会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明专利
    • Automated analysis of multiplexed probe-target interaction pattern: pattern matching and allele identification
    • 多路复用探测目标交互模式的自动分析:模式匹配和可识别
    • JP2012065653A
    • 2012-04-05
    • JP2011214277
    • 2011-09-29
    • Bioarray Solutions Ltdバイオアレイ ソリューションズ リミテッド
    • XIONGWU XIASEUL MICHAEL
    • C12Q1/68G01N33/48G01N33/50G06F19/10
    • C12Q1/6827G06F19/18G06F19/22
    • PROBLEM TO BE SOLVED: To provide methods and algorithms supporting the automated analysis and interactive review and refinement of the analysis within an integrated software environment, for automated allele assignments.SOLUTION: The method for setting a series of thresholds used for reducing erroneous allele assignments includes: (i) a step of generating a signal intensity pattern of signal intensity; (ii) a step of obtaining a normalized intensity ratio: r=(I-INC)/(IPC-INC) by subtracting a negative control signal INC from each signal intensity I, and dividing the result by a corrected positive control signal IPC-INC; (iii) a step of, to assign as a positive interaction between a probe and a sequence if the normalized intensity ratio exceeds the threshold, setting the threshold for the normalized intensity ratio so as to maximize the concordance between a reaction pattern and a reference reaction pattern of a target group of the probe in the group.
    • 要解决的问题:提供方法和算法,支持在集成软件环境中进行自动分析和互动审查和细化分析,以进行自动等位基因分配。 解决方案:用于设置用于减少错误等位基因分配的一系列阈值的方法包括:(i)产生信号强度的信号强度模式的步骤; (ii)通过从各信号强度I中减去负控制信号INC得到归一化强度比的步骤:r =(I-INC)/(IPC-INC),并将结果除以校正后的正控制信号IPC- INC; (iii)如果归一化强度比超过阈值,则设定探针和序列之间的正相互作用的步骤,设定归一化强度比的阈值以使反应图案与参考反应之间的一致性最大化 组中探针的目标组的模式。 版权所有(C)2012,JPO&INPIT