300/606 , D04B1/16 , D04B1/225 , D04B9/44 , D10B2403/0114 , D10B2509/06
摘要： A tubular prosthesis (10) including a tubular wall portion (12) of loosely interlocked pattern, e.g. of knitted loops, constructed to function within a body lumen. The loops are preferably formed of co-knitted strand materials. A first strand material (16) is a metal strand that structurally defines the tubular shape of the prosthesis and maintains the shape when positioned in the lumen. A second strand material (18) is a predetermined substance selected to provide desired characteristics to the wall of the prosthesis.
摘要翻译：一种管状假体（10），其包括松散地互锁图案的管状壁部分（12），例如，的针织圈，构造成在体腔内起作用。环优选由共同编织线材料形成。第一股线材料（16）是金属股线，其在结构上限定假体的管状形状并且当定位在内腔中时保持形状。第二股线材料（18）是被选择以向假体的壁提供期望特征的预定物质。

3. 发明申请

WO1993006781A1 IMPREGNATED STENT 审中-公开
标题翻译：隐含的矛盾
公开(公告)号：WO1993006781A1
公开(公告)日：1993-04-15
申请号：PCT/US1992008719
申请日：1992-10-06
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ANDERSEN, Erik
IPC分类号： A61B17/00
CPC分类号： A61F2/90 , A61F2/0077 , A61F2/95 , A61F2/958 , A61F2210/0019 , A61F2220/005
摘要： A stent assembly (20), delivery system (Fig. 5) and method of manufacture (Fig. 4) therefor. A stent assembly (20) includes a compact stent (10). A dissolvable material (35) impregnates the stent (10) in liquid form. In its cured, solid form, the material (35) contains the stent (10) in its compact form. When the stent (10) is positioned in a vessel (85), the temperature and liquids in the vessel (85) dissolve the material (35) thereby to release the stent (10) for positioning in a final configuration. The expansion of the stent (10) then allows removal of the delivery system.

4. 发明申请

WO1994023786A1 PROSTHESIS DELIVERY SYSTEM 审中-公开
标题翻译： PROSTHESIS交付系统
公开(公告)号：WO1994023786A1
公开(公告)日：1994-10-27
申请号：PCT/US1994003959
申请日：1994-04-12
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ROBERTS, George, T. , WILSON, Darin , ANDERSEN, Erik , STROHBAND, Hans-Peter
IPC分类号： A61M29/00
CPC分类号： A61F2/966 , A61F2/95 , A61F2002/9517
摘要： This invention provides prosthesis delivery systems (2) with a traumatic tip (26) that can be dislodged from the catheter (4) so that the catheter (4) can be easily removed from the body after expanding the prosthesis (14), by pulling the catheter (4) proximally. With the tip (26) dislodged, the catheter (4), which is of smaller diameter than the tip (26) can be removed even in instances where the prosthesis (14) does not expand the lumen to a large diameter. This invention also provides prosthesis delivery systems (2) with a contoured protective outer sheath (20) having smaller diameters in proximal portions that normally are acutely bent when the system is in the body, than in distal portions corresponding to the position of the prosthesis (14). These systems are more flexible and the sheaths (20) less likely to kink, especially when configured as part of a large delivery system.
摘要翻译：本发明提供了具有可以从导管（4）移出的创伤性尖端（26）的假体递送系统（2），使得在扩张假体（14）之后可以容易地从体内移除导管（4），通过拉动近端导管（4）。在尖端（26）移开时，甚至在假体（14）不将内腔膨胀到大直径的情况下也可以去除直径小于尖端（26）的导管（4）。本发明还提供了具有轮廓保护外护套（20）的假体输送系统（2），其在近端部分具有较小的直径，当系统在体内时通常会急剧弯曲，而不是对应于假体位置的远端部分 14）。这些系统更灵活，并且护套（20）不太可能扭结，特别是当配置为大型输送系统的一部分时。

5. 发明申请

WO1994023669A1 PROSTHESIS DELIVERY SYSTEM WITH DILATING TIP 审中-公开
标题翻译： PROSTHESIS交付系统与DILATING提示
公开(公告)号：WO1994023669A1
公开(公告)日：1994-10-27
申请号：PCT/US1994003942
申请日：1994-04-11
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ROBERTS, George, T. , ANDERSEN, Erik
IPC分类号： A61F02/06
CPC分类号： A61F2/95 , A61F2/966 , A61F2002/044
摘要： This invention provides prosthesis delivery systems (2) with tips (26) constructed to permit both easier advance into the body and easier removal from the body after expanding the prosthesis (14). The tip (26) includes a distal taper (28) that can gently widen a lumen during advance in instances where the lumen is narrower than the tip (26) and a proximal taper (29) that can gently widen the lumen on retraction in instances where the prosthesis (14) does not immediately expand the lumen to provide clearance for the larger diameter tip (26).
摘要翻译：本发明提供了假体输送系统（2），其具有构造成允许在扩张假体（14）之后容易地进入身体并且更容易地从身体移除的尖端（26）。尖端（26）包括远端锥体（28），远端锥体（28）可以在腔内比尖端（26）更窄的情况下预先轻轻地加宽内腔，而近端锥体（29）可以在收缩时轻轻加宽内腔其中假体（14）不立即膨胀管腔以为较大直径尖端（26）提供间隙。

6. 发明申请

WO1990007352A1 ANGIOPLASTY CATHETER 审中-公开
标题翻译：天鹅绒导管
公开(公告)号：WO1990007352A1
公开(公告)日：1990-07-12
申请号：PCT/US1990000083
申请日：1990-01-04
申请人： BOSTON SCIENTIFIC CORPORATION , TONNESEN, Knud, Henrik
发明人： BOSTON SCIENTIFIC CORPORATION , ANDERSEN, Erik
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61M25/1011 , A61M2025/1052
摘要： Method and apparatus for treatment of chronic arterial occlusion by combined transluminal angioplasty and topically enclosed thrombolytic enzyme (e.g. recombinant human type plasminogen activator) with the use of a multilumen catheter (4). The catheter has a pair of balloons (6, 8) spaced apart to define a treatment region therebetween, and the intermediate portion (10) of the catheter body defines a plurality of flushing ports (12) in the treatment region. Fibrinolytic agent, e.g. rt-PA, is delivered into the treatment region, and removed from the treatment region, through the flushing ports.
摘要翻译：使用多腔导管（4）治疗慢性动脉闭塞的方法和装置，其通过组合的腔内血管成形术和局部封闭的溶血栓酶（例如重组人型纤溶酶原激活物）。导管具有间隔开的一对气囊（6,8），以在其间限定一个治疗区域，导管主体的中间部分（10）在处理区域中限定多个冲洗口（12）。纤维蛋白溶解剂 rt-PA被输送到处理区域，并从处理区域中通过冲洗口移除。

7. 发明申请

WO1995009668A1 DILATATION CATHETER 审中-公开
标题翻译：电动吸尘器
公开(公告)号：WO1995009668A1
公开(公告)日：1995-04-13
申请号：PCT/US1994011323
申请日：1994-10-05
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ANDERSEN, Erik , JORGENSEN, Ib
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61M2025/0063 , A61M2025/0183
摘要： The invention features a catheter (10) having a stylet (12) that increases columnar strength and axial force transmission ("pushability") of the catheter shaft. This aspect of the invention features the stylet (12) extending distally beyond an exit port (54) which is used in rapid catheter exchange and being embedded in the catheter shaft, there being a stress-transferring relationship between the exterior of the stylet (12) and the substance defining the shaft at least in the vicinity of the exit port (54), the stylet (12) with the embedded relationship increasing the columnar strength of the shaft in the region of the port (54) and increasing the pushability of the catheter (10).
摘要翻译：本发明的特征在于具有提高导管轴的柱强度和轴向力传递（“推动性”）的探针（12）的导管（10）。本发明的该方面的特征在于，探针（12）向远侧延伸超过用于快速导管交换并且嵌入在导管轴中的出口（54），在探针（12）的外部之间存在应力转移关系）和至少在出口（54）附近限定轴的物质，具有嵌入关系的探针（12）增加了在端口（54）的区域中的轴的柱状强度，并增加了可伸缩性导管（10）。

8. 发明申请

WO1994012136A1 STENTS FOR BODY LUMENS EXHIBITING PERISTALTIC 审中-公开
标题翻译：身体透亮的胸肌
公开(公告)号：WO1994012136A1
公开(公告)日：1994-06-09
申请号：PCT/US1993009717
申请日：1993-10-13
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , ANDERSEN, Erik , STRECKER, Ernst, Peter , HESS, Kathleen, L. , UHOJ, Susan
IPC分类号： A61F21/06
CPC分类号： A61F2/95 , A61F2/0077 , A61F2/90 , A61F2/958 , A61F2/966 , A61F2002/046 , A61F2210/0019 , A61F2210/0076 , A61F2230/0013 , A61F2230/0067 , A61F2230/0076 , A61F2230/0078
摘要： A stent (100) for reinforcement of the lumen of a peristaltic organ, and methods for forming, shaping and heat-treating of such a stent. The stent (100) is formed by knitting preferably a nitinol wire into a pattern of overlapping loops selected such that from a relaxed state each row of loops may shift axially relative to and independently of the rows on either side. A stent is also shown which comprises two resilient cylindrical mesh layers (532, 534) and a semi-permeable compliant membrane (530) such as expanded polytetrafluoroethylene, sandwiched between. A method is also shown of manufacturing a delivery system for a resilient tubular device such as a stent so that the device can be inserted into the body in a substantially reduced diameter.
摘要翻译：用于加强蠕动器官腔的支架（100），以及用于形成，成形和热处理这种支架的方法。支架（100）通过优选将镍钛诺导线编织成选择的重叠环的图案形成，使得从松弛状态，每排环可以相对于并且独立于任一侧的行而轴向移动。还示出了一种支架，其包括两个弹性圆柱形网眼层（532,534）和夹在其间的半渗透柔性膜（530），例如膨胀聚四氟乙烯。还示出了制造用于诸如支架的弹性管状装置的输送系统的方法，使得该装置可以以基本上减小的直径插入到体内。

9. 发明申请

WO1992017236A1 ADJUSTABLY STIFFENABLE CONVERTIBLE CATHETER ASSEMBLY 审中-公开
标题翻译：可调节可调节导管总成
公开(公告)号：WO1992017236A1
公开(公告)日：1992-10-15
申请号：PCT/US1992002045
申请日：1992-03-12
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： BOSTON SCIENTIFIC CORPORATION , SCOPTON, Paul, M. , ANDERSEN, Erik , ABELE, John, E. , TARTAGLINO, Sandra, G. , WHEELER, Timothy, W.
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61M2025/0063 , A61M2025/0183 , A61M2025/1079
摘要： A stiffenable balloon catheter assembly (10) capable of being converted from an "over-the-wire" mode with respect to a guidewire extending therethrough to a "rapid-exchange" mode with respect to a guidewire extending therethrough, and vice versa. The catheter (10) has a plurality of lumens (14, 16, 18), one lumen however, having a side opening (30) with an obstructable gap, the orientation of which determines the utilization "mode" of the catheter assembly. Stiffening stylets (52) may be adjustably locked into the lumens, depending upon the "mode", to control the stiffness of the catheter assembly during its utilization within a patient.
摘要翻译：能够相对于穿过其延伸的导丝相对于穿过其延伸的导丝而以“快速交换”模式从“线上”模式转换成可加强气球导管组件（10），反之亦然。导管（10）具有多个管腔（14,16,18），但是一个管腔具有带有可阻挡间隙的侧开口（30），其取向决定了导管组件的利用“模式”。取决于“模式”，加强样式（52）可以可调节地锁定到腔中，以在患者使用期间控制导管组件的刚度。

10. 发明公开

EP0633800A1 BIOLOGICAL IN SITU ELECTRICAL CURRENT GENERATING APPARATUS 失效
标题翻译：原位植入生物发电。
公开(公告)号：EP0633800A1
公开(公告)日：1995-01-18
申请号：EP93908311.0
申请日：1993-03-03
申请人： BOSTON SCIENTIFIC CORPORATION
发明人： ANDERSEN, Erik
IPC分类号： A61N1
CPC分类号： A61N1/05
摘要： An apparatus (20) for the in situ generation of an electrical current in a biological environment characterized by including an electrolytic fluid. The apparatus comprises first (21) and second (23) electrodes of differing electrochemical potentials separated by an insulator (22). The apparatus is adapted to be implanted in the environment. The presence of the electrolytic fluid and formation of a current path by hyperplastic cells bridging the electrodes enables electrolysis to occur and a direct current to pass through the current path to impede hyperplastic cell growth.

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