专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0108704A3 Dendrimer-photosensitizer complexes for medical applications 审中-公开
标题翻译：树枝状聚合物 - 光敏剂复合物用于医疗应用
公开(公告)号：WO0108704A3
公开(公告)日：2001-08-23
申请号：PCT/IB0001165
申请日：2000-07-28
申请人： BIOLITEC AG , BIOLITEC INC , ROEDER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
发明人： ROEDER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
IPC分类号： A61K47/30 , A61K31/409 , A61K41/00 , A61K47/42 , A61K47/48 , A61N5/06 , A61P17/00 , A61P17/06 , A61P31/12 , A61P31/22 , A61P35/00
CPC分类号： A61K41/0071
摘要： A method for enhanced PhotoDynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple phototosensitizer moieties to a treatment site is provided. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers and are being separated in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After application, the photosensitizers are released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

2. 发明专利

BR0013304A 未知
公开(公告)号：BR0013304A
公开(公告)日：2003-01-07
申请号：BR0013304
申请日：2000-07-28
申请人： BIOLITEC AG , BIOLITEC INC
发明人： RODER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
IPC分类号： A61K47/30 , A61K31/409 , A61K41/00 , A61K47/42 , A61K47/48 , A61N5/06 , A61P17/00 , A61P17/06 , A61P31/12 , A61P31/22 , A61P35/00
摘要： A method for enhanced Photodynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple photosensitizer moieties to a treatment site is provided. The most benefit is derived for treatments using systemic introduction of the photosensitizer formulation. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers, using labile bonds which are breakable in preference over bonding within either photosensitizer or dendrimer, and the photosensitizers are separated from the complexes in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After introduction into a patient, the photosensitizers are controllably released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

3. 发明专利

DE19936997A1 未知
公开(公告)号：DE19936997A1
公开(公告)日：2001-02-15
申请号：DE19936997
申请日：1999-08-02
申请人： ROEDER BEATE
发明人： ROEDER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
IPC分类号： A61K47/30 , A61K31/409 , A61K41/00 , A61K47/42 , A61K47/48 , A61N5/06 , A61P17/00 , A61P17/06 , A61P31/12 , A61P31/22 , A61P35/00
摘要： A method for enhanced PhotoDynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple phototosensitizer moieties to a treatment site is provided. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers and are being separated in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After application, the photosensitizers are released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

4. 发明专利

DE19936997B4 未知
公开(公告)号：DE19936997B4
公开(公告)日：2007-06-14
申请号：DE19936997
申请日：1999-08-02
申请人： BIOLITEC AG
发明人： ROEDER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
IPC分类号： A61K41/00 , A61K47/30 , A61K31/409 , A61K47/42 , A61K47/48 , A61N5/06 , A61P17/00 , A61P17/06 , A61P31/12 , A61P31/22 , A61P35/00
摘要： A method for enhanced Photodynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple photosensitizer moieties to a treatment site is provided. The most benefit is derived for treatments using systemic introduction of the photosensitizer formulation. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers, using labile bonds which are breakable in preference over bonding within either photosensitizer or dendrimer, and the photosensitizers are separated from the complexes in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After introduction into a patient, the photosensitizers are controllably released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式