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1. 发明申请

WO2005029705A2 NUMBER CODING FOR IDENTIFICATION OF SUBTYPES OF CODED TYPES OF SOLID PHASE CARRIERS 审中-公开
标题翻译：用于识别编码类型固态相位载波子类型的编码
公开(公告)号：WO2005029705A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/030499
申请日：2004-09-17
申请人： BIOARRAY SOLUTIONS, LTD. , SEUL, Michael , CHAU, Chiu , TAN, Enqing
发明人： SEUL, Michael , CHAU, Chiu , TAN, Enqing
IPC分类号： H03M
CPC分类号： G01N33/6845 , G01N33/543 , G01N33/54313 , G01N33/564
摘要： Disclosed is number coding of pairs ("doublets") or small sets ("multiplets") of solid phase carriers provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a C-code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of "colors" (distinguishable sub-types). It can be applied, for example, in multiplexed nucleic acid or protein analysis.
摘要翻译：公开了固相载波的对（“双重”）或小集（“多重”）的编码编码提供给定类型的此类载波的可区分的子类型，其中每个载波类型是可区分的基于C代码。这种数字编码对于增强编码系统（例如色码）是有用的，并且因此有效地将“色彩” （可区分的子类型）。例如，它可以用于复合核酸或蛋白质分析。

2. 发明申请

WO2005006960A2 DETECTION OF CELL MEMBRANE-ASSOCIATED PROTEINS USING MEMBRANE FRAGMENTS DISPLAYED ON ENCODED MICROPARTICLE ARRAYS 审中-公开
标题翻译：用编码的微粒阵列显示膜片段检测细胞膜相关蛋白
公开(公告)号：WO2005006960A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/022782
申请日：2004-07-15
申请人： BIOARRAY SOLUTIONS LTD. , SEUL, Michael , YANG, Jiacheng , TAN, Enqing
发明人： SEUL, Michael , YANG, Jiacheng , TAN, Enqing
IPC分类号： A61B
CPC分类号： G01N33/5432 , G01N33/564 , G01N33/56972 , G01N33/6854 , Y10S435/971 , Y10T436/110833
摘要： Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be oriented with what was the outer surface of the cell membrane facing outwardly, so that the antigens associated with the membrane can be contact with ligands (including antibodies) to antigens in the membranes which would be accessible to antibodies in vivo. The system is useful, inter alia, for detection of panel reactive antibodies in donor serum, as well as detection of other cell membrane antigens; or quantitation of particular cell membrane antigens.
摘要翻译：公开了涉及与微珠相关的细胞膜片段的方法，从而可以确定片段起源于细胞的特征。片段可以用细胞膜的外表面朝外定向，使得与膜相关的抗原可以与配体（包括抗体）接触抗体在体内可接近的膜中的抗原。该系统尤其可用于检测供体血清中的组反应性抗体，以及检测其他细胞膜抗原; 或定量特定的细胞膜抗原。

3. 发明申请

WO2005043117A2 GEL-SHELL BEADS WITH ADSORBED OR BOUND BIOMOLECULES 审中-公开
标题翻译：具有吸附或固体生物分子的凝胶珠
公开(公告)号：WO2005043117A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/035437
申请日：2004-10-26
申请人： BIOARRAY SOLUTIONS LTD. , BANERJEE, Sukanta , TAN, Enqing
发明人： BANERJEE, Sukanta , TAN, Enqing
IPC分类号： G01N
CPC分类号： G01N33/5436
摘要： Disclosed are gel-coated beads (including Hydrogel TM -coated beads), which are capable of adsorbing, or absorbing, proteins and other biomolecules onto or into the gel coating. The gelcoated beads with absorbed or adsorbed biomolecules are suitable for use in an assays, purification or other purposes. The beads have a core made from any of a number of materials, including latex, coated with the gel shell. The biomolecules can be retained within the gel, following adsorption, by covalent attachment, or, by selection of conditions of ambient pH and/or ionic strength such that they are retained without further reaction. Therefore, adsorbed proteins would retain the ability to bind to their respective ligands.
摘要翻译：公开了能够吸附或吸收蛋白质和其它生物分子到凝胶涂层上或凝胶涂层上的凝胶涂覆的珠粒（包括水凝胶涂层的珠粒）。具有吸附或吸附的生物分子的凝胶珠适用于测定，纯化或其它目的。珠粒具有由许多材料制成的芯，包括用凝胶壳涂覆的胶乳。生物分子可以保留在凝胶内，吸附后，通过共价连接，或通过选择环境pH和/或离子强度的条件使得它们在没有进一步反应的情况下被保留。因此，吸附的蛋白质将保留结合其各自配体的能力。

4. 发明申请

WO2011066361A1 FLUID MIXING AND DELIVERY IN MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：流体系统中的流体混合和输送
公开(公告)号：WO2011066361A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/057969
申请日：2010-11-24
申请人： CLAROS DIAGNOSTICS, INC. , TAN, Enqing , LINDER, Vincent , TAYLOR, Jason , STEINMILLER, David
发明人： TAN, Enqing , LINDER, Vincent , TAYLOR, Jason , STEINMILLER, David
IPC分类号： B01L3/00
CPC分类号： B01L3/502723 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L2200/0673 , B01L2200/0684 , B01L2300/0867 , B01L2300/0877 , B01L2400/0487 , B01L2400/0694 , G01N33/54366 , Y10T137/0318 , Y10T137/0329 , Y10T137/86292 , Y10T137/87652
摘要： The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.
摘要翻译：本说明书通常公开了用于在微流体系统中混合和输送流体的系统和方法。在一些实施方案中，流体可包含可参与一种或多种化学或生物反应的试剂。一些实施例涉及采用一个或多个排气阀以可控地流动和/或混合微流体系统内的流体的部分的系统和方法。有利地，可以通过打开和关闭一个或多个排气阀并且通过施加在一个或多个排气阀上操作的单个流体流（例如真空）来实现诸如流体流动序列和/或流速变化的流体控制基本恒定的压力。这可以简化预期用户对设备的操作和使用。

5. 发明申请

WO2022115538A1 ANTI-SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS ANTIBODIES 审中-公开
公开(公告)号：WO2022115538A1
公开(公告)日：2022-06-02
申请号：PCT/US2021/060734
申请日：2021-11-24
申请人： BIO-TECHNE CORPORATION , GOETZ, Christine Andrea , BONNEVIER, Jody , HAMMERBECK, Christopher David , RESNIK, Ernesto Rubin , MUNSHI, Cyrus B. , TAN, Enqing
发明人： GOETZ, Christine Andrea , BONNEVIER, Jody , HAMMERBECK, Christopher David , RESNIK, Ernesto Rubin , MUNSHI, Cyrus B. , TAN, Enqing
IPC分类号： C07K16/10 , A61P31/14 , G01N33/53
摘要： Anti-SARS-CoV-specific monoclonal antibodies, methods of making and characterizing those antibodies, and methods of using those antibodies are described herein. In some embodiments, the antibodies may bind to both SARS-CoV-1 and SARS-CoV-2. In some embodiments, the antibodies bind to S1 of the spike protein of SARS-CoV-2 including, for example, to the receptor binding domain (RBD) of S1. In some embodiments, the antibodies may block the binding of SARS-CoV-1 and/or SARS-CoV-2 to ACE-2. Such antibodies are useful as diagnostic and therapeutic agents.

6. 发明公开

EP1682866A2 GEL-SHELL BEADS WITH ADSORBED OR BOUND BIOMOLECULES 审中-公开
标题翻译： GELHÜLLENKÜGELCHEN以吸附或结合的生物分子
公开(公告)号：EP1682866A2
公开(公告)日：2006-07-26
申请号：EP04817450.2
申请日：2004-10-26
申请人： Bioarray Solutions Ltd
发明人： BANERJEE, Sukanta , TAN, Enqing
IPC分类号： G01N1/00
CPC分类号： G01N33/5436
摘要： Disclosed are gel-coated beads (including HydrogelTM -coated beads), which are capable of adsorbing, or absorbing, proteins and other biomolecules onto or into the gel coating. The gelcoated beads with absorbed or adsorbed biomolecules are suitable for use in an assays, purification or other purposes. The beads have a core made from any of a number of materials, including latex, coated with the gel shell. The biomolecules can be retained within the gel, following adsorption, by covalent attachment, or, by selection of conditions of ambient pH and/or ionic strength such that they are retained without further reaction. Therefore, adsorbed proteins would retain the ability to bind to their respective ligands.

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