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1. 发明申请

WO2007120999A2 CHELATING MONOMERS AND POLYMERS 审中-公开
标题翻译：吸引单体和聚合物
公开(公告)号：WO2007120999A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/063388
申请日：2007-03-06
申请人： BIO-RAD LABORATORIES, INC. , ZHANG, Hongmin , BOSCHETTI, Egisto , LOMAS, Lee, O. , UM, Pil-je
发明人： ZHANG, Hongmin , BOSCHETTI, Egisto , LOMAS, Lee, O. , UM, Pil-je
IPC分类号： B01D3/00 , B01D59/44 , C08F30/04 , G01N24/00
CPC分类号： C08F220/36 , B01D71/28 , C02F1/683 , C02F2101/20 , C08F220/30 , C08F222/1006 , Y10T436/24
摘要： This invention provides chelating moieties that comprise an aryl group. Monomers that include the chelating moieties can be polymerized into chelating polymers. Chelating polymers are useful to chelate metals. Chelating polymers in the form of metal chelates are useful for binding analytes, such as polypeptides that comprise histidine residues. Chelating polymers can be includes in articles such as chips and chromatographic materials.
摘要翻译：本发明提供了包含芳基的螯合部分。包含螯合部分的单体可以聚合成螯合聚合物。螯合聚合物可用于螯合金属。金属螯合物形式的螯合聚合物可用于结合分析物，例如包含组氨酸残基的多肽。螯合聚合物可以包括在诸如芯片和色谱材料的制品中。

2. 发明申请

WO2007061643A3 POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2007061643A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/043695
申请日：2006-11-09
申请人： BIO-RAD LABORATORIES, INC. , BOSCHETTI, Egisto , LOMAS, Lee, O.
发明人： BOSCHETTI, Egisto , LOMAS, Lee, O.
IPC分类号： H01J49/40
摘要： A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.

3. 发明申请

WO2004024318A1 PREPARATION AND USE OF MIXED MODE SOLID SUBSTRATES FOR CHROMATOGRAPHY ADSORBENTS AND BIOCHIP ARRAYS 审中-公开
标题翻译：混合模式固体基质的制备和使用用于色谱吸附和生物体阵列
公开(公告)号：WO2004024318A1
公开(公告)日：2004-03-25
申请号：PCT/US2003/028688
申请日：2003-09-12
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , GIROT, Pierre , UM, Pil-Je
发明人： BOSCHETTI, Egisto , GIROT, Pierre , UM, Pil-Je
IPC分类号： B01J20/32
CPC分类号： B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
摘要： For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
摘要翻译：对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。合适的配体包括芳族基团，杂芳族基团或杂环基团，任选地稠合，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。这些树脂在其使用条件下具有阴离子特性。生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来完成，从而进行吸附和解吸附。

4. 发明申请

WO2010078554A1 PROCESS DESIGN USING MASS SPECTROMETRY 审中-公开
标题翻译：使用大量光谱的工艺设计
公开(公告)号：WO2010078554A1
公开(公告)日：2010-07-08
申请号：PCT/US2010/020047
申请日：2010-01-04
申请人： BIO-RAD LABORATORIES, INC. , BOSCHETTI, Egisto
发明人： BOSCHETTI, Egisto
IPC分类号： G01N33/68 , G01N30/00
CPC分类号： G01N33/6848 , C07K1/16 , G01N30/8675 , G01N2030/8831
摘要： The present invention provides a facile and efficient method for determining a chromatographic protocol for separating a target protein from one or more second protein impurity. Also provided is a database facilitating the determination of an appropriate separation protocol.
摘要翻译：本发明提供了一种用于确定用于从一种或多种第二种蛋白质杂质分离靶蛋白质的色谱方案的简便有效的方法。还提供了便于确定适当分离方案的数据库。

5. 发明申请

WO2004031724A2 APPARATUS AND METHOD FOR EXPRESSION AND CAPTURE OF BIOMOLECULES AND COMPLEXES ON ADSORBENT SURFACES 审中-公开
标题翻译：生物分子和复合物在吸附表面上的表达和捕获的装置和方法
公开(公告)号：WO2004031724A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/030760
申请日：2003-09-29
申请人： CIPHERGEN BIOSYSTEMS, INC. , LOMAS, Lee, O. , BOSCHETTI, Egisto , YIP, Tai-Tung
发明人： LOMAS, Lee, O. , BOSCHETTI, Egisto , YIP, Tai-Tung
IPC分类号： G01N
CPC分类号： G01N33/54366 , B01J2219/00283 , B01J2219/00317 , B01J2219/00423 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , G01N33/54353
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in a single step.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于检测和分离用于生物分子的结合配偶体和活性调节剂的装置和方法。所描述的装置允许在单个步骤中表达，捕获和分析一种或多种生物分子。

6. 发明申请

WO2004104586A1 ALLERGEN TEST DEVICES AND METHODS FOR THEIR USE 审中-公开
标题翻译：过敏试验装置及其使用方法
公开(公告)号：WO2004104586A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/015097
申请日：2004-05-14
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , LOMAS, Lee, O.
发明人： BOSCHETTI, Egisto , LOMAS, Lee, O.
IPC分类号： G01N33/53
CPC分类号： G01N33/6854
摘要： The present invention provides apparatus and methods for detecting the presence of antibodies associated with allergic reactions in a subject sample. By providing a one step analysis for determining potential subject hypersensitivity to a number of allergens, the present invention minimizes both the labor required to determine a subject's hypersensitivity profile and the discomfort that has routinely been suffered by the subject.
摘要翻译：本发明提供用于检测与受试样品中的过敏反应相关的抗体的存在的装置和方法。通过提供用于确定对许多过敏原的潜在受试者超敏反应的一步分析，本发明使确定受试者的超敏反应特征所需的劳动和受试者常规遭受的不适最小化。

7. 发明申请

WO2005089910A1 MULTI-COMPARTMENT FILTER AND METHOD OF FILTERING USING SAME 审中-公开
标题翻译：多层过滤器和使用该过滤器的过滤方法
公开(公告)号：WO2005089910A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/007054
申请日：2005-03-08
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , LOMAS, Lee, O. , GIROT, Pierre
发明人： BOSCHETTI, Egisto , LOMAS, Lee, O. , GIROT, Pierre
IPC分类号： B01D57/02
CPC分类号： G01N27/44704 , B01D57/02 , B01J20/3204 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J2220/54 , C07K1/24 , C07K1/34 , G01N27/44795
摘要： Each embodiment includes a central sample reservoir (110) and a plurality of satellite reservoirs (120 A-H). In a first embodiment, a first electrode (140) in electrical contact with the central reservoir is charged and second electrodes (150 A-H) in electrical contact with the satellite reservoirs are sequentially charged, thereby pI filtering molecules in the central reservoir into the satellite reservoirs. In a second embodiment, the central reservoir is configured to rotate so that molecules in a sample in the central reservoir are centrifugally pI-filtered into the satellite reservoirs. In a third embodiment, first and second electrodes proximate opposite first and second satellite reservoirs, respectively, are charged. Some molecules in a sample are pI filtered into the first and second satellite reservoirs. Third and fourth electrodes proximate opposite third and fourth satellite reservoirs, respectively, are then charged. Some molecules in a sample are pI filtered into the third and fourth satellite reservoirs.
摘要翻译：每个实施例包括中央样品储存器（110）和多个卫星储存器（120A-H）。在第一实施例中，与中央储存器电接触的第一电极（140）被充电，并且与卫星储存器电接触的第二电极（150AH）被顺序地充电，从而将中央储存器中的分子过滤到卫星储存器。在第二实施例中，中央储存器被配置为旋转，使得中央储存器中的样品中的分子被离心地pI过滤到卫星储存器中。在第三实施例中，分别与第一和第二卫星储存器相邻的第一和第二电极被充电。样品中的一些分子被pI过滤到第一和第二卫星储层中。然后分别靠近相对的第三和第四卫星储存器的第三和第四电极被充电。样品中的一些分子被pI过滤到第三和第四卫星储层中。

8. 发明申请

WO2004009798A3 PROTEIN INTERACTION DIFFERENCE MAPPING 审中-公开
公开(公告)号：WO2004009798A3
公开(公告)日：2004-01-29
申请号：PCT/US2003/023320
申请日：2003-07-23
申请人： CIPHERGEN BIOSYSTEMS, INC. , RICH, William , BOSCHETTI, Egisto , LOMAS, Lee, O. , YIP, Tai-Tung
发明人： RICH, William , BOSCHETTI, Egisto , LOMAS, Lee, O. , YIP, Tai-Tung
IPC分类号： G01N33/543
摘要： This invention provides methods and materials for mapping interaction characteristics between components of a multicomponent biological complex. The methods involve capturing a multicomponent complex on a solid support and washing the support with a series of elution washes forming a gradient of solute concentrations, and determining whether a particular elution wash eluted a particular component.

9. 发明申请

WO2005089911A1 MATERIALS, METHODS, AND SYSTEMS FOR SEPARATING AND IDENTIFYING PROTEINS FROM MIXTURES 审中-公开
标题翻译：用于从混合物分离和鉴定蛋白质的材料，方法和系统
公开(公告)号：WO2005089911A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/007762
申请日：2005-03-08
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , RIGHETTI, Pier, Giorgio
发明人： BOSCHETTI, Egisto , RIGHETTI, Pier, Giorgio
IPC分类号： B01D57/02
CPC分类号： G01N27/44747 , B01D57/02 , B01J20/26 , B01J20/3204 , B01J20/321 , B01J20/3268 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J20/3282 , B01J20/3293 , B01J2220/54 , C07K1/16 , C07K1/24 , C07K1/28 , G01N27/44795 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： Materials, apparatuses, methods, and systems for isolating and identifying mixture components on the basis of isoelectric point ("pI"). In one aspect, the materials are particles adapted to have a predetermined isoelectric point. The particles include a porous body into which a plurality of cavities extend. A substance of a predetermined isoelectric point is deposited in the cavities to provide thereby the particle's isoelectric value.
摘要翻译：用于基于等电点（“pI”）分离和鉴定混合物组分的材料，装置，方法和系统。在一个方面，材料是适于具有预定等电点的颗粒。颗粒包括多个空腔延伸到其中的多孔体。将预定等电点的物质沉积在空腔中，从而提供颗粒的等电位值。

10. 发明申请

WO2006102547A2 METHOD FOR PURIFYING PROTEINS 审中-公开
标题翻译：净化蛋白质的方法
公开(公告)号：WO2006102547A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010656
申请日：2006-03-22
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , LOMAS, Lee
发明人： BOSCHETTI, Egisto , LOMAS, Lee
IPC分类号： C40B40/04 , C40B40/08 , C40B40/10
CPC分类号： C07K1/047 , C07K1/22
摘要： The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.
摘要翻译：本发明提供了用于纯化靶蛋白质组的方法和试剂盒。该方法包括以下步骤：将包含至少95％的目标蛋白质组和至多5％的污染蛋白质的样品与具有不同结合部分的结合部分的文库结合，将污染性蛋白质和少量靶蛋白质组到结合部分的文库，将未结合的靶蛋白基团与结合到结合部分文库的蛋白质分离并收集未结合的靶蛋白质。收集的目标蛋白质比样品中的目标蛋白质组更为纯净。

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