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1. 发明申请

WO2009046370A3 BIOFUEL PRODUCTION 审中-公开
标题翻译：生物燃料生产
公开(公告)号：WO2009046370A3
公开(公告)日：2009-10-29
申请号：PCT/US2008078844
申请日：2008-10-03
申请人： BIO ARCHITECTURE LAB INC , UNIV WASHINGTON , KASHIYAMA YUKI , YOSHIKUNI YASUO , BAKER DAVID , SIEGEL JUSTIN B
发明人： KASHIYAMA YUKI , YOSHIKUNI YASUO , BAKER DAVID , SIEGEL JUSTIN B
IPC分类号： C12P7/00 , C12P1/00 , C12P1/02 , C12P1/04 , C12P7/08 , C12P7/16
CPC分类号： C12N15/70 , C12P5/02 , C12P5/026 , C12P7/02 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/18 , C12P7/22 , C12P7/26 , C12P7/38 , C12P17/10 , Y02E50/10 , Y02E50/17 , Y02T50/678
摘要： Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched refinery-produced petroleum products are also provided, as well as methods for producing the same.
摘要翻译：提供了方法，酶，重组微生物和微生物系统用于将多糖例如衍生自生物质的多糖转化成合适的单糖或低聚糖，以及用于将合适的单糖或寡糖转化为商品化学品，例如生物燃料。还提供了通过本文所述的方法生产的商品化学品。还提供了商品化学品富集的炼油厂生产的石油产品，以及生产该产品的方法。

2. 发明申请

WO2009046370A8 BIOFUEL PRODUCTION 审中-公开
公开(公告)号：WO2009046370A8
公开(公告)日：2009-07-23
申请号：PCT/US2008078844
申请日：2008-10-03
申请人： BIO ARCHITECTURE LAB INC , UNIV WASHINGTON , KASHIYAMA YUKI , YOSHIKUNI YASUO , BAKER DAVID , SIEGEL JUSTIN B
发明人： KASHIYAMA YUKI , YOSHIKUNI YASUO , BAKER DAVID , SIEGEL JUSTIN B
IPC分类号： C12P7/00 , C12P1/00 , C12P1/02 , C12P1/04 , C12P7/08 , C12P7/16
CPC分类号： C12N15/70 , C12P5/02 , C12P5/026 , C12P7/02 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/18 , C12P7/22 , C12P7/26 , C12P7/38 , C12P17/10 , Y02E50/10 , Y02E50/17 , Y02T50/678
摘要： Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched refinery-produced petroleum products are also provided, as well as methods for producing the same.

3. 发明申请

WO2012048115A3 POLYPEPTIDES AND THEIR USE IN TREATING AND LIMITING RESPIRATORY SYNCYTIAL VIRUS INFECTION 审中-公开
标题翻译：多肽及其在治疗和限制呼吸道感染病毒感染中的应用
公开(公告)号：WO2012048115A3
公开(公告)日：2012-06-21
申请号：PCT/US2011055113
申请日：2011-10-06
申请人： UNIV WASHINGTON CT COMMERCIALI , SCHIEF WILLIAM R , CORREIA BRUNO E , BAKER DAVID
发明人： SCHIEF WILLIAM R , CORREIA BRUNO E , BAKER DAVID
IPC分类号： C07K14/435
CPC分类号： C07K14/001 , A61K39/00 , A61K39/12 , A61K2039/552 , A61K2039/55566 , A61K2039/6075 , C07K14/005 , C12N2760/18522 , C12N2760/18534 , G06F19/16
摘要： The present invention provides polypeptides and compositions thereof for treating or limiting respiratory syncytial virus infection, and computational methods for designing such polypeptides.
摘要翻译：本发明提供了用于治疗或限制呼吸道合胞病毒感染的多肽及其组合物，以及用于设计这种多肽的计算方法。

4. 发明申请

WO2012037413A2 SYSTEMS AND METHODS FOR BIOTRANSFORMATION OF CARBON DIOXIDE INTO HIGHER CARBON COMPOUNDS 审中-公开
标题翻译：将二氧化碳生物转化为高碳化合物的系统和方法
公开(公告)号：WO2012037413A2
公开(公告)日：2012-03-22
申请号：PCT/US2011051847
申请日：2011-09-15
申请人： UNIV WASHINGTON CT COMMERCIALI , SIEGEL JUSTIN , BAKER DAVID , SMITH AMANDA LEE , LIDSTROM MARY E , LOUW CATHERINE
发明人： SIEGEL JUSTIN , BAKER DAVID , SMITH AMANDA LEE , LIDSTROM MARY E , LOUW CATHERINE
IPC分类号： C12P7/28 , C12N15/53 , C12N15/60 , C12P7/24
CPC分类号： C12N9/88 , C12P7/24 , C12P7/26 , C12Y401/02038
摘要： Systems, compounds and methods for the conversion of C1 carbon compounds to higher carbon compounds useful for the generation of commodity compounds.
摘要翻译：用于将C1碳化合物转化为可用于生成商品化合物的较高碳化合物的系统，化合物和方法。

5. 发明申请

WO2012018907A2 POLYPEPTIDES FOR TREATING AND/OR LIMITING INFLUENZA INFECTION 审中-公开
标题翻译：用于治疗和/或限制流感病毒感染的多肽
公开(公告)号：WO2012018907A2
公开(公告)日：2012-02-09
申请号：PCT/US2011046414
申请日：2011-08-03
申请人： UNIV WASHINGTON CT COMMERCIALI , BAKER DAVID , WHITEHEAD TIMOTHY A , FLEISHMAN SAREL
发明人： BAKER DAVID , WHITEHEAD TIMOTHY A , FLEISHMAN SAREL
IPC分类号： A61K38/10
CPC分类号： C07K7/08 , A61K38/00 , A61K38/10 , A61K38/16 , C07K14/00 , C07K14/001 , G01N33/53 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier. Additionally, the present invention provides methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection.
摘要翻译：本发明提供根据本文公开的通式的多肽，其识别并且是甲型流感血凝素的强结合剂，并且可以用于例如治疗和/或限制流感感染的发展。本发明还提供了编码本发明多肽的分离的核酸，包含编码本发明多肽的核酸的重组表达载体，其可操作地连接到合适的控制序列，以及包含本发明的重组表达载体的重组宿主细胞。本发明还提供了选择性结合本发明多肽的抗体，以及包含一种或多种本发明多肽和药学上可接受的载体的药物组合物。此外，本发明提供了用于治疗和/或限制流感感染的方法，用于诊断流感感染的方法或监测流感感染的进展，用于鉴定候选流感疫苗的方法，以及用于鉴定候选化合物的方法，用于治疗，限制，和/或诊断流感感染。

6. 发明申请

WO2009076655A3 SYNTHETIC ENZYMES DERIVED FROM COMPUTATIONAL DESIGN 审中-公开
标题翻译：从计算设计衍生的合成酶
公开(公告)号：WO2009076655A3
公开(公告)日：2009-12-30
申请号：PCT/US2008086715
申请日：2008-12-12
申请人： UNIV WASHINGTON , BAKER DAVID , ZANGHELLINI ALEXANDRE , JIANG LIN , WOLLACOTT ANDREW , GRABS-ROTHLISBERGER DANIELA , ALTHOFF ERIC
发明人： BAKER DAVID , ZANGHELLINI ALEXANDRE , JIANG LIN , WOLLACOTT ANDREW , GRABS-ROTHLISBERGER DANIELA , ALTHOFF ERIC
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , G06F19/24
摘要： Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases.
摘要翻译：本文公开了用于计算设计酶的技术。这些技术可用于设计天然存在的酶的变体，以及不具有天然对应物的新酶。这些技术基于首先鉴定促进所需反应所需的功能性反应位点。然后，使用散列算法来鉴定能够支持所需功能位点的潜在的蛋白质主链结构（即支架）。这些技术用于设计出显示醛醇反应催化功能的32种不同的蛋白质序列，其中31种在序列表中定义。提供了这31种不同合成醛缩酶的细节，包括如何将这些合成醛缩酶与天然存在的醛缩酶相区分。

7. 发明申请

WO2013003752A3 METHODS FOR DESIGN OF EPITOPE SCAFFOLDS 审中-公开
标题翻译： EPITOPE SCAFFOLDS的设计方法
公开(公告)号：WO2013003752A3
公开(公告)日：2014-11-27
申请号：PCT/US2012044996
申请日：2012-06-29
申请人： UNIV WASHINGTON CT COMMERCIALI , SCHIEF WILLIAM R , CORREIA BRUNO E , AZOITEI MIHAI L , BAN YIH-EN ANDREW , BAKER DAVID
发明人： SCHIEF WILLIAM R , CORREIA BRUNO E , AZOITEI MIHAI L , BAN YIH-EN ANDREW , BAKER DAVID
IPC分类号： G06F19/16
CPC分类号： G06F19/16
摘要： Methods and apparatus for designing a functional protein scaffold are disclosed. A scaffold search is performed using a computing device. The scaffold search includes a search of a protein structure library for a native structure similar to a structure of a functional motif. The native structure can be supported by a protein scaffold. The native structure can be removed from the protein scaffold to create a protein sequence gap. The functional protein scaffold can be designed by inserting the functional motif into the sequence gap. The functional protein scaffold can be for targeting mAb b12.
摘要翻译：公开了设计功能性蛋白质支架的方法和设备。使用计算设备执行脚手架搜索。支架搜索包括蛋白质结构库的搜索，其类似于功能基序的结构的天然结构。天然结构可以由蛋白质支架支持。可以从蛋白质支架中除去天然结构以产生蛋白质序列缺口。可以通过将功能基序插入到序列间隙中来设计功能性蛋白质支架。功能性蛋白质支架可用于靶向mAb b12。

8. 发明申请

WO2013023151A3 COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE 审中-公开
标题翻译：治疗CELIAC SPRUE疾病的组合物和方法
公开(公告)号：WO2013023151A3
公开(公告)日：2013-07-18
申请号：PCT/US2012050364
申请日：2012-08-10
申请人： UNIV WASHINGTON CT COMMERCIALI , SIEGEL JUSTIN , BAKER DAVID , GORDON SYDNEY RIN ANNA , PULTZ INGRID SWANSON , STANLEY ELIZABETH JOY , WOLF SARAH JANE
发明人： SIEGEL JUSTIN , BAKER DAVID , GORDON SYDNEY RIN ANNA , PULTZ INGRID SWANSON , STANLEY ELIZABETH JOY , WOLF SARAH JANE
IPC分类号： C12N15/09
CPC分类号： A61K38/482 , A61K38/48 , C12N9/50 , C12N9/52 , C12Y304/21
摘要： The invention provides compositions and methods for treating celiac sprue.
摘要翻译：本发明提供了用于治疗腹腔灌注的组合物和方法。

9. 发明申请

WO2010077470A3 ENZYME CATALYSTS FOR DIELS-ALDER REACTIONS 审中-公开
标题翻译：用于DIELS反应的酶催化剂
公开(公告)号：WO2010077470A3
公开(公告)日：2010-10-21
申请号：PCT/US2009065127
申请日：2009-11-19
申请人： UNIV WASHINGTON , BAKER DAVID , ZANGHELLINI ALEXANDRE , SIEGEL JUSTIN , SAINT-CLAIR JENNIFER
发明人： BAKER DAVID , ZANGHELLINI ALEXANDRE , SIEGEL JUSTIN , SAINT-CLAIR JENNIFER
IPC分类号： C12N9/10
CPC分类号： C12N9/90 , C12N9/10 , C12N9/16 , C12Y301/08002 , C12Y503/03001
摘要： The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of catalyzing a desired Diels-Alder reaction, including with a specified or desired stereo-selectivity.
摘要翻译：本发明提供了用于Diels-Alder反应的酶催化剂，包括分子间Diels-Alder反应，以及用于制备这种酶催化剂的蛋白质支架。在其他方面，本发明提供了制造酶催化剂的方法，包括通过从头计算设计。由此本发明提供了能够催化所需Diels-Alder反应的酶催化剂，包括具有特定或所需的立体选择性。

10. 发明申请

WO2008025015A8 EPITOPE-PROTEIN SCAFFOLDS AND THEIR USE 审中-公开
标题翻译： EPITOPE-蛋白质组合物及其使用
公开(公告)号：WO2008025015A8
公开(公告)日：2009-04-09
申请号：PCT/US2007076824
申请日：2007-08-24
申请人： US GOV HEALTH & HUMAN SERV , UNIV WASHINGTON , KWONG PETER , OFEK GILAD , GUENAGA JAVIER , WYATT RICHARD T , YANG ZHI-YONG , ZHOU TONGQING , NABEL GARY , TANG MIN , SCHIEF WILLIAM , BAKER DAVID
发明人： KWONG PETER , OFEK GILAD , GUENAGA JAVIER , WYATT RICHARD T , YANG ZHI-YONG , ZHOU TONGQING , NABEL GARY , TANG MIN , SCHIEF WILLIAM , BAKER DAVID
IPC分类号： G06F19/00
CPC分类号： G06F19/16
摘要： Computational protocols for the design of epitope-protein scaffolds which elicit selected neutralizing antibodies are disclosed, and related compositions and uses.
摘要翻译：公开了引发选定的中和抗体的表位 - 蛋白质支架设计的计算方案，以及相关的组合物和用途。

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