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1. 发明申请

WO2009079056A2 FLUORESCENT PARTICLES COMPRISING NANOSCALE ZNO LAYER AND EXHIBITING CELL-SPECIFIC TOXICITY 审中-公开
标题翻译：包含纳米ZNO层和展示细胞特异性毒性的荧光颗粒
公开(公告)号：WO2009079056A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/077284
申请日：2008-09-22
申请人： BOISE STATE UNIVERSITY , WANG, Hua , WINGETT, Denise , FERIS, Kevin , PUNNOOSE, Alex , KONGARA, Madhusudan, R.
发明人： WANG, Hua , WINGETT, Denise , FERIS, Kevin , PUNNOOSE, Alex , KONGARA, Madhusudan, R.
IPC分类号： B82B1/00 , C09B67/20 , C01G9/02
CPC分类号： A61K49/0043 , A61K31/315 , A61K49/0093 , B82Y5/00 , B82Y20/00 , B82Y30/00 , Y02A50/473 , Y10S977/701 , Y10S977/712 , Y10S977/715
摘要： Multifunctional "smart" nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FlTC core. These -200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations > 250- 500 μg/mL (for Staphylococcus aureus and Escherichia coli, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.
摘要翻译：公开了多功能“智能”纳米结构，其包括具有纳米级ZnO整理层的异氰酸荧光素（FITC） - 包封的SiO2核 - 壳颗粒，其中在SiO 2 -F1TC芯上形成外部ZnO层。这些-200nm大小的颗粒分别显示使用细菌大肠杆菌和Jurkat癌细胞的细胞成像和细胞摄取研究的希望。 FITC封装的ZnO颗粒在优先杀死Jurkat癌细胞中具有优异的选择性，对正常的初级免疫细胞具有最小的毒性（暴露于60μg/ mL后分别为18％和75％的活力），并抑制革兰氏阳性和浓度>250-500μg/ mL的革兰氏阴性细菌（分别用于金黄色葡萄球菌和大肠杆菌）。这些结果表明，具有纳米尺度ZnO表面层的FITC封装的多功能颗粒可用作微粒跟踪，细胞成像，抗菌治疗和癌症治疗的智能纳米结构。

2. 发明申请

WO2014100833A1 BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE 审中-公开
标题翻译：苯并咪唑化合物及相关使用方法
公开(公告)号：WO2014100833A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/077625
申请日：2013-12-23
申请人： NORTHWESTERN UNIVERSITY , SILVERMAN, Richard, B. , WANG, Hua , KHANFAR, Mohammad
发明人： SILVERMAN, Richard, B. , WANG, Hua , KHANFAR, Mohammad
IPC分类号： C07D213/72 , C07D213/75 , C07C233/07 , A61K31/44 , A61P25/14
CPC分类号： C07C311/21 , C07B2200/07 , C07C235/60 , C07C255/60 , C07C257/18 , C07C311/16 , C07C311/29 , C07C311/46 , C07C311/47 , C07C317/22 , C07C317/34 , C07C317/40 , C07C317/44 , C07C317/48 , C07C323/20 , C07C323/42 , C07C323/49 , C07C323/62 , C07C2601/02 , C07D207/16 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/85 , C07D217/04 , C07D223/04 , C07D237/20 , C07D239/42 , C07D261/14 , C07D271/113 , C07D277/46 , C07D295/26 , C07D305/06 , C07D311/16 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.
摘要翻译：苯甲酰胺化合物及其衍生物，可用于选择性抑制SIRT2酶和/或用于治疗亨廷顿病的治疗用途。

3. 发明申请

WO2011133742A2 CABLE TAMPER PREVENTION 审中-公开
标题翻译：电缆防篡改
公开(公告)号：WO2011133742A2
公开(公告)日：2011-10-27
申请号：PCT/US2011/033377
申请日：2011-04-21
申请人： LEVITON MANUFACTURING CO., INC. , WANG, Hua
发明人： WANG, Hua
IPC分类号： H01R13/648 , H01R24/58 , H01R13/639
CPC分类号： H01R13/6397 , G02B6/3817 , G02B6/3893 , G02B6/3898 , H01R24/64 , H01R2107/00 , Y10T29/49117
摘要： Apparatuses, devices, systems, and methods are provided for prevention of tampering with cables and associated systems. In one aspect, an anti-tamper adapter is provided that can inhibit or prohibit cable tampering for existing cables. In a further aspect, dummy plugs or blocking plugs can employ disclosed anti-tamper adapters to facilitate blocking ports or outlets that are intended to remain undisturbed for a period of time. The provided embodiments can economically and flexibly facilitate cable tamper prevention in a wide array of cable technologies.
摘要翻译：提供了用于防止篡改电缆和相关系统的设备，设备，系统和方法。在一个方面中，提供了一种防篡改适配器，其可以禁止或禁止用于现有电缆的电缆篡改。在另一方面，虚拟插头或阻塞插头可以使用所公开的防篡改适配器来促进阻止意图在一段时间内保持不受干扰的端口或插座。所提供的实施例能够经济且灵活地促进各种电缆技术中的电缆篡改防止。

4. 发明申请

WO2011112716A1 METHODS AND APPARATUS FOR SUPPORTING SYNCHRONIZATION BETWEEN GROUPS OF DEVICES 审中-公开
标题翻译：用于支持设备组之间的同步的方法和装置
公开(公告)号：WO2011112716A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027750
申请日：2011-03-09
申请人： QUALCOMM Incorporated , WANG, Hua , SHAKKOTTAI, Sanjay , WU, Xinzhou , LI, Junyi , JOVICIC, Aleksandar
发明人： WANG, Hua , SHAKKOTTAI, Sanjay , WU, Xinzhou , LI, Junyi , JOVICIC, Aleksandar
IPC分类号： H04W84/20
CPC分类号： H04W84/20 , H04W56/0015 , H04W92/10
摘要： Methods and apparatus related to supporting rapid synchronization between groups of wireless communications devices are described. Described methods and apparatus are well suited for use in peer to peer wireless communications systems in which a plurality of ad hoc peer to peer networks may be formed, each ad hoc network operating with its own notion of time. As two groups of devices, having different notions of time, come within proximity of one another, a wireless communications device of a first group detects the presence of a member of a second group. The wireless device determines that network timing re-synchronization is to be performed by one of the first and second groups and transmits a re-synchronization alert signal on a dedicated resource. Subsequently, the wireless device transmits a timing synchronization signal in accordance with new timing. Intended devices, which detect the alert signal and timing synchronization signal, adjust their internal timing.
摘要翻译：描述了支持无线通信设备组之间的快速同步的方法和装置。描述的方法和装置非常适合用于可以形成多个自组织对等网络的对等无线通信系统，每个自组织网络以其自己的时间概念运行。作为具有不同时间概念的两组设备彼此接近，第一组的无线通信设备检测第二组的成员的存在。无线设备确定网络定时重新同步将由第一组和第二组之一执行，并在专用资源上发送重新同步报警信号。随后，无线设备根据新的定时发送定时同步信号。用于检测报警信号和定时同步信号的设备调整其内部时序。

5. 发明申请

WO2010121223A2 ELECTROMAGNETIC MOLECULAR SENSORS AND METHODS OF USING SAME 审中-公开
标题翻译：电磁分子传感器及其使用方法
公开(公告)号：WO2010121223A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031517
申请日：2010-04-16
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , HAJIMIRI, Seyed, Ali , WANG, Hua
发明人： HAJIMIRI, Seyed, Ali , WANG, Hua
IPC分类号： G01N27/72 , G01N33/53 , C12Q1/68
CPC分类号： G01N27/745 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6832 , C12Q1/6834 , C12Q2525/161 , C12Q2525/197 , C12Q2525/301 , C12Q2563/143 , C12Q2565/519 , G01N27/3278 , G01N27/72 , G01N33/54326 , G01N33/54333 , G01N2446/00 , Y10T436/143333
摘要： Devices having an electromagnetic detector for the detection of analytes are disclosed. The devices include an electromagnetic detector, including effective inductance-change magnetic detectors, and a binding moiety. The device can include an electromagnetic material that can be detected by the detector. The device is configured such that binding of an analyte to the binding moiety changes the relationship between the electromagnetic detector and the electromagnetic material such that a change in electromagnetic field is detected by the electromagnetic detector.
摘要翻译：公开了具有用于检测分析物的电磁检测器的装置。这些装置包括电磁检测器，包括有效的电感变化磁性检测器和结合部分。该装置可以包括可由检测器检测的电磁材料。该装置被配置为使得分析物与结合部分的结合改变了电磁检测器和电磁材料之间的关系，使得电磁检测器检测到电磁场的变化。

6. 发明申请

WO2010099350A2 LOW COST BONDING TECHNIQUE FOR INTEGRATED CIRCUIT CHIPS AND PDMS STRUCTURES 审中-公开
标题翻译：用于集成电路板和PDMS结构的低成本接合技术
公开(公告)号：WO2010099350A2
公开(公告)日：2010-09-02
申请号：PCT/US2010/025456
申请日：2010-02-25
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , WANG, Hua , HAJIMIRI, Seyed, Ali
发明人： WANG, Hua , HAJIMIRI, Seyed, Ali
IPC分类号： H01L21/60
CPC分类号： G01R33/1269 , B81C1/0023 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/83 , H01L2224/45144 , H01L2224/48091 , H01L2224/48227 , H01L2224/49171 , H01L2224/83193 , H01L2224/83855 , H01L2924/01013 , H01L2924/01014 , H01L2924/01079 , H01L2924/10253 , H01L2924/14 , H01L2924/1461 , H01L2924/3011 , H01L2924/00014 , H01L2924/00
摘要： Methods of bonding a structure fabricated in polydimethylsiloxane (PDMS) and an integrated circuit chip. The procedures for bonding include providing a substrate, affixing the integrated circuit to the substrate, as needed preparing the surface of the integrated circuit chip to permit bonding, aligning the PDMS structure and the features of the integrated circuit chip, and applying a bonding agent. The bonding agent is cured by exposure to a thermal regime for a suitable length of time. Depending on relative sizes, in some cases, a plural number of PDMS structures can be attached to one chip, or a single PDMS structure can be bonded to multiple chips. In some cases, the integrated circuit chip operates wirelessly. In other situations, the substrate provides electrical communication from the integrated circuit chip to electronic components.
摘要翻译：将聚二甲基硅氧烷（PDMS）制造的结构与集成电路芯片结合的方法。接合的步骤包括提供基板，将集成电路固定到基板上，根据需要准备集成电路芯片的表面以允许粘合，对准PDMS结构和集成电路芯片的特征，以及施加粘合剂。粘合剂通过暴露于热状态固化适宜的时间长度。根据相对尺寸，在一些情况下，可以将多个PDMS结构附接到一个芯片，或者单个PDMS结构可以被结合到多个芯片。在某些情况下，集成电路芯片可以无线操作。在其他情况下，衬底提供从集成电路芯片到电子部件的电通信。

7. 发明申请

WO2008070670A2 ENHANCED IMMEDIATE RELEASE FORMULATIONS OF TOPIRAMATE 审中-公开
标题翻译：增强立即释放TOPIRAMATE的配方
公开(公告)号：WO2008070670A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/086391
申请日：2007-12-04
申请人： SUPERNUS PHARMACEUTICALS, INC. , LIANG, Likan , BHATT, Padmanabh, P. , WANG, Hua
发明人： LIANG, Likan , BHATT, Padmanabh, P. , WANG, Hua
IPC分类号： A61K9/48 , A61K9/56 , A61K31/35
CPC分类号： A61K47/4823 , A61K9/1652 , A61K9/19 , A61K9/5036 , A61K9/5047 , A61K31/35 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/46 , A61K47/61
摘要： The present invention provides enhanced immediate release formulations of topiramate, in which 80% of the active ingredient is released in the period of time of not more than 30 min. These formulations may be advantageously used for the treatment of acute neurological conditions, such as migraine.
摘要翻译：本发明提供托吡酯的增强的立即释放制剂，其中80％的活性成分在不超过30分钟的时间内释放。这些制剂可有利地用于治疗急性神经病症，例如偏头痛。

8. 发明申请

WO2008045629A2 PROCESS FOR REMOVING AT LEAST BENZENE FROM HYDROCARBON STREAMS 审中-公开
标题翻译：从碳氢化合物流中除去最少苯并呋喃的方法
公开(公告)号：WO2008045629A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/077109
申请日：2007-08-29
申请人： GENERAL ELECTRIC COMPANY , WANG, Hua , BAGGOTT, Sean, Russell , EGGERT, Harold, James , MOE, Neil, Edwin
发明人： WANG, Hua , BAGGOTT, Sean, Russell , EGGERT, Harold, James , MOE, Neil, Edwin
IPC分类号： C10G31/11 , C10G21/00 , C10G7/08 , C10G45/44 , C10G67/04
CPC分类号： C10G21/06 , B01D61/246 , B01D61/362 , C10G31/11 , C10G45/44 , C10G53/04 , C10G67/14 , Y10S203/20
摘要： A method of removing at least benzene from a hydrocarbon stream comprises concentrating aromatics in the hydrocarbon stream by passing the hydrocarbon stream through a membrane unit having at least one membrane to produce a permeate stream and a retentate stream, wherein the permeate stream is aromatics rich relative to the hydrocarbon stream; and extracting aromatics after concentrating using a selective aromatics extraction solvent in an extraction unit to produce an extract stream, wherein the extract stream is aromatics rich relative to the permeate stream.
摘要翻译：从烃流中至少除去苯的方法包括通过使烃流通过具有至少一个膜的膜单元以产生渗透物流和滞留物流来将芳烃浓缩在烃流中，其中渗透物流是富含芳烃的相对到烃流; 并且在萃取单元中使用选择性芳族化合物萃取溶剂浓缩后提取芳族化合物以产生萃取物流，其中提取物物流相对于渗透物流富含芳烃。

9. 发明申请

WO2007055870A2 HIGH RESOLUTION AUTO-TUNING FOR A VOLTAGE CONTROLLED OSCILLATOR 审中-公开
标题翻译：高分辨率自动调谐电压控制振荡器
公开(公告)号：WO2007055870A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/040284
申请日：2006-10-13
申请人： SKYWORKS SOLUTIONS, INC. , WANG, Hua , RIPLEY, David, S. , ROLL, Bryan, J.
发明人： WANG, Hua , RIPLEY, David, S. , ROLL, Bryan, J.
IPC分类号： H04B1/06
CPC分类号： H03L7/0992 , H03L7/099 , H03L7/10 , H03L7/18 , H03L7/187 , H03L7/193
摘要： According to one exemplary embodiment, an auto-tuning circuit (104) coupled to a voltage controlled oscillator (102) in a phase locked loop, where the voltage controlled oscillator is coupled to a capacitor array (105), includes a prescaler circuit (106) configured to provide a divided voltage controlled oscillator frequency, where the prescaler circuit is used in the phase locked loop during fine tuning of the voltage controlled oscillator in the auto-tuning circuit during coarse tuning of the voltage controlled oscillator. The auto-tuning circuit further includes a digital processing logic circuit (108) coupled to the prescaler circuit and configured to determine a capacitance of the capacitor array by comparing comp_cnt to a pre-determined value, where comp_cnt is determined by a number of cycles of the divided voltage controlled oscillator frequency that occur in a calibration interval.
摘要翻译：根据一个示例性实施例，耦合到锁相环中的压控振荡器（102）的自调谐电路（104），其中压控振荡器耦合到电容器阵列（105），包括预分频器电路（106）），其被配置为提供分压控制的振荡器频率，其中在电压控制振荡器的粗调谐期间，在自调谐电路中的压控振荡器进行微调时，预分频器电路用于锁相环。自动调谐电路还包括耦合到预分频器电路的数字处理逻辑电路（108），并配置为通过将comp_cnt与预定值进行比较来确定电容器阵列的电容，其中comp_cnt由多个周期的在校准间隔内发生的分压电压振荡器频率。

10. 发明申请

WO2007019424A2 SPECTRAL-SCANNING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：光谱扫描磁共振成像
公开(公告)号：WO2007019424A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/030681
申请日：2006-08-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , AL HAJIMIRI, Seyed , HASSIBI, Arjang , WANG, Hua
发明人： AL HAJIMIRI, Seyed , HASSIBI, Arjang , WANG, Hua
IPC分类号： G01V3/00 , A61B5/05
CPC分类号： G01R33/3808 , G01R33/3607 , G01R33/3642 , G01R33/3657 , G01R33/446 , G01R33/5612 , G01R33/56383
摘要： Spectral scanning magnetic resonance imaging methods and systems. In preferred methods and systems of the invention, to measure the resonance spectrum of the target object (18), a plurality of excitation signals in different frequencies and/or waveform shapes are introduced simultaneously to the imaging volume through one or more excitation coils (12,12a), and the response spectrum is measured also in real-time and/or after excitation. Systems of the invention can be compact and portable, with small magnets (10) providing the deterministic inhomogeneous magnetic field. Preferred embodiments include integrated circuit transmitters (22) and receivers (20). Preferred systems of the invention are suitable, for example, for point of care medical diagnostics.
摘要翻译：光谱扫描磁共振成像方法和系统。在本发明的优选方法和系统中，为了测量目标物体（18）的共振谱，通过一个或多个激励线圈（12）将多个不同频率和/或波形形状的激励信号同时引入成像体积，12a），并且响应谱也是在实时和/或激发后测量的。本发明的系统可以紧凑且便于携带，其中提供确定性非均匀磁场的小磁体（10）。优选实施例包括集成电路发射器（22）和接收器（20）。本发明的优选系统例如适用于护理点医疗诊断。

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