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1. 发明申请

WO0108704A3 Dendrimer-photosensitizer complexes for medical applications 审中-公开
标题翻译：树枝状聚合物 - 光敏剂复合物用于医疗应用
公开(公告)号：WO0108704A3
公开(公告)日：2001-08-23
申请号：PCT/IB0001165
申请日：2000-07-28
申请人： BIOLITEC AG , BIOLITEC INC , ROEDER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
发明人： ROEDER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
IPC分类号： A61K47/30 , A61K31/409 , A61K41/00 , A61K47/42 , A61K47/48 , A61N5/06 , A61P17/00 , A61P17/06 , A61P31/12 , A61P31/22 , A61P35/00
CPC分类号： A61K41/0071
摘要： A method for enhanced PhotoDynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple phototosensitizer moieties to a treatment site is provided. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers and are being separated in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After application, the photosensitizers are released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

2. 发明申请

WO2010078941A1 CALCIUMPHOSPHATE-BASED NANOPARTICLES AS CARRIER-SYSTEMS FOR PHOTODYNAMIC THERAPY 审中-公开
标题翻译：基于钙磷酸盐的纳米颗粒作为光化学治疗的载体系统
公开(公告)号：WO2010078941A1
公开(公告)日：2010-07-15
申请号：PCT/EP2009/009142
申请日：2009-12-18
申请人： BIOLITEC AG , UNIVERSITÄT DUISBURG-ESSEN , SCHWIERTZ, Janine , GANESAN, Kathirvel , EPPLE, Matthias , WIEHE, Arno , GRÄFE, Susanna , GITTER, Burkhard , ALBRECHT, Volker
发明人： SCHWIERTZ, Janine , GANESAN, Kathirvel , EPPLE, Matthias , WIEHE, Arno , GRÄFE, Susanna , GITTER, Burkhard , ALBRECHT, Volker
IPC分类号： A61K41/00 , A61K9/16
CPC分类号： A61K9/5115 , A61K41/0057 , A61K41/0071 , A61K49/0093 , Y10S977/773
摘要： The present invention provides pharmaceutical photosensitizer-loaded nanoparticle formulations and their methods of preparation for photodynamic therapy, comprising a hydrophobic or hydrophilic photosensitizer, nanoparticulate calcium phosphate and in certain cases auxiliary reagents such as stabilizers. The calcium phosphate-based nanoparticle formulations of the present invention provide excellent storage stability and therapeutically effective amounts of photosensitizer for intravenous or topical administration. In a preferred embodiment, tetrapyrrole derivatives such as porphyrins, chlorins and bacteriochlorins, are the preferred hydrophobic photosensitizers to be formulated in calcium phosphate nanoparticle formulations for photodynamic tumor therapy. Additionally, p TPPP is a preferred hydrophilic photosensitizer for photodynamic tumor therapy. In another preferred embodiment, hydrophilic cationic and anionic photosensitizers, especially those of the phenazinium, phenothiazinium and xanthenes series have been found to inactive pathogen bacteria and are the preferred photosensitizers to be formulated in calcium phosphate nanoparticle formulations for antibacterial photodynamic therapy. In another embodiment, photosensitizing nanoparticle formulations are useful to locate cells, tissues or bacteria by using fluorescence imaging methods.
摘要翻译：本发明提供负载药物的光敏剂纳米颗粒制剂及其制备光动力疗法的方法，其包括疏水或亲水性光敏剂，纳米颗粒磷酸钙，在某些情况下，辅助试剂如稳定剂。本发明的基于磷酸钙的纳米颗粒制剂提供优异的储存稳定性和用于静脉内或局部给药的治疗有效量的光敏剂。在优选的实施方案中，四吡咯衍生物如卟啉，二氢卟酚和细菌二氢卟酚是拟配制在用于光动力学肿瘤治疗的磷酸钙纳米颗粒制剂中的优选的疏水性光敏剂。另外，pTPPP是用于光动力学肿瘤治疗的优选的亲水性光敏剂。在另一个优选的实施方案中，亲水性阳离子和阴离子光敏剂，特别是phenazineium，吩噻嗪和呫吨系列的光敏剂已经被发现为无活性的病原体细菌，并且是配制在用于抗菌光动力学治疗的磷酸钙纳米颗粒制剂中的优选光敏剂。在另一个实施方案中，光敏纳米颗粒制剂可用于通过使用荧光成像方法定位细胞，组织或细菌。

3. 发明申请

WO2012032146A1 IMPLANTAT ZUR ANWENDUNG BEI EINER PHOTO-DYNAMISCHEN BEHANDLUNG 审中-公开
标题翻译：植入物用在动态光刻处理
公开(公告)号：WO2012032146A1
公开(公告)日：2012-03-15
申请号：PCT/EP2011/065619
申请日：2011-09-09
申请人： MATHYS AG BETTLACH , BIOLITEC AG , DELFOSSE, Daniel , OBERBACH, Thomas , GLASSER, Henning
发明人： DELFOSSE, Daniel , OBERBACH, Thomas , GLASSER, Henning
IPC分类号： A61C8/00 , A61F2/32 , A61F2/40 , A61F2/44 , A61N5/06
CPC分类号： B05D3/06 , A61C8/0006 , A61C8/0012 , A61F2/442 , A61F2002/30668 , A61F2002/30677 , A61F2002/30968 , A61F2310/00197 , A61F2310/00203 , A61F2310/00221 , A61F2310/00239 , A61L27/10 , A61L27/54 , A61L2300/102 , A61N5/062
摘要： Ein Implantat (10) zur Implantation in einen menschlichen oder tierischen Knochen (11) weist einen mit dem Knochen (11) in Berührung stehenden Knochenbereich (12) und einen nicht vom Knochen (10) überdeckten Lichtbereich auf. Es weist ebenfalls eine photo-aktivierbare Substanz (14) auf, die bei Beleuchtung mit Licht (2) aktiviert wird und anschließend Mikroben und Bakterien zerstört. Das Implantat (10) ist aus einem Werkstoff, der bei mindestens einer Aktivierungswellenlänge der photo-aktivierbaren Substanz (14) transparent ist, wobei die photo-aktivierbare Substanz (14) zumindest auf die Oberfläche des Knochenbereichs (12) des Implantats aufgebracht ist.
摘要翻译：在人或动物骨（11），用于植入的植入物（10）具有与在接触骨面积（12）和由非骨覆盖（10）光范围的骨（11）。它还包括当照射光（2），然后破坏微生物和细菌，其被激活的光可激活的物质（14）。的植入物（10）是由这是透明的，至少在光活化物质（14）的激活波长的材料，其中所述光可激活的物质（14）被至少施加到植入物的骨部分（12）的表面的。

4. 发明专利

AT544472T 未知
公开(公告)号：AT544472T
公开(公告)日：2012-02-15
申请号：AT08022155
申请日：2008-12-19
申请人： BIOLITEC AG , UNIV DUISBURG ESSEN
发明人： ALBRECHT VOLKER , GITTER BURKHARD , GRAEFE SUSANNA , WIEHE ARNO , EPPLE MATTHIAS , SCHWIERTZ JANINE , KATHINVEL GANESAN
IPC分类号： A61K41/00 , A61K9/16

5. 发明专利

DE102011075808A1 Implantat zur Anwendung bei einer photo-dynamischen Behandlung 未知
公开(公告)号：DE102011075808A1
公开(公告)日：2012-03-15
申请号：DE102011075808
申请日：2011-05-13
申请人： BIOLITEC AG , MATHYS AG
发明人： DELFOSSE DANIEL DR , OBERBACH THOMAS , GLASSER HENNING DR
IPC分类号： A61C8/00 , A61F2/28 , A61F2/32 , A61F2/40 , A61F2/44 , A61L27/10
摘要： Ein Implantat (10) zur Implantation in einen menschlichen oder tierischen Knochen (11) weist einen mit dem Knochen (11) in Berührung stehenden Knochenbereich (12) und einen nicht vom Knochen (10) überdeckten Lichtbereich auf. Es weist ebenfalls eine photo-aktivierbare Substanz (14) auf, die bei Beleuchtung mit Licht (2) aktiviert wird und anschließend Mikroben und Bakterien zerstört. Das Implantat (10) ist aus einem Werkstoff, der bei mindestens einer Aktivierungswellenlänge der photo-aktivierbaren Substanz (14) transparent ist, wobei die photo-aktivierbare Substanz (14) zumindest auf die Oberfläche des Knochenbereichs (12) des Implantats aufgebracht ist.

6. 发明专利

BR0013304A 未知
公开(公告)号：BR0013304A
公开(公告)日：2003-01-07
申请号：BR0013304
申请日：2000-07-28
申请人： BIOLITEC AG , BIOLITEC INC
发明人： RODER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
IPC分类号： A61K47/30 , A61K31/409 , A61K41/00 , A61K47/42 , A61K47/48 , A61N5/06 , A61P17/00 , A61P17/06 , A61P31/12 , A61P31/22 , A61P35/00
摘要： A method for enhanced Photodynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple photosensitizer moieties to a treatment site is provided. The most benefit is derived for treatments using systemic introduction of the photosensitizer formulation. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers, using labile bonds which are breakable in preference over bonding within either photosensitizer or dendrimer, and the photosensitizers are separated from the complexes in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After introduction into a patient, the photosensitizers are controllably released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

7. 发明专利

DE102011075808B4 Implantat zur Anwendung bei einer photo-dynamischen Behandlung sowie Verfahren zur Herstellung des Implantats 未知
公开(公告)号：DE102011075808B4
公开(公告)日：2017-06-29
申请号：DE102011075808
申请日：2011-05-13
申请人： BIOLITEC AG , MATHYS AG
发明人： DELFOSSE DANIEL DR , OBERBACH THOMAS , GLASSER HENNING DR
IPC分类号： A61C8/00 , A61F2/28 , A61F2/32 , A61F2/40 , A61F2/44 , A61L27/10
摘要： Ein Implantat (10) zur Implantation in einen menschlichen oder tierischen Knochen (11) weist einen mit dem Knochen (11) in Berührung stehenden Knochenbereich (12) und einen nicht vom Knochen (10) überdeckten Lichtbereich auf. Es weist ebenfalls eine photo-aktivierbare Substanz (14) auf, die bei Beleuchtung mit Licht (2) aktiviert wird und anschließend Mikroben und Bakterien zerstört. Das Implantat (10) ist aus einem Werkstoff, der bei mindestens einer Aktivierungswellenlänge der photo-aktivierbaren Substanz (14) transparent ist, wobei die photo-aktivierbare Substanz (14) zumindest auf die Oberfläche des Knochenbereichs (12) des Implantats aufgebracht ist.

8. 发明专利

ES2381022T3 Nanopartículas de fosfato de calcio como vehículo de colorantes para la terapia fotodinámica 未知
公开(公告)号：ES2381022T3
公开(公告)日：2012-05-22
申请号：ES08022155
申请日：2008-12-19
申请人： BIOLITEC AG , UNI DUISBURG ESSEN
发明人： ALBRECHT VOLKER , GITTER BURKHARD , GRAEFE SUSANNA , WIEHE ARNO , EPPLE MATTHIAS , SCHWIERTZ JANINE , KATHINVEL GANESAN
IPC分类号： A61K41/00 , A61K9/16
摘要： Formulación de nanopartículas farmacéutica para uso en terapia fotodinámica que comprende: - un núcleo cerámico biodegradable cristalino o amorfo con un diámetro en el rango de 5 - 1000nm; más específicamente en el rango de 50 - 250nm; - una cantidad terapéuticamente eficaz de fotosensibilizador hidrófobo o hidrófilo; - un agente estabilizante; donde dicho núcleo cerámico es sólido o hueco y el material de dicho núcleo es seleccionado del grupo que consiste en fosfato de calcio o carbonato de calcio donde el Ca2+ también puede ser sustituido (parcial o completamente) por otros iones, por ej. Mg2+, Al3+, o Sr2+; donde dicho fotosensibilizador hidrófobo o hidrófilo es seleccionado del grupo que consiste en derivados de tetrapirroles (a saber porfirinas, clorinas, y bacterioclorinas), colorantes fenazinio y fenotiazinio (a saber, azul de toluidina, azul de metileno, safranina), y colorantes de xanteno (a saber eritrosina); y donde dichos agente estabilizante es seleccionado del grupo de polímeros catiónicos, no-iónicos, o aniónicos (a saber poliestireno sulfonado (PSS), carboximetilcelulosa (CMC), polialilamina hidroclorada (PAH), polietilenimina (PEI) .

9. 发明专利

CA2381143C DENDRIMER-PHOTOSENSITIZER COMPLEXES FOR MEDICAL APPLICATIONS 未知
公开(公告)号：CA2381143C
公开(公告)日：2011-12-20
申请号：CA2381143
申请日：2000-07-28
申请人： BIOLITEC AG , BIOLITEC INC
发明人： RODER BEATE , HACKBARTH STEFFEN , WOHLECKE GISELA
IPC分类号： A61K47/30 , A61K47/48 , A61K31/409 , A61K41/00 , A61K47/42 , A61N5/06 , A61P17/00 , A61P17/06 , A61P31/12 , A61P31/22 , A61P35/00
摘要： A method for enhanced PhotoDynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple phototosensitizer moieties to a treatment site is provided. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers and are being separated in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After application, the photosensitizers are released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

10. 发明专利

DE19936997B4 未知
公开(公告)号：DE19936997B4
公开(公告)日：2007-06-14
申请号：DE19936997
申请日：1999-08-02
申请人： BIOLITEC AG
发明人： ROEDER BEATE , HACKBARTH STEFFEN , WOEHLECKE GISELA
IPC分类号： A61K41/00 , A61K47/30 , A61K31/409 , A61K47/42 , A61K47/48 , A61N5/06 , A61P17/00 , A61P17/06 , A61P31/12 , A61P31/22 , A61P35/00
摘要： A method for enhanced Photodynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple photosensitizer moieties to a treatment site is provided. The most benefit is derived for treatments using systemic introduction of the photosensitizer formulation. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers, using labile bonds which are breakable in preference over bonding within either photosensitizer or dendrimer, and the photosensitizers are separated from the complexes in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After introduction into a patient, the photosensitizers are controllably released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

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