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1. 发明申请

WO9624581A2 NEW DERIVATIVES OF PYRIDIL PIPERAZINE OR PYRIDAZINYL PIPERAZYL, PROCESS FOR PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译：新的吡啶基或哒嗪基，哌嗪衍生物，其制造方法相同，并且含药物
公开(公告)号：WO9624581A2
公开(公告)日：1996-08-15
申请号：PCT/EP9600524
申请日：1996-02-08
申请人： BOEHRINGER MANNHEIM GMBH , TSAKLAKIDIS CHRISTOS , MERTENS ALFRED , ZIMMERMANN GERD , SCHAEFER WOLFGANG , DOERGE LIESEL
发明人： TSAKLAKIDIS CHRISTOS , MERTENS ALFRED , ZIMMERMANN GERD , SCHAEFER WOLFGANG , DOERGE LIESEL
IPC分类号： C07D237/20 , A61K31/495 , A61K31/50 , A61P7/02 , C07D213/74 , C07D , A61K
CPC分类号： C07D213/74
摘要： Compounds of formula (I), in which R stands for hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, a possibly substituted mono-or bi-cyclic aryl, a possibly substituted hetaryl, a possibly substituted aryl alkyl or one of the groups -OR , -NR R , W stands for nitrogen or -CR , X, Z independently of each other stands for nitrogen or -CH, and where W stands for a nitrogen atom, X must be the group -CH, A stands for a valency bond or the carbonyl group, B stands for a valency bond or a C1-C6 alkyl chain possibly substituted once or several times by lower alkyl or an OR group, D stands for a valency bond, and, where X is a nitrogen atom, can also be the carbonyl group, A, B and D being unable to represent the valency bond simultaneously, R stands for hydrogen, lower alkyl or aryl alkyl, R , R independently of each other stand for hydrogen or lower alkyl, or form a five- or six-membered heterocyclic ring together with the nitrogen atom to which they are linked, R stands for hydrogen or a group OR . The invention also relates to a process for the production of these compounds, and medicaments containing them for the treatment of diseases which are attributable to thromboembolic conditions.
摘要翻译：式（I），其中R <1>是氢，低级烷基，低级烯基，环烷基，环烯基的化合物，任选取代的单环或双环芳基，任选取代的杂芳基，任选取代的芳基烷基或以下基团之一-OR < 2>，-NR <3> [R <4>中，W为氮或-CR <5>，X，Z独立地为氮或-CH，以及用于其中W代表氮原子的情况下，X为基团 - 一个必须是CH，表示价键或羰基，B代表被低级烷基或一个或或多取代C1-C6亚烷基链价键或任选的单 - <2>基，D表示化合价键，并且在壳体在于X是氮原子，也可以是羰基，其中A，B和D不能同时意味着价键，R <2>是氢，低级烷基或芳烷基，R <3>，R <4>独立地是氢，或妮 ederes烷基，或与氮原子一起形成它们所连接形成五至六元杂环，R <5>是氢或基团或<2>，它们的制备方法和含有这些化合物的药物组合物用于治疗疾病的那是由于血栓栓塞事件。

2. 发明申请

WO2005097783A8 THIOCARBAMOYLPROLINES 审中-公开
标题翻译： THIOCARBAMOYLPROLINE
公开(公告)号：WO2005097783A8
公开(公告)日：2007-04-19
申请号：PCT/EP2005002745
申请日：2005-03-15
申请人： MERCK PATENT GMBH , MEDERKSI WERNER , TSAKLAKIDIS CHRISTOS , DORSCH DIETER , CEZANNE BERTRAM , GLEITZ JOHANNES
发明人： MEDERKSI WERNER , TSAKLAKIDIS CHRISTOS , DORSCH DIETER , CEZANNE BERTRAM , GLEITZ JOHANNES
IPC分类号： C07D413/12 , A61K31/5377 , A61P7/00
CPC分类号： C07D413/12
摘要： The invention relates to novel compounds of formula (I) wherein R, R 1 , R 2 , R 3 and R 4 have the meaning cited in claim 1, inhibit coagulation factors Xa and can be used in the prophylaxis and/or therapy of thromboembolic diseases and for treating tumours.
摘要翻译：式（I）的新化合物; 其中R，R ^{1 ，R ^{2 ，R ^{3 和R ^{4 具有权利要求1所指明的含义是凝血因子Xa的抑制剂，可用于预防和/或血栓栓塞性疾病的治疗和用于治疗肿瘤。}}}}

3. 发明申请

WO0230880A3 N-SUBSTITUTED AMINO ACID DERIVATIVES (FACTOR XA INHIBITORS) 审中-公开
标题翻译： N-取代的氨基酸衍生物（因子Xa抑制剂）
公开(公告)号：WO0230880A3
公开(公告)日：2002-10-03
申请号：PCT/EP0111833
申请日：2001-10-12
申请人： MERCK PATENT GMBH , JURASZYK HORST , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BARNES CHRISTOPHER , GLEITZ JOHANNES
发明人： JURASZYK HORST , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BARNES CHRISTOPHER , GLEITZ JOHANNES
IPC分类号： A61P7/02 , C07C237/22 , C07C311/46 , C07C317/48 , C07C323/60 , C07C327/48 , C07D213/40 , C07D213/56 , C07D213/74 , C07D233/54 , C07D295/088 , A61K31/44 , C07C317/40 , C07C327/58
CPC分类号： C07D213/40 , C07C237/22 , C07C311/46 , C07C317/48 , C07C323/60 , C07C327/48 , C07C2601/14 , C07D213/56 , C07D213/74 , C07D233/64 , C07D295/088
摘要： The invention relates to compounds of formula (I) wherein the substituents R , R , R , R , R , X, Y, U, V and W have the designation cited in patent claim 1. The compounds are suitable for producing pharmaceuticals for fighting thromboembolic diseases.
摘要翻译：本发明涉及式（I）的化合物，其中取代基R <1>，R <2>，R <3>，R <4>，R <5>，X，Y，U，V和W在苛刻的具有给出的含义。1 所述化合物适用于生产药物，以打击血栓栓塞Erkankungen。

4. 发明申请

WO0208177A8 N-SUBSTITUTED-1-AMINO-1,1-DIALKYLCARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译： N-取代的1-氨基-1,1-DIALKYLCARBONSÄUREDERIVATE
公开(公告)号：WO0208177A8
公开(公告)日：2002-04-18
申请号：PCT/EP0107596
申请日：2001-07-03
申请人： MERCK PATENT GMBH , JURASZYK HORST , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BARNES CHRISTOPHER , GLEITZ JOHANNES
发明人： JURASZYK HORST , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BARNES CHRISTOPHER , GLEITZ JOHANNES
IPC分类号： A61K31/18 , A61K31/277 , A61K31/4245 , A61P7/02 , A61P9/00 , A61P9/10 , A61P29/00 , A61P35/00 , A61P35/04 , C07B61/00 , C07C311/46 , C07D211/66 , C07D213/40 , C07D271/06 , C07D309/14 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/165
CPC分类号： C07D213/40 , C07C311/46 , C07C2601/08 , C07C2601/14 , C07D211/66 , C07D271/06 , C07D309/14 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The novel compounds of formula (I), wherein R , R , R , R , R , R , R , R , R , R , R , X, Y, U, V and W have the meanings given in patent claim no. 1, are inhibitors of the coagulation factors Xa and VIIa and can be used for treating thromboses, myocardial infarction, arteriosclerosis, inflammations, apoplexy, angina pectoris, restenosis following angioplasty, intermittent claudication, tumours, tumour diseases and/or tumour metastases.
摘要翻译：式（I）的新化合物，其中R 1，R 2，R 2，R 2，R 3，R 4，R 5，R 5），R <5“>，R <5 '' '>，R <' ''>，X，Y，U，V和W的含义如权利要求1中给出，是凝血因子Xa和Ⅶa因子的抑制剂，并可以用于被用于治疗血栓形成，心肌梗塞，动脉硬化，炎症，中风，心绞痛，再狭窄血管成形术后，间歇性跛行，肿瘤，肿瘤疾病和/或肿瘤转移的。

5. 发明申请

WO0040583A3 IMIDAZO[4,5-C]-PYRIDINE-4-ON-DERIVATIVES 审中-公开
标题翻译：咪唑并[4,5-C]吡啶-4-酮衍生物
公开(公告)号：WO0040583A3
公开(公告)日：2000-09-21
申请号：PCT/EP9910236
申请日：1999-12-21
申请人： MERCK PATENT GMBH , MEDERSKI WERNER , JURASZYK HORST , WURZIGER HANNS , TSAKLAKIDIS CHRISTOS , DORSCH DIETER , BERNOTAT DANIELOWSKI SABINE , MELZER GUIDO , ANZALI SOHEILA
发明人： MEDERSKI WERNER , JURASZYK HORST , WURZIGER HANNS , TSAKLAKIDIS CHRISTOS , DORSCH DIETER , BERNOTAT-DANIELOWSKI SABINE , MELZER GUIDO , ANZALI SOHEILA
IPC分类号： A61K31/437 , A61P7/02 , A61P9/10 , A61P29/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to novel compounds of formula (I) wherein R, R , R , R and n have the meaning given in Claim 1. Said compounds are inhibitors of the coagulation factor Xa and can be used for the prophylaxis and/or therapy of thrombo-embolic diseases.
摘要翻译：式（I）的新化合物：其中R，R <1>，R <2>，R <3>和n具有权利要求1中给出的含义，是凝血因子Xa的抑制剂，并可以血栓栓塞症用于预防和/或治疗疾病被使用。

6. 发明申请

WO2004087646A3 PYRROLIDINO-1,2-DICARBOXY-1-(PHENYLAMIDE)-2-(4-(3-OXO-MORPHOLINO-4-YL)-PHENYLAMIDE) DERIVATIVES AND RELATED COMPOUNDS FOR USE AS INHIBITORS OF COAGULATION FACTOR XA IN THE TREATMENT OF THROMBO-EMBOLIC DISEASES 审中-公开
标题翻译：吡咯烷-1,2-二羧酸1-（苯基氨基）-2-（4-（3-氧代 - 吗啉-4-基）-PHENYLAMID）作为凝血因子的抑制剂衍生物和相关化合物XA治疗血栓栓塞性病症的
公开(公告)号：WO2004087646A3
公开(公告)日：2005-01-06
申请号：PCT/EP2004002350
申请日：2004-03-08
申请人： MERCK PATENT GMBH , TSAKLAKIDIS CHRISTOS , DORSCH DIETER , MEDERSKI WERNER , CEZANNE BERTRAM , GLEITZ JOHANNES
发明人： TSAKLAKIDIS CHRISTOS , DORSCH DIETER , MEDERSKI WERNER , CEZANNE BERTRAM , GLEITZ JOHANNES
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/5377 , A61P7/02 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , C07C275/26 , C07D20060101 , C07D265/32 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D413/12 , C07D207/16 , C07D207/27 , C07D211/60 , C07D211/76 , C07D213/64 , C07D213/68 , C07D223/10 , C07D241/18 , C07D265/08 , C07D265/32 , C07D267/10 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/02 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08
摘要： The invention relates to the compounds of formula (I), wherein W represents N, CR , or a sp hybridized C atom, E, together with W, represents a 3- to 7-membered saturated carbocylic or heterocyclic ring having 0 to 3 N atoms, 0 to 2 O atoms and/or 0 to 2 S atoms, which ring may contain a double bond, D represents a mononuclear or binuclear unsubstituted aromatic carbocycle or heterocycle having 0 to 4 N atoms, O atoms and/or S atoms or being monosubstituted or polysubstituted by Hal, A, OR , N(R )2, NO2, CN, COOR or CON(R )2, G represents -[C(R )2]n-, -[C(R )2]nNR -, -[C(R )2]nO-, -[C(R )2]nS- or -[C(R )=C(R )]n-, X represents -[C(R )2]nCONR [C(R )2]n-, -[C(R )2]nNR CO[C(R )2]n-, -[C(R )2]nNR [C(R )2]n-, -[C(R )2]nO[C(R )2]n-, -[C(R )2]nCO[C(R )2]n- or -[C(R )2]nCOO[C(R )2]n-, Y represents alkylene, cycloalkylene, Het-diyl or Ar-diyl, T represents a mononuclear or binuclear saturated or unsaturated carbocycle or heterocycle having 0 to 4 N atoms, O atoms and/or S atoms, which is monosubstituted or polysubstituted by =O, =S, =NR , =N-CN, =N-NO2, =NOR , =NCOR , =NCOOR , =NOCOR and which may further be monosubstituted, disubstituted or trisubstituted by R , Hal, A,-[C(R )2]n, -Ar, -[C(R )2]n-het, -[C(R )2]n-cycloalkyl, OR , N(R )2, NO2, CN, COOR , CON(R )2, NR COA, NR CON(R )2, NR SO2A, COR , SO2NR and/or S(O)nA, and R and R are defined as in claim 1. The inventive compounds inhibit coagulation factor Xa and can be used in the prophylaxis and/or therapy of thrombo-embolic diseases and for treating tumors.
摘要翻译：式（I），其中，WN，CR <3>，或SP <2>杂化的碳原子，E为W一起是3-至7-元饱和的碳环或具有杂环的化合物，0〜3 N，0 2个O和/或0至2个S原子，其可以包含双键，D为单 - 或被Hal，A或<3>，N（R <3>）2 zwelkernigen unsubstlituierten或单 - 或多取代，NO 2，CN，COOR <3>或CON（R <3>）2取代的具有0的芳族碳环或杂环至4个N，O和/或S原子，G - [C（R <4>） 2] N - ， - [C（R <4>）2] n的NR <3> - ， - [C（R <4>）2] n的O-， - [C（R <4>）2] n的S-，或 - [C（R <4>）= C（R <4>）] n的，X - [C（R <4>）2] NCONR [（<4> R）2 C] n的<3>， - [C（R <4>）2] n的NR <3> CO [C（R <4>）2] N - ， - [C（R <4>）2] n的NR <3> [C（R <4 >）2] N - ， - [C（R <4>）2]无[C（R <4>）2] N - ， - [C（R <4>）2] n的CO [C（R <4 >）2] n-或 - [C（R <4>）2] n的COO [C（R <4>）2] N-，Y是亚烷基，环亚烷基中，Het二基，T表示一个单环或双环饱和或不饱和碳环或杂环具有0至4个N，O，其为单取代或由= O，= S，= NR <二取代的和/或S原子的3 >，= N-CN，= N-NO 2，= NOR <3>，= NCOR <3>，= NCOOR <3> = NOCOR <3>）是取代的，并且进一步的单 - ，二 - 或由R <三取代 3>中，Hal，A， - [C（R <4>）2] n的基-Ar， - [C（R <4>）2]正的Het， - [C（R <4>）2] N- 环烷基，OR <3>，N（R <3>）2，NO 2，CN，COOR <3>，CON（R <3>）2，NR <3> COA，NR <3> CON（R <3> ）2，NR <3> SO2A，COR <3>，SO 2 NR可以是<3>和/或S（O）nA的取代，R <1>和R <2>具有权利要求1中所示的含义，是抑制剂凝血因子Xa和可用于血栓栓塞性疾病的预防和/或治疗和用于肿瘤的治疗。

7. 发明申请

WO0208177A3 N-SUBSTITUTED-1-AMINO-1,1-DIALKYLCARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译： N-取代的1-氨基-1,1-DIALKYLCARBONSÄUREDERIVATE
公开(公告)号：WO0208177A3
公开(公告)日：2002-07-25
申请号：PCT/EP0107596
申请日：2001-07-03
申请人： MERCK PATENT GMBH , JURASZYK HORST , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BARNES CHRISTOPHER , GLEITZ JOHANNES
发明人： JURASZYK HORST , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BARNES CHRISTOPHER , GLEITZ JOHANNES
IPC分类号： A61K31/18 , A61K31/277 , A61K31/4245 , A61P7/02 , A61P9/00 , A61P9/10 , A61P29/00 , A61P35/00 , A61P35/04 , C07B61/00 , C07C311/46 , C07D211/66 , C07D213/40 , C07D271/06 , C07D309/14 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/165
CPC分类号： C07D213/40 , C07C311/46 , C07C2601/08 , C07C2601/14 , C07D211/66 , C07D271/06 , C07D309/14 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The novel compounds of formula (I), wherein R1, R2, R2', R2", R3, R4, R5, R5', R5", R5''', R'''', X, Y, U, V and W have the meanings given in patent claim no. 1, are inhibitors of the coagulation factors Xa and VIIa and can be used for treating thromboses, myocardial infarction, arteriosclerosis, inflammations, apoplexy, angina pectoris, restenosis following angioplasty, intermittent claudication, tumours, tumour diseases and/or tumour metastases.
摘要翻译：式（I）的新化合物：其中R1，R2，R2”，R2”，R3，R4，R5，R5' ，R5" ，R 5 '' 'R' ''”，X，Y，U，V和W 具有权利要求1中给出的含义，是凝血因子Xa和Ⅶa因子的抑制剂，可用于治疗血栓形成的，心肌梗塞，动脉硬化，炎症，中风，心绞痛，血管成形术后再狭窄，间歇性跛行，肿瘤，肿瘤疾病和/或肿瘤转移可以使用。

8. 发明申请

WO0170678A3 SUBSTITUTED BIPHENYL DERIVATIVES 审中-公开
标题翻译：取代的联苯
公开(公告)号：WO0170678A3
公开(公告)日：2002-04-04
申请号：PCT/EP0103375
申请日：2001-03-23
申请人： MERCK PATENT GMBH , JURASZYK HORST , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BARNES CHRISTOPHER , GLEITZ JOHANNES
发明人： JURASZYK HORST , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , BARNES CHRISTOPHER , GLEITZ JOHANNES
IPC分类号： C07D317/60 , A61K31/167 , A61K31/216 , A61K31/235 , A61K31/27 , A61K31/36 , A61P7/02 , A61P9/08 , A61P9/10 , A61P29/00 , A61P43/00 , C07C257/18 , C07C317/32 , C07C317/40 , A61K31/155 , C07C251/24
CPC分类号： C07C317/40 , C07C257/18 , Y02P20/55
摘要： The invention relates to compounds of general formula (I) where R = -C(=NH)NH2 optionally substituted with COA, -CO-, [C(R )2]n-Ar', -COOA, OR , OCOA, OCO-[C(R )2]n-Ar', -OH or by a conventional amino protecting group, -NHC(=NH)-NH2, -CON=C(NH2)2, (II), or (III), substituted phenyl or naphthyl, optionally substituted with A, -OR , -N(R )2, -NO2, -CAN, -Hal, -NR COA, -NR COAr', -NR SO2A, - NR SO2Ar', -COOR , -CON(R )2, -COR , -COAr' or S(O)nA; R = -S(O)nA, -CF3, -COOR , -OA and R , R , R , R , R and X have the meanings given in the text. Said compounds have factor Xa and VIIa inhibitory effects and can thus be used for the treatment and prevention of thromboembolitic diseases such as thromboses, myocardial infarct, arterioscleroses, inflammations, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.
摘要翻译：本发明涉及式（I）的化合物，其中R <1>：由-C（= NH）NH 2，这也是简单地通过-COA，-CO- [C（R <7>）2]正的Ar' -COOA，OR 7，OCOA，OCO- N2-的Ar”，-OH，或通过常规的氨基，-NHC（= NH）-NH 2' 取代的[C（R 7）2]，-CON = C（NH 2） 2，取代的苯基或萘基，任选地被-A，或取代的<6>，-N（R <6>）2，-NO 2，-CN，-Hal，-NR <5> COA，-NR <5> COAR ' - NR <6> SO2A，-NR <5> SO2Ar' 取代，-COOR <5>，-CON（R <5>）2，-COR <7>，-COAr“或S（O）nA的即可; [R <2>：-S（O）NA，-CF 3，-COOR <7>，-OA; 的意思是，和其中R <3>，R <4>，R <5>，R <7>中，A和X具有文中所指出的含义。的化合物作为因子Xa和Ⅶa因子的抑制剂，可用于对抗和预防血栓栓塞疾病，如血栓形成，心肌梗塞，动脉硬化，炎症，中风，心绞痛，再狭窄血管成形术和间歇性跛行后因此eingsetzt。

9. 发明申请

WO2009124962A3 SULFONAMIDES 审中-公开
标题翻译：磺胺类药物
公开(公告)号：WO2009124962A3
公开(公告)日：2010-01-28
申请号：PCT/EP2009054204
申请日：2009-04-08
申请人： MERCK SERONO SA , CROSIGNANI STEFANO , CLEVA CHRISTOPHE , TSAKLAKIDIS CHRISTOS , BURGDORF LARS
发明人： CROSIGNANI STEFANO , CLEVA CHRISTOPHE , TSAKLAKIDIS CHRISTOS , BURGDORF LARS
IPC分类号： C07C311/19 , A61K31/18 , A61P9/10 , C07C311/29 , C07D213/36 , C07D213/42 , C07D213/71 , C07D213/82 , C07D217/16 , C07D239/52 , C07D241/12 , C07D257/04 , C07D261/04 , C07D265/36 , C07D295/135
CPC分类号： C07C311/21 , C07C311/19 , C07C311/29 , C07C311/51 , C07C2601/02 , C07C2602/08 , C07D209/52 , C07D213/42 , C07D239/26 , C07D257/04 , C07D307/14 , C07D333/20 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R4, Ra, Rb, Rc, Re, A*, W1, W2 and W3 are as defined in claim 1, for the treatment of CXCR3 related diseases.
摘要翻译：本发明涉及式（I）化合物，其中R1，R2，R4，Ra，Rb，Rc，Re，A *，W1，W2和W3如权利要求1所定义，用于治疗CXCR3相关疾病。

10. 发明申请

WO2006032342A3 CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF 审中-公开
标题翻译：药物含羰及其用途
公开(公告)号：WO2006032342A3
公开(公告)日：2007-01-11
申请号：PCT/EP2005009124
申请日：2005-08-24
申请人： MERCK PATENT GMBH , CEZANNE BERTRAM , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , GLEITZ JOHANNES
发明人： CEZANNE BERTRAM , DORSCH DIETER , MEDERSKI WERNER , TSAKLAKIDIS CHRISTOS , GLEITZ JOHANNES
IPC分类号： A61P7/02 , A61K31/4025 , A61K31/427 , A61K31/4412 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5355 , A61K31/5377 , A61K31/553 , C07D413/12 , C07D417/12
CPC分类号： A61K31/4545 , A61K31/4025 , A61K31/427 , A61K31/4412 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5355 , A61K31/5377 , A61K31/553 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of the compounds of formula (I), wherein D, E, G, W, X, Y, T, R 1 and R 2 are defined as in claim 1, in the prophylaxis and/or therapy of thromboembolic diseases.
摘要翻译：式I化合物的使用（I），其中D，E，G，W，X，Y，T，R ^{1 和R ^{2 是如在权利要求1重要性定义对血栓栓塞性病症的预防和/或治疗。}}

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