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1. 发明申请

WO2012023722A2 LOW HEAT CAPACITY COMPOSITE FOR THERMAL CYCLER 审中-公开
标题翻译：用于热循环的低热容复合材料
公开(公告)号：WO2012023722A2
公开(公告)日：2012-02-23
申请号：PCT/KR2011/005756
申请日：2011-08-08
申请人： BIONEER CORPORATION. , PARK, Han Oh , KIM, Jae Ha
发明人： PARK, Han Oh , KIM, Jae Ha
IPC分类号： C09K5/14 , C22C26/00 , B01L7/00
CPC分类号： B01L7/52 , B22F2998/10 , B22F2999/00 , C09K5/14 , C22C1/0416 , C22C1/0425 , C22C1/0466 , C22C1/0483 , C22C13/00 , C22C13/02 , C22C26/00 , C22C1/1084 , B22F3/14 , B22F3/18 , C22C1/02
摘要： Provided is a low heat capacity composite for a thermal cycler. The low heat capacity composite of the present invention is a low heat capacity composite for a thermal cycler capable of overcoming difficulty in manufacture and reproducibility due to uniqueness of the existing PCR thermal cycler only. The low heat capacity composite of the present invention can reduce the cost of raw material and retain excellent heat property due to the improvement in low heat capacity and physical and mechanical properties, thereby remarkably shortening PCR reaction time and saving energy when used as a thermal block for a thermal cycler.
摘要翻译：提供用于热循环仪的低热容量复合材料。本发明的低热容复合材料是用于热循环仪的低热容复合材料，由于现有PCR热循环仪的独特性，所述复合材料能够克服制造和再现性的困难。本发明的低热容量复合材料由于改善了低热容量和物理机械性能，因此可以降低原料成本并保持优异的热性能，因此当用作热块时显着缩短PCR反应时间并节省能量用于热循环仪。

2. 发明申请

WO2011049312A9 HIGH THROUGHPUT OLIGONUCLEOTIDE SYNTHESIZER 审中-公开
公开(公告)号：WO2011049312A9
公开(公告)日：2011-04-28
申请号：PCT/KR2010/006933
申请日：2010-10-11
申请人： BIONEER CORPORATION , PARK, Han Oh , PARK, Han Ee , SONG, Gu Young , LEE, Yang Won , JANG, Dae Jin
发明人： PARK, Han Oh , PARK, Han Ee , SONG, Gu Young , LEE, Yang Won , JANG, Dae Jin
IPC分类号： C12M1/36 , G01N35/00 , C12Q1/68
摘要： There is provided a high throughput oligonucleotide synthesizer used for the chemical synthesis of oligo DNA/RNA or protein in which a high throughput oligonucleotide synthesizer in which one or more synthetic reactor modules (plate) with hundreds or thousands of individual synthetic reactors are installed, a reagent valve for inputting a reagent required to synthesis into each of the individual synthetic reactors is mounted, the synthetic reactor modules are moved and arranged to match valve nozzles (inlets), and the reagents are divisionally provided to the individual synthetic reactors in sequence in accordance with sequence information (arrangement) which is inputted by a user to chemically synthesize oligo DNA/RNA or protein with a reactive microparticle media in the synthetic reactor module, in an automation synthesizer used for the chemical synthesis of oligo DNA/RNA or protein.

3. 发明申请

WO2007094581A1 DRIED OLIGONUCLEOTIDE COMPOSITION AND METHOD OF PRODUCING THE SAME 审中-公开
标题翻译：干燥寡核苷酸组合物及其制备方法
公开(公告)号：WO2007094581A1
公开(公告)日：2007-08-23
申请号：PCT/KR2007/000662
申请日：2007-02-07
申请人： BIONEER CORPORATION , PARK, Han Oh , KIM, Jae Ha
发明人： PARK, Han Oh , KIM, Jae Ha
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The present invention relates to a dried oligonucleotide composition and a method for producing the same. More specifically, it relates to a dried oligonucleotide composition produced by the steps comprising adding a substance for preventing the oligonucleotide from being separated and lost, which is adhesive to a storage container containing the oligonucleotide composition, in order to prevent the oligonucleotide from being separated and lost during manufacturing and distributing the dried oligonucleotide composition, optionally adding a non-reactive dye substance, and drying the resulting solution. The dried oligonucleotide composition of the present invention can be prevented from being separated and lost during manufacturing step, or transporting step after packaging, and the presence or absence of the oligonucleotide in the storage container can be easily confirmed with naked eyes. Accordingly, unnecessary labor waste and time waste caused by the separation of the oligonucleotide upon experiment can be overcome.
摘要翻译：本发明涉及干燥的寡核苷酸组合物及其制备方法。更具体地说，涉及通过以下步骤制备的干燥的寡核苷酸组合物：为了防止寡核苷酸分离，添加防止寡核苷酸分离和丢失的物质，其与含有寡核苷酸组合物的储存容器粘合，在制备和分配干燥的寡核苷酸组合物期间损失，任选地加入非活性染料物质，并干燥所得溶液。可以防止本发明的干燥的寡核苷酸组合物在制造步骤或包装后的运输步骤中分离和丢失，并且可以用肉眼容易地确认存储容器中存在或不存在寡核苷酸。因此，可以克服由实验中的寡核苷酸分离引起的不必要的劳动力浪费和时间浪费。

4. 发明申请

WO2015005669A1 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性siRNA，包含siRNA的双链寡聚RNA分子，以及用于预防或治疗包含其的癌症的组合物
公开(公告)号：WO2015005669A1
公开(公告)日：2015-01-15
申请号：PCT/KR2014/006145
申请日：2014-07-09
申请人： BIONEER CORPORATION , SANOFI-AVENTIS KOREA CO., LTD.
发明人： CHAE, Jeiwook , PARK, Han Oh , YOON, Pyoung Oh , HAN, Boram , KIM, Han-Na , YUN, Sung-Il , PARK, Jun Hong , KO, Youngho , CHOI, Gi-Eun , JUNG, Junsoo , KIM, Jae Eun
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , A61P35/00
CPC分类号： C12N15/1135 , A61K9/0019 , A61K9/51 , A61K31/713 , A61K47/60 , C12N2310/14
摘要： There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly Gankyrin or BMI-1 specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
摘要翻译：提供了与相关肝癌相关的特异性siRNA和高效双链寡聚RNA分子。双链寡RNA分子具有通过简单的共价键或连接体介导的共价键将亲水和疏水化合物与双链寡RNA分子的两端缀合以便有效地递送到细胞中的结构，可以通过双链寡聚RNA分子的疏水相互作用在水溶液中转化成纳米颗粒。双链寡核苷酸分子中含有的siRNA可能是肝癌相关基因，特别是Gankyrin或BMI-1特异性siRNA。此外，本发明涉及制备双链寡聚RNA分子的方法和用于预防或治疗包含双链寡RNA分子的癌症，特别是肝癌的药物组合物。

5. 发明申请

WO2012157955A2 OIL PURIFICATION METHOD AND APPARATUS WITH POROUS MEMBRANE 审中-公开
标题翻译：油多孔方法和装置
公开(公告)号：WO2012157955A2
公开(公告)日：2012-11-22
申请号：PCT/KR2012/003836
申请日：2012-05-16
申请人： BIONEER CORPORATION , PARK, Han Oh , KIM, Jae Ha , KIM, Jun Pyo
发明人： PARK, Han Oh , KIM, Jae Ha , KIM, Jun Pyo
CPC分类号： B01D69/12 , B01D71/021 , B01D71/022 , B01D71/024 , B01D2311/04 , C10M175/0091 , B01D2311/103
摘要： Provided is a method of purifying oil by which nano particles are effectively removed from the oil. According to the oil purifying method, oil is effectively purified at a high temperature using a carbon nanostructure-metal or -metal oxide composite nano porous membrane composed of a carbon nanostructure-metal composite.
摘要翻译：提供了一种净化油的方法，通过该方法可以有效地从油中除去纳米颗粒。根据油净化方法，使用由碳纳米结构金属复合材料构成的碳纳米结构金属或金属氧化物复合纳米多孔膜，在高温下有效地纯化油。

6. 发明申请

WO2009045067A2 PRIMERS FOR PCR AMPLIFICATION COMPRISING ABASIC PARTS WITHIN THE PRIMER SEQUENCES 审中-公开
标题翻译：用于在放大器序列中包含ABASIC部分的PCR扩增的引物
公开(公告)号：WO2009045067A2
公开(公告)日：2009-04-09
申请号：PCT/KR2008/005821
申请日：2008-10-02
申请人： BIONEER CORPORATION , KIM, Hyun Bae , KIM, Seong Youl , GIL, Jun Mo , PARK, Hae Joon , PARK, Han Oh
发明人： KIM, Hyun Bae , KIM, Seong Youl , GIL, Jun Mo , PARK, Hae Joon , PARK, Han Oh
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2525/119
摘要： The present invention relates to primers for PCR amplification comprising abasic parts within the primer sequences and a method for PCR amplification using the same. More precisely, the present invention relates to primers capable of amplifying different templates and having abasic parts complementary to mutated site or polymorphic site of template DNA and a method for PCR amplification comprising the steps of mixing the composition for PCR amplification comprising the primers with nucleic acid template; and performing PCR with the mixture. The primers for PCR amplification of the present invention contain abasic parts not having specific coding information in their nucleotide sequences, so that they can amplify different templates having mutated sites at the same time.
摘要翻译：本发明涉及用于PCR扩增的引物，其包括引物序列内的无碱部分和使用其的PCR扩增方法。更确切地说，本发明涉及能够扩增不同模板并具有与模板DNA的突变位点或多态位点互补的脱碱基的引物，以及用于PCR扩增的方法，其包括将包含引物的PCR扩增组合物与核酸模板; 并用混合物进行PCR。用于本发明的PCR扩增的引物含有在其核苷酸序列中不具有特定编码信息的脱碱基，从而可以同时扩增具有突变位点的不同模板。

7. 发明申请

WO2009002034A3 REAL-TIME PCR MONITORING APPARATUS 审中-公开
标题翻译：实时PCR监测装置
公开(公告)号：WO2009002034A3
公开(公告)日：2008-12-31
申请号：PCT/KR2008/003408
申请日：2008-06-17
申请人： BIONEER CORPORATION , PARK, Hanee , CHOI, il kyu , PARK, Han Oh
发明人： PARK, Hanee , CHOI, il kyu , PARK, Han Oh
IPC分类号： C12Q1/68
摘要： The present invention relates to a real-time PCR monitoring apparatus for real-time monitoring production of reaction product produced during the reaction while performing nucleic acid amplification such as PCR for various kinds of trace samples. Specifically, the present invention relates to an apparatus for real-time monitoring biochemical reaction for efficiently dividing interference between an excitation light and a fluorescence, which includes a polarizer, a polarizing beam splitter, a polarization converter and so on.
摘要翻译：本发明涉及一种实时PCR监测装置，用于实时监测反应过程中产生的反应产物的生产，同时对各种痕量样品进行核酸扩增如PCR。具体而言，本发明涉及一种用于实时监测生物化学反应的装置，用于有效地分隔激发光和荧光之间的干涉，其包括偏振器，偏振分束器，偏振转换器等。

8. 发明申请

WO2007108621A1 SIRNA FOR INHIBITING NF-KB/RELA EXPRESSION 审中-公开
标题翻译： SIRNA抑制NF-KB / RELA表达
公开(公告)号：WO2007108621A1
公开(公告)日：2007-09-27
申请号：PCT/KR2007/001319
申请日：2007-03-17
申请人： BIONEER CORPORATION , CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim , KIM, Seon Hoe , KIM, Ji Young , LEE, Eun Ju , LEE, Mi Young , KIM, Young Joo , LEE, Ui Jin , HAN, Chang Whan
发明人： CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim , KIM, Seon Hoe , KIM, Ji Young , LEE, Eun Ju , LEE, Mi Young , KIM, Young Joo , LEE, Ui Jin , HAN, Chang Whan
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3521
摘要： The present invention relates to siRNA for inhibiting NF-κB/RelA and a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition for treating rheumatoid arthritis of present invention comprises an active ingredient of siRNA which binds with mRNA transcribed from a gene coding for NF-κB/RelA to inhibit NF-κB/RelA expression in a cell. The pharmaceutical composition for treating rheumatoid arthritis can directly inhibit NF-κB/RelA expression in the gene level as well as induce the death of abnormally proliferated synovial cells, which makes possible its practical application for the treatment of rheumatoid arthritis in a more efficient manner.
摘要翻译：本发明涉及用于抑制NF-κB/ RelA的siRNA和用于治疗类风湿性关节炎的药物组合物。用于治疗本发明类风湿性关节炎的药物组合物包含与编码NF-κB/ RelA的基因转录的mRNA结合以抑制细胞中NF-κB/ RelA表达的siRNA活性成分。用于治疗类风湿性关节炎的药物组合物可以直接抑制基因水平的NF-κB/ RelA表达，并诱导异常增殖的滑膜细胞死亡，这使其成为可能以更有效的方式治疗类风湿性关节炎的实际应用。

9. 发明申请

WO2015005670A1 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性siRNA，包含siRNA的双链寡聚RNA分子，以及用于预防或治疗包含其的癌症的组合物
公开(公告)号：WO2015005670A1
公开(公告)日：2015-01-15
申请号：PCT/KR2014/006146
申请日：2014-07-09
申请人： BIONEER CORPORATION , SANOFI-AVENTIS KOREA CO., LTD.
发明人： CHAE, Jeiwook , YOON, Pyoung Oh , KIM, Han-Na , PARK, Han Oh , HAN, Boram , KO, Youngho , CHOI, Gi-Eun , KIM, Jae Eun
IPC分类号： C12N15/113 , A61K48/00 , A61K31/7088 , A61P35/00
CPC分类号： C12N15/1137 , A61K9/1075 , A61K31/713 , A61K47/6907 , C12N15/113 , C12N15/1135 , C12N2310/14 , C12N2310/31 , C12N2310/351 , C12N2320/30
摘要： There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly ZBTB7A, YAP1 or CHD1L specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
摘要翻译：提供了与相关肝癌相关的特异性siRNA和高效双链寡聚RNA分子。双链寡RNA分子具有通过简单的共价键或连接体介导的共价键将亲水和疏水化合物与双链寡RNA分子的两端缀合以便有效地递送到细胞中的结构，可以通过双链寡聚RNA分子的疏水相互作用在水溶液中转化成纳米颗粒。双链寡核苷酸分子中包含的siRNA可能是肝癌相关基因，特别是ZBTB7A，YAP1或CHD1L特异性siRNA。此外，本发明涉及制备双链寡聚RNA分子的方法和用于预防或治疗包含双链寡RNA分子的癌症，特别是肝癌的药物组合物。

10. 发明申请

WO2012030196A9 OLIGONUCLEOTIDE MARKER AND METHOD FOR IDENTIFYING THE SAME 审中-公开
公开(公告)号：WO2012030196A9
公开(公告)日：2012-03-08
申请号：PCT/KR2011/006540
申请日：2011-09-02
申请人： BIONEER CORPORATION. , PARK, Han Oh , LEE, Jae-Don , SONG, Gu-Young , OH, Jong Wak , KIM, Hyun-Bae , BYUN, Sang-Jin , JANG, Jin-Wong , JANG, Won-Seok , CHOI, Jong-Deok
发明人： PARK, Han Oh , LEE, Jae-Don , SONG, Gu-Young , OH, Jong Wak , KIM, Hyun-Bae , BYUN, Sang-Jin , JANG, Jin-Wong , JANG, Won-Seok , CHOI, Jong-Deok
IPC分类号： C12N15/11 , C12Q1/68 , G01N33/58
摘要： Provided are an oligonucleotide marker and a method of identifying a material using the same. The oligonucleotide marker makes it possible to analyze a trace amount of the material with high precision within a short time, has improved solubility in an oily solvent, and can improve a detection method such that the oligonucleotide marker can be detected within 2 hours. The oligonucleotide marker can label various products, including oil products and petroleum products, works of art and collections, and can also be used to conduct criminal investigations.

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