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1. 发明申请

WO2005028639A3 ENVIRONMENTS THAT MAINTAIN FUNCTION OF PRIMARY LIVER CELLS 审中-公开
标题翻译：保持主要肝细胞功能的环境
公开(公告)号：WO2005028639A3
公开(公告)日：2005-06-16
申请号：PCT/US2004029466
申请日：2004-09-10
申请人： BECTON DICKINSON CO , GUARINO RICHARD DAVID , PRESNELL SHARON C , LIEBMANN-VINSON ANDREA , HEIDARAN MOHAMMAD A , HEMPERLY JOHN J , JURGENSEN STEWART , LAETHEM RONALD M , ROBBINS NEIL
发明人： GUARINO RICHARD DAVID , PRESNELL SHARON C , LIEBMANN-VINSON ANDREA , HEIDARAN MOHAMMAD A , HEMPERLY JOHN J , JURGENSEN STEWART , LAETHEM RONALD M , ROBBINS NEIL
IPC分类号： C12N5/071 , G01N33/50 , C12N5/06 , C12N5/08
CPC分类号： G01N33/5067 , C12N5/067 , C12N5/0671 , C12N2533/32 , C12N2533/54
摘要： Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, an ECM protein, or a biologically active fragment or variant thereof such as elastin, fibronectin, vitronectin, laminin, collagen I, collagen III, collagen IV, and collagen VI. Also, optionally present on the surface is an active factor, preferably a polycationic polymer or a biologically active fragment or variant thereof, such as polyethyleneimine (PEI), poly-D-lysine (PDL), poly-L-lysine (PLL), poly-D-ornithine (PDO) or poly-L-ornithine (PLO). This surface is used in cell culture to promote cell attachment, survival, maintenance of function, and/or proliferation of primary liver cells. The invention also relates to methods utilizing this surface, such as methods for attachment, survival, maintenance of function, and/or proliferation of cells. Further disclosed is the use of the surface in cell culture with serum-free medium. Methods of screening using the surface of the invention are also disclosed.
摘要翻译：用于细胞培养的表面包括与CAR材料结合的载体，并结合CAR材料，ECM蛋白或其生物活性片段或变体如弹性蛋白，纤连蛋白，玻连蛋白，层粘连蛋白，胶原I，胶原 III，胶原IV和胶原蛋白VI。此外，表面上任选存在的是活性因子，优选聚阳离子聚合物或其生物活性片段或变体，例如聚乙烯亚胺（PEI），聚-D-赖氨酸（PDL），聚-L-赖氨酸（PLL），聚-D-鸟氨酸（PDO）或聚-L-鸟氨酸（PLO）。该表面用于细胞培养以促进细胞附着，存活，功能的维持和/或原代肝细胞的增殖。本发明还涉及利用该表面的方法，例如附着，存活，维持功能和/或细胞增殖的方法。进一步披露的是用无血清培养基在细胞培养中使用表面。还公开了使用本发明的表面进行筛选的方法。

2. 发明申请

WO2005016283A3 PEPTIDES FOR ENHANCED CELL ATTACHMENT AND GROWTH 审中-公开
标题翻译：用于增强细胞附着和生长的肽
公开(公告)号：WO2005016283A3
公开(公告)日：2005-03-31
申请号：PCT/US2004026372
申请日：2004-08-13
申请人： BECTON DICKINSON CO , GUARINO RICHARD DAVID , CHANEY BRYCE NELSON , LIEBMANN-VINSON ANDREA , HAALAND PERRY D , HEIDARAN MOHAMMAD A
发明人： GUARINO RICHARD DAVID , CHANEY BRYCE NELSON , LIEBMANN-VINSON ANDREA , HAALAND PERRY D , HEIDARAN MOHAMMAD A
IPC分类号： A61K20060101 , C07K5/083 , C07K5/103 , C07K5/11 , C07K7/06 , C07K14/78 , C07K17/02 , C12N5/02 , C12N5/06
CPC分类号： C07K7/06 , B33Y70/00 , B33Y80/00 , C07K5/0806 , C07K5/1008 , C07K5/1019
摘要： The present invention relates to cell adhesion promoting ("CAP") peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant "CAR". The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created on a polystyrene surface, promote cell attachment, growth differentiation, and execution of other desired cellular functions in culture.
摘要翻译：本发明涉及促进细胞附着或细胞粘附于培养表面的细胞粘附促进（“CAP”）肽组合，所述培养表面否则为细胞粘附抗性的“CAR”。本发明提供了肽的组合，当共价偶联到已经在聚苯乙烯表面上产生的透明质酸等CAR层时，促进细胞附着，生长分化和在培养中执行其他期望的细胞功能。

3. 发明申请

WO2004031266A3 CELL ADHESION RESISTING SURFACES 审中-公开
标题翻译：细胞粘附电阻表面
公开(公告)号：WO2004031266A3
公开(公告)日：2004-12-23
申请号：PCT/US0330479
申请日：2003-09-29
申请人： BECTON DICKINSON CO , LIEBMANN-VINSON ANDREA , CLARKE RICHARD P , XU RUILING , HEIDARAN MOHAMMAD A
发明人： LIEBMANN-VINSON ANDREA , CLARKE RICHARD P , XU RUILING , HEIDARAN MOHAMMAD A
IPC分类号： C12N5/00 , H05H1/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00
CPC分类号： C12N5/0068 , C12N2533/80 , Y10T428/13 , Y10T428/1352
摘要： A coated surface that resists cell adhesion comprising hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).
摘要翻译：一种抗细胞粘附的涂层表面，其包含与等离子体处理的聚合物表面直接结合的透明质酸。通过连接配体结合多肽（抗体或抗体结合蛋白），透明质酸的进一步修饰也被公开。

4. 发明申请

WO2005035735A2 PROGRAMMABLE SCAFFOLD, AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：可编程脚手架，以及制造和使用它的方法
公开(公告)号：WO2005035735A2
公开(公告)日：2005-04-21
申请号：PCT/US2004027865
申请日：2004-08-26
申请人： BECTON DICKINSON CO , ROWLEY JONATHAN A , HEIDARAN MOHAMMAD A
发明人： ROWLEY JONATHAN A , HEIDARAN MOHAMMAD A
IPC分类号： A61K35/12 , A61L27/38 , A61L27/54 , A61L27/56 , C12N5/00 , C12N5/02 , C12N5/08
CPC分类号： C12N5/0068 , A61K35/12 , A61L27/38 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , A61L2300/604 , C12N2501/998 , C12N2533/30 , C12N2533/54 , C12N2533/72 , C12N2533/74 , C12N2533/80 , C12N2533/90
摘要： The present invention relates to a programmable scaffold, which is a three-dimensional scaffold having interconnected pores and biologically active molecules physically entrapped therein. The scaffold is a lyophilized hydrogel of a polymer. The scaffold can be used in an array on a platform and loaded with various combinations of biologically active molecules for high throughput and parallel screening, as well as tissue engineering. The present invention also relates to methods for making and modifying the scaffolds.
摘要翻译：可编程脚手架本发明涉及一种可编程脚手架，其是具有相互连接的孔和物理包埋在其中的生物活性分子的三维支架。支架是聚合物的冻干水凝胶。该支架可以用于平台上的阵列，并装载有生物活性分子的各种组合用于高通量和平行筛选以及组织工程。本发明还涉及制造和改性支架的方法。

5. 发明申请

WO2005033833A3 COMPUTER SOFTWARE AND ALGORITHMS FOR SYSTEMS BIOLOGICALLY LINKED TO CELLULAR PHENOTYPE 审中-公开
标题翻译：系统的计算机软件和算法生物学链接到细胞基因
公开(公告)号：WO2005033833A3
公开(公告)日：2006-07-20
申请号：PCT/US2004027862
申请日：2004-08-26
申请人： BECTON DICKINSON CO , HAALAND PERRY D , HEIDARAN MOHAMMAD A
发明人： HAALAND PERRY D , HEIDARAN MOHAMMAD A
IPC分类号： G06K9/00 , C12M1/34 , C12M3/00 , C40B60/14 , G01N33/48 , G01N33/50 , G06F20060101 , G06F15/00 , G06F17/18 , G06F19/00 , G06G7/48 , G06G7/58 , G06Q50/00
CPC分类号： G06F19/18 , B01J2219/00306 , B01J2219/00691 , B01J2219/00695 , B01J2219/007 , B01J2219/00743 , C40B60/14 , G06F19/20 , G06F19/28
摘要： An automated method and system for identifying agents capable of eliciting a phenotypic change in a cell-type is provided. The method includes the steps of: providing receptacles in an array; and providing a statistical design including generic factor names, factor levels and experimental runs. The method further includes the steps of utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, by mapping the concentration or amounts of the agents to the factor levels and by mapping the locations of the receptacles within the array to the experimental runs. The method also includes placing different mixtures of single agents into receptacles in the array based on the computer representation of the statistical design; contacting the placed mixtures with cells; acquiring experimental data from the contacted cells; and utilizing a processor including an algorithm for comparing the acquired data with the statistical design to identify particular agent mixtures or single agents that cause a phenotypic change in the contacted cells.
摘要翻译：提供了一种用于鉴定能够引发细胞型表型变化的试剂的自动化方法和系统。该方法包括以下步骤：提供阵列中的插座; 并提供统计设计，包括通用因素名称，因子水平和实验运行。该方法还包括以下步骤：利用软件程序通过将代理的身份自动映射到通用因素名称来生成统计设计的计算机表示，通过将代理的浓度或数量映射到因子级别并通过映射阵列内的插座的位置到实验运行。该方法还包括基于统计设计的计算机表示将单个试剂的不同混合物放置在阵列中的容器中; 将放置的混合物与细胞接触; 从接触的细胞获取实验数据; 以及利用包括用于将所获取的数据与所述统计设计进行比较的算法的处理器，以识别在所接触的细胞中引起表型变化的特定试剂混合物或单一试剂。

6. 发明申请

WO2007146123A3 PLACENTAL NICHE AND USE THEREOF TO CULTURE STEM CELLS 审中-公开
标题翻译：特别的NICHE及其用于培养干细胞
公开(公告)号：WO2007146123A3
公开(公告)日：2008-04-24
申请号：PCT/US2007013507
申请日：2007-06-08
申请人： ANTHROGENESIS CORP , HEIDARAN MOHAMMAD A
发明人： HEIDARAN MOHAMMAD A
IPC分类号： C12N5/073
CPC分类号： C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/92
摘要： The present invention provides methods for culturing, expanding and differentiating stem cells, particularly human embryonic stem cells. The methods comprise culturing the stem cells for a period of time on a collagen biofabric, particularly a collagen biofabric derived from the amniotic membrane, chorion, or both, from mammalian placenta.
摘要翻译：本发明提供了培养，扩增和分化干细胞，特别是人胚胎干细胞的方法。所述方法包括在哺乳动物胎盘上胶原生物制剂，特别是衍生自羊膜，绒毛膜或两者的胶原生物制剂将干细胞培养一段时间。

7. 发明公开

EP1664994A4 COMPUTER SOFTWARE AND ALGORITHMS FOR SYSTEMS BIOLOGICALLY LINKED TO CELLULAR PHENOTYPE 审中-公开
标题翻译：计算机软件和算法对生物与细胞表型链系统
公开(公告)号：EP1664994A4
公开(公告)日：2010-03-31
申请号：EP04782358
申请日：2004-08-26
申请人： BECTON DICKINSON CO
发明人： HAALAND PERRY D , HEIDARAN MOHAMMAD A
IPC分类号： G06F19/00 , C12M1/34 , C12M3/00 , C40B60/14 , G01N33/48 , G01N33/50 , G06F20060101 , G06F15/00 , G06F17/18 , G06G7/48 , G06G7/58 , G06K9/00 , G06Q50/00
CPC分类号： G06F19/18 , B01J2219/00306 , B01J2219/00691 , B01J2219/00695 , B01J2219/007 , B01J2219/00743 , C40B60/14 , G06F19/20 , G06F19/28

8. 发明公开

EP1547451A4 CELL ADHESION RESISTING SURFACES 审中-公开
标题翻译：细胞责任反对常设曲面
公开(公告)号：EP1547451A4
公开(公告)日：2007-03-07
申请号：EP03770507
申请日：2003-09-29
申请人： BECTON DICKINSON CO
发明人： LIEBMANN-VINSON ANDREA , CLARKE RICHARD P , XU RUILING , HEIDARAN MOHAMMAD A
IPC分类号： H05H1/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00 , C12N5/00
CPC分类号： C12N5/0068 , C12N2533/80 , Y10T428/13 , Y10T428/1352
摘要： A coated surface that resists cell adhesion comprising hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).

9. 发明专利

AU2002334746B2 Methods and devices for the integrated discovery of cell culture environments 未知
公开(公告)号：AU2002334746B2
公开(公告)日：2007-10-11
申请号：AU2002334746
申请日：2002-09-30
申请人： BECTON DICKINSON CO
发明人： HEIDARAN MOHAMMAD A , ROWLEY JOHN A , MEYER MARY K , HEMPERLY JOHN J
IPC分类号： C12M3/00 , C12M1/22 , C12M1/34 , C12N5/00 , C12N5/077 , G01N33/53 , G01N33/567
摘要： The present invention is directed to methods and devices which can be used to test bioactive agents alone or in conjunction with 3D scaffolds for their effect on cell growth, differentiation, and other cellular functions.

10. 发明专利

BR0314825A 未知
公开(公告)号：BR0314825A
公开(公告)日：2005-08-16
申请号：BR0314825
申请日：2003-09-29
申请人： BECTON DICKINSON CO
发明人： LIEBMANN-VINSON ANDREA , CLARKE RICHARD P , XU RUILING , HEIDARAN MOHAMMAD A
IPC分类号： C12N5/00
摘要： A coated surface that resists cell adhesion comprises hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).

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