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1. 发明申请

WO2012177726A1 MICROORGANISM FOR PRODUCING PRIMARY ALCOHOLS AND RELATED COMPOUNDS AND METHODS RELATED THERETO 审中-公开
标题翻译：生产主要酒精的微生物及相关化合物及其相关方法
公开(公告)号：WO2012177726A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043293
申请日：2012-06-20
申请人： GENOMATICA, INC. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P5/02 , C12N15/74 , C12N1/00
CPC分类号： C12P7/04 , C12N15/52 , C12P7/24 , C12P7/6409 , C12P7/6436
摘要： The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols and at least one exogenous nucleic acid that encodes an enzyme that increases the yields of the primary alcohol by (i) enhancing carbon fixation via the reductive TCA cycle, and/or (ii) accessing additional reducing equivalents from gaseous carbon sources and/or syngas components such as CO, C02, and/or H2. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.
摘要翻译：本发明提供了具有至少一种外源基因插入和/或一种或多种基因破坏的非天然存在的微生物生物体，所述基因破坏产生伯醇和至少一种编码增加产量的酶的外源核酸通过（i）通过还原TCA循环增强碳固定，和/或（ii）从气态碳源和/或合成气组分如CO，CO 2和/或H 2获得另外的还原当量。制备长链醇的方法包括培养这些非天然存在的微生物。

2. 发明申请

WO2012177619A2 MICROORGANISMS FOR PRODUCING 1,3-BUTANEDIOL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产1,3-丁二醇的微生物及其相关方法
公开(公告)号：WO2012177619A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043117
申请日：2012-06-19
申请人： GENOMATICA, INC. , BURGARD, Anthony, P. , BURK, Mark, J. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony, P. , BURK, Mark, J. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12N1/21 , C12P7/18
CPC分类号： C12P7/18 , C12N15/52
摘要： Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3 -BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3 -BDO pathway enzyme expressed in a sufficient amount to produce 1,3 -BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
摘要翻译：本文提供了具有1,3-丁二醇（1,3-BOD）途径的非天然存在的微生物生物，并且包含至少一种编码1,3 -BDO途径酶的外源核酸，其以足够的量表达以产生1 ，3 -BDO。在一些实施方案中，该途径包括从CO或氢中还原当量。在某些实施方案中，1,3-BDO途径通过中枢代谢物丙酮酸，琥珀酸或α-酮戊二酸进行。本文还提供了一种生产1,3-BDO的方法，包括在条件和足够的时间内培养这些微生物以产生1,3-BDO。

3. 发明申请

WO2012135789A2 MICROORGANISMS FOR PRODUCING METHACRYLIC ACID AND METHACRYLATE ESTERS AND METHODS RELATED THERETO 审中-公开
标题翻译：生产甲基丙烯酸和甲基丙烯酸酯的微生物及其相关方法
公开(公告)号：WO2012135789A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/031733
申请日：2012-03-30
申请人： GENOMATICA, INC. , BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P7/40
CPC分类号： C12P7/40 , C12P7/42 , C12P7/62 , C12P19/32
摘要： The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2- hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.
摘要翻译：本发明提供具有甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯途径的非天然存在的微生物生物。微生物生物体含有编码甲基丙烯酸途径中的酶的至少一种外源核酸。本发明另外提供了生产甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的方法。该方法可以包括培养产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的微生物，其中微生物生物体表达至少一种编码甲基丙烯酸途径酶的外源核酸，其量足以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯在条件下和足够的时间以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯。

4. 发明申请

WO2013012975A1 METHODS FOR INCREASING PRODUCT YIELDS 审中-公开
标题翻译：增加产品线的方法
公开(公告)号：WO2013012975A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/047278
申请日：2012-07-19
申请人： GENOMATICA, INC. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P1/04 , C12N1/21
CPC分类号： C12P7/04 , C12N15/52 , C12P7/18 , C12P7/42
摘要： A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a precursor. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.
摘要翻译：非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为前体的产物。另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

5. 发明申请

WO2012177710A1 MICROORGANISMS FOR PRODUCING BUTADIENE AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产二苯乙烯的微生物及其相关方法
公开(公告)号：WO2012177710A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043270
申请日：2012-06-20
申请人： GENOMATICA, INC. , BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C07C29/00 , C12N1/20 , C12N1/00 , C12P7/16
CPC分类号： C12P7/04 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/16
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
摘要翻译：本发明提供具有丁二烯或巴豆醇途径的非天然存在的微生物。本发明另外提供了使用这种生物体来生产丁二烯或巴豆醇的方法。

6. 发明申请

WO2013003432A1 MICROORGANISMS FOR PRODUCING SUCCINATE AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产成功的微生物和与之相关的方法
公开(公告)号：WO2013003432A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/044352
申请日：2012-06-27
申请人： GENOMATICA, INC. , BURGARD, Anthony P. , OSTERHOUT, Robin E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony P. , OSTERHOUT, Robin E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P7/04 , C12N1/21
CPC分类号： C12P7/46 , C12N9/0004
摘要： The invention provides microbial organisms comprising a genetic modification, including one or more genetic modifications, conferring to the microbial organism an increased production of succinate relative to the microbial organism in the absence of the genetic modification. The microbial organism additionally comprises pathways for reductive TCA and/or CO dehydrogenase and/or H 2 hydrogenase.
摘要翻译：本发明提供了包含一种或多种遗传修饰的遗传修饰的微生物生物体，在不存在遗传修饰的情况下赋予微生物生物相对于微生物生物增加的琥珀酸生产。微生物生物体另外包含还原性TCA和/或CO脱氢酶和/或H2氢化酶的途径。

7. 发明申请

WO2012177983A2 MICROORGANISMS FOR PRODUCING ETHYLENE GLYCOL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产乙烯甘油的微生物及其相关方法
公开(公告)号：WO2012177983A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043714
申请日：2012-06-22
申请人： GENOMATICA, INC. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P7/18
CPC分类号： C12P7/18 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms having an ethylene glycol pathway. The invention additionally provides methods of using such organisms to produce ethylene glycol.
摘要翻译：本发明提供了具有乙二醇途径的非天然存在的微生物。本发明另外提供了使用这些生物体生产乙二醇的方法。

8. 发明申请

WO2011031897A1 MICROORGANISMS AND METHODS FOR THE CO-PRODUCTION OF ISOPROPANOL WITH PRIMARY ALCOHOLS, DIOLS AND ACIDS 审中-公开
标题翻译：用主要醇，二醇和酸共同生产异丙酚的微生物和方法
公开(公告)号：WO2011031897A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048318
申请日：2010-09-09
申请人： GENOMATICA, INC. , PHARKYA, Priti , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , BURK, Mark, J. , SUN, Jun
发明人： PHARKYA, Priti , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , BURK, Mark, J. , SUN, Jun
IPC分类号： C12P7/04 , C12N15/74
CPC分类号： C12P7/40 , C12N15/52 , C12P7/04 , C12P7/18
摘要： The invention provides a non-naturally occurring microbial organism having n-propanol and isopropanol pathways, 1,4-butanediol (14-BDO) and isopropanol pathways, 1,3-butanediol (13- BDO) and isopropanol pathways or methylacrylic acid (MAA) and isopropanolpathways. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in each of the respective n-propanol, 14-BDO, 13-BDO or MAA and isopropanol pathways. The invention additionally provides a method for co-producing n-propanol and isopropanol, 14-BDO and isopropanol, 13-BDO and isopropanol or MAA and isopropanol. The method can include culturing an n-propanol and an isopropanol co-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an n-propanol, an isopropanol, a 14-BDO, a 13-BDO and/or a MAA pathway enzyme in a sufficient amount to produce each of the respective products, under conditions and for a sufficient period of time to produce each of the respective products.
摘要翻译：本发明提供具有正丙醇和异丙醇途径的非天然存在的微生物生物，1,4-丁二醇（14-BDO）和异丙醇途径，1,3-丁二醇（13-BDO）和异丙醇途径或甲基丙烯酸（MAA ）和异丙醇通道。微生物生物体含有至少一种外源核酸，其编码在各自的正丙醇，14-BDO，13-BDO或MAA和异丙醇途径中的酶。本发明另外提供了共同生产正丙醇和异丙醇，14-BDO和异丙醇，13-BDO和异丙醇或MAA和异丙醇的方法。该方法可以包括培养正丙醇和异丙醇共同生产微生物，其中微生物生物体表达至少一种编码正丙醇，异丙醇，14-BDO，13-BDO和/或足够量的MAA途径酶，以在产生各个产物的条件下和足够的时间段内产生各个产物。

9. 发明申请

WO2012177943A1 MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及其相关方法
公开(公告)号：WO2012177943A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043638
申请日：2012-06-21
申请人： GENOMATICA, INC. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P7/04 , C12N1/12
CPC分类号： C12N15/52 , C12N9/0008 , C12P7/16 , C12P7/18 , C12P7/42 , C12Y102/99006 , Y02E50/10
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4- hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A， - 羟基丁醛或腐胺通路酶以足够的量表达以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺，并进一步优化BDO的表达。本发明另外提供了使用这些微生物生产BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

10. 发明申请

WO2012106516A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE 审中-公开
标题翻译：二苯乙烯生物合成的微生物和方法
公开(公告)号：WO2012106516A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023632
申请日：2012-02-02
申请人： GENOMATICA, INC. , BURK, Mark, J. , BURGARD, Anthony, P. , SUN, Jun , OSTERHOUT, Robin, E. , PHARKYA, Priti
发明人： BURK, Mark, J. , BURGARD, Anthony, P. , SUN, Jun , OSTERHOUT, Robin, E. , PHARKYA, Priti
IPC分类号： C12P5/02
CPC分类号： C12P5/02 , C07C1/24 , C07C2521/04 , C07C2521/12 , C07C2521/16 , C07C2523/10 , C07C2523/28 , C07C2523/31 , C07C2523/745 , C07C2527/167 , C07C2527/173 , C12N15/52 , C12P5/026 , C12P7/04 , Y02E50/343 , C07C11/167
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene. In some aspects, embodiments disclosed herein relate to a process for the production of butadiene that includes (a) culturing by fermentation in a sufficient amount of nutrients and media a non-naturally occurring microbial organism that produces crotyl alcohol; and (b) converting crotyl alcohol, produced by culturing the non-naturally occurring microbial organism, to butadiene.
摘要翻译：本发明提供了具有丁二烯途径的非天然存在的微生物。本发明另外提供了使用这些生物体来生产丁二烯的方法。在一些方面，本文公开的实施方案涉及生产丁二烯的方法，其包括（a）通过发酵培养足量的营养物和培养基，产生产生巴豆醇的非天然存在的微生物; 和（b）将通过培养非天然存在的微生物生物产生的巴豆醇转化为丁二烯。

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