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1. 发明申请

WO2005089911A1 MATERIALS, METHODS, AND SYSTEMS FOR SEPARATING AND IDENTIFYING PROTEINS FROM MIXTURES 审中-公开
标题翻译：用于从混合物分离和鉴定蛋白质的材料，方法和系统
公开(公告)号：WO2005089911A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/007762
申请日：2005-03-08
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , RIGHETTI, Pier, Giorgio
发明人： BOSCHETTI, Egisto , RIGHETTI, Pier, Giorgio
IPC分类号： B01D57/02
CPC分类号： G01N27/44747 , B01D57/02 , B01J20/26 , B01J20/3204 , B01J20/321 , B01J20/3268 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J20/3282 , B01J20/3293 , B01J2220/54 , C07K1/16 , C07K1/24 , C07K1/28 , G01N27/44795 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： Materials, apparatuses, methods, and systems for isolating and identifying mixture components on the basis of isoelectric point ("pI"). In one aspect, the materials are particles adapted to have a predetermined isoelectric point. The particles include a porous body into which a plurality of cavities extend. A substance of a predetermined isoelectric point is deposited in the cavities to provide thereby the particle's isoelectric value.
摘要翻译：用于基于等电点（“pI”）分离和鉴定混合物组分的材料，装置，方法和系统。在一个方面，材料是适于具有预定等电点的颗粒。颗粒包括多个空腔延伸到其中的多孔体。将预定等电点的物质沉积在空腔中，从而提供颗粒的等电位值。

2. 发明申请

WO2007018589A2 SEPARATION OF PROTEINS BASED ON ISOELECTRIC POINT USING SOLID-PHASE BUFFERS 审中-公开
标题翻译：基于等电点的蛋白质分离使用固相缓冲液
公开(公告)号：WO2007018589A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/001686
申请日：2006-01-19
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , RIGHETTI, Pier, Giorgio , GIROT, Pierre , FORTIS, Frederic
发明人： BOSCHETTI, Egisto , RIGHETTI, Pier, Giorgio , GIROT, Pierre , FORTIS, Frederic
IPC分类号： B01D15/08
CPC分类号： B01D15/362 , B01D15/1871 , B01D15/36 , B01D15/363 , B01J20/28033 , B01J39/26 , B01J41/20 , B01J47/018 , B01J2220/603 , B01J2220/82 , C07K1/18 , G01N30/461
摘要： Proteins can be separated from mixtures, based on their pi values, through the use of a series of chromatographic materials, each comprising a solid buffer and an ion exchange resin. Each solid buffer generates a stable pH, such that passing proteins possess a net charge and can be separated by means of an appropriate ion exchanger. In this fashion, proteins from complex biological fluids can be separated for identification and study.
摘要翻译：通过使用一系列色谱材料，基于它们的pI值，蛋白质可以从混合物中分离，每种色谱材料包含固体缓冲液和离子交换树脂。每种固体缓冲液产生稳定的pH，使得通过的蛋白质具有净电荷并且可以通过合适的离子交换剂分离。以这种方式，可以分离复杂生物体液中的蛋白质进行鉴定和研究。

3. 发明申请

WO2006102547A2 METHOD FOR PURIFYING PROTEINS 审中-公开
标题翻译：净化蛋白质的方法
公开(公告)号：WO2006102547A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010656
申请日：2006-03-22
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , LOMAS, Lee
发明人： BOSCHETTI, Egisto , LOMAS, Lee
IPC分类号： C40B40/04 , C40B40/08 , C40B40/10
CPC分类号： C07K1/047 , C07K1/22
摘要： The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.
摘要翻译：本发明提供了用于纯化靶蛋白质组的方法和试剂盒。该方法包括以下步骤：将包含至少95％的目标蛋白质组和至多5％的污染蛋白质的样品与具有不同结合部分的结合部分的文库结合，将污染性蛋白质和少量靶蛋白质组到结合部分的文库，将未结合的靶蛋白基团与结合到结合部分文库的蛋白质分离并收集未结合的靶蛋白质。收集的目标蛋白质比样品中的目标蛋白质组更为纯净。

4. 发明申请

WO2004094989A2 METHODS OF HOST CELL PROTEIN ANALYSIS 审中-公开
标题翻译：宿主细胞蛋白质分析方法
公开(公告)号：WO2004094989A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012062
申请日：2004-04-19
申请人： CIPHERGEN BIOSYSTEMS, INC. , ALLIOUX, Catherine , BOSCHETTI, Egisto , BRENAC, Virginie , SANTAMBIEN, Patrick , SPENCER, James
发明人： ALLIOUX, Catherine , BOSCHETTI, Egisto , BRENAC, Virginie , SANTAMBIEN, Patrick , SPENCER, James
IPC分类号： G01N
CPC分类号： G01N33/567 , C07K1/22 , G01N33/543 , G01N33/6803 , G01N33/6842 , G01N33/6851
摘要： The invention provides methods of determining the presence of host cell proteins in sample. The invention further provides methods of following the purification of target proteins. Kits and articles of manufacture are also provided.
摘要翻译：本发明提供了确定样品中宿主细胞蛋白质存在的方法。本发明还提供了追踪靶蛋白纯化的方法。还提供了工具包和制品。

5. 发明申请

WO2004031724A2 APPARATUS AND METHOD FOR EXPRESSION AND CAPTURE OF BIOMOLECULES AND COMPLEXES ON ADSORBENT SURFACES 审中-公开
标题翻译：生物分子和复合物在吸附表面上的表达和捕获的装置和方法
公开(公告)号：WO2004031724A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/030760
申请日：2003-09-29
申请人： CIPHERGEN BIOSYSTEMS, INC. , LOMAS, Lee, O. , BOSCHETTI, Egisto , YIP, Tai-Tung
发明人： LOMAS, Lee, O. , BOSCHETTI, Egisto , YIP, Tai-Tung
IPC分类号： G01N
CPC分类号： G01N33/54366 , B01J2219/00283 , B01J2219/00317 , B01J2219/00423 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , G01N33/54353
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in a single step.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于检测和分离用于生物分子的结合配偶体和活性调节剂的装置和方法。所描述的装置允许在单个步骤中表达，捕获和分析一种或多种生物分子。

6. 发明申请

WO2005094467A2 METHODS FOR REDUCING THE RANGE IN CONCENTRATIONS OF ANALYTE SPECIES IN A SAMPLE 审中-公开
标题翻译：降低分析物种浓度范围的方法
公开(公告)号：WO2005094467A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/009539
申请日：2005-03-23
申请人： CIPHERGEN BIOSYSTEMS, INC. , AMERICAN NATIONAL RED CROSS , BOSCHETTI, Egisto , HAMMOND, David
发明人： BOSCHETTI, Egisto , HAMMOND, David
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6803 , C40B30/04 , G01N33/543 , G01N33/54306 , G01N33/6845
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒。

7. 发明申请

WO2006102542A2 DIVERSE CHEMICAL LIBRARIES BOUND TO SMALL PARTICLES WITH PARAMAGNETIC PROPERTIES 审中-公开
标题翻译：分散化学图书馆附有具有参照性质的小颗粒
公开(公告)号：WO2006102542A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010647
申请日：2006-03-22
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , LOMAS, Lee
发明人： BOSCHETTI, Egisto , LOMAS, Lee
IPC分类号： C40B40/04 , C40B40/08 , C40B40/10
CPC分类号： C07K1/047 , C07K1/22
摘要： The present invention provides diverse chemical libraries bound to small particle with paramagnetic properties. Typically, the chemical structures comprise a plurality of different chemical moieties, the particles are paramagnetic and have a diameter between about 100 nm and about 10 microns, the chemical structures bound to each particular particle have substantially the same structure and the combinatorial library comprises at least 100,000 different chemical structures.
摘要翻译：本发明提供了与具有顺磁特性的小颗粒结合的不同化学文库。通常，化学结构包括多个不同的化学部分，颗粒是顺磁性的并且具有约100nm至约10微米之间的直径，与每个特定颗粒结合的化学结构具有基本上相同的结构，组合文库至少包含 100,000种不同的化学结构。

8. 发明申请

WO2006007429A1 MULTICHEMISTRY FRACTIONATION 审中-公开
标题翻译：多化学分析
公开(公告)号：WO2006007429A1
公开(公告)日：2006-01-19
申请号：PCT/US2005/021489
申请日：2005-06-16
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , GUERRIER, Luc , FORTIS, Frédéric
发明人： BOSCHETTI, Egisto , GUERRIER, Luc , FORTIS, Frédéric
IPC分类号： A61K37/00
CPC分类号： G01N33/6803 , B01D15/1871 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3809 , B01D15/3847 , B01J20/28052 , B01J20/3242 , B01J2220/54 , B01J2220/603 , C07K1/16 , C07K1/36 , G01N27/44773 , G01N33/6842 , G01N2030/027
摘要： Methods, apparatuses, and kits for fractionating complex mixtures of biological molecules are provided. In one aspect the methods provided include providing a series of different sorbents, introducing the complex mixture to the series of sorbents, contacting serially the complex mixture with each of the sorbents, and capturing biomolecular components from the complex mixture on the sorbents so that each of the sorbents captures a substantially unique subset of said plurality of biomolecular components.
摘要翻译：提供了用于分离生物分子的复杂混合物的方法，装置和试剂盒。在一个方面，提供的方法包括提供一系列不同的吸附剂，将复杂混合物引入到一系列吸附剂中，将复合混合物与每种吸附剂连续地接触，并从吸附剂上的复合物混合物捕获生物分子组分，吸附剂捕获所述多个生物分子组分的基本独特的子集。

9. 发明申请

WO2004104586A1 ALLERGEN TEST DEVICES AND METHODS FOR THEIR USE 审中-公开
标题翻译：过敏试验装置及其使用方法
公开(公告)号：WO2004104586A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/015097
申请日：2004-05-14
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , LOMAS, Lee, O.
发明人： BOSCHETTI, Egisto , LOMAS, Lee, O.
IPC分类号： G01N33/53
CPC分类号： G01N33/6854
摘要： The present invention provides apparatus and methods for detecting the presence of antibodies associated with allergic reactions in a subject sample. By providing a one step analysis for determining potential subject hypersensitivity to a number of allergens, the present invention minimizes both the labor required to determine a subject's hypersensitivity profile and the discomfort that has routinely been suffered by the subject.
摘要翻译：本发明提供用于检测与受试样品中的过敏反应相关的抗体的存在的装置和方法。通过提供用于确定对许多过敏原的潜在受试者超敏反应的一步分析，本发明使确定受试者的超敏反应特征所需的劳动和受试者常规遭受的不适最小化。

10. 发明申请

WO2004060296A2 SORBENT AND METHOD FOR THE SEPARATION OF PLASMID DNA 审中-公开
标题翻译：用于分离PLASMID DNA的分离和方法
公开(公告)号：WO2004060296A2
公开(公告)日：2004-07-22
申请号：PCT/US2003/041030
申请日：2003-12-23
申请人： CIPHERGEN BIOSYSTEMS, INC. , GUERRIER, Luc , BOSCHETTI, Egisto
发明人： GUERRIER, Luc , BOSCHETTI, Egisto
IPC分类号： A61K
CPC分类号： C12N15/101 , C08L33/14 , C08L33/24 , C08L51/003 , C08L53/00 , C12N15/1006 , C08L2666/04 , C08L2666/02
摘要： A polymer that is useful for separating plasmid DNA from cell lysates can be dispersed throughout the pores of a porous matrix, forming a chromatographic sorbent. Illustrative of such a polymer is one that comports with the formula (I): where R 1 is C 1-6 alkyl; each R 2 is independently selected from the group consisting of H and C 1-6 alkyl, optionally substituted with 1 to 3 OH groups; R 3 is selected from H, C 1-14 alkyl, and (C 1-14 alkyl)aryl; each n is independently an integer from 1 to 6; a is at least 1; b is at least 1; w is an integer from 0 to 10; and z is at least 1. X is an anion; each Y is independently selected from the group consisting of H, C 1-6 alkyl, and a linear homopolymer comprised of monomers, each of them substituted with pendant amines, provided that at least one Y is the linear homopolymer; and "-----" represents the remainder of the polymer.
摘要翻译：可用于从细胞裂解物分离质粒DNA的聚合物可分散在多孔基质的整个孔中，形成色谱吸附剂。这样的聚合物的例子是与式（I）化合的聚合物：其中R 1是C 1-6烷基; 每个R 2独立地选自H和C 1-6烷基，任选被1至3个OH基团取代; R 3选自H，C 1-4烷基和（C 1-4烷基）芳基; 每个n独立地为1至6的整数; a至少为1; b至少为1; w为0〜10的整数; z为至少1. X为阴离子; 每个Y独立地选自H，C 1-6烷基和由单体组成的线性均聚物，它们各自被侧胺取代，条件是至少一个Y是线性均聚物; 和“-----”表示聚合物的其余部分。

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