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1. 发明申请

WO2009039508A2 PREFERENTIAL KILLING OF CANCER CELLS AND ACTIVATED HUMAN T CELLS USING ZNO NANOPARTICLES 审中-公开
标题翻译：使用ZNO纳米颗粒优先杀死癌细胞和活化的人类T细胞
公开(公告)号：WO2009039508A2
公开(公告)日：2009-03-26
申请号：PCT/US2008077252
申请日：2008-09-22
申请人： UNIV BOISE STATE , WINGETT DENISE , PUNNOOSE ALEX , KONGARA MADHUSUDAN R
发明人： WINGETT DENISE , PUNNOOSE ALEX , KONGARA MADHUSUDAN R
CPC分类号： A61K33/30 , A61K9/0019 , A61K9/14
摘要： Here we disclose the response of normal human cells to ZnO nanoparticles under different signaling environments and compare it to the response of cancerous cells. ZnO nanoparticles exhibit a strong preferential ability to kill cancerous T cells (-28-35X) compared to normal cells. Interestingly, the activation state of the cell contributes toward nanoparticle toxicity as resting T cells display a relative resistance while cells stimulated through the T cell receptor and CD28 costimulatory pathway show greater toxicity in direct relation to the level of activation. The novel findings of cell selective toxicity towards potential disease causing cells indicate a potential utility of ZnO nanoparticle in the treatment of cancer and/or autoimmunity.
摘要翻译：在这里，我们公开了正常人细胞在不同信号环境下对ZnO纳米颗粒的反应，并将其与癌细胞的反应进行比较。与正常细胞相比，ZnO纳米颗粒显示出强烈的杀伤癌细胞（-28-35X）的优先能力。有趣的是，细胞的激活状态有助于纳米颗粒毒性，因为静息T细胞显示相对抗性，而通过T细胞受体和CD28共刺激途径刺激的细胞与活化水平直接相关显示更大的毒性。细胞对潜在致病细胞的选择性毒性的新发现表明ZnO纳米颗粒在治疗癌症和/或自身免疫中的潜在用途。

2. 发明申请

WO2006015321A9 TRANSITION METAL-DOPED OXIDE SEMICONDUCTOR EXHIBITING ROOM-TEMPERATURE FERROMAGNETISM AND METHOD OF SENSING A GAS BY DETECTING CHANGE IN MAGNETIC PROPERTIES 审中-公开
标题翻译：过渡金属氧化物半导体展示室温度检测方法及通过检测磁性变化检测气体的方法
公开(公告)号：WO2006015321A9
公开(公告)日：2007-04-26
申请号：PCT/US2005027269
申请日：2005-08-01
申请人： UNIV BOISE STATE , PUNNOOSE ALEX
发明人： PUNNOOSE ALEX
CPC分类号： C01G19/00 , C01G19/02 , C01G49/06 , C01P2002/72 , C01P2002/82 , C01P2006/42 , G01N27/74 , G01N33/0027 , H01F1/401 , H01F10/193 , H01L29/24 , H01L29/26 , Y10S977/773 , Y10S977/811
摘要： An oxide semiconductor doped with a transition metal and exhibiting room-temperature ferromagnetism is disclosed. The transition metal-doped oxide semiconductor is preferably manufactured in powder form, and the transition metal is preferably evenly distributed throughout the oxide semiconductor. The preferred embodiments are iron-doped tin dioxide and cobalt-doped tin dioxide. Gases may be detected by passing them across a material and measuring the change in magnetic properties of the material; the preferred material is iron-doped tin dioxide.
摘要翻译：公开了掺杂有过渡金属并呈现室温铁磁性的氧化物半导体。过渡金属掺杂氧化物半导体优选以粉末形式制造，并且过渡金属优选均匀分布在整个氧化物半导体中。优选的实施方案是铁掺杂二氧化锡和掺钴二氧化锡。可以通过将它们穿过材料并测量材料的磁性的变化来检测气体; 优选的材料是掺铁二氧化锡。

3. 发明申请

WO2009079056A3 FLUORESCENT PARTICLES COMPRISING NANOSCALE ZNO LAYER AND EXHIBITING CELL-SPECIFIC TOXICITY 审中-公开
标题翻译：包含纳米ZNO层和展示细胞特异性毒性的荧光颗粒
公开(公告)号：WO2009079056A3
公开(公告)日：2009-10-22
申请号：PCT/US2008077284
申请日：2008-09-22
申请人： UNIV BOISE STATE , WANG HUA , WINGETT DENISE , FERIS KEVIN , PUNNOOSE ALEX , KONGARA MADHUSUDAN R
发明人： WANG HUA , WINGETT DENISE , FERIS KEVIN , PUNNOOSE ALEX , KONGARA MADHUSUDAN R
IPC分类号： B82B1/00 , C01G9/02 , C09B67/20
CPC分类号： A61K49/0043 , A61K31/315 , A61K49/0093 , B82Y5/00 , B82Y20/00 , B82Y30/00 , Y10S977/701 , Y10S977/712 , Y10S977/715
摘要： Multifunctional "smart" nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FlTC core. These -200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 µg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations > 250-500 µg/mL (for Staphylococcus aureus and Escherichia coli, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.
摘要翻译：公开了多功能“智能”纳米结构，其包括具有纳米级ZnO整理层的异氰酸荧光素（FITC） - 包封的SiO2核 - 壳颗粒，其中在SiO 2 -F1TC芯上形成外部ZnO层。这些-200nm大小的颗粒分别显示使用细菌大肠杆菌和Jurkat癌细胞的细胞成像和细胞摄取研究的希望。 FITC封装的ZnO颗粒在优先杀死Jurkat癌细胞中具有优异的选择性，对正常的初级免疫细胞具有最小的毒性（暴露于60μg/ mL后分别为18％和75％的活力），并抑制革兰氏阳性和浓度> 250-500μg/ mL的革兰阴性菌（分别为金黄色葡萄球菌和大肠杆菌）。这些结果表明，具有纳米尺度ZnO表面层的FITC封装的多功能颗粒可用作微粒跟踪，细胞成像，抗菌治疗和癌症治疗的智能纳米结构。

4. 发明申请

WO2009079056A2 FLUORESCENT PARTICLES COMPRISING NANOSCALE ZNO LAYER AND EXHIBITING CELL-SPECIFIC TOXICITY 审中-公开
标题翻译：包含纳米ZNO层和展示细胞特异性毒性的荧光颗粒
公开(公告)号：WO2009079056A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/077284
申请日：2008-09-22
申请人： BOISE STATE UNIVERSITY , WANG, Hua , WINGETT, Denise , FERIS, Kevin , PUNNOOSE, Alex , KONGARA, Madhusudan, R.
发明人： WANG, Hua , WINGETT, Denise , FERIS, Kevin , PUNNOOSE, Alex , KONGARA, Madhusudan, R.
IPC分类号： B82B1/00 , C09B67/20 , C01G9/02
CPC分类号： A61K49/0043 , A61K31/315 , A61K49/0093 , B82Y5/00 , B82Y20/00 , B82Y30/00 , Y02A50/473 , Y10S977/701 , Y10S977/712 , Y10S977/715
摘要： Multifunctional "smart" nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FlTC core. These -200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations > 250- 500 μg/mL (for Staphylococcus aureus and Escherichia coli, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.
摘要翻译：公开了多功能“智能”纳米结构，其包括具有纳米级ZnO整理层的异氰酸荧光素（FITC） - 包封的SiO2核 - 壳颗粒，其中在SiO 2 -F1TC芯上形成外部ZnO层。这些-200nm大小的颗粒分别显示使用细菌大肠杆菌和Jurkat癌细胞的细胞成像和细胞摄取研究的希望。 FITC封装的ZnO颗粒在优先杀死Jurkat癌细胞中具有优异的选择性，对正常的初级免疫细胞具有最小的毒性（暴露于60μg/ mL后分别为18％和75％的活力），并抑制革兰氏阳性和浓度>250-500μg/ mL的革兰氏阴性细菌（分别用于金黄色葡萄球菌和大肠杆菌）。这些结果表明，具有纳米尺度ZnO表面层的FITC封装的多功能颗粒可用作微粒跟踪，细胞成像，抗菌治疗和癌症治疗的智能纳米结构。

5. 发明申请

WO2006015321A2 TRANSITION METAL-DOPED OXIDE SEMICONDUCTOR EXHIBITING ROOM-TEMPERATURE FERROMAGNETISM AND METHOD OF SENSING A GAS BY DETECTING CHANGE IN MAGNETIC PROPERTIES 审中-公开
标题翻译：过渡金属氧化物半导体展示室温度和通过检测磁性变化检测气体的方法
公开(公告)号：WO2006015321A2
公开(公告)日：2006-02-09
申请号：PCT/US2005027269
申请日：2005-08-01
申请人： UNIV BOISE STATE , PUNNOOSE ALEX
发明人： PUNNOOSE ALEX
IPC分类号： A42B1/04
CPC分类号： C01G19/00 , C01G19/02 , C01G49/06 , C01P2002/72 , C01P2002/82 , C01P2006/42 , G01N27/74 , G01N33/0027 , H01F1/401 , H01F10/193 , H01L29/24 , H01L29/26 , Y10S977/773 , Y10S977/811
摘要： An oxide semiconductor doped with a transition metal and exhibiting room-temperature ferromagnetism is disclosed. The transition metal-doped oxide semiconductor is preferably manufactured in powder form, and the transition metal is preferably evenly distributed throughout the oxide semiconductor. The preferred embodiments are iron-doped tin dioxide and cobalt-doped tin dioxide. Gases may be detected by passing them across a material and measuring the change in magnetic properties of the material; the preferred material is iron-doped tin dioxide.
摘要翻译：公开了掺杂有过渡金属并呈现室温铁磁性的氧化物半导体。过渡金属掺杂氧化物半导体优选以粉末形式制造，并且过渡金属优选均匀分布在整个氧化物半导体中。优选的实施方案是铁掺杂二氧化锡和掺杂钴的二氧化锡。可以通过将它们穿过材料并测量材料的磁性的变化来检测气体; 优选的材料是掺铁二氧化锡。

6. 发明申请

WO2006015321A1 TRANSITION METAL-DOPED OXIDE SEMICONDUCTOR EXHIBITING ROOM-TEMPERATURE FERROMAGNETISM AND METHOD OF SENSING A GAS BY DETECTING CHANGE IN MAGNETIC PROPERTIES 审中-公开
标题翻译：显示室温铁磁性的过渡金属掺杂氧化物半导体及通过检测磁特性变化来检测气体的方法
公开(公告)号：WO2006015321A1
公开(公告)日：2006-02-09
申请号：PCT/US2005/027269
申请日：2005-08-01
申请人： BOISE STATE UNIVERSITY , PUNNOOSE, Alex
发明人： PUNNOOSE, Alex
IPC分类号： A42B1/04
摘要： An oxide semiconductor doped with a transition metal and exhibiting room-temperature ferromagnetism is disclosed. The transition metal-doped oxide semiconductor is preferably manufactured in powder form, and the transition metal is preferably evenly distributed throughout the oxide semiconductor. The preferred embodiments are iron-doped tin dioxide and cobalt-doped tin dioxide. Gases may be detected by passing them across a material and measuring the change in magnetic properties of the material; the preferred material is iron-doped tin dioxide.
摘要翻译：公开了掺杂有过渡金属并显示出室温铁磁性的氧化物半导体。过渡金属掺杂氧化物半导体优选以粉末形式制造，并且过渡金属优选均匀分布在整个氧化物半导体中。优选的实施方案是铁掺杂二氧化锡和钴掺杂二氧化锡。可以通过将气体穿过材料并测量材料的磁性变化来检测气体; 优选的材料是铁掺杂的二氧化锡。

7. 发明申请

WO2009039508A9 PREFERENTIAL KILLING OF CANCER CELLS AND ACTIVATED HUMAN T CELLS USING ZNO NANOPARTICLES 审中-公开
公开(公告)号：WO2009039508A9
公开(公告)日：2009-03-26
申请号：PCT/US2008/077252
申请日：2008-09-22
申请人： BOISE STATE UNIVERSITY , WINGETT, Denise , PUNNOOSE, Alex , KONGARA, Madhusudan, R.
发明人： WINGETT, Denise , PUNNOOSE, Alex , KONGARA, Madhusudan, R.
IPC分类号： A61K33/30 , A61P35/00 , A61K9/16 , A61K9/14 , A61P37/00

8. 发明申请

WO2008153603A1 MAGNETIC GAS SENSOR AND METHODS USING ANTIFERROMAGNETIC HEMATITE NANOPARTICLES 审中-公开
标题翻译：磁性气体传感器及使用抗真菌吸收纳米粒子的方法
公开(公告)号：WO2008153603A1
公开(公告)日：2008-12-18
申请号：PCT/US2007/088864
申请日：2007-12-26
申请人： BOISE STATE UNIVERSITY , PUNNOOSE, Alex
发明人： PUNNOOSE, Alex
IPC分类号： C12Q1/68
CPC分类号： G01N33/005 , B82Y15/00
摘要： A nanoscale antiferromagnetic gas sensing apparatus and methods of measuring gas using the apparatus are described. The use of the magnetic properties of an antiferromagnetic material as gas sensing parameters explores the concept of magnetic gas sensing. According to a preferred embodiment, a nanoscale magnetic hydrogen sensor apparatus is developed based on varying of the saturation magnetization and remanence of nanoscale antiferiOmagnetic hematite with hydrogen flow. For example, the saturation magnetization and remanence of nanoscale hematite has been shown to increase one to two orders of magnitude in the presence of flowing hydrogen gas at concentrations in the 1-10% range and at 575 K, indicating that a magnetic hydrogen sensor using hematite material may be practical and useful for detecting hydrogen in various environments such as those wherein production, storage, transportation, and/or vehicle use of hydrogen is being conducted.
摘要翻译：描述了使用该装置测量气体的纳米级反铁磁性气体检测装置和方法。使用反铁磁性材料的磁特性作为气体检测参数，探讨了磁性气体检测的概念。根据优选实施例，基于随着氢气流量的纳米级抗磁赤铁矿的饱和磁化强度和剩磁度的变化而开发出纳米级的磁性氢传感器装置。例如，纳米尺度赤铁矿的饱和磁化强度和剩磁性在1-10％范围和575 K浓度范围内流动的氢气存在时可以增加一到两个数量级，表明使用了一个磁性氢传感器赤铁矿材料在各种环境（例如正在进行氢气的生产，储存，运输和/或车辆使用的那些环境中）中检测氢气可能是实用和有用的。

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